Navigation Links
Immune Response May Hinder Stem Cell Treatments
Date:8/18/2008

This unexpected reaction must be overcome to ensure therapeutic success, experts say

MONDAY, Aug. 18 (HealthDay News) -- Human embryonic stem cells trigger an immune response in mice, a new study finds. If the same thing happens in humans, it could prove a big roadblock to stem cell-based treatments, researchers say.

Researchers at Stanford University School of Medicine found that common anti-rejection medications could counter the mice's immune response. However, the new finding dashes prior hopes that the immune system gave foreign embryonic stem cells a "free pass" through the body.

"It's getting harder and harder to believe that these cells are immunoprivileged," senior author Dr. Joseph Wu, assistant professor of cardiovascular medicine and of radiology at Stanford, said in a news release issued by the university. "In fact, the rejection of these cells confirms our suspicions that they do cause an immune response."

The findings were to be published in the Aug.18 online edition of the journal Proceedings of the National Academy of Sciences.

Embryonic stem cells form all cells in an embryo. Many researchers have suggested that the immune system ignores them to allow the growth of a fetus that contains both maternal and paternal genetic material. Such an immunological exemption would counter concerns about using cells therapeutically that don't exactly match the recipient's immune system.

After injecting human embryonic stem cells into mice, those cells died within 10 days in mice with good immune systems but survived and multiplied in the mice with impaired immune responses. Further injections into the normally functioning mice led to more rapid cell death, a sign that the mice's immune system was getting better at recognizing and rejecting the cells.

"The data is quite convincing," Wu said. "Based on these results, we believe that transplanting these cells into humans would also cause an immune response."

Medicating the mice with normal immune systems with a combination of two common anti-rejection compounds -- tacrolimus and sirolimus -- allowed those cells to survive for up to 28 days, the team said.

More information

The U.S. National Institutes of Health has more about stem cells.



-- Kevin McKeever



SOURCE: Stanford University School of Medicine, news release, Aug. 18, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Penn study finds pro-death proteins required to regulate healthy immune function
2. Immune deficiency linked to a type of eye cancer
3. Tumors use enzyme to recruit regulatory T-cells and suppress immune response
4. Melanoma drug revs immune cells but cancer cells ignore it
5. Study identifies key player in the bodys immune response to chronic stress
6. MedImmune Resolves FDA Observations Regarding Manufacturing Process for FluMist(R)
7. UVA researchers find important clue to immune infertility
8. M.D. Anderson-led team reports possible key to autoimmune disease
9. Their immune cells, fighting your cancer
10. MedImmune Licenses Reverse Genetics Technology to GlaxoSmithKline for Use in Influenza Vaccine Development and Production
11. Occupational exposures may be linked to death from autoimmune disease
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Immune Response May Hinder Stem Cell Treatments
(Date:10/12/2017)... , ... October 12, 2017 , ... ... now treating sleep apnea using cutting-edge Oventus O2Vent technology. As many ... sleep disorder characterized by frequent cessation in breathing. Oral appliances can offer significant ...
(Date:10/12/2017)... (PRWEB) , ... October 12, 2017 , ... IsoComforter, Inc. ... products, announced today the introduction of an innovative new design of the shoulder pad. ... so you get maximum comfort while controlling your pain while using cold therapy. By ...
(Date:10/12/2017)... ... October 12, 2017 , ... Information about the technology: ... develop to enable prevention of a major side effect of chemotherapy in children. ... pediatric patients. For cisplatin, hearing loss is FDA listed on-label as a dose ...
(Date:10/12/2017)... ... October 12, 2017 , ... Leading pediatric oncology experts ... Washington, D.C., for the 49th Congress of the International Society of Paediatric Oncology ... of the Center for Cancer and Blood Disorders at Children’s National, and ...
(Date:10/12/2017)... ... 12, 2017 , ... Health Literacy Innovations (HLI), creator of ... and the Cancer Patient Education Network (CPEN), an independent professional organization that shares ... strategic alliance. , As CPEN’s strategic partner, HLI will help support CPEN ...
Breaking Medicine News(10 mins):
(Date:10/4/2017)... Mass. , Oct. 4, 2017  According to the Centers for ... the end of October . PhysicianOne Urgent Care is helping communities across ... Westchester, NY , by offering no-cost* flu shots through the ... as mandated by certain health insurance regulations. ... The best time to get a flu shot is by the ...
(Date:10/2/2017)... 2, 2017  AllianceRx Walgreens Prime, the combined central ... and pharmacy benefit manager Prime Therapeutics LLC (Prime), today ... included the unveiling of new signage at its headquarters ... as at a few other company-owned facilities across the ... patients, some of whom will begin to see the ...
(Date:9/28/2017)... 2017 Cohen Veterans Bioscience and Early Signal ... wearable and home sensors for real-time monitoring of patients ... a nonprofit organization focused on disruptive health solutions for ... analytical system to record and integrate behavioral, cognitive, physiological ... ...
Breaking Medicine Technology: