Navigation Links
If you don't snooze, do you lose?
Date:10/9/2011

MADISON An ongoing lack of sleep during adolescence could lead to more than dragging, foggy teens, a University of Wisconsin-Madison study suggests.

Researchers have found that short-term sleep restriction in adolescent mice prevented the balanced growth and depletion of brain synapses, connections between nerve cells where communication occurs.

"One possible implication of our study is that if you lose too much sleep during adolescence, especially chronically, there may be lasting consequences in terms of the wiring of the brain," says Dr. Chiara Cirelli, associate professor in the department of psychiatry at the School of Medicine and Public Health.

Mental illnesses such as schizophrenia tend to start during adolescence but the exact reasons remain unclear. The National Institute of Mental Health funded Cirelli's study; the findings appear in the current issue of Nature Neuroscience (Advance Online Publication).

"Adolescence is a sensitive period of development during which the brain changes dramatically," Cirelli says. "There is a massive remodeling of nerve circuits, with many new synapses formed and then eliminated."

Cirelli and colleagues wanted to see how alterations to the sleep-wake cycle affected the anatomy of the developing adolescent brain.

Their earlier molecular and electro-physiological studies showed that during sleep, synapses in adult rodents and flies become weaker and smaller, presumably preparing them for another period of wakefulness when synapses will strengthen again and become larger in response to ever-changing experiences and learning. They call this the synaptic homeostasis hypothesis of sleep.

Using a two-photon microscope, researchers indirectly followed the growth and retraction of synapses by counting dendritic spines, the elongated structures that contain synapses and thus allow brain cells to receive impulses from other brain cells. They compared adolescent mice that for eight to 10 hours were spontaneously awake, allowed to sleep or forced to stay awake.

The live images showed that being asleep or awake made a difference in the dynamic adolescent mouse brain: the overall density of dendritic spines fell during sleep and rose during spontaneous or forced wakefulness.

"These results using acute manipulations of just eight to 10 hours show that the time spent asleep or awake affects how many synapses are being formed or removed in the adolescent brain," Cirelli says. "The important next question is what happens with chronic sleep restriction, a condition that many adolescents are often experiencing."

The experiments are under way, but Cirelli can't predict the outcome. "It could be that the changes are benign, temporary and reversible," she says, "or there could be lasting consequences for brain maturation and functioning."


'/>"/>

Contact: Dian Land
dj.land@hosp.wisc.edu
608-770-7808
University of Wisconsin-Madison
Source:Eurekalert

Related medicine news :

1. Orthodontic Retainers Can Harbor Harmful Microbes
2. Successful periodontal therapy may reduce the risk of preterm birth, according to Penn dental study
3. Researchers study relationship of oral cancers and periodontal disease
4. Long Island Children's Orthodontist Announces Office Improvements And New Staff Member
5. EDS Announces New SafeSiders Endodontic Glide Path Kit
6. National Prosthodontics Awareness Week Serves and Educates Consumers About Proper Oral Health Care
7. Successful treatment of periodontal disease lowered preterm birth incidences
8. Periodontal pathogens enhance HIV-1 promoter activation in T cells
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/24/2016)... ... 24, 2016 , ... Those who have experienced traumatic events may suffer from ... avenues, such as drug or alcohol abuse, as a coping mechanism. To avoid this ... coping following a traumatic event. , Trauma sufferers tend to feel a range of ...
(Date:6/24/2016)... ... ... crisis. Her son James, eight, was out of control. Prone to extreme mood shifts and ... him, he couldn’t control his emotions,” remembers Marcy. “If there was a knife on ... say he was going to kill them. If we were driving on the freeway, ...
(Date:6/24/2016)... ... June 24, 2016 , ... Global law firm Greenberg Traurig, P.A. announced ... attorneys chosen by their peers for this recognition are considered among the top 2 ... received special honors as members of this year’s Legal Elite Hall of Fame: ...
(Date:6/24/2016)... ... June 24, 2016 , ... Comfort Keepers® of San ... Society and the Road To Recovery® program to drive cancer patients to and from ... adults to ensure the highest quality of life and ongoing independence. Getting to ...
(Date:6/24/2016)... ... ... People across the U.S. are sharpening their pencils and honing their writing skills ... patients and their families pay tribute to a genetic counselor by nominating him or ... Counselors (NSGC) Annual Education Conference (AEC) this September. , In April, Genome magazine ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... , June 24, 2016 VolitionRx ... of Dr. Edward Futcher to the ... effective June 23, 2016.Dr. Futcher was also appointed ... Governance Committees.  As a non-executive member of the ... and strategic counsel to VolitionRx in connection with ...
(Date:6/23/2016)... Research and Markets has announced the addition ... Chemical (Sugar, Petrochemical, Glycerin), Inorganic Chemical), Functionality (Filler, Binder, ... Forecast to 2021" report to their offering. ... excipients market is projected to reach USD 8.1 Billion ... forecast period 2016 to 2021. The ...
(Date:6/23/2016)... 23, 2016 Research and Markets has ... 52" report to their offering. ... creates a favourable commercial environment for MedImmune to enter. The ... that will serve to drive considerable growth for effective anti-influenza ... to cap sales considerably, but development is still in its ...
Breaking Medicine Technology: