Navigation Links
Immune Cells Shrink Tumors in Mice
Date:2/13/2009

They target a protein found in some cancers, study finds

FRIDAY, Feb. 13 (HealthDay News) -- Scientists say certain tumors in mice have shrunk or disappeared after the animals were injected with genetically engineered immune system cells that target a protein found in certain human cancers.

The lab-altered T-cells zeroed in on mesothelin, a still mysterious protein produced in abundance by all pancreatic cancers and mesotheliomas, as well as many ovarian and non-small-cell lung cancers. The protein is believed to play a role in the spread and growth of cancer cells, a theory backed by past animal and human studies that found attacking mesothelin can shrink tumors.

"Based on the size of the tumors and the number of cells administered, we estimate that one mesothelin-targeted T-cell was able to kill about 40 tumor cells," study leader Dr. Carl H. June, a professor of pathology and laboratory medicine at the University of Pennsylvania School of Medicine, said in a news release issued by the school and its partner in the research, the U.S. National Institutes of Health. "This finding indicates that small doses of these cells may have potential in treating patients with large tumors."

According to the study, published in this week's online issue of the Proceedings of the National Academy of Sciences, the altered T-cells secrete proteins attracted to mesothelin. Once bound to the mesothelin, the T-cells fighting ability shifts into overdrive, producing multiple cytokines that boost the immune system. Other proteins are released by the T-cells to make them less susceptible to tumor's defenses.

The researchers tested the new T-cells on mice with tumors that developed from the implantation of human mesothelioma cells in their skin. When the T-cells were injected into tumors or into the veins of the mice, the tumors disappeared or shrank.

"Mesothelin is a promising candidate for generating tumor-targeting T-cells, given its limited expression in normal tissues and high expression in several cancers," study collaborator Dr. Ira Pastan, chief of the molecular biology laboratory of the U.S. National Cancer Institute's Center for Cancer Research, said in the news release.

Clinical trials that would use the altered T-cells in patients with mesothelioma and ovarian cancer are in the works, June said.

More information

The U.S. National Cancer Institute has more about mesothelioma.



-- Kevin McKeever



SOURCE: U.S. National Institutes of Health/University of Pennsylvania, news release, Feb. 9, 2009


'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Penn study finds pro-death proteins required to regulate healthy immune function
2. Immune deficiency linked to a type of eye cancer
3. Tumors use enzyme to recruit regulatory T-cells and suppress immune response
4. Melanoma drug revs immune cells but cancer cells ignore it
5. Study identifies key player in the bodys immune response to chronic stress
6. MedImmune Resolves FDA Observations Regarding Manufacturing Process for FluMist(R)
7. UVA researchers find important clue to immune infertility
8. M.D. Anderson-led team reports possible key to autoimmune disease
9. Their immune cells, fighting your cancer
10. MedImmune Licenses Reverse Genetics Technology to GlaxoSmithKline for Use in Influenza Vaccine Development and Production
11. Occupational exposures may be linked to death from autoimmune disease
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Immune Cells Shrink Tumors in Mice
(Date:5/28/2016)... ... 2016 , ... After a year and a half of planning the Multiple Pathways of ... Multiple Pathways of Recovery Conference was held May 2 -4, 2016 at the Mystic ... came together to explore the many pathways individuals use to get into and sustain their ...
(Date:5/27/2016)... ... May 27, 2016 , ... Two director-level employees of Horizon Blue Cross Blue ... Industry (TWIN) 2016 honorees. The award recognizes businesswomen who excel in their fields ... Director of the MLTSS (Managed Long-Term Services and Supports) Program at Horizon NJ Health ...
(Date:5/27/2016)... ... , ... This campaign aims to provide a path to improved education and ... and change. , As nearly 795,000 Americans suffering from a new or recurrent stoke ... with an estimated 129,000 of these people dying from stroke, it’s become our nation’s ...
(Date:5/27/2016)... ... 27, 2016 , ... Aimed at nurses and employees in ... courtesy of leaders in the nursing and health care industry. It also provides ... and associations—namely Jones & Bartlett Learning. , Jones & Bartlett Learning is adding ...
(Date:5/26/2016)... ... ... Despite last week’s media reports hinting at a June rate hike after the ... for an interest rate increase, according to Rajeev Dhawan of the Economic Forecasting Center ... Market Committee (FOMC) dot charts are of interest to the press for their noise ...
Breaking Medicine News(10 mins):
(Date:5/27/2016)... PUNE, India , May 27, 2016 ... in the instances of hypertension is driving ambulatory blood ... muscles lose their elasticity and their ability to respond ... blood pressure. This condition can lead to various cardiovascular ... and peripheral vascular disease. These diseases are growing in ...
(Date:5/26/2016)... , May 26, 2016 According ... "Medical Waste Management Market - U.S. Industry Analysis, Size, Share, ... management market in the U.S. was valued at US$ 5.89 ... CAGR of 3.4% from 2015 to 2023 to reach US$ ... analysis of current and emerging needle free drug delivery devices ...
(Date:5/25/2016)... May 25,2016 FDA 510(k) ... Cellvizio platform for urological and surgical applications ... inventor of Cellvizio®, the multidisciplinary confocal laser endomicroscopy ... in the US with the 12 th ... Administration (FDA). This new FDA clearance covers Confocal ...
Breaking Medicine Technology: