Navigation Links
Immune System Gene Discovery Sheds Light on Staph Infections
Date:7/21/2009

Findings could lead to better therapies for severe forms of the disease

TUESDAY, July 21 (HealthDay News) -- Researchers at the University of Texas Southwestern Medical Center have figured what genes turn on and off in a person's immune system when he or she has a severe staph infection.

The work, done on children with severe Staphylococcus aureus infections but applicable to all people, could lead to better treatments for these diseases, including the methicillin-resistant (MRSA) version known as the "super bug" because most antibiotics do not work on it.

According to the findings, published in the online journal PLoS One, the genes in children's innate immune system, which provides the most immediate response to infection, became overactive when S. aureus hits. Meanwhile, the genes in the children's adaptive immune systems, which recall past battles to better fight later infections, are shut down.

"It's a very sophisticated and complex dysregulation of the immune system, but our findings prove that there's consistency in the immune response to the staphylococcus bacterium," lead author Monica Ardura, an instructor of pediatrics at UT Southwestern, said in a school news release. "Now that researchers know how the immune system responds, the question is whether this methodology can be used to predict patient outcomes or differentiate the sickest patients from the less sick ones and, ultimately, how this knowledge can be used to develop better therapies?"

She emphasized, though, that the findings were only a snapshot of what occurs during a staph infection at a single moment.

The researchers conducted gene expression profiling with blood taken from 53 otherwise healthy children who had contracted one of the strains of S. aureus during a five-year period and 24 healthy control patients.

The team plans to try to study other conditions surrounding the period before, during and after infection in patients, and how different staph-infection therapies affect treatment.

More information

The Nemours Foundation has more about staph infections.



-- Kevin McKeever



SOURCE: University of Texas Southwestern Medical Center, news release, July 14, 2009


'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Cell division find prompts overhaul of immune response modeling
2. Intravenous Immune Biologics Will Suffer from the Pending Shift in Coverage from the Medical to the Pharmacy Benefit
3. Researchers map how staph infections alter immune system
4. Immune Response May Speed AIDS Progression in Women
5. UCLA scientists identify how immune cells may help predict Alzheimers risk
6. Strep B Seems to Trick Immune System
7. Post-transplant combo can replace toxic immune-suppressing drugs in monkeys
8. Catalyst Biosciences Announces Agreement With MedImmune to Discover and Develop Engineered Protease Therapeutics
9. CU-Boulder study shows brains immune system may cause chronic seizures
10. Autism May Be Linked to Moms Autoimmune Disease
11. Microscopic beads could help create designer immune cells that ignore transplanted organs
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Immune System Gene Discovery Sheds Light on Staph Infections
(Date:5/31/2016)... ... May 31, 2016 , ... ... Houston Healthconnect’s (Healthconnect) regional health information exchange, which enables physicians at SJMC’s two ... their patients from other participating organizations in the exchange. SJMC’s membership in the ...
(Date:5/31/2016)... ... May 31, 2016 , ... CallTrackingMetrics's ... advertising campaigns, to monitor the performance of sales and support staff, and to ... revenue. The software allows customers to record, transcribe, route, document, and report on ...
(Date:5/31/2016)... ... ... The Global Wellness Summit (GWS), an annual conference for international ... travel, spa and beauty in Europe. The organization asked its partner experts in Europe ... researchers - to forecast where wellness is headed in Europe. Predictions range from European ...
(Date:5/31/2016)... ... 2016 , ... Interest is on the rise for using the CRISPR-Cas9 system ... for RNAi hit validation. A key reason may be that high-throughput synthesis—combined with a ... RNA (crRNA) collections in arrayed formats. , Arrayed crRNA screens have ...
(Date:5/31/2016)... , ... May 31, 2016 , ... Dr. Charles A. ... Dentistry of New Jersey in the class of 1986, where he graduated in the ... at his current location in Livingston since 1989. He has been a member in ...
Breaking Medicine News(10 mins):
(Date:5/30/2016)... 30, 2016 Eye expert s ... babies to seek an eye examination ...   Moorfields Eye Hospital Dubai, the first ... London , has identified premature babies as a special concern ... their particular vulnerability to retinopathy of prematurity (ROP). ROP is a ...
(Date:5/27/2016)... , May 27, 2016 ... innovative biopharma company focused on the highly lucrative ... a substantial pipeline of potential first-in-class or best-in-class ... are in development with strategic partners. HCM,s profitable ... fast-growing domestic market. We expect progress of the ...
(Date:5/26/2016)... , May 26, 2016 According to ... Waste Management Market - U.S. Industry Analysis, Size, Share, Growth, ... market in the U.S. was valued at US$ 5.89 Bn ... of 3.4% from 2015 to 2023 to reach US$ 7.99 ... of current and emerging needle free drug delivery devices and ...
Breaking Medicine Technology: