Navigation Links
Imaging study examines effect of fructose on brain regions that regulate appetite
Date:1/1/2013

CHICAGO In a study examining possible factors regarding the associations between fructose consumption and weight gain, brain magnetic resonance imaging of study participants indicated that ingestion of glucose but not fructose reduced cerebral blood flow and activity in brain regions that regulate appetite, and ingestion of glucose but not fructose produced increased ratings of satiety and fullness, according to a preliminary study published in the January 2 issue of JAMA.

"Increases in fructose consumption have paralleled the increasing prevalence of obesity, and high-fructose diets are thought to promote weight gain and insulin resistance. Fructose ingestion produces smaller increases in circulating satiety hormones compared with glucose ingestion, and central administration of fructose provokes feeding in rodents, whereas centrally administered glucose promotes satiety," according to background information in the article. "Thus, fructose possibly increases food-seeking behavior and increases food intake." How brain regions associated with fructose- and glucose-mediated changes in animal feeding behaviors translates to humans is not completely understood.

Kathleen A. Page, M.D., of Yale University School of Medicine, New Haven, Conn., and colleagues conducted a study to examine neurophysiological factors that might underlie associations between fructose consumption and weight gain. The study included 20 healthy adult volunteers who underwent two magnetic resonance imaging sessions in conjunction with fructose or glucose drink ingestion. The primary outcome measure for the study was the relative changes in hypothalamic (a region of the brain) regional cerebral blood flow (CBF) after glucose or fructose ingestion.

The researchers found that there was a significantly greater reduction in hypothalamic CBF after glucose vs. fructose ingestion. "Glucose but not fructose ingestion reduced the activation of the hypothalamus, insula, and striatumbrain regions that regulate appetite, motivation, and reward processing; glucose ingestion also increased functional connections between the hypothalamic-striatal network and increased satiety."

"The disparate responses to fructose were associated with reduced systemic levels of the satiety-signaling hormone insulin and were not likely attributable to an inability of fructose to cross the blood-brain barrier into the hypothalamus or to a lack of hypothalamic expression of genes necessary for fructose metabolism."


'/>"/>

Contact: Helen Dodson
helen.dodson@yale.edu
303-436-3984
JAMA and Archives Journals
Source:Eurekalert

Related medicine news :

1. Combination of imaging exams improves Alzheimers diagnosis
2. Prostate cancer now detectable by imaging-guided biopsy
3. Springer launches new journal with the Italian Association of Nuclear Medicine and Molecular Imaging
4. PET imaging used to more accurately manage treatment, predict survival for patients with gliomas
5. Amyloid imaging helps in evaluating possible Alzheimer disease
6. Breast cancer risk estimates increased with repeated prior ct and nuclear imaging
7. University Hospitals & Philips Healthcare to showcase imaging technology at Cleveland Medical Mart
8. Imaging shows some brains compensate after traumatic injury
9. Neuroimaging study: Negative messages less effective on those who are substance dependent
10. How do cells tell time? Scientists develop single-cell imaging to watch the cell clock
11. Mayo Clinic gets FDA approval for new imaging agent for recurrent prostate cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/24/2017)... ... July 24, 2017 , ... Clinical Quality Assurance:, Roles and ... 22-23, 2017 – Arlington, VA, http://www.fdanews.com/cqa , Early bird pricing for ... growing demands to track and report adverse events place even greater pressure on ...
(Date:7/24/2017)... Province (PRWEB) , ... July 24, 2017 , ... ... Medicine's "Chinese Medicine Clinical Vitiligo Hospital" was set up, and the awarding ceremony ... of traditional Chinese medicine, the head of the army's health system, and national ...
(Date:7/24/2017)... ... 2017 , ... “The Perfect Gift”: a customizable and interactive Bible study guide for children. “The ... born-again Christian. She has always accepted Christ as her Savior, yet never studied His ... the Spirit when she wrote this book to her children, so they would know the ...
(Date:7/24/2017)... ... ... “A Short Walk to the Mailbox”: a remarkable memoir of an unconventional ... Ed Clark. Ed Clark is a church music director and choral conductor. ... music and worship leader for over fifty years. He has a master’s degree ...
(Date:7/24/2017)... ... 24, 2017 , ... The Center for Addiction Recovery Training ... host a second Multiple Pathways of Recovery Conference on October 23-26, 2017. This ... from CCAR’s foundational principle – a belief in multiple pathways of recovery, aims ...
Breaking Medicine News(10 mins):
(Date:7/10/2017)... S.C. , July 10, 2017  BDI ... purchasing and patient support services organization serving specialty ... today the launch of four significant, value-added member ... market insights, better manage reimbursement and improve access ... and factor therapies. ...
(Date:7/6/2017)... division of Diplomat Specialty Infusion Group, is celebrating a decade of empowering ... celebrate its anniversary, ThriveRx recently launched a redesigned website at thriverx.diplomat.is ... to create the best user experience for consumers and health care professionals. ... Diplomat Pharmacy ... "We,ve made several great strides throughout the past 10 years," ...
(Date:7/5/2017)... , July 5, 2017 Pace Analytical, a company of over 2,000 ... that they have acquired ESC Lab Sciences, further solidifying their position as the ... States . ... Vanderboom- President and CEO of Pace Analytical ... Lab Sciences out of Mt Juliet, TN , enhances Pace ...
Breaking Medicine Technology: