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Immune cells ameliorate hypertension-induced cardiac damage in mice
Date:6/9/2009

rdiac damage.

And indeed, hypertensive mice that had received Treg cells, exhibited less cardiac damage. "Hypertrophy and the thickening of the cardiac walls were reduced, also fibrosis and arrhythmia", Dr. Kvakan explains. The Treg cells had brought the immune cells under their control.

The work of Dr. Kvakan and Dr. Mller is the first study to examine the role of immunosuppressive Treg cells in the pathogenesis of hypertensive target organ damage. They conclude that hypertension-induced cardiac damage is partly due to immunological processes.

No Therapy

The two hypertension researchers make it clear that their experiments with Treg cells in mice are in no case suited for therapy in humans. One reason is that Treg cells are much more difficult to identify in humans than in mice. In addition, it is not known what side effects would occur in human patients following suppression of the immune system with Treg cells .

Nevertheless, Dr. Kvakan and Dr. Mller point out that hypertension can be treated well today.

It remains to be seen, if Treg cells will ever be used for short-time therapy. However, perhaps the body's own Treg could be recruited as a treatment.


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Contact: Barbara Bachtler
bachtler@mdc-berlin.de
49-309-406-3896
Helmholtz Association of German Research Centres
Source:Eurekalert

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