Navigation Links
If you don't snooze, do you lose?
Date:10/9/2011

MADISON An ongoing lack of sleep during adolescence could lead to more than dragging, foggy teens, a University of Wisconsin-Madison study suggests.

Researchers have found that short-term sleep restriction in adolescent mice prevented the balanced growth and depletion of brain synapses, connections between nerve cells where communication occurs.

"One possible implication of our study is that if you lose too much sleep during adolescence, especially chronically, there may be lasting consequences in terms of the wiring of the brain," says Dr. Chiara Cirelli, associate professor in the department of psychiatry at the School of Medicine and Public Health.

Mental illnesses such as schizophrenia tend to start during adolescence but the exact reasons remain unclear. The National Institute of Mental Health funded Cirelli's study; the findings appear in the current issue of Nature Neuroscience (Advance Online Publication).

"Adolescence is a sensitive period of development during which the brain changes dramatically," Cirelli says. "There is a massive remodeling of nerve circuits, with many new synapses formed and then eliminated."

Cirelli and colleagues wanted to see how alterations to the sleep-wake cycle affected the anatomy of the developing adolescent brain.

Their earlier molecular and electro-physiological studies showed that during sleep, synapses in adult rodents and flies become weaker and smaller, presumably preparing them for another period of wakefulness when synapses will strengthen again and become larger in response to ever-changing experiences and learning. They call this the synaptic homeostasis hypothesis of sleep.

Using a two-photon microscope, researchers indirectly followed the growth and retraction of synapses by counting dendritic spines, the elongated structures that contain synapses and thus allow brain cells to receive impulses from other brain cells. They compared adolescent mice that for eight to 10 hours were spontaneously awake, allowed to sleep or forced to stay awake.

The live images showed that being asleep or awake made a difference in the dynamic adolescent mouse brain: the overall density of dendritic spines fell during sleep and rose during spontaneous or forced wakefulness.

"These results using acute manipulations of just eight to 10 hours show that the time spent asleep or awake affects how many synapses are being formed or removed in the adolescent brain," Cirelli says. "The important next question is what happens with chronic sleep restriction, a condition that many adolescents are often experiencing."

The experiments are under way, but Cirelli can't predict the outcome. "It could be that the changes are benign, temporary and reversible," she says, "or there could be lasting consequences for brain maturation and functioning."


'/>"/>

Contact: Dian Land
dj.land@hosp.wisc.edu
608-770-7808
University of Wisconsin-Madison
Source:Eurekalert

Related medicine news :

1. Orthodontic Retainers Can Harbor Harmful Microbes
2. Successful periodontal therapy may reduce the risk of preterm birth, according to Penn dental study
3. Researchers study relationship of oral cancers and periodontal disease
4. Long Island Children's Orthodontist Announces Office Improvements And New Staff Member
5. EDS Announces New SafeSiders Endodontic Glide Path Kit
6. National Prosthodontics Awareness Week Serves and Educates Consumers About Proper Oral Health Care
7. Successful treatment of periodontal disease lowered preterm birth incidences
8. Periodontal pathogens enhance HIV-1 promoter activation in T cells
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/27/2017)... (PRWEB) , ... March 27, 2017 , ... ... recently received the CE Certificate of Conformity for the Smart System® 20/20. CE ... exceed the highest industry standards and specifications such as ANSI, ISO and proven ...
(Date:3/27/2017)... , ... March 27, 2017 , ... ... comprehensive weight management program at Women’s Excellence will help patients lose weight and ... physical exam. The specialists at Women's Excellence will measure BMI, body fat ...
(Date:3/27/2017)... ... March 27, 2017 , ... The ... supply chain professionals, will hold their first Northeast Regional AHVAP Meeting. For 2017, ... , “Increasingly, supply chain and value analysis professionals have a ‘seat at the ...
(Date:3/27/2017)... ... March 27, 2017 , ... Sodium determination is consistently ... and require expert user knowledge. In a live webinar on April 11th and ... yet highly accurate, determination of sodium. , It has long been known that ...
(Date:3/27/2017)... Fla. (PRWEB) , ... March 27, 2017 , ... ... overdose deaths soared 167%,(1) with opioids alone responsible for over 33,000 of the ... McCarty has sponsored Assembly Bill (AB) 1512, which proposes a tax on prescription ...
Breaking Medicine News(10 mins):
(Date:3/27/2017)... 27, 2017  Twist Bioscience, a company accelerating science ... that it raised an additional $33 million. To date, ... "It is an exciting time to ... and continue to deliver industry-leading gene volume to our ... Emily M. Leproust, Ph.D., CEO of Twist Bioscience. "We ...
(Date:3/27/2017)... March 27, 2017 Arena Pharmaceuticals, Inc. ... developing novel, small molecule drugs across multiple therapeutic areas, today ... Executive Officer, will present a corporate update at the 16th ... ET.  The conference will take place April 4-5, 2017 at ... York , NY.  A live audio ...
(Date:3/24/2017)... , March 24, 2017 New England ... recipient of an award including funding and in-kind service ... draw technology.  "Making blood draws less ... making their whole hospital experience better.  We,re looking forward ... technology can help improve care for the kids we ...
Breaking Medicine Technology: