Navigation Links
Immune Response May Hinder Stem Cell Treatments
Date:8/18/2008

This unexpected reaction must be overcome to ensure therapeutic success, experts say

MONDAY, Aug. 18 (HealthDay News) -- Human embryonic stem cells trigger an immune response in mice, a new study finds. If the same thing happens in humans, it could prove a big roadblock to stem cell-based treatments, researchers say.

Researchers at Stanford University School of Medicine found that common anti-rejection medications could counter the mice's immune response. However, the new finding dashes prior hopes that the immune system gave foreign embryonic stem cells a "free pass" through the body.

"It's getting harder and harder to believe that these cells are immunoprivileged," senior author Dr. Joseph Wu, assistant professor of cardiovascular medicine and of radiology at Stanford, said in a news release issued by the university. "In fact, the rejection of these cells confirms our suspicions that they do cause an immune response."

The findings were to be published in the Aug.18 online edition of the journal Proceedings of the National Academy of Sciences.

Embryonic stem cells form all cells in an embryo. Many researchers have suggested that the immune system ignores them to allow the growth of a fetus that contains both maternal and paternal genetic material. Such an immunological exemption would counter concerns about using cells therapeutically that don't exactly match the recipient's immune system.

After injecting human embryonic stem cells into mice, those cells died within 10 days in mice with good immune systems but survived and multiplied in the mice with impaired immune responses. Further injections into the normally functioning mice led to more rapid cell death, a sign that the mice's immune system was getting better at recognizing and rejecting the cells.

"The data is quite convincing," Wu said. "Based on these results, we believe that transplanting these cells into humans would also cause an immune response."

Medicating the mice with normal immune systems with a combination of two common anti-rejection compounds -- tacrolimus and sirolimus -- allowed those cells to survive for up to 28 days, the team said.

More information

The U.S. National Institutes of Health has more about stem cells.



-- Kevin McKeever



SOURCE: Stanford University School of Medicine, news release, Aug. 18, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Penn study finds pro-death proteins required to regulate healthy immune function
2. Immune deficiency linked to a type of eye cancer
3. Tumors use enzyme to recruit regulatory T-cells and suppress immune response
4. Melanoma drug revs immune cells but cancer cells ignore it
5. Study identifies key player in the bodys immune response to chronic stress
6. MedImmune Resolves FDA Observations Regarding Manufacturing Process for FluMist(R)
7. UVA researchers find important clue to immune infertility
8. M.D. Anderson-led team reports possible key to autoimmune disease
9. Their immune cells, fighting your cancer
10. MedImmune Licenses Reverse Genetics Technology to GlaxoSmithKline for Use in Influenza Vaccine Development and Production
11. Occupational exposures may be linked to death from autoimmune disease
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Immune Response May Hinder Stem Cell Treatments
(Date:5/23/2017)... Beach, CA (PRWEB) , ... May 23, 2017 ... ... Certified Facial Plastic and Reconstructive Surgeon Dr. Kevin Sadati, is pleased to announce ... interested in building collagen and elastin in their face, neck, and body through ...
(Date:5/23/2017)... ... May 23, 2017 , ... MedTech ... in the modern ART laboratory, to provide hands-on training utilizing cutting-edge equipment at ... NextGen LifeLabs, a MedTech Group Purchasing vendor , will provide specialized equipment ...
(Date:5/23/2017)... ... May 23, 2017 , ... Orbita’s Nathan Treloar will discuss the role of ... Francisco. Titled Connected Health and IoT: Technology Innovators and Disruption , the workshop ... Associates, a market research and consulting firm specializing in emerging consumer technology products and ...
(Date:5/23/2017)... ... ... Therachat , a smart guided journaling tool for improving mental health, ... of anxiety in support of National Mental Health Awareness Month. , The nationwide survey ... general anxiety levels as well as identified the top triggers, impact to regular activities ...
(Date:5/22/2017)... ... 2017 , ... Patients who avoid necessary dental and endodontic treatments because of ... NY from Advanced Endodontics of Westchester. This highly-trained team of endodontists offer three different ... sedation methods may be recommended based on the severity of the anxiety experienced by ...
Breaking Medicine News(10 mins):
(Date:5/15/2017)... 2017  Amy Baxter MD, chief executive officer and ... pain relief, was awarded a 2017 Top 40 Healthcare ... recognized at the MM&M Top 40 Healthcare Transformers dinner ... on May 10, 2017. The dinner followed a ... "beyond the pill."  "Innovation goes beyond invention," ...
(Date:5/10/2017)... , May 10, 2017 Global Health Intelligence ... Latin America , published its 2017 ranking of ... is based on extensive data analysis from GHI,s hospitals ... hospitals database for the region. The GHI database covers 86% ... offering more than 130 data points for each institution in ...
(Date:5/9/2017)... , May 9, 2017  Demonstrating its ... board of directors for the Pharmaceutical Research and ... for membership. Biopharmaceutical companies will now have to ... order to be eligible to join PhRMA. ... the board is sending a clear message that ...
Breaking Medicine Technology: