Navigation Links
Immune Cells Shrink Tumors in Mice
Date:2/13/2009

They target a protein found in some cancers, study finds

FRIDAY, Feb. 13 (HealthDay News) -- Scientists say certain tumors in mice have shrunk or disappeared after the animals were injected with genetically engineered immune system cells that target a protein found in certain human cancers.

The lab-altered T-cells zeroed in on mesothelin, a still mysterious protein produced in abundance by all pancreatic cancers and mesotheliomas, as well as many ovarian and non-small-cell lung cancers. The protein is believed to play a role in the spread and growth of cancer cells, a theory backed by past animal and human studies that found attacking mesothelin can shrink tumors.

"Based on the size of the tumors and the number of cells administered, we estimate that one mesothelin-targeted T-cell was able to kill about 40 tumor cells," study leader Dr. Carl H. June, a professor of pathology and laboratory medicine at the University of Pennsylvania School of Medicine, said in a news release issued by the school and its partner in the research, the U.S. National Institutes of Health. "This finding indicates that small doses of these cells may have potential in treating patients with large tumors."

According to the study, published in this week's online issue of the Proceedings of the National Academy of Sciences, the altered T-cells secrete proteins attracted to mesothelin. Once bound to the mesothelin, the T-cells fighting ability shifts into overdrive, producing multiple cytokines that boost the immune system. Other proteins are released by the T-cells to make them less susceptible to tumor's defenses.

The researchers tested the new T-cells on mice with tumors that developed from the implantation of human mesothelioma cells in their skin. When the T-cells were injected into tumors or into the veins of the mice, the tumors disappeared or shrank.

"Mesothelin is a promising candidate for generating tumor
'/>"/>

Copyright©2009 ScoutNews,LLC.
All rights reserved  

0

GOOD

Page: 1 2

Related medicine news :

1. Penn study finds pro-death proteins required to regulate healthy immune function
2. Immune deficiency linked to a type of eye cancer
3. Tumors use enzyme to recruit regulatory T-cells and suppress immune response
4. Melanoma drug revs immune cells but cancer cells ignore it
5. Study identifies key player in the bodys immune response to chronic stress
6. MedImmune Resolves FDA Observations Regarding Manufacturing Process for FluMist(R)
7. UVA researchers find important clue to immune infertility
8. M.D. Anderson-led team reports possible key to autoimmune disease
9. Their immune cells, fighting your cancer
10. MedImmune Licenses Reverse Genetics Technology to GlaxoSmithKline for Use in Influenza Vaccine Development and Production
11. Occupational exposures may be linked to death from autoimmune disease
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Immune Cells Shrink Tumors in Mice
(Date:5/19/2013)... The muscles in the human body are ... of the biggest and most significant nervous systems in ... system comprises of peripheral nerves that reside outside of ... that the limbs and hands, as well as other ... damaged due to trauma or physical injury, their functionality ...
(Date:5/19/2013)... Los Angeles, California (PRWEB) May 19, 2013 ... more damage than just losing sleep, or annoying your ... 9, 2013 report by CNY Central (“Snoring and Teeth ... a certain type of teeth grinding can be hard ... around 12 million Americans, and one of its symptoms ...
(Date:5/19/2013)... Christi, TX (PRWEB) May 19, 2013 ... security systems companies. Homeowners who are considering an ... and services of the nation's leading security system providers ... systems reviews the best DIY home security system ... Every year 6Webs.com reviews dozens of home security companies ...
(Date:5/19/2013)... 19, 2013 The report “Feed Additives ... & Forecasts up to 2017” published by MarketsandMarkets, defines ... analysis and forecasting of the global volume and revenue ... driving and restraining factors for the global market with ... challenges. The market is segmented and revenue is forecasted ...
(Date:5/19/2013)... (PRWEB) May 19, 2013 The Pradaxa ... Management Conference was recently convened for hundreds of ... litigation now underway in U.S. District Court, Southern District ... Court’s website on May 14th, the Conference addressed the ... also reported during the Conference that Defendants submitted a ...
Breaking Medicine News(10 mins):Health News:Ultimate Neuropathy Support System Launched by Neuracel - Reaching New Heights in Herbal Medication for Peripheral Neuropathy 2Health News:Dr. Kanani, Woodland Hills Dentist: Dangers of Tooth Damage and Obstructive Sleep Disorder 2Health News:Dr. Kanani, Woodland Hills Dentist: Dangers of Tooth Damage and Obstructive Sleep Disorder 3Health News:Top Rated DIY Home Security System Companies Published by 6Webs.com 2Health News:Feed Additives Market to Reach $19.5 Billion by 2017 at a CAGR of 3.8% - New Report by MarketandMarkets 2Health News:Feed Additives Market to Reach $19.5 Billion by 2017 at a CAGR of 3.8% - New Report by MarketandMarkets 3Health News:Pradaxa Lawyers at Bernstein Liebhard LLP Report on Recent Status Conference in Federal Pradaxa Litigation 2Health News:Pradaxa Lawyers at Bernstein Liebhard LLP Report on Recent Status Conference in Federal Pradaxa Litigation 3
... to the British throne has extended his generosity and assistance ... dire need of measures to get back the lost splendour. ... Clarence House, his London residence, to launch an international campaign ... a chain of palaces and temples built by Nepal's Malla ...
... a B.C. youngster a bowel, liver, pancreas and stomach. Lori MacIver ... of her son. She said, "They were telling me to prepare ... ,Her son Gairett, 18, is now recovering following a high-risk, ... now has a new bowel, stomach, liver and pancreas, all from ...
... of American families has revealed that only half of drug- ... doing so often gives positive results to 82% of them. ... Gallup poll, the USA Today/HBO Family Drug Addiction poll revealed ... addicted to drugs or alcohol. ,The findings of the ...
... milestone in the mapping of the bovine genome, which will ... disease// control in cattle. This research is slated to benefit ... up on a sequence of 2.9 million DNA base pairs, ... in one pair, which can alter the productivity of the ...
... technique for pain relief has been developed at the ... a lot of promise// in alleviating extreme pain, during ... Neurolytic block, which is a concoction of anaesthetic and ... into the para vertebral space. This works by blocking ...
... virus has afflicted 487 children and has claimed the ... the state.,The disease has been recently named// as Acute ... family welfare ministry. ,Experts at the Sanjay ... of professor in Microbiology department, Dr TN Dhole, had ...
Cached Medicine News:Health News:A Princely Assistance to the Nepal Heritage 2Health News:Rare Transplant Gives B.C Youngster 4 New Organs 2Health News:Rare Transplant Gives B.C Youngster 4 New Organs 3Health News:Eastern UP hit by killer virus – Coxsacki 2
(Date:5/17/2013)... , May 17, 2013  TechAtlas Group has ... their competitive landscape map for the Chronic Kidney ... 90 international companies with drugs and devices currently ... and its sequelae. (Logo:  ... , hypertension - renal denervation , ...
(Date:5/17/2013)... Fuse Science, Inc. (OTCQB: DROP), ( www.fusescience.com ) ... new, patent-pending technologies poised to redefine how consumers receive energy, ... a business update teleconference and webcast for shareholders and the ... 4:30 PM ET. Fuse Science, Inc. CEO, ... and will be joined by Rubin Hanan ...
(Date:5/17/2013)... -- Sanofi (EURONEXT: SAN and NYSE: SNY ) announced ... , examining the selective JAK2 inhibitor SAR302503 for myelofibrosis ... The primary endpoint assessed the proportion of patients achieving ... in previous trials, the most common adverse events were ... presented at an upcoming medical congress. ...
Breaking Medicine Technology:TechAtlas Group Releases Innovative Chronic Kidney Disease Landscape Map 2Fuse Science, Inc. to Hold Business Update Webcast and Teleconference on May 22nd 2Sanofi Reports Positive Topline Results from Pivotal Phase III JAKARTA Study for JAK2 Inhibitor in Myelofibrosis 2Sanofi Reports Positive Topline Results from Pivotal Phase III JAKARTA Study for JAK2 Inhibitor in Myelofibrosis 3Sanofi Reports Positive Topline Results from Pivotal Phase III JAKARTA Study for JAK2 Inhibitor in Myelofibrosis 4Sanofi Reports Positive Topline Results from Pivotal Phase III JAKARTA Study for JAK2 Inhibitor in Myelofibrosis 5Sanofi Reports Positive Topline Results from Pivotal Phase III JAKARTA Study for JAK2 Inhibitor in Myelofibrosis 6
... Optimer Pharmaceuticals, Inc. (Nasdaq: OPTR ) ... difficile infection using National health insurance claims and ... 2, 2011 at the 21st Annual Scientific ... (SHEA).   (Logo:   http://photos.prnewswire.com/prnh/20090413/LA97352LOGO )Poster Presentation ...
... March 27, 2011 /PRNewswire-Asia/ -- Guangzhou General Hospital of ... the first Chinese regional military and civilian ... (mHealth) system is now in full operation. This network ... and a Remote Electrocardiograph (ECG) Diagnostic Center run by ...
Cached Medicine Technology:Optimer Pharmaceuticals Announces Presentation at Upcoming SHEA Annual Meeting Regarding Hospital CDI Patients at Risk of Recurrence and Mortality 2Chinese Army Established the First Chest Pain Rescue Network in China by Using IVT mHealth System 2
... The instrument includes the ... has increased illumination for ... illumination. The Copeland retinoscope ... handle, and extended battery ...
... stereopsis from 800 to 40 ... young as 2 years of ... from left to right., ,Randot ... Book #1: 200 & 100 ...
... EasyEye is the only handheld non-contact tonometer with ... is streamlined, quiet and now, with constant ... a gentle puff of air. You can prove ... on the patient's hand before you start. ...
... 2000 Phenytoin Assay is a ... use in the quantitative analysis ... or plasma. Kits are packaged ... Roche COBAS MIRA, COBAS MIRA ...
Medicine Products: