Navigation Links
Immune Cells Shrink Tumors in Mice
Date:2/13/2009

They target a protein found in some cancers, study finds

FRIDAY, Feb. 13 (HealthDay News) -- Scientists say certain tumors in mice have shrunk or disappeared after the animals were injected with genetically engineered immune system cells that target a protein found in certain human cancers.

The lab-altered T-cells zeroed in on mesothelin, a still mysterious protein produced in abundance by all pancreatic cancers and mesotheliomas, as well as many ovarian and non-small-cell lung cancers. The protein is believed to play a role in the spread and growth of cancer cells, a theory backed by past animal and human studies that found attacking mesothelin can shrink tumors.

"Based on the size of the tumors and the number of cells administered, we estimate that one mesothelin-targeted T-cell was able to kill about 40 tumor cells," study leader Dr. Carl H. June, a professor of pathology and laboratory medicine at the University of Pennsylvania School of Medicine, said in a news release issued by the school and its partner in the research, the U.S. National Institutes of Health. "This finding indicates that small doses of these cells may have potential in treating patients with large tumors."

According to the study, published in this week's online issue of the Proceedings of the National Academy of Sciences, the altered T-cells secrete proteins attracted to mesothelin. Once bound to the mesothelin, the T-cells fighting ability shifts into overdrive, producing multiple cytokines that boost the immune system. Other proteins are released by the T-cells to make them less susceptible to tumor's defenses.

The researchers tested the new T-cells on mice with tumors that developed from the implantation of human mesothelioma cells in their skin. When the T-cells were injected into tumors or into the veins of the mice, the tumors disappeared or shrank.

"Mesothelin is a promising candidate for generating tumor-targeting T-cells, given its limited expression in normal tissues and high expression in several cancers," study collaborator Dr. Ira Pastan, chief of the molecular biology laboratory of the U.S. National Cancer Institute's Center for Cancer Research, said in the news release.

Clinical trials that would use the altered T-cells in patients with mesothelioma and ovarian cancer are in the works, June said.

More information

The U.S. National Cancer Institute has more about mesothelioma.



-- Kevin McKeever



SOURCE: U.S. National Institutes of Health/University of Pennsylvania, news release, Feb. 9, 2009


'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Penn study finds pro-death proteins required to regulate healthy immune function
2. Immune deficiency linked to a type of eye cancer
3. Tumors use enzyme to recruit regulatory T-cells and suppress immune response
4. Melanoma drug revs immune cells but cancer cells ignore it
5. Study identifies key player in the bodys immune response to chronic stress
6. MedImmune Resolves FDA Observations Regarding Manufacturing Process for FluMist(R)
7. UVA researchers find important clue to immune infertility
8. M.D. Anderson-led team reports possible key to autoimmune disease
9. Their immune cells, fighting your cancer
10. MedImmune Licenses Reverse Genetics Technology to GlaxoSmithKline for Use in Influenza Vaccine Development and Production
11. Occupational exposures may be linked to death from autoimmune disease
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Immune Cells Shrink Tumors in Mice
(Date:1/24/2017)... , ... January 24, 2017 , ... “Speaking With God’s ... With God’s Voice” is the creation of published author, Louis A. Miraglia, a born-again ... how best to deliver God’s great, impactful Word. , “There is little doubt ...
(Date:1/24/2017)... ... January 24, 2017 , ... “The Octagon of Spiritual Balances”: a ... Balances” is the creation of published author, Pastor Bernard J. Weathers, pastor of Word ... bachelor degree in religious education and a master degree in theology. , ““The Octagon ...
(Date:1/24/2017)... ... 2017 , ... OSF Ventures, the corporate investment arm of ... headquartered in Silicon Valley that connects startups to corporations and invests in more ... agreement to be a corporate sponsor of Plug and Play’s program for Health ...
(Date:1/24/2017)... (PRWEB) , ... January 23, 2017 , ... ... men who support them, Dr. Carol Francis, Psychologist in the South Bay ... pay, humane respectful governing for all people and by all people shines as ...
(Date:1/23/2017)... Alto, CA (PRWEB) , ... ... ... a provider of translation and localization services for life science companies, has ... and inspection organization, TÜV SÜD America. ISO 17100 is the globally recognized ...
Breaking Medicine News(10 mins):
(Date:1/23/2017)... -- Research and Markets has announced the addition of the ... Forecast to 2025" report to their offering. ... Report Highlights: The report ... the investment opportunities Market forecasts till 2025, using estimated ... across the business segments, Regions and Countries Key developments ...
(Date:1/23/2017)... , Jan. 23, 2017  Using Astute ... at high risk for acute kidney injury (AKI) ... by globally-recognized care guidelines significantly improved ... severe AKI more than 33 percent, according to ... the journal Intensive Care Medicine. ...
(Date:1/23/2017)... 23, 2017 Ahead of today,s trading session, ... they have fared at the close: Kite Pharma Inc. (NASDAQ: ... OVAS ), and Regeneron Pharmaceuticals Inc. (NASDAQ: REGN ... relative laggards on Friday, January 20 th , 2017, down on ... reports on these stocks now at: ...
Breaking Medicine Technology: