Navigation Links
Immune cells need a second opinion
Date:2/4/2014

sible," reports Prof. Kurts. The neutrophils are regulated by other immune cells, known as macrophages. It has been known for a long time that macrophages produce various messengers which influence other immune cells. How they regulate the neutrophils has been unclear to date, however.

The team of researchers has now figured out that this regulation takes place through two types of macrophages. "An important result is that these two types of macrophages perform different functions," says Prof. Kurts. One type of macrophage is present in all tissues and exerts a sentinel function. As soon as pathogens penetrate, they are detected by these sentinel macrophages which then trigger an alarm. This takes place through the release of certain messenger moleculess, the chemokines, which lure the neutrophils into infected tissue in the bladder, in this case.

Safety mechanism for potent defense cells

In addition, the sentinel macrophages lure the other type, which the scientists refer to as helper macrophages. These cells likewise discern that there is an infection and communicate this to the sentinel macrophages. The latter then begin to release other chemokines, which allows the neutrophils to reach the bacteria in the infected part of the bladder. "The sentinel macrophages obtain a second opinion as to whether the infection they discerned is so dangerous that the neutrophils should be activated," explains Dr. Engel. This is a safety mechanism whereby the potent defense cells only penetrate into the infected part of the bladder if there is actual danger.

The communication between the two types of macrophages takes place via the messenger tumor necrosis factor (TNF). "This molecule plays a central role in various immune-mediated diseases," says Prof. Kurts. Using drugs that block TNF, rheumatoid arthritis or chronic inflammatory bowel disease, for example, can be treated very effectively. However, bacterial infections, including uri
'/>"/>

Contact: Dr. Daniel Engel
daniel.engel@uni-bonn.de
49-228-287-11050
University of Bonn
Source:Eurekalert  

Page: 1 2 3

Related medicine news :

1. Benaroya Research Institute receives 7-year award to lead Immune Tolerance Network
2. FASEB announces 2014 Science Research Conference: Biology of the Immune System
3. Voices Against Brain Cancer Comments On How Boosting One’s Immune System Can Help Fight Tumor Growth
4. Platinum Soursop: The Natural Health Supplement Helps to Improve Cells Functions & Supports Immune System Now with 1 Extra Bottle Offer
5. Does the bodys immune response to viral vector delivery systems affect the safety or efficacy of gene therapy?
6. Platinum Soursop-The natural health supplement to improve immune system and enhance Mood is finally available for purchase
7. PDL-1 antibody could help immune system fight off influenza viral infection, study suggests
8. Boosting the immune system to treat brain cancer
9. Predicting ovarian cancer survival through tumor-attacking immune cells
10. Golden staph paralyzes our immune defenses
11. Study identifies protein essential for immune recognition, response to viral infection
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Immune cells need a second opinion
(Date:12/25/2014)... “Every three months the trends for ... evening dress will be one of the hottest styles in ... says. Today, the company releases 26 A-line sweetheart evening dresses, ... off. , “We are trying our best to help ... latest designs. Along with affordable prices, we provide discounted delivery ...
(Date:12/25/2014)... Los Angeles, CA (PRWEB) December 25, 2014 ... Blaise Dolcemaschio was created in honor of a true ... premiere at two film festivals including the 24 hours of ... Film Festival in Bangladesh. , Actress, screenwriter and ... and helped produce this film together with her husband, ...
(Date:12/25/2014)... Helen Harris’ RP (Retinitis Pigmentosa) International founder ... an 8 year battle with breast cancer. , ... her home in Woodland Hills California after an 8 ... , As the founder and volunteer President of ... championed many of today's greatest breakthroughs in restoring and ...
(Date:12/25/2014)... Dennis Thompson HealthDay Reporter ... children with complex chronic illnesses can receive effective, less expensive ... with easy access to a team of dedicated health care ... to become seriously ill and need either hospitalization or a ... an enhanced medical home clinic at the University of Texas ...
(Date:12/25/2014)... -- Among early stage breast cancer patients who undergo ... percent will eventually develop leukemia as a result of ... comes from a review of more than 20,000 breast ... suggests that the risk for developing treatment-related leukemia, though ... "The frequency of bone marrow cancers such as ...
Breaking Medicine News(10 mins):Health News:The True 9/11 Hero Story “Color of Honor” Premieres in Germany and Bangladesh: Luciana Lagana Plays the Mother of the Lead and Co-Produces with Blaise Dolcemaschio. 2Health News:The True 9/11 Hero Story “Color of Honor” Premieres in Germany and Bangladesh: Luciana Lagana Plays the Mother of the Lead and Co-Produces with Blaise Dolcemaschio. 3Health News:RP International founder, Helen Harris Dies on Christmas Eve Just Hours Before Her Holiday Television Broadcast to Raise Funds to Cure Blindness was Broadcasted Nationally 2Health News:RP International founder, Helen Harris Dies on Christmas Eve Just Hours Before Her Holiday Television Broadcast to Raise Funds to Cure Blindness was Broadcasted Nationally 3Health News:RP International founder, Helen Harris Dies on Christmas Eve Just Hours Before Her Holiday Television Broadcast to Raise Funds to Cure Blindness was Broadcasted Nationally 4Health News:Coordinated Care Through 'Medical Home' Best for Chronically Ill Kids: Study 2Health News:Coordinated Care Through 'Medical Home' Best for Chronically Ill Kids: Study 3Health News:Breast Cancer Chemo Tied to Small But Significant Leukemia Risk 2Health News:Breast Cancer Chemo Tied to Small But Significant Leukemia Risk 3
... CST-Arwin will represent the complete AC and DC line of axial ... more than 100 axial fans ranging in size from 25mm to ... ... -- NMB Technologies Corporation, a Minebea Group Company, and CST-Arwin, a ...
... WASHINGTON, DC, November 3, 2008 Parents are surprisingly ... visit to their child,s pediatrician, including those who have ... would look to their pediatrician for a referral, according ... the journal Pediatrics . , "This is a ...
... 3, 2008) Influenza vaccination rates for adolescents who suffer ... low, according to a recent study. , ... Pediatrics, was based at the Department of ... Harvard Pilgrim Health Care. , "Influenza vaccination has been ...
... RAMSEY, N.J., Nov. 3 Konica Minolta ... the industrial measurement of color,light and shape, ... Analysis Software.,This new software product used in ... accurate measurement of skin,color simultaneously with a ...
... two-pronged attack, a novel designer molecule fights malignant melanoma. It ... led by the University of Bonn. On the one hand, ... this way alerts the immune system. The body,s own defences ... the same time, the novel molecule also puts pressure on ...
... to Ask Voters ... of Health Care, TRENTON, N.J., Nov. 1 Calling themselves ... forces to ask the state,s public policy makers to put health ... level. The First Ladies,joined the newest members of the Partnership to ...
Cached Medicine News:Health News:NMB's Fans and Blowers to be Represented in Canada by CST-Arwin 2Health News:Parents comfortable with alcohol screening in pediatricians' offices 2Health News:Parents comfortable with alcohol screening in pediatricians' offices 3Health News:Flu vaccination rates lag for at-risk adolescents 2Health News:Konica Minolta Sensing Americas Announces the Launch of the CM-SA Skin Analysis Software 2Health News:Substance tackles skin cancer from 2 sides 2Health News:On Weekend Before the Election, New Jersey's First Ladies Speak Out for Healthcare 2Health News:On Weekend Before the Election, New Jersey's First Ladies Speak Out for Healthcare 3
(Date:12/24/2014)... PHILADELPHIA , Dec. 23, 2014 ... a medical device company focused on skin permeation, ... that Scott W. Hollander has been ... Mr. Hollander has more than 20 years of ... equipment industries, and most recently served as Vice ...
(Date:12/24/2014)... 23, 2014 ResMed (NYSE: RMD ) ... against Chinese medical device manufacturer BMC Medical Co., Ltd. ... BMC,s masks listed below infringe ResMed,s patents, and entered an ... in the United States : ... , Willow nasal pillows mask , iVolve full ...
(Date:12/24/2014)... 2014   Synageva BioPharma Corp. (NASDAQ: ... therapeutic products for rare disorders, today announced validation ... Marketing Authorization Application (MAA) for sebelipase alfa for ... request for accelerated assessment, which has the potential ... The MAA, and the Biologics License ...
Breaking Medicine Technology:Echo Therapeutics Announces Scott W. Hollander as President & Chief Executive Officer 2Echo Therapeutics Announces Scott W. Hollander as President & Chief Executive Officer 3ResMed Wins Patent Infringement Lawsuit Against Chinese Manufacturer BMC Medical 2Synageva BioPharma Announces Sebelipase Alfa Marketing Authorization Application Validated By The EMA 2Synageva BioPharma Announces Sebelipase Alfa Marketing Authorization Application Validated By The EMA 3
... from Mayo ClinicROCHESTER, Minn., March 23 Here ... Edge, Mayo Clinic,s research magazine. You may cite ... you wish. Reprinting is allowed with proper attribution. ... editorial policies permit: Visit http://discoverysedge.mayo.edu for ...
... Since 1993, when the PLCO trial was started, we have ... have others. The initial report of the results of this ... published last week in the New England Journal of Medicine ... The studies offer conflicting evidence about the possibility of a ...
Cached Medicine Technology:Discovery's Edge Spring Issue - http://discoverysedge.mayo.edu 2A Joint Statement From America's Prostate Cancer Advocacy, Education, and Support Organizations 2A Joint Statement From America's Prostate Cancer Advocacy, Education, and Support Organizations 3
Microalbumin Linearity Control...
Total IgE Control...
The K-ASSAY Lipid Controls are assayed controls produced from fresh human sera to monitor the accuracy and precision of quantitative lipid determinations of human sera specimens....
The K-ASSAY hs-CRP Control Set is intended to be used as a consistent test sample of known concentrations for monitoring the performance of hs-CRP (high sensitive C-Reactive Protein) immunoturbimetri...
Medicine Products: