Navigation Links
Immune cells ameliorate hypertension-induced cardiac damage in mice

Researchers in Berlin, Germany have found that a specific type of immune cell, the regulatory T lymphocyte (Treg) plays an important role in hypertension-induced cardiac damage. The injected Treg that they harvested from donor mice into recipient mice were infused with angiotensin II, a blood pressure-raising peptide. The Tregs had no influence on the blood pressure response to angiotensin II. Nonetheless, cardiac enlargement, fibrosis, and inflammation was sharply reduced by Treg treatment. Furthermore, the tendency to develop abnormal heart rhythms that could lead to sudden cardiac death was also reduced. Dr. Heda Kvakan and Dr. Dominik N. Mller at the Experimental and Clinical Research Center at the Max Delbrck Center do not intend Treg as a therapy. However, a better understanding of how the immune system fits into hypertension-induced organ damage could result from these studies (Circulation, Vol. 119, No. 22, June 9, 2009, 2904-2912 ).*

The researchers transferred Treg cells into mice. These cells normally keep the immune system in balance. If the number of Treg cells is reduced or their function impaired, the immune system gets out of balance and, rather than recognizing and destroying bacteria or viruses, the immune cells attack body tissue or organs instead. Autoimmune diseases, such as diabetes type I or Multiple sclerosis, result from the malfunctioning of the immune system.

Aside from its physiological role in maintaining blood pressure, it has long been known that the hormone angiotensin II plays a pivotal role in the onset of hypertension and in subsequnt hypertensive organ damage, e.g. cardiac hypertrophy.

Angiotensin II also has proinflammatory properties and actives the cells of the immune system. The activation of these cells also seems to have a major part in Angiotension II-induced target organ damage. The researchers wanted to know if the suppression of activated immune cells by Treg cells could reduce cardiac damage.

And indeed, hypertensive mice that had received Treg cells, exhibited less cardiac damage. "Hypertrophy and the thickening of the cardiac walls were reduced, also fibrosis and arrhythmia", Dr. Kvakan explains. The Treg cells had brought the immune cells under their control.

The work of Dr. Kvakan and Dr. Mller is the first study to examine the role of immunosuppressive Treg cells in the pathogenesis of hypertensive target organ damage. They conclude that hypertension-induced cardiac damage is partly due to immunological processes.

No Therapy

The two hypertension researchers make it clear that their experiments with Treg cells in mice are in no case suited for therapy in humans. One reason is that Treg cells are much more difficult to identify in humans than in mice. In addition, it is not known what side effects would occur in human patients following suppression of the immune system with Treg cells .

Nevertheless, Dr. Kvakan and Dr. Mller point out that hypertension can be treated well today.

It remains to be seen, if Treg cells will ever be used for short-time therapy. However, perhaps the body's own Treg could be recruited as a treatment.


Contact: Barbara Bachtler
Helmholtz Association of German Research Centres

Related medicine news :

1. New Immune Approach for Treatment of Alzheimer's Disease
2. Herb May Offer Hope for Autoimmune Diseases
3. Penn study demonstrates new way to boost immune memory
4. Immune-Based Lymphoma Treatment Shows Promise
5. Although the Health Care Market is Recession-Resistant, It Is Not Recession-Immune, According to Millennium Research Groups Medtech Economic Quarterly Publication
6. Immunologists identify biochemical signals that help immune cells remember how to fight infection
7. New therapy enlists immune system to boost cure rate in a childhood cancer
8. Computer simulation captures immune response to flu
9. Immune Therapy May Aid Kids With Neuroblastoma
10. Immune exhaustion driven by antigen in chronic viral infection
11. Scientists develop mathematical model to predict the immune response to influenza
Post Your Comments:
(Date:11/30/2015)... BALTIMORE, Md. (PRWEB) , ... November 30, 2015 ... ... be rewarding, but also extremely stressful. At the VA Maryland Health Care ... who care for veterans patients. “Caregivers have a difficult job. Seventy-four percent ...
(Date:11/30/2015)... , ... November 30, 2015 , ... ... (Meso Foundation) released information for caregivers and held two webinars on topics of ... on demand free of charge at . , With a loved ...
(Date:11/30/2015)... ... 30, 2015 , ... According to research by the National ... technicians to be certified or obtain continuing education. To increase awareness of the ... Mouth?” campaign to inform dentists that the technicians they trust could lack the ...
(Date:11/30/2015)... , ... November 30, 2015 , ... ... . The directory is specialized and only includes chiropractic clinics in the ... a competent and trustworthy alternative health practitioner when back pain sets in. When ...
(Date:11/30/2015)... ... 30, 2015 , ... The Museum of Science & Industry ... new era of publicly accessible automated technology. Now, by popular demand, the Meridian ... an up-close look at the shuttle at MOSI’s main entrance. This experience continues ...
Breaking Medicine News(10 mins):
(Date:11/30/2015)... Diplomat Pharmacy, Inc. (NYSE: DPLO ) ... Free Press as a Top Workplace , among the ... work for in 2015. ... annually, based on employee surveys rating company leadership, career opportunities, ... based solely on employee feedback. The survey is conducted by ...
(Date:11/30/2015)... Va. , Nov. 30, 2015  IBA Molecular ... manufacture and distribution of radiopharmaceuticals, announced that as of ... Pharma, Inc. (Zevacor Pharma). The decision to rebrand the ... the firm as well as its close relationship with ... by Illinois Health and Science (IHS). ...
(Date:11/30/2015)... , Nov. 30, 2015 Baxalta ... biopharmaceutical leader dedicated to delivering transformative therapies ... medical conditions, today announced the launch and ... PEGylated], an extended circulating half-life recombinant factor ... on full-length ADVATE [Antihemophilic Factor (Recombinant)]. The ...
Breaking Medicine Technology: