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Immune Therapy Shows Early Promise for Advanced Leukemia
Date:3/21/2013

r T-cell therapy alone can bring about a long-term remission for patients with recurrent ALL. Most patients in this study got a bone marrow transplant because that is the standard of care, Brentjens said.

But as the researchers treat more patients, they can follow those who are ineligible for a bone marrow transplant and see how they fare after the immunotherapy alone.

Sadelain said that it's possible that the T-cell therapy might need to be repeated.

Safety questions exist as well. "The risk of this therapy would be creating an overwhelming immune response," Sadelain said. That could lead to extremely high fever or other potentially life-threatening effects.

In this study, funded by the cancer institute, two patients had signs of an overly strong immune response. But it was manageable with anti-inflammatory steroid drugs, Sadelain added.

Another expert, Richard Winneker, senior vice president of research for the Leukemia & Lymphoma Society, said he was encouraged by the results. "And this should certainly stimulate further work," he said.

The leukemia society has funded Penn's work on adoptive T-cell therapy, and Winneker said, "We're thrilled to see this field showing positive results."

Brentjens and Sadelain hold a patent on the CAR used in the therapy.

More information

Learn more about adult ALL from the American Cancer Society.

SOURCES: Renier Brentjens, M.D., Ph.D., leukemia service, Memorial Sloan-Kettering Cancer Center, New York City; Michel Sadelain, M.D., Ph.D., director, Center for Cell Engineering and Gene Transfer, Memorial Sloan-Kettering Cancer Center; David Porter, M.D., director, blood and marrow transplantation, Abramson Cancer Center, University of Pennsylvania, Philadelphia; Richard Winneker, Ph.D., senior vice-president of research, Leukemi
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