Navigation Links
Images shed new light on inflammation
Date:10/15/2010

Calgary, AB - Researchers at the University of Calgary Faculty of Medicine are using an innovative new imaging technique to study how white blood cells (called neutrophils) respond to inflammation, and have revealed new targets to inhibit the response.

When the body is invaded by infection, the immune system counters by generating inflammation with deployment of white blood cells to the site of danger to kill invading bacteria. However, inappropriate inflammation occurs in the absence of infection when tissues are damaged, and this inappropriate response contributes to diseases such as heart attacks and stroke. Researchers used both experimental animal models and human white blood cells to discover that damaged tissue can release signals that attract white blood cells, and blocking these signal can prevent inappropriate inflammation.

The findings are published in the October 15th edition of Science.

"We have known how white blood cells find their way to sites of infection for many years, but understanding how, or even why white blood cells go to sites of sterile non-infectious tissue damage has been a real dilemma," says Dr. Paul Kubes, PhD, senior author of the study as well as Director of the Snyder Institute of Infection, Immunity and Inflammation. "Recognizing that damaged cells release "bacteria-like" signals that attract white blood cells and cause inflammation might allow for the development of a whole new class of therapeutics to combat inflammatory diseases."

Another remarkable aspect of the research is that scientists were able to take unprecedented real-time videos of the white blood cells activity at sites of inflammation. The University of Calgary is one of very few centers in the world using this imaging technology, called spinning disk confocal intravial microscopy, to study the inflammatory response.

"These powerful imaging systems allow us to tackle complicated problems by directly observing the activity of the immune system in the body. Our laboratory is perhaps the only in Canada, and amongst a select few in the world that have this technology, so it is truly a privilege to contribute to this research," says Braedon McDonald, the lead author of the study and PhD candidate.


'/>"/>

Contact: Marta Cyperli
mcyperli@ucalgary.ca
403-210-3835
University of Calgary
Source:Eurekalert

Related medicine news :

1. Movies Loaded With Images of Junk Food
2. CT and MRI Images Now Seen in a 3D Virtual Reality World
3. Heart Aflutter? Remarkable New Images Show What it Looks Like in 4-D
4. Compton's by Britannica Revised for 2010; Hundreds of Articles Rewritten, Hundreds of New Photos, Images
5. Reflex Stock Limited Announces Two New Ways to Buy Stock Images and Stock Photos
6. Citizen Stock Launches Industry's First Rights Managed Database of Images Shot Exclusively Against White
7. NYUs Movshon receives Champalimaud Vision Award for work on how brain reconstructs images
8. Brainstem, spinal cord images hidden in Michelangelos Sistine Chapel fresco
9. ClearWay Minnesota(SM) Shines a Spotlight on a Reinvented Tobacco Industry
10. Cyndi Lauper, Lady Gaga Put Spotlight on Women and HIV
11. Virtual Global Highlights Top Ten Misconceptions about Cloud Computing
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/31/2016)... ... June 01, 2016 , ... ... smoking: links and risks ”. , As corresponding author Professor Luigi Naldi says ... between smoking habits and psoriasis. Smoking influences the onset and the severity of ...
(Date:5/31/2016)... GA (PRWEB) , ... May 31, 2016 , ... ... Contact Center Solutions , today announced it has been included by Gartner, Inc. ... report mentions a wide range of Contact Center Infrastructure technologies, some of which ...
(Date:5/31/2016)... ... May 31, 2016 , ... When ... he knew it was something that contractors should have at their disposal on ... gets,” says Butch, CertainTeed’s Director of Contractor Programs. , As a result, ...
(Date:5/31/2016)... ... May 31, 2016 , ... The successful implementation of ... their laboratories as well. However, laboratories have different challenges compared to manufacturing environments. ... operations in the lab, METTLER TOLEDO has developed the Lean Lab Checklist . ...
(Date:5/31/2016)... ... ... Spectrum Aquatics has launched a brand new ADA pool lift, the Motion Trek ... in mind. , “Over the last two years our key customers and designers plus ... is a necessary requirement for certain facilities with specific needs,” said Nabil Khaled, Spectrum ...
Breaking Medicine News(10 mins):
(Date:5/27/2016)... highlights the necessity of health literacy within the technology advancement of diagnostic imaging. According to ... a majority of oncology patients undergo imaging screenings without understanding the nuanced risks associated ... ... ... Medical Diagnostic Imaging Ampronix ...
(Date:5/27/2016)... May 27, 2016 Hutchison ... company focused on the highly lucrative global oncology ... pipeline of potential first-in-class or best-in-class tyrosine kinase ... development with strategic partners. HCM,s profitable Chinese healthcare ... market. We expect progress of the mid-to-late-stage pipeline ...
(Date:5/27/2016)... NEW YORK , May 27, 2016 ... with biotechs, drug manufacturers, health insurance companies all falling ... very small healthcare companies. While not often talked about, ... The United States is by ... the world. Advanced Medical Isotope Corp. (OTC: ADMD), Nutranomics ...
Breaking Medicine Technology: