Navigation Links
Immune Response Better With Skin Scratch Vaccination
Date:1/17/2010

'Scarification' offered greater protection than injection in study

SUNDAY, Jan. 17 (HealthDay News) -- Giving a vaccine through a scratch on the skin (scarification) triggers a stronger immune response than injected vaccines, say U.S. researchers, who also found that scarification requires 100 times less vaccine to prompt an immune response.

Scarification was first used nearly two centuries ago to give the first smallpox vaccinations. Nearly all modern vaccines are given via injection, according to background information in a news release about the study, which is published in the Jan. 17 issue of Nature Medicine.

In a series of tests, the Brigham and Women's Hospital researchers also found that the memory of T-cells -- the cells that mount an immune response against invading viruses -- may be more important than the antibodies generated by injected vaccines. T-cells are located in lymph nodes and blood, as well as in peripheral tissues such as skin and lung.

"This research illustrates the remarkable capacity of the most superficial layer of skin to generate powerful protective immune responses after vaccination," study senior researcher Dr. Thomas Kupper, chairman of the dermatology department at the hospital, said in a news release from the hospital.

"The ability of vaccination through injured epidermis -- or scarification -- to generate such powerful tissue-resident protective T-cells is a completely novel observation that should make us reconsider the way we think about vaccine delivery for all infectious diseases, as well as cancer. After all, our immune system evolved over millions of years to respond to infections of injured skin, not vaccines delivered by hypodermic syringe into muscle," he noted.

In their experiments, Kupper and colleagues found that scarification with the vaccinia virus offered much greater protection against smallpox than injecting the vaccine. They also found that a melanoma vaccine delivered by scarification was much more effective than injected vaccines in protecting animals against melanoma tumor growth.

"The lessons we are learning from these studies of vaccination by scarification could help us develop new and more powerful vaccines for influenza, HIV, malaria and other infectious diseases," Kupper explained. "We should also continue to explore the implications for developing powerful cancer vaccines, like the one demonstrated by melanoma vaccine results in this study."

More information

The U.S. National Institute of Allergy and Infectious Diseases has more about vaccines.



-- Robert Preidt



SOURCE: Brigham and Women's Hospital, news release, Jan. 17, 2010


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Penn study finds pro-death proteins required to regulate healthy immune function
2. Immune deficiency linked to a type of eye cancer
3. Tumors use enzyme to recruit regulatory T-cells and suppress immune response
4. Melanoma drug revs immune cells but cancer cells ignore it
5. Study identifies key player in the bodys immune response to chronic stress
6. MedImmune Resolves FDA Observations Regarding Manufacturing Process for FluMist(R)
7. UVA researchers find important clue to immune infertility
8. M.D. Anderson-led team reports possible key to autoimmune disease
9. Their immune cells, fighting your cancer
10. MedImmune Licenses Reverse Genetics Technology to GlaxoSmithKline for Use in Influenza Vaccine Development and Production
11. Occupational exposures may be linked to death from autoimmune disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/5/2016)... ... May 05, 2016 , ... With May flowers, summer is just around the corner. ... a welcome respite from school and the ability to play all day and night. Parents ... children or watch the little tykes themselves. Summer also means trips to the beach, backyard ...
(Date:5/5/2016)... ... 05, 2016 , ... Dermatologic surgeons performed nearly 10 million medically necessary and ... since 2012. , The results of the 2015 ASDS Survey on Dermatologic Procedures released ... treatments and the growing popularity of soft-tissue fillers and body sculpting procedures. , ...
(Date:5/5/2016)... (PRWEB) , ... May 05, ... ... Executive Director 703.462.0658, ctellez(at)msnva.org , The Medical Society of Northern Virginia, Announces ... their patients , The Medical Society of Northern Virginia (MSNVA) launches DoctorsTelemed?, ...
(Date:5/5/2016)... ... ... Nepenthe Laboratory Services (NLS), a premier drug monitoring and toxicology laboratory, held ... donations for Food for Lane County, and to help support awareness for the upcoming ... assembly was to create an exciting atmosphere for the kids at Riverbend to aspire ...
(Date:5/5/2016)... ... May 05, 2016 , ... Is the part in ... Day just a few days away, it’s a good opportunity to raise awareness about ... the American Academy of Dermatology, 40% of women experience hair loss or ‘thinning’ by ...
Breaking Medicine News(10 mins):
(Date:5/3/2016)... Pa. , May 3, 2016 ACME ... Jack Whelan and Delaware County ... (naloxone HCI) Nasal Spray in all ACME ... U.S. Centers for Disease Control and Prevention (CDC), naloxone has saved ... when police officers in Delaware County were ...
(Date:5/3/2016)... -- Pharmaceutical giant Johnson & Johnson has ... who says its talc-based powder products caused ovarian cancer. ... $5 million in compensatory damages and $50 million in ... ) , This is the second in ... the same court awarded $72 million to the family ...
(Date:5/3/2016)... 3, 2016 Global and ... a basic overview of the industry that covers ... surgical mesh report explores into the international and ... report on Surgical Mesh market spread across 150 ... and figures is available at http://www.reportsnreports.com/reports/470569-global-and-chinese-surgical-mesh-industry-2016-market-research-report.html ...
Breaking Medicine Technology: