Navigation Links
Immune System Gene Discovery Sheds Light on Staph Infections
Date:7/21/2009

Findings could lead to better therapies for severe forms of the disease

TUESDAY, July 21 (HealthDay News) -- Researchers at the University of Texas Southwestern Medical Center have figured what genes turn on and off in a person's immune system when he or she has a severe staph infection.

The work, done on children with severe Staphylococcus aureus infections but applicable to all people, could lead to better treatments for these diseases, including the methicillin-resistant (MRSA) version known as the "super bug" because most antibiotics do not work on it.

According to the findings, published in the online journal PLoS One, the genes in children's innate immune system, which provides the most immediate response to infection, became overactive when S. aureus hits. Meanwhile, the genes in the children's adaptive immune systems, which recall past battles to better fight later infections, are shut down.

"It's a very sophisticated and complex dysregulation of the immune system, but our findings prove that there's consistency in the immune response to the staphylococcus bacterium," lead author Monica Ardura, an instructor of pediatrics at UT Southwestern, said in a school news release. "Now that researchers know how the immune system responds, the question is whether this methodology can be used to predict patient outcomes or differentiate the sickest patients from the less sick ones and, ultimately, how this knowledge can be used to develop better therapies?"

She emphasized, though, that the findings were only a snapshot of what occurs during a staph infection at a single moment.

The researchers conducted gene expression profiling with blood taken from 53 otherwise healthy children who had contracted one of the strains of S. aureus during a five-year period and 24 healthy control patients.

The team plans to try to study other conditions surrounding the period before, during and after infection in patients, and how different staph-infection therapies affect treatment.

More information

The Nemours Foundation has more about staph infections.



-- Kevin McKeever



SOURCE: University of Texas Southwestern Medical Center, news release, July 14, 2009


'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Cell division find prompts overhaul of immune response modeling
2. Intravenous Immune Biologics Will Suffer from the Pending Shift in Coverage from the Medical to the Pharmacy Benefit
3. Researchers map how staph infections alter immune system
4. Immune Response May Speed AIDS Progression in Women
5. UCLA scientists identify how immune cells may help predict Alzheimers risk
6. Strep B Seems to Trick Immune System
7. Post-transplant combo can replace toxic immune-suppressing drugs in monkeys
8. Catalyst Biosciences Announces Agreement With MedImmune to Discover and Develop Engineered Protease Therapeutics
9. CU-Boulder study shows brains immune system may cause chronic seizures
10. Autism May Be Linked to Moms Autoimmune Disease
11. Microscopic beads could help create designer immune cells that ignore transplanted organs
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Immune System Gene Discovery Sheds Light on Staph Infections
(Date:1/19/2017)... (PRWEB) , ... January 19, ... ... introducing the Aerolib Learning Management System: an On-demand E-learning system for Clinical ... and Hospital Administration that is based on Aerolib`s successful education methodology of ...
(Date:1/19/2017)... , ... January 19, 2017 , ... ... SF expansion and facility enhancement of their 503A compounding pharmacy located in Ocala, ... growing demand of physicians and patients throughout the United States for high-quality human ...
(Date:1/19/2017)... ... 2017 , ... This month, the CEO and Clinical Director of Sober Living ... center in Delray Beach, Florida has been changed from Sober Living Outpatient to ‘SLO ... Seymour Hoffman and Chris Farley are dying from heroin overdoses, but thousands of unnamed ...
(Date:1/19/2017)... ... 19, 2017 , ... WhoHaha , a digital media company dedicated to ... (AHA) to produce a three-part video series that uses humor to highlight ways to ... launch of AHA’s Healthy For Good™ movement, which is designed to inspire all Americans ...
(Date:1/19/2017)... ... 2017 , ... Cosmetic Town, an online plastic surgery community, begins 2017 with ... easier for their readers to get the information they desire. The procedures are now ... techniques used on those particular areas. , “We are excited to streamline our listings ...
Breaking Medicine News(10 mins):
(Date:1/19/2017)... , , Marks E-QURE , ... agreement, following similar agreements in Israel and ... 5 billion global market ... leader in medical devices for the treatment of advanced wound care, announced today ... in Colombia for the Company,s patented Bio-electrical Signal Therapy ...
(Date:1/19/2017)... Jan. 18, 2017 The Global Therapy Partnering ... access to partnering deals and agreements entered into by ... partnering deals - Top deals by value - Deals ... technology type The report provides understanding and access ... the world,s leading healthcare companies. The report provides ...
(Date:1/19/2017)... , Jan. 18, 2017   Synthetic Biologics, ... company developing therapeutics designed to preserve the microbiome ... today confirmed plans to initiate a Phase 2b/3 ... reformulation of lovastatin lactone designed to reduce methane ... in the gut to treat the underlying cause ...
Breaking Medicine Technology: