Navigation Links
Immune cells ameliorate hypertension-induced cardiac damage in mice
Date:6/9/2009

Researchers in Berlin, Germany have found that a specific type of immune cell, the regulatory T lymphocyte (Treg) plays an important role in hypertension-induced cardiac damage. The injected Treg that they harvested from donor mice into recipient mice were infused with angiotensin II, a blood pressure-raising peptide. The Tregs had no influence on the blood pressure response to angiotensin II. Nonetheless, cardiac enlargement, fibrosis, and inflammation was sharply reduced by Treg treatment. Furthermore, the tendency to develop abnormal heart rhythms that could lead to sudden cardiac death was also reduced. Dr. Heda Kvakan and Dr. Dominik N. Mller at the Experimental and Clinical Research Center at the Max Delbrck Center do not intend Treg as a therapy. However, a better understanding of how the immune system fits into hypertension-induced organ damage could result from these studies (Circulation, Vol. 119, No. 22, June 9, 2009, 2904-2912 ).*

The researchers transferred Treg cells into mice. These cells normally keep the immune system in balance. If the number of Treg cells is reduced or their function impaired, the immune system gets out of balance and, rather than recognizing and destroying bacteria or viruses, the immune cells attack body tissue or organs instead. Autoimmune diseases, such as diabetes type I or Multiple sclerosis, result from the malfunctioning of the immune system.

Aside from its physiological role in maintaining blood pressure, it has long been known that the hormone angiotensin II plays a pivotal role in the onset of hypertension and in subsequnt hypertensive organ damage, e.g. cardiac hypertrophy.

Angiotensin II also has proinflammatory properties and actives the cells of the immune system. The activation of these cells also seems to have a major part in Angiotension II-induced target organ damage. The researchers wanted to know if the suppression of activated immune cells by Treg cells could reduce cardiac damage.

And indeed, hypertensive mice that had received Treg cells, exhibited less cardiac damage. "Hypertrophy and the thickening of the cardiac walls were reduced, also fibrosis and arrhythmia", Dr. Kvakan explains. The Treg cells had brought the immune cells under their control.

The work of Dr. Kvakan and Dr. Mller is the first study to examine the role of immunosuppressive Treg cells in the pathogenesis of hypertensive target organ damage. They conclude that hypertension-induced cardiac damage is partly due to immunological processes.

No Therapy

The two hypertension researchers make it clear that their experiments with Treg cells in mice are in no case suited for therapy in humans. One reason is that Treg cells are much more difficult to identify in humans than in mice. In addition, it is not known what side effects would occur in human patients following suppression of the immune system with Treg cells .

Nevertheless, Dr. Kvakan and Dr. Mller point out that hypertension can be treated well today.

It remains to be seen, if Treg cells will ever be used for short-time therapy. However, perhaps the body's own Treg could be recruited as a treatment.


'/>"/>

Contact: Barbara Bachtler
bachtler@mdc-berlin.de
49-309-406-3896
Helmholtz Association of German Research Centres
Source:Eurekalert

Related medicine news :

1. New Immune Approach for Treatment of Alzheimer's Disease
2. Herb May Offer Hope for Autoimmune Diseases
3. Penn study demonstrates new way to boost immune memory
4. Immune-Based Lymphoma Treatment Shows Promise
5. Although the Health Care Market is Recession-Resistant, It Is Not Recession-Immune, According to Millennium Research Groups Medtech Economic Quarterly Publication
6. Immunologists identify biochemical signals that help immune cells remember how to fight infection
7. New therapy enlists immune system to boost cure rate in a childhood cancer
8. Computer simulation captures immune response to flu
9. Immune Therapy May Aid Kids With Neuroblastoma
10. Immune exhaustion driven by antigen in chronic viral infection
11. Scientists develop mathematical model to predict the immune response to influenza
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/8/2016)... ... December 08, 2016 , ... The Compretta Insurance Agency, a family ... in and around the Hancock County area, is announcing the launch of a charity ... , The Hancock County Food Pantry has worked for more than 30 years to ...
(Date:12/8/2016)... (PRWEB) , ... December 08, 2016 , ... ... consultation services to families and business owners in and around central Kansas, is ... assistance to at-risk youth in the region. , Headquartered in Wichita, Youth Horizons ...
(Date:12/7/2016)... ... December 07, 2016 , ... Students ... have the unique opportunity to get hands-on experience in an emergency medical simulation, ... immersive experience to gain invaluable, real-life medical skills that are critical success in ...
(Date:12/7/2016)... ... December 07, 2016 , ... Kenall Manufacturing, a leader in ... MPCNGX . The MPCNGX is a multi-function, sealed, LED luminaire that meets the needs ... where and when it’s needed. , A 2’ x 4’ model features ...
(Date:12/7/2016)... ... December 07, 2016 , ... ... wrinkles and deep lines by smoothing and tightening the skin of the face ... there to address facial aging with very little downtime, Silhouette Instalift is a ...
Breaking Medicine News(10 mins):
(Date:12/8/2016)... Dec. 8, 2016 Dignitana, a world leader ... with Boa® Technology, creator of the award-winning, patented Boa® ... use with the DigniCap® scalp cooling system. DigniCap® was ... December 2015, and is the first medical scalp cooling ... scalp cooling system features a patented tight-fitting silicone cooling ...
(Date:12/8/2016)... According to a new ... (Actual Sugars, Sugar Alcohols, Artificial Sweeteners), Type (Powder/Granule, ... Formulation (Oral, Topical, Parenteral) - Global Forecast to ... healthy growth during the last decade, and is ... between 2016 and 2021 to reach USD 1,060.6 ...
(Date:12/8/2016)... , Dec. 8, 2016  Hanson Research, an ... dissolution testing and diffusion testing instruments for the ... by Teledyne Instruments, Inc. ("Teledyne"). The move is ... of precision testing instruments, as well as expand ... of new products and services. Logo - ...
Breaking Medicine Technology: