Navigation Links
Immune Molecule Key to Preventing Organ Rejection
Date:6/23/2008

Measuring HLA-G dimer may identify patients who need little, if any, immune suppression

MONDAY, June 23 (HealthDay News) -- An immune molecule called HLA-G dimer plays a powerful role in preventing the immune system from rejecting transplanted organs and tissue, Medical College of Georgia researchers say.

They found that HLA-G helped prolong skin graft survival in mice and are currently studying whether this molecule is at work in kidney transplant patients who don't experience organ rejection.

"This is a molecule with huge potential to regulate immune response," Dr. Anatolij Horuzsko, a reproductive immunologist at the Medical College of Georgia Center for Molecular Chaperone/Radiobiology and Cancer Virology, said in a prepared statement.

He and his colleagues found that when HLA-G dimer binds with its inhibitory receptor ILT4, it triggers a signaling pathway in which immune molecules IL-6 and STAT3 play a major role.

"Biologically, this is an interaction that requires several important suppressive molecules," said Horuzsko, corresponding author of the study, which was published online in the journal Proceedings of the National Academy of Sciences.

The researchers looked at the resulting strong signal in culture and then assessed its impact on skin graft survival in mice.

Horuzsko and colleagues believe HLA-G dimer's action can be boosted in order to suppress immune activity in people with organ transplants and autoimmune diseases, and turned down in order to increase immune system activity against tumors. Measuring levels of HLA-G dimer may also help doctors identify transplant patients who require little, if any, immune system suppression.

More information

The MedlinePlus Medical Encyclopedia has more about transplant rejection.



-- Robert Preidt



SOURCE: Medical College of Georgia, news release, June 16, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Nasal spray using bodys immune system provides hope of cure for common cold
2. Immune Design Announces $18 Million Series A Financing
3. Autoimmune Disease Treatment May Not Dampen Immune System
4. Immune molecule that plays a powerful role in avoiding organ rejection identified
5. Specific location of the TRAF1/C5 gene associated with multiple autoimmune diseases
6. TB treatment for the elderly likely requires a boost to immune response
7. FDA Starts Safety Review of Autoimmune Disorder Drugs
8. OHSU Cancer Institute finds that drug stimulated immune system in prostate cancer
9. Weizmann Institute scientists develop a new approach to treating autoimmune disease
10. Cell-Mediated Immunity and Anti-HLA Antibody Tests Provide Insight to Immune Response in Renal Transplant Patients
11. Multiple Independent Studies Report on Use of Cylexs Immune Cell Function Assay in Postoperative Monitoring of Kidney, Liver, and Heart Transplant Recipients
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/28/2017)... , ... June 28, 2017 , ... ... management and financial planning assistance to clients in southern Montana, is announcing a ... by Zoo Montana. , The outreach programs offered by Zoo Montana provide students ...
(Date:6/28/2017)... (PRWEB) , ... June 28, 2017 , ... ... consulting firm servicing communities throughout the greater Cincinnati metropolitan area, is teaming up ... temporary lodgings for families with children receiving treatment in nearby hospitals. , Ronald ...
(Date:6/27/2017)... (PRWEB) , ... June 27, 2017 , ... DrugDev ... study is whether they can trust the sponsor to pay them correctly and on ... sponsors and CROs establish payment strategies that encourage sites to work on their studies. ...
(Date:6/27/2017)... ... 2017 , ... The Congressional Budget Office (CBO) projects that the Better Care ... Protection and Affordable Care Act (ACA), would result in 22 million Americans losing their ... , More than 20 million Americans have gained health insurance under the ACA, and ...
(Date:6/27/2017)... ... , ... A January 18th article on medGadget reports that the ... the year 2024 according to a new report. The article also notes that the ... Los Angeles area clinic Beverly Hills Periodontics & Dental Implant Center says that it ...
Breaking Medicine News(10 mins):
(Date:6/19/2017)... HORSHAM, Pa. , June 19, 2017  Researchers ... announced today that they will host a live, complimentary ... Perspectives from the benchtop to the real world" on ... PM EDT. This webinar will feature ... a rare look into the manipulation techniques abusers use ...
(Date:6/14/2017)... The Bio Supply Management Alliance (BSMA) has ... and the Biomedical Manufacturing Network to advance ... California by providing a platform for ... workforce development. The primary focus of this alliance is ... well as small and mid-sized biomedical companies. ...
(Date:6/11/2017)... June 10, 2017  Eli Lilly and Company (NYSE: ... Phase 3 studies of galcanezumab, an investigational treatment for ... data on several key secondary endpoints for galcanezumab compared ... these studies (EVOLVE-1, EVOLVE-2 and REGAIN) will be presented ... meeting in Boston . ...
Breaking Medicine Technology: