Navigation Links
Immune cells ameliorate hypertension-induced cardiac damage in mice
Date:6/9/2009

Researchers in Berlin, Germany have found that a specific type of immune cell, the regulatory T lymphocyte (Treg) plays an important role in hypertension-induced cardiac damage. The injected Treg that they harvested from donor mice into recipient mice were infused with angiotensin II, a blood pressure-raising peptide. The Tregs had no influence on the blood pressure response to angiotensin II. Nonetheless, cardiac enlargement, fibrosis, and inflammation was sharply reduced by Treg treatment. Furthermore, the tendency to develop abnormal heart rhythms that could lead to sudden cardiac death was also reduced. Dr. Heda Kvakan and Dr. Dominik N. Mller at the Experimental and Clinical Research Center at the Max Delbrck Center do not intend Treg as a therapy. However, a better understanding of how the immune system fits into hypertension-induced organ damage could result from these studies (Circulation, Vol. 119, No. 22, June 9, 2009, 2904-2912 ).*

The researchers transferred Treg cells into mice. These cells normally keep the immune system in balance. If the number of Treg cells is reduced or their function impaired, the immune system gets out of balance and, rather than recognizing and destroying bacteria or viruses, the immune cells attack body tissue or organs instead. Autoimmune diseases, such as diabetes type I or Multiple sclerosis, result from the malfunctioning of the immune system.

Aside from its physiological role in maintaining blood pressure, it has long been known that the hormone angiotensin II plays a pivotal role in the onset of hypertension and in subsequnt hypertensive organ damage, e.g. cardiac hypertrophy.

Angiotensin II also has proinflammatory properties and actives the cells of the immune system. The activation of these cells also seems to have a major part in Angiotension II-induced target organ damage. The researchers wanted to know if the suppression of activated immune cells by Treg cells could reduce ca
'/>"/>

Contact: Barbara Bachtler
bachtler@mdc-berlin.de
49-309-406-3896
Helmholtz Association of German Research Centres
Source:Eurekalert

Page: 1 2

Related medicine news :

1. New Immune Approach for Treatment of Alzheimer's Disease
2. Herb May Offer Hope for Autoimmune Diseases
3. Penn study demonstrates new way to boost immune memory
4. Immune-Based Lymphoma Treatment Shows Promise
5. Although the Health Care Market is Recession-Resistant, It Is Not Recession-Immune, According to Millennium Research Groups Medtech Economic Quarterly Publication
6. Immunologists identify biochemical signals that help immune cells remember how to fight infection
7. New therapy enlists immune system to boost cure rate in a childhood cancer
8. Computer simulation captures immune response to flu
9. Immune Therapy May Aid Kids With Neuroblastoma
10. Immune exhaustion driven by antigen in chronic viral infection
11. Scientists develop mathematical model to predict the immune response to influenza
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/17/2014)... Smart Flour Foods™ has been chosen as one ... trade magazine targeted toward food retailers. The delicious Uncured ... other attributes. Smart Flour Foods’ Uncured Pepperoni Pizza will ... print issue of Progressive Grocer as well as on ... on its superior performance in the following criteria: innovation ...
(Date:9/17/2014)... 2014 Cadiz Laser Spa offers ... procedures to clients throughout Central Texas. The newest ... Collagen Induction Therapy. Using the revolutionary Rejuvapen micro-needling ... help clients correct a wide variety of skin ... and Cadiz Laser Spa is currently offering a ...
(Date:9/17/2014)... News) -- Managing diabetes, quitting smoking, controlling high blood ... the risk for dementia -- even late in life, ... Report 2014, commissioned by Alzheimer,s Disease International, revealed that ... percent. The study noted that obesity and an inactive ... as high blood pressure. The researchers suggested ...
(Date:9/17/2014)... an analysis of genetic information among more than 87,000 ... found 23 new genetic variants common differences in ... for prostate cancer. The so-called "meta-analysis," believed to be ... mutations among men in a broad array of ethnic ... ancestry. , The meta-analysis combined information from smaller studies, ...
(Date:9/17/2014)... In a country where 77% of inhabitants ... basis, how can Americans find healthy and fulfilling ways ... Challenge , a 5-day interactive journey to putting stress ... From September 29th – October 3rd, the Hyland’s Stress ... specific topics that promote natural solutions for managing stress. ...
Breaking Medicine News(10 mins):Health News:Smart Flour Foods Wins 2014 Progressive Grocer Editor’s Pick Award 2Health News:Revolutionary Collagen Induction Therapy is Now Available at Cadiz Laser Spa 2Health News:Healthy Lifestyle Changes Linked to Reduced Risk for Dementia 2Health News:Healthy Lifestyle Changes Linked to Reduced Risk for Dementia 3Health News:Large study reveals new genetic variants that raise risk for prostate cancer 2Health News:Stress Less with the Hyland's 5-Day Stress Challenge 2
... ... ,and Create New Categories that Advance Consumer Wellness,XanGo continues to expand mangosteen category it ... Conlee, President and CEO of XanGo, LLC, , ... Lehi, UT (PRWEB) March 13, 2010 -- Global wellness ...
... knee (anterior cruciate ligament) reconstruction with a patellar tendon ... of the tibia or shin bone) graft continue at ... to a study presented today at the American Orthopaedic ... Louisiana (March 13). Additionally, these patients have not developed ...
... by Indiana University Bloomington and Arizona State University geographers could ... reforming sex offender laws. The researchers describe the model and ... Papers in Regional Science. By forcing ... model can help the policymakers of concerned communities to focus ...
... LOS ANGELES , March 12 Persistent back ... as well as with a person,s enjoyment of life; from sports ... a critical key to remaining mobile. For people who have tried ... Orthopedic Spine Surgery is an inevitable course of treatment. ...
... , FRANKLIN, Tenn. , March 12 ... chairman, president and chief executive officer, Wayne T. Smith , ... , have been recognized by Institutional Investor magazine as ... the healthcare and managed care sectors. This is the fourth consecutive ...
... U.S. Army Accessions Command (USAAC) and Health Occupations Students of America, Inc. (HOSA) today signed a Memorandum of ... leadership qualities necessary for success in health care-focused careers and beyond. , ... ... , ...
Cached Medicine News:Health News:State of the Health & Wellness Category: 2010 2Health News:State of the Health & Wellness Category: 2010 3Health News:State of the Health & Wellness Category: 2010 4Health News:State of the Health & Wellness Category: 2010 5Health News:15 years after ACL knee reconstruction, 84 percent of male patients still highly active, study says 2Health News:Mathematical model can help communities better evaluate sex offender policies 2Health News:Mathematical model can help communities better evaluate sex offender policies 3Health News:World Renowned Los Angeles Surgeon Pioneers Alternative Orthopedic Spine Surgery 2Health News:Community Health Systems, Inc.'s Wayne T. Smith and Larry Cash Named America's Top Healthcare CEO and CFO 2Health News:Health Occupations Students of America, Inc. and the U.S. Army Sign Memorandum of Understanding in Support of Improving Career Options for Nation's Students 2Health News:Health Occupations Students of America, Inc. and the U.S. Army Sign Memorandum of Understanding in Support of Improving Career Options for Nation's Students 3
(Date:9/17/2014)... NEW YORK and SAN JOSE, Calif. ... Systems has been named as a laureate of The ... recognized for applying technology to benefit humanity and spark global ... Museum of Innovation, and presented by Applied Materials, Inc., selected ... Award category. Photo - http://photos.prnewswire.com/prnh/20140917/146680 ...
(Date:9/17/2014)... 17, 2014  Lightbeam Health Solutions announced today ... (Physician Direct ACO) to deploy the Lightbeam population ... better care while reducing costs. Photo ... Direct Accountable Care Organization is the ACO operating ... OPNS mission is to be the premier integrated ...
(Date:9/17/2014)... , Sept. 17, 2014 An analysis ... regarding patients taking Sovaldi® (sofosbuvir), a new and expensive ... shows that over the last several months (May through ... downward trend in Sovaldi utilization. This suggests another surge ... new therapeutic regimens of similar efficacy and shorter duration ...
Breaking Medicine Technology:Gradian Health Systems Named A 2014 Laureate of The Tech Awards 2Gradian Health Systems Named A 2014 Laureate of The Tech Awards 3Physician Direct Accountable Care Organization Selects Lightbeam Health to Enable Better Care at a Lower Cost 2Physician Direct Accountable Care Organization Selects Lightbeam Health to Enable Better Care at a Lower Cost 3CVS Health Research Institute Provides First Look at Treatment with New Hepatitis C Therapies 2CVS Health Research Institute Provides First Look at Treatment with New Hepatitis C Therapies 3CVS Health Research Institute Provides First Look at Treatment with New Hepatitis C Therapies 4
... This direct-acting inserter grasps the thinnest portion ... resulting in a minimum incision requirement. The ... the thicker center of the optic and ... resulting in delivery of an implant through ...
... inserter allows insertion of AMO SI-30 and SI-40 ... millimeters, and is perfect for clear corneal and ... has highly polished 6.5 millimeter rounded blades for ... tips of the blades have a .15 millimeter ...
... KR-8000PA Supra Auto-Kerato Refractometer combines an auto-refractor, ... mapping system all in a single, compact ... three times the diagnostic capabilities in one-third ... cost of the individual instruments. By implementing ...
Neomycin and Polymyxin B Sulfates and Hydrocortisone ophthalmic suspension is a sterile antimicrobial and anti-inflammatory suspension for ophthalmic use....
Medicine Products: