Navigation Links
Images shed new light on inflammation

Calgary, AB - Researchers at the University of Calgary Faculty of Medicine are using an innovative new imaging technique to study how white blood cells (called neutrophils) respond to inflammation, and have revealed new targets to inhibit the response.

When the body is invaded by infection, the immune system counters by generating inflammation with deployment of white blood cells to the site of danger to kill invading bacteria. However, inappropriate inflammation occurs in the absence of infection when tissues are damaged, and this inappropriate response contributes to diseases such as heart attacks and stroke. Researchers used both experimental animal models and human white blood cells to discover that damaged tissue can release signals that attract white blood cells, and blocking these signal can prevent inappropriate inflammation.

The findings are published in the October 15th edition of Science.

"We have known how white blood cells find their way to sites of infection for many years, but understanding how, or even why white blood cells go to sites of sterile non-infectious tissue damage has been a real dilemma," says Dr. Paul Kubes, PhD, senior author of the study as well as Director of the Snyder Institute of Infection, Immunity and Inflammation. "Recognizing that damaged cells release "bacteria-like" signals that attract white blood cells and cause inflammation might allow for the development of a whole new class of therapeutics to combat inflammatory diseases."

Another remarkable aspect of the research is that scientists were able to take unprecedented real-time videos of the white blood cells activity at sites of inflammation. The University of Calgary is one of very few centers in the world using this imaging technology, called spinning disk confocal intravial microscopy, to study the inflammatory response.

"These powerful imaging systems allow us to tackle complicated problems by directly observing the activity of the immune system in the body. Our laboratory is perhaps the only in Canada, and amongst a select few in the world that have this technology, so it is truly a privilege to contribute to this research," says Braedon McDonald, the lead author of the study and PhD candidate.


Contact: Marta Cyperli
University of Calgary

Related medicine news :

1. Movies Loaded With Images of Junk Food
2. CT and MRI Images Now Seen in a 3D Virtual Reality World
3. Heart Aflutter? Remarkable New Images Show What it Looks Like in 4-D
4. Compton's by Britannica Revised for 2010; Hundreds of Articles Rewritten, Hundreds of New Photos, Images
5. Reflex Stock Limited Announces Two New Ways to Buy Stock Images and Stock Photos
6. Citizen Stock Launches Industry's First Rights Managed Database of Images Shot Exclusively Against White
7. NYUs Movshon receives Champalimaud Vision Award for work on how brain reconstructs images
8. Brainstem, spinal cord images hidden in Michelangelos Sistine Chapel fresco
9. ClearWay Minnesota(SM) Shines a Spotlight on a Reinvented Tobacco Industry
10. Cyndi Lauper, Lady Gaga Put Spotlight on Women and HIV
11. Virtual Global Highlights Top Ten Misconceptions about Cloud Computing
Post Your Comments:
(Date:10/13/2015)... California (PRWEB) , ... October ... ... launched Postnatal Omega-3, a first-of-its kind product that targets the unique health ... Postnatal Omega-3” of the American Pregnancy Association ( ), utilizes Nordic ...
(Date:10/13/2015)... ... October 13, 2015 , ... T-System and Centegra Health ... 59,000 emergency department visits per year, today announced the successful and rapid deployment ... clinical, operational and financial outcomes. , In less than four days, ...
(Date:10/13/2015)... ... October 13, 2015 , ... Tempe Dental Care, a leading Tempe dentists’ office, ... IV sedation dentistry for more than 5 years. A leading cause of emergency ... painful if treatment is not timely. , Sedation dentistry provides an ...
(Date:10/13/2015)... ... 2015 , ... World Patent Marketing , a vertically integrated manufacturer and ... helps people in clearing snow away from the streets and driveways. , "The Snowplowing ... year," says Scott Cooper, CEO and Creative Director of World Patent Marketing and ...
(Date:10/13/2015)... ... October 13, 2015 , ... According to an ESPN report published ... a teammate accidentally elbowed him in the left eye during the first day of ... one of a series of setbacks, including a knee injury that has interfered with ...
Breaking Medicine News(10 mins):
(Date:10/13/2015)... , Oct. 13 2015 ... addition of the "US & European ... Countries (2010-2021)" report to their offering. ... the addition of the "US & ... 16 Countries (2010-2021)" report to their ...
(Date:10/13/2015)... -- Graduate students across the country, with an interest ... have the opportunity to learn about a lesser-known ... and development process. Eli Lilly and Company (NYSE: ... from academic institutions to create an elective graduate ... Development."  Lilly will formally unveil the eLearning course ...
(Date:10/13/2015)... WuXi PharmaTech (Cayman) Inc. (NYSE:  WX), a ... serving the pharmaceutical, biotechnology, and medical device industries, ... version of OncoWuXi, the first App in the ... and data on the go.  The OncoWuXi App ... to identify relevant tumor models for use in ...
Breaking Medicine Technology: