Navigation Links
Imaging gives clearer picture of cancer drugs' chances of success
Date:4/28/2014

The quest for new cancer treatments could be revolutionised by advances in technology that can visualise living cells and tissues, scientists claim.

Leading edge imaging techniques will make it easier to identify which are the most promising new drugs to take forward for patient testing, a review of the technology suggests.

Applying such techniques early in the drug discovery process could improve the success rate of new medicines by helping to rule out drugs that are unlikely to work.

Researchers at the University of Edinburgh are leading the way in using biological imaging to make the development of new cancer treatments more efficient.

Recent advances mean that scientists can now check how experimental drugs are working inside living cells and in real time.

Using automated microscopes to track fluorescent dyes, researchers can rapidly test thousands of potential drugs in different cancer cell types to find the most promising new treatments.

This pioneering approach known as phenotypic drug discovery monitors the effect of a trial drug on the disease as a whole rather than its impact on an individual target protein, which has been the approach until now.

Writing in the journal Nature Reviews Cancer, scientists argue that the new technologies will help to better predict how a drug will work in real life, not just in the test tube.

Currently, just five per cent of drugs tested in clinical trials are approved as therapies for patients. Often drugs do not work in a person as they do in an artificial environment. Sometimes treatments have unexpected side effects that are only picked up in the later stages of the development process.

Report author Dr Neil Carragher, of the Edinburgh Cancer Research UK Centre at the University of Edinburgh, said: "The drug discovery process is hugely expensive and inefficient. In Edinburgh we are leading the way in using biological imaging to streamline the process, allowing us to better select drug candidates with the lowest risk of side effects and the best chances of success in treating patients."


'/>"/>

Contact: Jen Middleton
jen.middleton@ed.ac.uk
44-131-650-6514
University of Edinburgh
Source:Eurekalert  

Related medicine news :

1. Neuroimaging: Live from inside the cell
2. Live cell imaging reveals distinct alterations of subcellular glutathione potentials
3. Tumors light up with new, unique imaging system using scorpion venom protein and a laser
4. Using susceptibility-weighted imaging to study concussion in college ice hockey players
5. A silk coat for diamonds makes sleek new imaging and drug delivery tool
6. New biomedical diagnostics using personalized 3-D imaging
7. North Shore-LIJ Completes Last Phase of $50M Upgrade of its Diagnostic Imaging Systems, $12M for GE Low-Dose CT Scanners to Reduce Patients’ Radiation Exposure
8. Olea Medical® Receives FDA 510(k) Clearance for Olea Sphere v2.3 Medical Imaging Software
9. Chemical imaging brings cancer tissue analysis into the digital age
10. Thermal Imaging Market (Solutions & Applications) Worth $5.84 Billion by 2018 - New Report by MarketsandMarkets
11. Pre-Clinical Imaging (In Vivo) Market worth $1.55 Billion by 2017 - New Report by MarketsandMarkets
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Imaging gives clearer picture of cancer drugs' chances of success
(Date:2/18/2017)... ... February 18, 2017 , ... ... Use Pixel Film Studios ’ ProParagraph Fashion Volume 2 for all multi-line ... other applications. Users can pick and choose from hand-crafted trend-setting designs with ...
(Date:2/17/2017)... ... February 17, 2017 , ... Wells Pharmacy Network offers ... of controlled and non-controlled substances plus the ability to manage orders on their ... States now accept electronic prescriptions, according to the Office of the National Coordinator ...
(Date:2/17/2017)... ... February 17, 2017 , ... ... been named a finalist in the 8th Annual DecisionHealth Platinum Awards in recognition ... system. Qualis Health’s work is recognized across multiple award categories, highlighting four of ...
(Date:2/17/2017)... ... February 17, 2017 , ... PrideStaff, a national staffing ... named to Staffing Industry Analysts' 2017 "Staffing 100 North America" list. , ... notable contributions to the staffing industry over the last twelve months. Industry insiders ...
(Date:2/17/2017)... ... 17, 2017 , ... Dillon Ruxton Insurance, a Florida-based agency ... in the greater Fort Lauderdale metropolitan region, is embarking on a cooperative food ... years, LifeNet 4 Families has provided a broad range of food provision services ...
Breaking Medicine News(10 mins):
(Date:2/17/2017)... , Feb. 17, 2017  Ethicon, Inc. today ... Inc., a privately held medical device company that ... Management System, a novel minimally invasive device for ... Torax Medical will enable Ethicon to offer patients ... laparoscopic Nissen fundoplication surgical procedure. 1 ...
(Date:2/17/2017)... 17, 2017 Research and Markets has announced the ... report to their offering. ... The report provides separate comprehensive analytics for the US, Canada ... Asia-Pacific , and Rest of World. Annual estimates and ... historic analysis is provided for these markets. Market data and analytics are ...
(Date:2/17/2017)... AMSTERDAM , Feb. 17, ... connected health offerings at the  ...  (NYSE: PHG,AEX: PHIA), a global ... a broad range of population ... personal health solutions, fully integrated in a ...
Breaking Medicine Technology: