Navigation Links
Immortality gene mutation identifies brain tumors and other cancers
Date:3/18/2013

ity in those diseases.

But the Duke-led research team also identified nine tumor types highly associated with TERT promoter mutations. These cancers generally share a common feature: they arise in tissues with relatively low rates of cell renewal, suggesting they require the mutation to trigger the abnormal telomerase production.

These cancer types include melanomas, liposarcomas, hepatocellular carcinomas, transitional cell carcinomas of the urinary tract, squamous cell carcinomas of the tongue, medulloblastomas, and subtypes of gliomas, including 83 percent of primary glioblastomas, the most common brain tumor in adults with a median survival of only 15 months.

"The results in brain tumors were quite striking," said Patrick J. Killela, co-lead author of the study and a Duke graduate student. "For primary glioblastoma, this is the most frequent genetic mutation yet identified in this tumor."

Four years ago, Yan's laboratory at Duke identified critical gene mutations associated with glioblastoma. But those mutations in the IDH1 and IDH2 genes -- were found only in rare glioblastomas that arose from other, lower-grade tumors known as astrocytomas and oligodendrogliomas. The main cancer-causing mutation for the other primary glioblastomas remained elusive.

"Now we see this," said Zachary J. Reitman, Ph.D., an associate in research at Duke and co-lead author of the study. "This is a major discovery in brain tumors, because this single mutation can now distinguish one tumor from another and these are tumors that are difficult to classify with a typical pathology test. For primary glioblastoma, the TERT mutation is remarkably common, while for astrocytomas, it is rare. Using both IDH1 and TERT, we can greatly improve diagnosis and prognosis."

Yan said the TERT mutations also provide a biomarker that may be useful for early detection of urinary tract and liver tumors. The finding provides new targets for drug devel
'/>"/>

Contact: Sarah Avery
sarah.avery@duke.edu
919-660-1306
Duke University Medical Center
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Pursuing literary immortality illuminates how the mind works, finds CWRU researcher
2. KRAS gene mutation and amplification status affects sensitivity to antifolate therapy
3. Researchers Find Gene Mutations That May Be a Key to Autism
4. Mayo Clinic breast cancer study finds new type of mutation
5. Scientists make breakthrough in bile duct cancer with discovery of new gene mutations
6. Cancer may require simpler genetic mutations than previously thought
7. Mutations impair childhood growth and development by disrupting organization of chromosome pairs
8. Study sheds new light on role of genetic mutations in colon cancer development
9. Mutations in JAK3 gene identified in subtype of lymphoma provide potential drug target
10. Study finds new gene mutations that lead to enlarged brain size, cancer, autism, epilepsy
11. Gene Mutation Linked to Facial, Skull Abnormalities
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/24/2014)... The typical American diet includes foods that ... consuming a diet high in calories and carbohydrates only ... that typically accumulate around the internal organs exposing people ... in the form of love handles, beer bellies and ... to rid themselves of the burden of embarrassing, unhealthy ...
(Date:11/24/2014)... Gersowitz Libo & Korek, P.C., a leading ... Tier recognition in the 2015 Edition of U.S. News-Best Lawyers ... a unique combination of quality law practice and breadth of ... honor and especially grateful to our clients whose continued support ... possible,” said Jeff S. Korek, senior partner at Gersowitz ...
(Date:11/23/2014)... Dallas, TX (PRWEB) November 24, 2014 ... Trials Review, H2, 2014" provides data on the ... information and data relating to the clinical trials ... trial numbers and their recruitment status as per ... The databook offers a preliminary coverage of disease ...
(Date:11/23/2014)... TX (PRWEB) November 23, 2014 ... Devices Market 2006 to 2020 - Asia-Pacific” provides ... energy devices market segments: minimally invasive body contouring ... devices. The analysis includes market size data by ... for the following countries: China, Japan, South Korea, ...
(Date:11/23/2014)... (PRWEB) November 23, 2014 Nearly ... heart attacks, strokes, deep vein thrombosis and other ... a federal multidistrict litigation (MDL) underway in the ... , Court documents updated on November 17th ... (JPML) show the filing of 259 lawsuits against ...
Breaking Medicine News(10 mins):Health News:Ketogenic Diet is the Perfect Solution for Diet Doc Patients Who Want to Learn How to Lose Weight over the Holidays 2Health News:Ketogenic Diet is the Perfect Solution for Diet Doc Patients Who Want to Learn How to Lose Weight over the Holidays 3Health News:Ketogenic Diet is the Perfect Solution for Diet Doc Patients Who Want to Learn How to Lose Weight over the Holidays 4Health News:U.S. News-Best Lawyers “Best Law Firms” Names Gersowitz Libo & Korek P.C. a 2015 Tier 1 Ranking Firm 2Health News:Aspergillosis Pipeline and Clinical Trials Market (Compnies and Drugs) Review H2 2014 Report at ReportsnReports.com 2Health News:Aspergillosis Pipeline and Clinical Trials Market (Compnies and Drugs) Review H2 2014 Report at ReportsnReports.com 3Health News:Aspergillosis Pipeline and Clinical Trials Market (Compnies and Drugs) Review H2 2014 Report at ReportsnReports.com 4Health News:Aesthetic Lasers and Energy Devices Market in APAC (China, Japan, South Korea, Australia and India) to 2020 2Health News:Aesthetic Lasers and Energy Devices Market in APAC (China, Japan, South Korea, Australia and India) to 2020 3Health News:Aesthetic Lasers and Energy Devices Market in APAC (China, Japan, South Korea, Australia and India) to 2020 4Health News:Testosterone Lawsuits Approach 260 in Illinois Federal Court Litigation, Bernstein Liebhard LLP Reports 2Health News:Testosterone Lawsuits Approach 260 in Illinois Federal Court Litigation, Bernstein Liebhard LLP Reports 3
... hospital,s PackardVisionsystemPALO ALTO, Calif., March 3 Bedtime Bingo. ... few of the reasons Lucile Packard Children,s Hospital at ... environment. Now, with the launch of a "live" video ... hospital is offering kids and their families a Northern ...
... Tyco International Ltd. (NYSE: TYC ; BSX: ... Special General Meeting of shareholders on March 12, 2009 at ... The Annual General Meeting will begin at 9:00 a.m. Atlantic ... at 9:30 a.m. Atlantic Time. During the meetings, shareholders ...
... Calif., March 3 Onyx Pharmaceuticals, Inc. (Nasdaq: ... at the Barclays Capital Global Healthcare Conference on Tuesday, ... parties may access a live webcast of the presentation ... that listeners log on 15 minutes early in order ...
... Second Year with New Vendors for 2009COLUMBUS, Ohio, March ... an expansion of health information technology (HIT) use by ... budget has provisions for an increase in HIT funds ... $19 billion in Medicare and Medicaid HIT incentives including ...
... and 14th year of consecutive product revenue growth. ... support growing non-US business.Q4 2008 Highlights:- Product revenues ... 161% to $4.7 million - Over 31,700 Masimo ... were shipped in Q4 2008- International realignment results ...
... Informational Site -COMMACK, N.Y., March 3 ... an informational website devoted to their revolutionary ... GlycoCarn(R), "the ultimate nitric oxide and performance ... in the athletic, fitness and health world ...
Cached Medicine News:Health News:Monterey Bay Aquarium Channels Its Way to Kids at Packard Children's 2Health News:Monterey Bay Aquarium Channels Its Way to Kids at Packard Children's 3Health News:Tyco to Host 2009 Annual General Meeting and Special General Meeting of Shareholders 2Health News:OSMA's EMR Standards of Excellence Program Eases EMR Adoption Process 2Health News:OSMA's EMR Standards of Excellence Program Eases EMR Adoption Process 3Health News:Masimo Reports Fourth Quarter and Full Year 2008 Financial Results 2Health News:Masimo Reports Fourth Quarter and Full Year 2008 Financial Results 3Health News:Masimo Reports Fourth Quarter and Full Year 2008 Financial Results 4Health News:Masimo Reports Fourth Quarter and Full Year 2008 Financial Results 5Health News:Masimo Reports Fourth Quarter and Full Year 2008 Financial Results 6Health News:Masimo Reports Fourth Quarter and Full Year 2008 Financial Results 7Health News:Masimo Reports Fourth Quarter and Full Year 2008 Financial Results 8Health News:Masimo Reports Fourth Quarter and Full Year 2008 Financial Results 9Health News:Masimo Reports Fourth Quarter and Full Year 2008 Financial Results 10Health News:Masimo Reports Fourth Quarter and Full Year 2008 Financial Results 11Health News:Masimo Reports Fourth Quarter and Full Year 2008 Financial Results 12Health News:Masimo Reports Fourth Quarter and Full Year 2008 Financial Results 13Health News:Masimo Reports Fourth Quarter and Full Year 2008 Financial Results 14Health News:Masimo Reports Fourth Quarter and Full Year 2008 Financial Results 15Health News:Masimo Reports Fourth Quarter and Full Year 2008 Financial Results 16Health News:Sigma-tau HealthScience Launches www.GlycoCarn.com 2
(Date:11/22/2014)... -- Statistics released from a number of organizations show ... the holidays, beginning with Thanksgiving eve, which is now ... The data, highlighted in an Infographic released ... their annual Sober Days for the Holidays public ... and increased rates of DUI injuries and deaths during ...
(Date:11/22/2014)... CHAPEL HILL, N.C. , Nov. 21, 2014 ... the healthcare system. Undoubtedly, the growing influence of ... and spend for marketing interactions. Now, more than ... and retain patients for medical products is essential. ... benchmarking firm, Best Practices, LLC, benchmarked companies spent ...
(Date:11/21/2014)... DIEGO , Nov. 21, 2014  Tandem ... TNDM ), a medical device company and manufacturer ... announced a partnership with Tidepool, a non-profit dedicated ... open source software platform that increases diabetes data ... Tidepool Platform, which is currently under development, to ...
Breaking Medicine Technology:Alarming Stats Show Holiday Drinking an Issue for Many 2New Report Details Importance of Adopting a "Patient Journey" Framework in Marketing 2Tandem Diabetes Care Announces Partnership with Tidepool to Further Expand Access to Diabetes Device Data 2Tandem Diabetes Care Announces Partnership with Tidepool to Further Expand Access to Diabetes Device Data 3
... PTCB today announced that the Department of Veterans Affairs (VA) requires ... at grade GS-6 and above. VA,s decision came after formal recommendations ... the VA Handbook 5005/15 . , ... The incorporation of these new requirements ...
... Nash Corporation (Nasdaq: KNSY ) is scheduled to present at the Jefferies ... , on Thursday, June 10, 2010 . , ... Joseph W. Kaufmann , Kensey Nash,s President & CEO, ...  To hear the live webcast of the Kensey Nash presentation, go to ...
Cached Medicine Technology:PTCB Certification Required for Pharmacy Technician Employment by Department of Veterans Affairs 2PTCB Certification Required for Pharmacy Technician Employment by Department of Veterans Affairs 3Kensey Nash to Present at the Jefferies 2010 Global Life Sciences Conference 2
The Concept Plus also allows users to transfer large bottles, flasks and other equipment, quickly and efficiently. The front-loading interlock features class leading one touch operation and easy acce...
Providing a perfect combination of capacity, speed and innovation, the Concept 400 delivers simple sophistication and new levels of comfort and convenience....
Lose the variability of anaerobic jars and step into the 21st century with the anaerobic workstation that provides the answer to the common problems associated with anaerobic microbiology....
... operating table MARS Enduro is the ... interventions are required before, during or ... the motorised longitudinal adjustment and the ... working conditions in examination, induction and ...
Medicine Products: