Navigation Links
Immune Therapy Shows Early Promise for Advanced Leukemia
Date:3/21/2013

By Amy Norton
HealthDay Reporter

WEDNESDAY, March 20 (HealthDay News) -- An experimental therapy that targets the immune system might offer a new way to treat an often deadly form of adult leukemia, a preliminary study suggests.

The research involved only five adults with recurrent B-cell acute lymphoblastic leukemia (ALL), a cancer of the blood and bone marrow. ALL progresses quickly, and patients can die within weeks if untreated. The typical first treatment is three separate phases of chemotherapy drugs.

For many patients, that beats back the cancer. But it often returns. At that point, the only hope for long-term survival is to have another round of chemo that wipes out the cancer, followed by a bone marrow transplant.

But when the disease recurs, it is often resistant to many chemo drugs, explained Dr. Renier Brentjens, an oncologist at Memorial Sloan-Kettering Cancer Center in New York City.

So, Brentjens and his colleagues tested a different approach. They took immune system T-cells from the blood of five patients, then genetically engineered the cells to express so-called chimeric antigen receptors (CARs), which help the T-cells recognize and destroy ALL cells.

The five patients received infusions of their tweaked T-cells after having standard chemotherapy. All five quickly saw a complete remission -- within eight days for one patient, the researchers found.

Four patients went on to a bone marrow transplant, the researchers reported March 20 in the journal Science Translational Medicine. The fifth was ineligible because he had heart disease and other health conditions that made the transplant too risky.

"To our amazement, we got a full and a very rapid elimination of the tumor in these patients," said Dr. Michel Sadelain, another Sloan-Kettering researcher who worked on the study.

Many questions remain, however. And the treatment -- known as adoptive T-cell therapy -
'/>"/>

Copyright©2012 ScoutNews,LLC.
All rights reserved  

Page: 1 2 3 4

Related medicine news :

1. Study reveals potential immune benefits of vitamin D supplements in healthy individuals
2. Delgado Protocol Announces Adrenal DMG, An Amazing New Supplement Designed to Support the Immune, Circulatory and Cardiovascular Systems
3. Evidence supports blocking immune response to enhance viral therapy against solid tumors
4. Football Injuries May Trigger Harmful Immune System Response
5. Tumors deliberately create conditions that inhibit bodys best immune response
6. Leukemia Patients Get Treatment Boost From Donors Immune Cells
7. Shi DeRu Shaolin Annual Qi Retreat 2013:Tai Gong-Immune Defense Gets Rave Reviews
8. Scientists find calcium is the initial trigger in our immune response to healing
9. Immune cells engineered in lab to resist HIV infection, Stanford study shows
10. Immune-Boosting Foods May Add to Flu Defense
11. Foot soldiers of the immune system
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Immune Therapy Shows Early Promise for Advanced Leukemia
(Date:12/25/2014)... (PRWEB) December 25, 2014 Thousands of ... move forward in a number of multidistrict litigations currently ... Virginia, Bernstein Liebhard LLP reports. According to an Order ... to convene a Joint Status Conference in all of ... Parties have been directed to submit a proposed agenda ...
(Date:12/25/2014)... Plugin creators from Pixel Film Studios have ... business presentation tool made specifically for Final Cut ... tool, users can now display their stats and facts ... Studios. “ProFire 5k gives users a multiple options to ... a presentation” , Pixel Film Studios takes the heat ...
(Date:12/25/2014)... CA (PRWEB) December 25, 2014 Each ... visits and 2 million hospital admissions across the nation ... Prevention ). The CDC’s National Hospital Ambulatory Medical ... through a survey conducted in 2010. They estimated that ... visits that resulted in a primary diagnosis of broken ...
(Date:12/24/2014)... Wi (PRWEB) December 25, 2014 AlignLife ... are unable to afford certain items. During the holiday season, ... "We collected over 70 toys," says Dr. Sara Mahalko-Leonhardt, owner ... and staff such joy, knowing that we are able to ... present had it not been for the generosity of our ...
(Date:12/24/2014)... Epigenetics finds applications in a large number of fields ... biology, and research for metabolic and genetic disorders. It ... used techniques for the discovery and development of cancer ... rapidly growing worldwide. In 2012, there were 14.1 million ... million people living with cancer (within five years of ...
Breaking Medicine News(10 mins):Health News:Federal Court Overseeing Thousands of Transvaginal Mesh Lawsuits Set to Convene Joint Status Conference for All Litigations, Bernstein Liebhard LLP Reports 2Health News:Federal Court Overseeing Thousands of Transvaginal Mesh Lawsuits Set to Convene Joint Status Conference for All Litigations, Bernstein Liebhard LLP Reports 3Health News:Federal Court Overseeing Thousands of Transvaginal Mesh Lawsuits Set to Convene Joint Status Conference for All Litigations, Bernstein Liebhard LLP Reports 4Health News:Announcing a new ProFire 5k plugin from Pixel Film Studios for Final Cut Pro X Professionals 2Health News:Every Year Four Million Emergency Department Visits Result from Accidents Involving Bone Trauma 2Health News:Every Year Four Million Emergency Department Visits Result from Accidents Involving Bone Trauma 3Health News:Every Year Four Million Emergency Department Visits Result from Accidents Involving Bone Trauma 4Health News:AlignLife of Wauwatosa Brings Joy to Less Fortunate Families 2Health News:Global Epigenetics Market Was Valued at $413.24 Million in 2014 - New Research Report by MarketsandMarkets 2Health News:Global Epigenetics Market Was Valued at $413.24 Million in 2014 - New Research Report by MarketsandMarkets 3
... April 1, 2008 The American College of ... labor, and employer organizations to endorse the Patient ... Programs. These organizations believe that health plans that ... should be independently assessed. The review and standardization ...
... 2008 Grubb &,Ellis Healthcare REIT, Inc. today announced ... Located at 3035, 3037, 3131, and 3133 Lakeland Hills ... four identical buildings. Each,building has approximately 8,000 square feet ... 1996 and 1998 on approximately 4.64,acres, the buildings are ...
... April 2, 2008 The following,statement was issued today ... Medical Association applauds the U.S. House Energy and,Commerce Committee ... The AMA urges the full House to take a ... this year, giving the,FDA needed regulatory authority over tobacco ...
... the House Floor, WASHINGTON, April 2, 2008 ... and CEO, American Lung,Association:, The American Lung Association ... for its passage of the Family,Smoking Prevention and Tobacco ... quickly take action to move this life-saving legislation forward,so ...
... most common treatment , , WEDNESDAY, April 2 (HealthDay ... highly effective treatment for precancerous lesions on the vulva, ... disease itself, the cream works by helping the body,s ... -- which is often the root cause of the ...
... J.,Gallagher & Co. today announced the acquisition of ... of the transaction,were not disclosed., Founded in ... broker,that provides life insurance programs for estate planning, ... arranging premium,financing of large life insurance policies for ...
Cached Medicine News:Health News:Patient charter ensures that reports on physicians are meaningful, reliable and fair 2Health News:Grubb & Ellis Healthcare REIT Acquires Vista Professional Center in Lakeland, Fla. 2Health News:Grubb & Ellis Healthcare REIT Acquires Vista Professional Center in Lakeland, Fla. 3Health News:Grubb & Ellis Healthcare REIT Acquires Vista Professional Center in Lakeland, Fla. 4Health News:Topical Cream Treats Precancerous Lesions of Vulva 2Health News:Topical Cream Treats Precancerous Lesions of Vulva 3
(Date:12/24/2014)... -- Tianyin Pharmaceutical Inc. (NYSE Amex: ... the patented biopharmaceutical, modernized traditional Chinese medicine (mTCM), ... unaudited preliminary financial results for the first quarter ... 2015 Ended September 30, 2014 Financial Highlights: ... million in 1Q14 with gross margins improved to ...
(Date:12/24/2014)... N.J. , Dec. 24, 2014 ... a late-stage biopharmaceutical company developing products that address ... oncology and biodefense, announced today that on December ... public offering. The Company raised approximately ... and intends to use the net proceeds from ...
(Date:12/24/2014)... 2014  Conkwest, Inc., the Natural Killer Cell ... Killer (NK) cell-line platform, Neukoplast® (NK-92™) as an ... , NantWorks founder, physician scientist and biotechnology entrepreneur, ... approximately $48 million of the Company,s Class A ... will be named Co-Chairman of the Conkwest Board ...
Breaking Medicine Technology:TPI Presents Unaudited Preliminary First Quarter Fiscal Year 2015 Financial Results 2TPI Presents Unaudited Preliminary First Quarter Fiscal Year 2015 Financial Results 3TPI Presents Unaudited Preliminary First Quarter Fiscal Year 2015 Financial Results 4TPI Presents Unaudited Preliminary First Quarter Fiscal Year 2015 Financial Results 5TPI Presents Unaudited Preliminary First Quarter Fiscal Year 2015 Financial Results 6TPI Presents Unaudited Preliminary First Quarter Fiscal Year 2015 Financial Results 7TPI Presents Unaudited Preliminary First Quarter Fiscal Year 2015 Financial Results 8TPI Presents Unaudited Preliminary First Quarter Fiscal Year 2015 Financial Results 9TPI Presents Unaudited Preliminary First Quarter Fiscal Year 2015 Financial Results 10TPI Presents Unaudited Preliminary First Quarter Fiscal Year 2015 Financial Results 11TPI Presents Unaudited Preliminary First Quarter Fiscal Year 2015 Financial Results 12Soligenix Announces Closing of Public Offering of Units 2Soligenix Announces Closing of Public Offering of Units 3Conkwest Announces $50m In Strategic Investments And Appoints NantWorks Founder, Dr. Patrick Soon-Shiong As Co-Chairman Of The Board 2Conkwest Announces $50m In Strategic Investments And Appoints NantWorks Founder, Dr. Patrick Soon-Shiong As Co-Chairman Of The Board 3Conkwest Announces $50m In Strategic Investments And Appoints NantWorks Founder, Dr. Patrick Soon-Shiong As Co-Chairman Of The Board 4Conkwest Announces $50m In Strategic Investments And Appoints NantWorks Founder, Dr. Patrick Soon-Shiong As Co-Chairman Of The Board 5
... Hereditary hearing loss is the most common sensory disorder in ... the Institute of Human Genetics at the ... methods, including Roche,s NimbleGen Custom Sequence Capture 385K array to ... X-chromosome of a Spanish family with hereditary hearing loss (1). ...
... Inc. announced today that the first patient has been ... an oligoclonal therapeutic consisting of a mixture of three ... epitopes of the epidermal growth factor receptor (EGFR). ... safety of MM-151 and determine the recommended Phase 2 ...
Cached Medicine Technology:Roche's Sequence Capture Technology Used to Identify SMPX Mutations Underlying Human Hereditary Hearing Loss 2Roche's Sequence Capture Technology Used to Identify SMPX Mutations Underlying Human Hereditary Hearing Loss 3
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
Medicine Products: