Navigation Links
Identified: Switch that turns on allergic disease in people
Date:1/20/2010

WHAT: A new study in human cells has singled out a molecule that specifically directs immune cells to develop the capability to produce an allergic response. The signaling molecule, called thymic stromal lymphopoietin (TSLP), is key to the development of allergic diseases such as asthma, atopic dermatitis (eczema) and food allergy.

The study team, led by Yong-Jun Liu, M.D., Ph.D., at the University of Texas M.D. Anderson Cancer Center, Houston, focused on dendritic cells, immune cells that initiate the primary immune response. Dendritic cells come into contact with other immune cells known as T cells, causing them to develop into different subsets of T cells, including helper 1 (Th1) and helper 2 (Th2) cells. These T-cell subsets are involved in protective immune responses, but the Th2 cells can also drive an allergic response. Until now, it was not known how dendritic cells induced T cells to become Th2 cells.

The investigators used dendritic cells isolated from the blood of healthy donors and found that the binding of TSLP to these cells activates a distinct set of signaling pathways within the cells. As a result, the dendritic cells produce messenger molecules that act on the T cells, causing them to develop into Th2 cells.

The study identifies TSLP as a switch that causes the development of the allergic response in people and suggests that this molecule may be a potential therapeutic target to treat and prevent allergic diseases.

Dr. Liu and his colleagues are supported by the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health. The investigators are with the Asthma and Allergic Diseases Cooperative Research Centers program, now in its fourth decade of continuous funding as the cornerstone of NIAID's asthma and allergy research portfolio.


'/>"/>

Contact: Julie Wu
wujuli@niaid.nih.gov
301-402-1663
NIH/National Institute of Allergy and Infectious Diseases
Source:Eurekalert

Page: 1

Related medicine news :

1. Schizophrenia Gene May Have On/Off Switch
2. Brain Switch Helps Doctors Deal With Patients Pain
3. Switching to MA Coverage Unlikely for Current Beneficiaries With MediGap or Medicare Only
4. Scientists Spot Eye Development Switch
5. A molecular switch is linked to a common breast cancer
6. Researchers identify unusual molecular switch for common form of advanced breast cancer
7. Cell Structure Helps Direct Cancer Gene Switch
8. Childrens Hospital researchers identify molecular switch that could save very young lives
9. Protein-dependent switch regulates intracellular trafficking in epithelial cells
10. Switch for Internal Body Clock Found
11. Women With IBS Unable to Switch Off Pain Response
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/21/2017)... ... April 21, 2017 , ... Contrary to popular perception, a ... declining—and at noteworthy rates. Between 2002 and 2014, Salas-Wright and his colleagues found ... in the United States. The study, Trends in Fighting and Violence Among ...
(Date:4/21/2017)... ... April 21, 2017 , ... Dudnyk has announced the launch of its ... that the full potential of specialty and orphan brands can only be achieved when ... , “The Unifying Effect is at the heart of a true partnership between our ...
(Date:4/21/2017)... ... April 21, 2017 , ... Crossover Symmetry ... O2X , an active lifestyle company that provides Human Performance Training and education ... police offers, first responders, military officers and others in service through the development ...
(Date:4/21/2017)... , ... April 21, 2017 , ... ... in the category of International Trade, the UK’s most prestigious award for business ... which represents 95% of total revenues and has grown by a total of ...
(Date:4/21/2017)... ... April 21, 2017 , ... Yisrayl Hawkins, Pastor and Overseer at The House of ... in hopes of squashing a global crisis with solution to peace plan. Yisrayl says war ... because the plan is given by the Creator Himself. , Yisrayl says war drums ...
Breaking Medicine News(10 mins):
(Date:4/19/2017)... April 19, 2017 The Mobile X-Ray product segment ... healthy CAGR during the forecast period Mobile X-Ray ... global digital mobile X-Ray devices market, which is estimated to ... expanding at a CAGR of 7% over the forecast period. ... of more than US$ 100 Mn in 2017 over 2016. ...
(Date:4/19/2017)... India , April 19, 2017 ... and Application, Forecast to 2022 report has covered and analysed ... statistics and information on market size, shares and growth factors. ... major drivers, challenges and opportunities in the global market. ... Browse 152 Tables and Figures, ...
(Date:4/19/2017)... 2017  SARES•REGIS Group leased the first of ... Conejo Spectrum Business Park in Thousand ... Inc. , a biopharmaceutical company developing meaningful therapies ... have been underserved by scientific innovation, with an ... autoimmune and infectious disease. Before commencement ...
Breaking Medicine Technology: