Navigation Links
Immortality gene mutation identifies brain tumors and other cancers
Date:3/18/2013

ity in those diseases.

But the Duke-led research team also identified nine tumor types highly associated with TERT promoter mutations. These cancers generally share a common feature: they arise in tissues with relatively low rates of cell renewal, suggesting they require the mutation to trigger the abnormal telomerase production.

These cancer types include melanomas, liposarcomas, hepatocellular carcinomas, transitional cell carcinomas of the urinary tract, squamous cell carcinomas of the tongue, medulloblastomas, and subtypes of gliomas, including 83 percent of primary glioblastomas, the most common brain tumor in adults with a median survival of only 15 months.

"The results in brain tumors were quite striking," said Patrick J. Killela, co-lead author of the study and a Duke graduate student. "For primary glioblastoma, this is the most frequent genetic mutation yet identified in this tumor."

Four years ago, Yan's laboratory at Duke identified critical gene mutations associated with glioblastoma. But those mutations in the IDH1 and IDH2 genes -- were found only in rare glioblastomas that arose from other, lower-grade tumors known as astrocytomas and oligodendrogliomas. The main cancer-causing mutation for the other primary glioblastomas remained elusive.

"Now we see this," said Zachary J. Reitman, Ph.D., an associate in research at Duke and co-lead author of the study. "This is a major discovery in brain tumors, because this single mutation can now distinguish one tumor from another and these are tumors that are difficult to classify with a typical pathology test. For primary glioblastoma, the TERT mutation is remarkably common, while for astrocytomas, it is rare. Using both IDH1 and TERT, we can greatly improve diagnosis and prognosis."

Yan said the TERT mutations also provide a biomarker that may be useful for early detection of urinary tract and liver tumors. The finding provides new targets for drug devel
'/>"/>

Contact: Sarah Avery
sarah.avery@duke.edu
919-660-1306
Duke University Medical Center
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Pursuing literary immortality illuminates how the mind works, finds CWRU researcher
2. KRAS gene mutation and amplification status affects sensitivity to antifolate therapy
3. Researchers Find Gene Mutations That May Be a Key to Autism
4. Mayo Clinic breast cancer study finds new type of mutation
5. Scientists make breakthrough in bile duct cancer with discovery of new gene mutations
6. Cancer may require simpler genetic mutations than previously thought
7. Mutations impair childhood growth and development by disrupting organization of chromosome pairs
8. Study sheds new light on role of genetic mutations in colon cancer development
9. Mutations in JAK3 gene identified in subtype of lymphoma provide potential drug target
10. Study finds new gene mutations that lead to enlarged brain size, cancer, autism, epilepsy
11. Gene Mutation Linked to Facial, Skull Abnormalities
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/31/2015)... ... July 31, 2015 , ... The 2nd annual Ride to Fight On will ... October 3, 2015. The Ride to Fight On is a cycling fundraiser that benefits ... The West Clinic and The University of Tennessee Health Science Center. A health and ...
(Date:7/31/2015)... ... 31, 2015 , ... Coco Libre announced today that their flagship Organic Coconut ... 2015 Vans US Open of Surfing, July 25 through August 2 in Huntington Beach, ... on the market, is a natural choice given the Open’s commitment to sustainable practices. ...
(Date:7/31/2015)... ... July 31, 2015 , ... Well-known for its unique pastries ... wedding cakes with custom designs, making life just a little bit sweeter for ... cakes for each customer who orders one. , The bakery provides a full line ...
(Date:7/31/2015)... ... 2015 , ... Transfinder, a software company based in Schenectady, N.Y., achieved record ... year-over-year for the first six months ended June 30, 2015 compared with the same ... last year’s record-revenue mark of $10.4 million. , “We know what our customers need ...
(Date:7/31/2015)... NY (PRWEB) , ... July 31, 2015 , ... The ... marijuana, on research projects that evaluate the potential of related, experimental treatments. The collaboration ... Department of Health to award Columbia Care one of five state licenses to produce ...
Breaking Medicine News(10 mins):Health News:West Cancer Center Announces 2nd Annual Ride to Fight On 2Health News:West Cancer Center Announces 2nd Annual Ride to Fight On 3Health News:Coco Libre Brings Eco-conscious Hydration to Vans US Open of Surfing 2Health News:Pastry Palace of Las Vegas Announces It Is Now Offering Custom Wedding Cakes in Las Vegas 2Health News:Transfinder Closes First Half of 2015 with Record Revenue 2Health News:Mount Sinai to Collaborate with Columbia Care on Medical Marijuana Research 2Health News:Mount Sinai to Collaborate with Columbia Care on Medical Marijuana Research 3
... Translational Science Institute (CTSI) and Tufts University today announced ... from the National Institutes of Health. These new ... original Clinical and Translational Science Award (CTSA) grant, UL1 ... National Center for Research Resources. "Community Engagement ...
... , TUESDAY, Oct. 27 (HealthDay News) -- Researchers are reporting ... D2 can eliminate vitamin D deficiency, and twice-monthly doses can ... , The dosage -- 50,000 international units (IU) every ... to be toxic, according to the study published in the ...
... ... and severe sciatica causes widespread disability, and represents a significant unmet medical ... new approach for reducing nerve root inflammation. This off-label treatment method, invented ... including new data from randomized, placebo-controlled studies. , ...
... , ... Emdeon,s vast reach across the U.S. healthcare industry with Susan G. Komen,s mission to ... ... partnership with Susan G. Komen for the Cure®, the world,s largest breast cancer advocacy ...
... Oct. 27 Health Fitness Corporation (NYSE Amex: FIT ... management solutions, will conduct a conference call to discuss its ... The call is scheduled for 4:30 p.m. ET on Wednesday, ... (412) 858-4600 to access the conference call, or can listen ...
... Oct. 27 , Robert A. Douglas, 1st ... , RJR Focus: SHC Career Division national sales growth, ... 20 years of previous sales management experience and over 6 ... SHC he has been fundamental in the development and implementation ...
Cached Medicine News:Health News:Tufts CTSI and Tufts University receive 4 NIH supplemental grant awards 2Health News:Tufts CTSI and Tufts University receive 4 NIH supplemental grant awards 3Health News:Short-Term, High-Dose Vitamin D2 May Ease Deficiency 2Health News:Revolutionary New Treatment for Sciatica Advances in the Clinic 2Health News:Revolutionary New Treatment for Sciatica Advances in the Clinic 3Health News:Revolutionary New Treatment for Sciatica Advances in the Clinic 4Health News:Susan G. Komen for the Cure Partners with Healthcare IT Leader Emdeon for Innovative Breast Health Awareness Campaigns 2Health News:Susan G. Komen for the Cure Partners with Healthcare IT Leader Emdeon for Innovative Breast Health Awareness Campaigns 3Health News:Susan G. Komen for the Cure Partners with Healthcare IT Leader Emdeon for Innovative Breast Health Awareness Campaigns 4Health News:Senior Healthcare Consultants and RJR Insurance Services, Inc. Announce 4th Quarter 2009 and 1st Quarter 2010 Sales Management Promotions 2Health News:Senior Healthcare Consultants and RJR Insurance Services, Inc. Announce 4th Quarter 2009 and 1st Quarter 2010 Sales Management Promotions 3Health News:Senior Healthcare Consultants and RJR Insurance Services, Inc. Announce 4th Quarter 2009 and 1st Quarter 2010 Sales Management Promotions 4
(Date:7/31/2015)... Ill. , July 31, 2015 ... ® (NABP ® ) issued a report ... ensuring that action is taken against websites illegally ... Internet Drug Outlet Identification Program Progress Report ... , thousands of websites illegally distribute ...
(Date:7/31/2015)... 2015  Xcelience, a contract development and manufacturing ... a structured cash investment in Powdersize, a ... micronization and powder size classification within the pharmaceutical ... while simultaneously adding a complete set of particle ... "As we continue to build ...
(Date:7/31/2015)... 2015  Xencor, Inc. (NASDAQ: XNCR ), a ... treatment of autoimmune diseases, asthma and allergic diseases, and ... Hata to its board of directors. ... development is a tremendous asset to our board," said ... officer of Xencor. "Xencor faces a range of opportunities ...
Breaking Medicine Technology:NABP Stresses Need for Accountability in Enforcing Internet Policies to Protect the Public From Illegal Online Drug Sellers 2NABP Stresses Need for Accountability in Enforcing Internet Policies to Protect the Public From Illegal Online Drug Sellers 3Xcelience Makes Structured Cash Investment in Powdersize 2Xcelience Makes Structured Cash Investment in Powdersize 3Xencor Appoints Yujiro S. Hata to Board of Directors 2Xencor Appoints Yujiro S. Hata to Board of Directors 3
... (Pink Sheets: CLSC ) makers of ... that they have received a $415,000 opening purchase order ... one of the nation,s two leading chain pharmacies, as ... regional healthcare product distributors and retailers; thus signaling the ...
... Jan. 12, 2011 The Long Term Care Pharmacy ... short-cycle dispensing within the long-term care (LTC) setting.  In ... cost savings generated by implementing a short-cycle, 7-day fill ... fees resulting from the quadrupling the number of dispenses ...
Cached Medicine Technology:Cobalis Corp. Receives $415,000 First Purchase Order from Major Retail Pharmacy for PreHistin® Allergy Defense Formula 2Cobalis Corp. Receives $415,000 First Purchase Order from Major Retail Pharmacy for PreHistin® Allergy Defense Formula 3Long Term Care Pharmacy Alliance Concerned with Proposed CMS Rule; New Study Confirms LTCPA Position 2Long Term Care Pharmacy Alliance Concerned with Proposed CMS Rule; New Study Confirms LTCPA Position 3
Multipiece PMMA IOL - Sulcus Fixation....
Hydrophilic Acrylic Intraocular Lens (Refractive and Bifocal). Anterior Chamber Lens....
Raysoft Foldable Intraocular Lens....
HAPTIBAG Hydrophilic Acrylic Lens....
Medicine Products: