Navigation Links
Imaging technique IDs plaques, tangles in brains of severely depressed older adults
Date:11/8/2011

Depression is one of the most common mental disorders in the elderly, but little is known about the underlying biology of its development in older adults.

In a small study published in the November issue of the peer-reviewed journal Archives of General Psychiatry, UCLA researchers used a unique brain scan to assess the levels of amyloid plaques and tau tangles in older adults with a type of severe depression called major depressive disorder (MDD).

Previous research has suggested that plaque and tangle deposits in the brain -- hallmarks of Alzheimer's disease and many dementias -- are associated not only with memory loss but also with mild symptoms of depression and anxiety in middle-aged and older individuals. The team wanted to see what the brain-scanning technique developed at UCLA would find in older people with MDD.

UCLA researchers have created a chemical marker called FDDNP that binds to both plaque and tangle deposits, which can then be viewed through a positron emission tomography (PET) brain scan, providing a "window into the brain." Using this method, researchers are able to pinpoint where in the brain these abnormal protein deposits are accumulating.

Researchers compared the FDDNP brain scans of 20 older adults between ages 60 to 82 who had been diagnosed with MDD with the scans of 19 healthy controls of similar age, education and gender.

They found that in patients with MDD, FDDNP binding was significantly higher throughout the brain and in critical brain regions, including the posterior cingulate and lateral temporal areas, that are involved in decision-making, complex reasoning, memory and emotions.

"This is the first study using FDDNP to assess the abnormal protein levels in brains of older adults with severe depression," said the study's senior author, Dr. Gary Small, UCLA's Parlow-Solomon Professor on Aging and a professor of psychiatry at the Semel Institute for Neu
'/>"/>

Contact: Rachel Champeau
rchampeau@mednet.ucla.edu
310-794-2270
University of California - Los Angeles Health Sciences
Source:Eurekalert  

Page: 1 2

Related medicine news :

1. Neuroimaging study may pave way for effective Alzheimers treatments
2. SNMs Conjoint Mid-Winter Meetings continue to advance molecular imaging
3. Medical Imaging Northwest Completes Phase I of Its Healthcare IT Integration to Maintain Patient Care Improvements
4. Less is more in cancer imaging
5. Imaging manufacturers: Plan to reduce unnecessary radiation exposure and medical errors
6. National Council on Aging Releases Survey on Medical Imaging Safety
7. Artists, Product Designers, Printing Gurus, Game Developers, Manufacturing Engineers Will Converge at RAPID 2010/3D IMAGING Conference/Expo, May 18-20 in LA
8. Promega - TOP srl Agreement Enables Live Animal Imaging for Cancer Studies
9. Imaging fat layer around heart can help predict disease
10. ModiFace Launches VuMe in Southern Florida – the World's First Full-Featured Touch-Screen Cosmetic Surgery Imaging System
11. Midroog Ltd., an Affiliate of Moodys Investors Services, Rates Potential new Debt of Elbit Imaging
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Imaging technique IDs plaques, tangles in brains of severely depressed older adults
(Date:11/23/2014)... Newport Beach, CA (PRWEB) November 23, 2014 ... founder of American Medical Aesthetics & Wellness was ... Dr. Asher Milgrom, Ph.D. is president and CEO of ... Skincare. Dr. Asher Milgrom received a full scholarship ... Sciences and the Medical School at the University of ...
(Date:11/23/2014)... BambooFlooringChina.com , the world’s leader in bamboo ... bamboo flooring collection. Now, the business is announcing big ... the promotion is valid until Dec. 20, 2014. , The ... and dust-free surface, which makes it very easy to maintain. ... company wants to make its website the best shopping platform ...
(Date:11/22/2014)... 2014 PrettyTailor , an outstanding ... new big promotion. Customers can buy new dresses at ... can visit its website. , As a matter of ... dresses. It mainly provides four types of wedding outfits, ... flower girl dresses. It also provides a variety of ...
(Date:11/22/2014)... 23, 2014 Today, Dylan Queen, a ... collection of wedding dresses; the business offers a wide ... accessories for ladies worldwide, allowing them to create multiple ... the company, this new collection of chic wedding dresses ... they are offered at discounted rates now. Dylan Queen ...
(Date:11/22/2014)... 22, 2014 Nocturia is defined ... complaint that the individual has to wake at ... report “Nocturia – Pipeline Review, H2 2014” provides ... complete with comparative analysis at various stages, therapeutics ... route of administration (RoA) and molecule type, along ...
Breaking Medicine News(10 mins):Health News:Asher Milgrom Is the Founding Doctor of AMA Skincare and Is Featured in the International Business Times 2Health News:Asher Milgrom Is the Founding Doctor of AMA Skincare and Is Featured in the International Business Times 3Health News:Asher Milgrom Is the Founding Doctor of AMA Skincare and Is Featured in the International Business Times 4Health News:Click Strand Woven Bamboo Flooring From Famous Bamboo Flooring Company BambooFlooringChina.com 2Health News:Customers Are Welcome to Shop at PrettyTailor.com 2Health News:Dylan Queen Introduces Its New Wedding Dresses 2Health News:Nocturia Therapeutic Pipeline Market Review by Drugs and Companies H2 2014 Report at RnRMarketResearch.com 2Health News:Nocturia Therapeutic Pipeline Market Review by Drugs and Companies H2 2014 Report at RnRMarketResearch.com 3Health News:Nocturia Therapeutic Pipeline Market Review by Drugs and Companies H2 2014 Report at RnRMarketResearch.com 4
... Reporter , MONDAY, Aug. 23 (HealthDay News) -- Another ... play a role in chronic fatigue syndrome, a poorly ... , Using blood samples collected in the mid-1990s from ... found evidence of gene sequences for murine leukemia virus ...
... In a Policy Forum published this week in ... Graham review different population strategies for preventing cardiovascular ... individuals may be ineffective and widen social inequalities. ... prevention strategies for screening and treating high-risk individuals ...
... receptor-positive breast cancer, but not necessarily invasive ductal carcinomas, ... The Journal of the National Cancer Institute., ... factor for overall breast cancer, few studies have looked ... risk by subtype of breast cancer. While some studies ...
... specific drugs can protect nerve cells in mice from ... are published in the August 22 issue of ... a protein that, when altered in people, leads to ... system that leads to tremors and problems with muscle ...
... plays a significant role in the survival of cells that ... (TUM) uncovered this protein,s mode of operation some time ago ... an unexpected pattern of motion. The results are published in ... and may help researchers discover specific cancer medication. Proteins ...
... University of Cincinnati (UC) analysis of 10 years ... that patients removed from a corticosteroid regimen shortly ... survival rates and fewer cardiovascular events than patients ... The analysis shows that, out of 904 ...
Cached Medicine News:Health News:More Evidence Virus Plays Role in Chronic Fatigue Syndrome 2Health News:More Evidence Virus Plays Role in Chronic Fatigue Syndrome 3Health News:Alcohol intake increases certain types of breast cancer 2Health News:A promising target for developing treatments against Parkinson's disease 2Health News:Munich researchers demonstrate rocking movement in the anti-stress protein Hsp90 2Health News:Decade-long trial confirms benefts of steroid withdrawal for transplant patients 2
(Date:11/22/2014)... , Nov. 21, 2014 Statistics released ... and drunk driving increase astronomically during the holidays, beginning ... in many cities. The data, ... Monitoring Systems as part of their annual ... paints a picture of high-risk drinking and increased rates ...
(Date:11/21/2014)... 21, 2014  Alere Inc. (NYSE: ALR ... appointed Juliet Cunningham as Vice President, Investor ... responsible for driving communications with the investment community. ... of changes to increase shareholder value, it is critical ... Namal Nawana, Chief Executive Officer. "We are delighted that ...
(Date:11/21/2014)... Nov. 21, 2014   Rock Creek Pharmaceuticals, Inc., ... Company is scheduled to present at the Biotech Showcase™ ... on January 12-14, 2015. ... of Rock Creek Pharmaceuticals, will present preclinical and clinical ... which exhibits anti-inflammatory pharmacological characteristics. Dr. Mullan will outline ...
Breaking Medicine Technology:Alarming Stats Show Holiday Drinking an Issue for Many 2Alere Appoints Juliet Cunningham to Lead Investor Relations 2Rock Creek Pharmaceuticals to Present at the Biotech Showcase 2015 2Rock Creek Pharmaceuticals to Present at the Biotech Showcase 2015 3Rock Creek Pharmaceuticals to Present at the Biotech Showcase 2015 4
... Sept. 29, 2011 The U.S. Food and Drug ... the International Internet Week of Action (IIWA), a cooperative ... and illegal medical products. (Logo: http://photos.prnewswire.com/prnh/20090824/FDALOGO ... between Sept. 20 and Sept. 27 is called OPERATION ...
... Sept. 29, 2011 CIVCO ... installed at the Instituto Radioterapia del Este in Puerto ... the Protura system elevates the level of radiation therapy ... need for many patients to travel for treatment. ...
Cached Medicine Technology:FDA Participates in Global Efforts to Protect Consumers and Patients from Unsafe Drugs on the Internet 2FDA Participates in Global Efforts to Protect Consumers and Patients from Unsafe Drugs on the Internet 3FDA Participates in Global Efforts to Protect Consumers and Patients from Unsafe Drugs on the Internet 4CIVCO's Protura™ Installed at Puerto Rico's Instituto Radioterapia del Este 2CIVCO's Protura™ Installed at Puerto Rico's Instituto Radioterapia del Este 3
... DAPII brain biopsy needle guide housing. ... Screw mount. Placed through a ... Non-sterile; sterilize via autoclave Guide sphere assembly ... with biopsy needles with barium sleeves. Sterile; ...
A complete system of cannulas, needles and rasps specifically designed for inside-out meniscal repair procedures....
Part of the GraFix® Cruciate Reconstruction System, which is designed to facilitate arthroscopic anterior cruciate ligament reconstructions....
... (KGTI) system offers the latest technology and ... The implant system is anatomically designed and ... KGTI is the most advanced reconstructive device ... the market today. The system consists of ...
Medicine Products: