Navigation Links
Immune Therapy May Aid Kids With Neuroblastoma

Researchers praise new treatment for deadly cancer,,

THURSDAY, May 14 (HealthDay News) -- In a phase 3 clinical trial, an experimental immune-based treatment boosted by 20 percent the overall survival of those with tough-to-treat neuroblastoma, which affects mostly children.

The findings are to be presented at the American Society for Clinical Oncology annual meeting, which starts later this month in Florida.

The trial involved 226 patients newly diagnosed with high-risk neuroblastoma, a cancer of the nervous system. Standard treatment includes surgery, aggressive chemotherapy with "stem cell rescue" (where the patient's stem cells are removed before treatment, then returned after chemotherapy to boost blood/immune function) and radiation therapy.

"Even though we treat it with aggressive therapy, high-risk neuroblastoma often returns, and most patients do not survive," Dr. Alice Yu, a professor of hematology/oncology at the University of California, San Diego, and the school's Moores Cancer Center, said in a news release from the society.

The new immune-based treatment -- called chimeric anti-GD2 antibody ch14.18 -- targets a key sugar-and-fat molecule lying on neuroblastoma cells called GD2. Left alone, the molecule inhibits the immune system from attacking the cancer cells. But the new antibody binds to GD2, encouraging such attacks, the researchers explained.

In the new trial, half of the patients received chemotherapy/stem cell rescue plus standard treatment (retinoic acid), as well as the new immunotherapy. The others received standard treatment only.

After two years, the number of participants who had survived without a relapse reached 66 percent in the immunotherapy groups, compared with 46 percent among those who did not get the new treatment. Overall survival after two years reached 86 percent in the immunotherapy cohort and 75 percent among those who got standard treatment.

"It is very exciting to have a new treatment option for this disease," Yu said, "and we hope to make this immunotherapy available to more children with neuroblastoma."

The study is to be presented June 2 at the meeting but was described in a news conference Thursday.

More information

The University of Chicago has more on neuroblastoma in children.

-- E.J. Mundell

SOURCE: American Society of Clinical Oncology, news release, May 14, 2009

Copyright©2009 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Immune exhaustion driven by antigen in chronic viral infection
2. Scientists develop mathematical model to predict the immune response to influenza
3. Scientists discover how smallpox may derail human immune system
4. Immune Deficiency Foundation Honors Cerda Family and Volunteers From ABCs Extreme Makeover: Home Edition
5. Researcher IDs Narcolepsy as Autoimmune Disease
6. Narcolepsy is an autoimmune disorder, Stanford researcher says
7. 7 Top Rated Immune Support Products from Swanson Vitamins
8. Ingredient in Probiotic Sweetener Boosts Immune System
9. Scientists discover how to improve immune response to cancer at Princess Margaret Hospital
10. New Bill Offers Medicare Reimbursement Fix for Intravenous Immune Globulin
11. Instead of fighting breast cancer, immune cell promotes its spread
Post Your Comments:
Related Image:
Immune Therapy May Aid Kids With Neuroblastoma
(Date:11/27/2015)... ... November 27, 2015 , ... ... convenient way to dispense prescription medications at home, so he invented the patent-pending ... monitor and dispense prescription medications. In doing so, it could help to prevent ...
(Date:11/27/2015)... ... , ... MPWH, the No.1 Herpes-only dating community in the world, revealed that over 50% of ... than 3.7 billion people under the age of 50 – or 67% of the population ... global estimates of HSV-1 infection . , "The data shocks us highly!" said Michelle ...
(Date:11/27/2015)... ... November 27, 2015 , ... ... online platform for mental health and wellness consultation, has collaborated with a leading ... bridge the knowledge gap experienced by parents and bring advice from parenting experts ...
(Date:11/27/2015)... ... November 27, 2015 , ... Indosoft ... announces the incorporation of Asterisk 11 LTS (Long Term Support) into its Q-Suite ... LTS brings Q-Suite 5.10 up-to-date with a version of Asterisk that will receive ...
(Date:11/26/2015)... ... 2015 , ... The Catalent Applied Drug Delivery Institute today ... dose form selection in early phase drug development. The first of these is ... together the UK’s emerging life sciences companies, corporate partners, and investors, at Milton ...
Breaking Medicine News(10 mins):
(Date:11/26/2015)... 2015 Research and Markets ( ) has ... Market Outlook to 2019 - Rise in Cardiac Disorders and ... report to their offering. Boston ... scientific and others. --> The ... Boston scientific and others. ...
(Date:11/26/2015)... -- Research and Markets ( ) has ... Horizons and Growth Strategies in the Japanese Therapeutic ... Forecasts, Competitive Intelligence, Emerging Opportunities" report to ... --> This new 247-page report provides ... monitoring market, including emerging tests, technologies, instrumentation, sales ...
(Date:11/26/2015)... DUBLIN , November 26, 2015 ... has announced the addition of the  ... in the Global Cell Surface Testing ... Opportunities" report to their offering.  ... the addition of the  "2016 Future ...
Breaking Medicine Technology: