Navigation Links
Images shed new light on inflammation
Date:10/15/2010

Calgary, AB - Researchers at the University of Calgary Faculty of Medicine are using an innovative new imaging technique to study how white blood cells (called neutrophils) respond to inflammation, and have revealed new targets to inhibit the response.

When the body is invaded by infection, the immune system counters by generating inflammation with deployment of white blood cells to the site of danger to kill invading bacteria. However, inappropriate inflammation occurs in the absence of infection when tissues are damaged, and this inappropriate response contributes to diseases such as heart attacks and stroke. Researchers used both experimental animal models and human white blood cells to discover that damaged tissue can release signals that attract white blood cells, and blocking these signal can prevent inappropriate inflammation.

The findings are published in the October 15th edition of Science.

"We have known how white blood cells find their way to sites of infection for many years, but understanding how, or even why white blood cells go to sites of sterile non-infectious tissue damage has been a real dilemma," says Dr. Paul Kubes, PhD, senior author of the study as well as Director of the Snyder Institute of Infection, Immunity and Inflammation. "Recognizing that damaged cells release "bacteria-like" signals that attract white blood cells and cause inflammation might allow for the development of a whole new class of therapeutics to combat inflammatory diseases."

Another remarkable aspect of the research is that scientists were able to take unprecedented real-time videos of the white blood cells activity at sites of inflammation. The University of Calgary is one of very few centers in the world using this imaging technology, called spinning disk confocal intravial microscopy, to study the inflammatory response.

"These powerful imaging systems allow us to tackle complicated problems by directly observing the activity of the immune system in the body. Our laboratory is perhaps the only in Canada, and amongst a select few in the world that have this technology, so it is truly a privilege to contribute to this research," says Braedon McDonald, the lead author of the study and PhD candidate.


'/>"/>

Contact: Marta Cyperli
mcyperli@ucalgary.ca
403-210-3835
University of Calgary
Source:Eurekalert

Related medicine news :

1. Movies Loaded With Images of Junk Food
2. CT and MRI Images Now Seen in a 3D Virtual Reality World
3. Heart Aflutter? Remarkable New Images Show What it Looks Like in 4-D
4. Compton's by Britannica Revised for 2010; Hundreds of Articles Rewritten, Hundreds of New Photos, Images
5. Reflex Stock Limited Announces Two New Ways to Buy Stock Images and Stock Photos
6. Citizen Stock Launches Industry's First Rights Managed Database of Images Shot Exclusively Against White
7. NYUs Movshon receives Champalimaud Vision Award for work on how brain reconstructs images
8. Brainstem, spinal cord images hidden in Michelangelos Sistine Chapel fresco
9. ClearWay Minnesota(SM) Shines a Spotlight on a Reinvented Tobacco Industry
10. Cyndi Lauper, Lady Gaga Put Spotlight on Women and HIV
11. Virtual Global Highlights Top Ten Misconceptions about Cloud Computing
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/18/2017)... ... ... Park Cities Pet Sitter President, Joette White, has been featured on Episode ... The episode, which was posted this week, features a 30-minute interview of White by ... Pet Sitter’s being awarded the 2017 National Association of Professional Pet Sitter’s Business of ...
(Date:2/17/2017)... TN (PRWEB) , ... February 17, 2017 , ... ... mobility has not kept pace. Enovate Medical has introduced an innovative workstation designed ... years of supporting nurses, the Encore Mobile EHR Workstation offers a lightweight, highly ...
(Date:2/17/2017)... Church, VA (PRWEB) , ... ... ... Integrate FDA Device Approval and Reimbursement , **An FDAnews Webinar**, Feb. 22, ... , What are the critical reimbursement questions manufacturers should be asking before ...
(Date:2/17/2017)... (PRWEB) , ... February 17, 2017 , ... ... at the HIMSS17 Conference & Exhibition in Orlando, Fla., February 19-23. Visitors to ... of the most widely used electronic patient signatures solution in healthcare . ...
(Date:2/17/2017)... ... February 17, 2017 , ... PrideStaff, a national ... was named to Staffing Industry Analysts' 2017 "Staffing 100 North America" list. ... made notable contributions to the staffing industry over the last twelve months. Industry ...
Breaking Medicine News(10 mins):
(Date:2/20/2017)... 2017  National Decision Support Company (NDSC) announces ... CareSelect Imaging platform within the full range of ... technical foundation for MEDITECH sites, through a directly ... Decision Support Mechanism through the MEDITECH EHR. ... support the integration of NDSC,s mechanism, which enables ...
(Date:2/20/2017)... , Feb. 20, 2017 Research and Markets ... Market: Insights, Opportunity, Analysis, Market Shares & Forecast 2017 - 2022" ... ... reach nearly USD 2 Billion by the year end of 2022 ... Market growth can be attributed to factors such ...
(Date:2/20/2017)... , Feb. 20, 2017   Orion Health ... its Amadeus precision medicine platform to the ... currently manages over 110 million patient records globally. ... developing cloud-based, big data solutions built on modern, scalable ... Healthcare and Life Sciences. "The AWS Cloud gives healthcare ...
Breaking Medicine Technology: