Navigation Links
Immune Molecule Key to Preventing Organ Rejection
Date:6/23/2008

Measuring HLA-G dimer may identify patients who need little, if any, immune suppression

MONDAY, June 23 (HealthDay News) -- An immune molecule called HLA-G dimer plays a powerful role in preventing the immune system from rejecting transplanted organs and tissue, Medical College of Georgia researchers say.

They found that HLA-G helped prolong skin graft survival in mice and are currently studying whether this molecule is at work in kidney transplant patients who don't experience organ rejection.

"This is a molecule with huge potential to regulate immune response," Dr. Anatolij Horuzsko, a reproductive immunologist at the Medical College of Georgia Center for Molecular Chaperone/Radiobiology and Cancer Virology, said in a prepared statement.

He and his colleagues found that when HLA-G dimer binds with its inhibitory receptor ILT4, it triggers a signaling pathway in which immune molecules IL-6 and STAT3 play a major role.

"Biologically, this is an interaction that requires several important suppressive molecules," said Horuzsko, corresponding author of the study, which was published online in the journal Proceedings of the National Academy of Sciences.

The researchers looked at the resulting strong signal in culture and then assessed its impact on skin graft survival in mice.

Horuzsko and colleagues believe HLA-G dimer's action can be boosted in order to suppress immune activity in people with organ transplants and autoimmune diseases, and turned down in order to increase immune system activity against tumors. Measuring levels of HLA-G dimer may also help doctors identify transplant patients who require little, if any, immune system suppression.

More information

The MedlinePlus Medical Encyclopedia has more about transplant rejection.



-- Robert Preidt



SOURCE: Medical College of Georgia, news release, June 16, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Nasal spray using bodys immune system provides hope of cure for common cold
2. Immune Design Announces $18 Million Series A Financing
3. Autoimmune Disease Treatment May Not Dampen Immune System
4. Immune molecule that plays a powerful role in avoiding organ rejection identified
5. Specific location of the TRAF1/C5 gene associated with multiple autoimmune diseases
6. TB treatment for the elderly likely requires a boost to immune response
7. FDA Starts Safety Review of Autoimmune Disorder Drugs
8. OHSU Cancer Institute finds that drug stimulated immune system in prostate cancer
9. Weizmann Institute scientists develop a new approach to treating autoimmune disease
10. Cell-Mediated Immunity and Anti-HLA Antibody Tests Provide Insight to Immune Response in Renal Transplant Patients
11. Multiple Independent Studies Report on Use of Cylexs Immune Cell Function Assay in Postoperative Monitoring of Kidney, Liver, and Heart Transplant Recipients
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/8/2016)... ... December 08, 2016 , ... ... that serve communities in and around the greater Phoenix metropolitan region, is announcing ... Connection. , The mission of the Homeless Youth Connection is to promote community ...
(Date:12/8/2016)... Louis, MS (PRWEB) , ... December 08, 2016 , ... ... that serve commercial and residential clients in and around the Hancock County area, is ... for the Hancock County Food Pantry. , The Hancock County Food Pantry has worked ...
(Date:12/8/2016)... ... December 08, 2016 , ... ... to families and business owners in and around central Kansas, is joining the ... at-risk youth in the region. , Headquartered in Wichita, Youth Horizons works to ...
(Date:12/7/2016)... ... 07, 2016 , ... Students attending Envision’s summer 2017 ... get hands-on experience in an emergency medical simulation, When Care is Hours Away. ... real-life medical skills that are critical success in a future career and beyond. ...
(Date:12/7/2016)... ... December 07, 2016 , ... Kenall Manufacturing, a leader in ... MPCNGX . The MPCNGX is a multi-function, sealed, LED luminaire that meets the needs ... where and when it’s needed. , A 2’ x 4’ model features ...
Breaking Medicine News(10 mins):
(Date:12/8/2016)... Dec. 8, 2016 CANTEL MEDICAL CORP. (NYSE: ... $18,800,000, or $0.45 per diluted share, on a 22.1% increase ... ended October 31, 2016. This compares with net income of ... for the first quarter ended October 31, 2015. ... ended October 31, 2016 to $21,323,000, or $0.51 per diluted ...
(Date:12/8/2016)... December 8, 2016 Stock-Callers.com revisits ... research, distribution, and marketing of pharmaceutical drug products. Companies ... protection and expiration. Additionally, these firms typically have dividend ... a whole. Up for review this morning are: Novo ... Inc. (NASDAQ: SGYP ), Pernix Therapeutics Holdings ...
(Date:12/8/2016)... , Dec. 8, 2016 ... company advancing technologies designed to address rare, emerging ... Chitra Edwin , Ph.D., RAC, as Senior ... Edwin will provide leadership for all U.S. and ... approvals, preparation of regulatory submissions, serving as the ...
Breaking Medicine Technology: