Navigation Links
Images shed new light on inflammation

Calgary, AB - Researchers at the University of Calgary Faculty of Medicine are using an innovative new imaging technique to study how white blood cells (called neutrophils) respond to inflammation, and have revealed new targets to inhibit the response.

When the body is invaded by infection, the immune system counters by generating inflammation with deployment of white blood cells to the site of danger to kill invading bacteria. However, inappropriate inflammation occurs in the absence of infection when tissues are damaged, and this inappropriate response contributes to diseases such as heart attacks and stroke. Researchers used both experimental animal models and human white blood cells to discover that damaged tissue can release signals that attract white blood cells, and blocking these signal can prevent inappropriate inflammation.

The findings are published in the October 15th edition of Science.

"We have known how white blood cells find their way to sites of infection for many years, but understanding how, or even why white blood cells go to sites of sterile non-infectious tissue damage has been a real dilemma," says Dr. Paul Kubes, PhD, senior author of the study as well as Director of the Snyder Institute of Infection, Immunity and Inflammation. "Recognizing that damaged cells release "bacteria-like" signals that attract white blood cells and cause inflammation might allow for the development of a whole new class of therapeutics to combat inflammatory diseases."

Another remarkable aspect of the research is that scientists were able to take unprecedented real-time videos of the white blood cells activity at sites of inflammation. The University of Calgary is one of very few centers in the world using this imaging technology, called spinning disk confocal intravial microscopy, to study the inflammatory response.

"These powerful imaging systems allow us to tackle complicated problems by directly observing the activity of the immune system in the body. Our laboratory is perhaps the only in Canada, and amongst a select few in the world that have this technology, so it is truly a privilege to contribute to this research," says Braedon McDonald, the lead author of the study and PhD candidate.


Contact: Marta Cyperli
University of Calgary

Related medicine news :

1. Movies Loaded With Images of Junk Food
2. CT and MRI Images Now Seen in a 3D Virtual Reality World
3. Heart Aflutter? Remarkable New Images Show What it Looks Like in 4-D
4. Compton's by Britannica Revised for 2010; Hundreds of Articles Rewritten, Hundreds of New Photos, Images
5. Reflex Stock Limited Announces Two New Ways to Buy Stock Images and Stock Photos
6. Citizen Stock Launches Industry's First Rights Managed Database of Images Shot Exclusively Against White
7. NYUs Movshon receives Champalimaud Vision Award for work on how brain reconstructs images
8. Brainstem, spinal cord images hidden in Michelangelos Sistine Chapel fresco
9. ClearWay Minnesota(SM) Shines a Spotlight on a Reinvented Tobacco Industry
10. Cyndi Lauper, Lady Gaga Put Spotlight on Women and HIV
11. Virtual Global Highlights Top Ten Misconceptions about Cloud Computing
Post Your Comments:
(Date:6/26/2016)... ... 26, 2016 , ... On June 10-11, 2016, A Forever Recovery, a holistic ... World’s Longest Breakfast Table in Battle Creek, MI, where the rehabilitation facility is located. ... some of the world’s leading providers of cereal and other breakfast foods. Its residents ...
(Date:6/26/2016)... ... June 26, 2016 , ... Brent Kasmer, a legally blind and certified personal trainer is ... a fitness app. The fitness app plans to fix the two major problems leading the ... one size fits all type program , They don’t eliminate all the reasons ...
(Date:6/25/2016)... ... ... Austin residents seeking Mohs surgery services, can now turn to Dr. Jessica ... Peckham for medical and surgical dermatology. , Dr. Dorsey brings specialization to include Mohs ... Mohs Micrographic Surgery completed by Dr. Dorsey was under the direction of Glenn Goldstein, ...
(Date:6/25/2016)... , ... June 25, 2016 , ... First Choice ... States, named Dr. Sesan Ogunleye, as the Medical Director of its new Mesquite-Samuell Farm ... Medical Director of our new Mesquite location,” said Dr. James M. Muzzarelli, Executive Medical ...
(Date:6/25/2016)... ... June 25, 2016 , ... On Friday, June 10, Van Mitchell, ... at Work award to iHire in recognition of their exemplary accomplishments in worksite health ... annual Maryland Workplace Health & Wellness Symposium at the BWI Marriott in Linthicum Heights. ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... 24, 2016  Arkis BioSciences, a leading innovator ... more durable cerebrospinal fluid treatments, today announced it ... funding is led by Innova Memphis, followed by ... private investors.  Arkis, new financing will accelerate the ... market release of its in-licensed Endexo® technology. ...
(Date:6/23/2016)... 23, 2016 Research and Markets has ... - Forecast to 2022" report to their offering. ... for the patients with kidney failure, it replaces the function ... the patient,s blood and thus the treatment helps to keep ... in balance. Increasing number of ESRD patients ...
(Date:6/23/2016)... , June 23, 2016 ... "Pharmaceutical Excipients Market by Type (Organic Chemical (Sugar, ... Formulation (Oral, Topical, Coating, Parenteral) - Global Forecast to ... The global pharmaceutical excipients market ... at a CAGR of 6.1% in the forecast period ...
Breaking Medicine Technology: