Navigation Links
Immune Therapy May Aid Kids With Neuroblastoma
Date:5/14/2009

Researchers praise new treatment for deadly cancer,,

THURSDAY, May 14 (HealthDay News) -- In a phase 3 clinical trial, an experimental immune-based treatment boosted by 20 percent the overall survival of those with tough-to-treat neuroblastoma, which affects mostly children.

The findings are to be presented at the American Society for Clinical Oncology annual meeting, which starts later this month in Florida.

The trial involved 226 patients newly diagnosed with high-risk neuroblastoma, a cancer of the nervous system. Standard treatment includes surgery, aggressive chemotherapy with "stem cell rescue" (where the patient's stem cells are removed before treatment, then returned after chemotherapy to boost blood/immune function) and radiation therapy.

"Even though we treat it with aggressive therapy, high-risk neuroblastoma often returns, and most patients do not survive," Dr. Alice Yu, a professor of hematology/oncology at the University of California, San Diego, and the school's Moores Cancer Center, said in a news release from the society.

The new immune-based treatment -- called chimeric anti-GD2 antibody ch14.18 -- targets a key sugar-and-fat molecule lying on neuroblastoma cells called GD2. Left alone, the molecule inhibits the immune system from attacking the cancer cells. But the new antibody binds to GD2, encouraging such attacks, the researchers explained.

In the new trial, half of the patients received chemotherapy/stem cell rescue plus standard treatment (retinoic acid), as well as the new immunotherapy. The others received standard treatment only.

After two years, the number of participants who had survived without a relapse reached 66 percent in the immunotherapy groups, compared with 46 percent among those who did not get the new treatment. Overall survival after two years reached 86 percent in the immunotherapy cohort and 75 percent among those who got standard treatment.

"It is very exciting to have a new treatment option for this disease," Yu said, "and we hope to make this immunotherapy available to more children with neuroblastoma."

The study is to be presented June 2 at the meeting but was described in a news conference Thursday.

More information

The University of Chicago has more on neuroblastoma in children.



-- E.J. Mundell



SOURCE: American Society of Clinical Oncology, news release, May 14, 2009


'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Immune exhaustion driven by antigen in chronic viral infection
2. Scientists develop mathematical model to predict the immune response to influenza
3. Scientists discover how smallpox may derail human immune system
4. Immune Deficiency Foundation Honors Cerda Family and Volunteers From ABCs Extreme Makeover: Home Edition
5. Researcher IDs Narcolepsy as Autoimmune Disease
6. Narcolepsy is an autoimmune disorder, Stanford researcher says
7. 7 Top Rated Immune Support Products from Swanson Vitamins
8. Ingredient in Probiotic Sweetener Boosts Immune System
9. Scientists discover how to improve immune response to cancer at Princess Margaret Hospital
10. New Bill Offers Medicare Reimbursement Fix for Intravenous Immune Globulin
11. Instead of fighting breast cancer, immune cell promotes its spread
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Immune Therapy May Aid Kids With Neuroblastoma
(Date:5/25/2016)... New York, NY (PRWEB) , ... May 25, ... ... of Medicine and Florida International University (FIU) Herbert Wertheim College of Medicine announced ... receive a Medical Doctor Degree and Global Health Certificate from AUA and a ...
(Date:5/25/2016)... ... 25, 2016 , ... The World Molecular Imaging Society (WMIS) ... The focus of ADDMI-IG will be geared towards how using molecular imaging can ... ADDMI-IG WMIS will provide a platform for productive discussions about the implementation of ...
(Date:5/25/2016)... ... 25, 2016 , ... TransactRx announces the release of enhanced ... service claims by Pharmacy Benefit Managers that were submitted by Retail Clinics and ... Cross Benefit Clearinghouse receives standard professional medical claims submitted from the retail clinic’s ...
(Date:5/25/2016)... ... 2016 , ... For more than fifty years, we've suffered whiplash as each new scientific study ... to the latest nutritional advice – advice that was supposed to keep us healthy and ... 3 American adults are considered to be overweight and more than 1 in 3 adults ...
(Date:5/25/2016)... ... May 25, 2016 , ... Consumer access to organic foods and grower ... a maker of whole grain cereals and other plant-based foods, will introduce the first ... red winter wheat processed by Hesco/Dakota Organic Products. , The transitional designation means the ...
Breaking Medicine News(10 mins):
(Date:5/25/2016)... May 25, 2016  According to Kalorama Information, the ... in 2015.  Though these are challenging times in ... for success for companies that remain optimistic and ... new growth prospects medical device companies spend a ... development (R&D) than do companies in other industries.  ...
(Date:5/25/2016)... NEW YORK , May 25, 2016 ... Device Market Size, Share, Development, Growth and Demand Forecast ... Insulin Syringe, Insulin Pump and Others)" published by P&S ... valued at $9,998.3 million in 2015, and it is ... 2016-2022. Based on type, the insulin pump segment is ...
(Date:5/25/2016)... 25, 2016 As illustrated by ... this month, the numbers and momentum of cannabis in ... into the billions, more research and development push the ... State of Legal Marijuana Markets Report  from from ArcView ... much of the increase in sector is attributed to ...
Breaking Medicine Technology: