Navigation Links
Identification of new genes shows a complex path to cell death
Date:12/14/2007

WORCESTER, Mass. Can a tiny winged insects salivary glands really tell us about processes relevant to human disease" Yes, according to a new study by researchers at the University of Massachusetts Medical School (UMMS), who gained new insights into autophagya cellular degradation process associated with a form of programmed cell deathby studying the salivary gland cells of the fruit fly.

Since its initial discovery in the 1960s, programmed cell death has been a primary focus of studies for investigators across a wide array of scientific disciplines. An essential mechanism in development and homeostasis, programmed cell death allows for the clean intracellular destruction of unnecessary or damaged cells. While apoptosis is the most understood type of programmed cell death, recently scientists have begun to take a closer look at autophagy a highly regulated, catabolic process that essentially allows a cell to eat itself. Paradoxically, autophagy is not only a major mechanism by which a starving cell reallocates nutrients to ensure survival, scientists are now demonstrating that autophagy also provides cells that cannot undergo apoptosis with an alternate form of self-destruction.

In Growth arrest and autophagy are required for salivary gland cell degradation in Drosophila, published in the December 14 issue of Cell, Eric Baehrecke, PhD, UMMS Associate Professor of Cancer Biology, and colleagues examined fly salivary glands, which contain all of the machinery required to dismantle and recycle their own cellular components and thus provide a genetic model system for elucidating the complex functions of autophagy. The paper describes the cellular components required for autophagic cell death and defines multiple pathways that cooperate in the clearance of cells during fly development. Further, their findings demonstrate a critical relationship between growth and this form of cell death.

When cells keep growing, they dont die well, Dr. Baehrecke explained. We show that an arrest of growth preceded the death of these cells. If we maintain growth by turning on certain genes, we can block the death of these cells, and this has potential clinical implications. Therapies directed at apoptotic mechanisms have resulted in limited success; we hope that further studies of autophagy could lead to new approaches to the treatment of human disease.

Its becoming increasingly important to understand how the various cell death pathways connect and how they affect development, the stress response, and disease, said Marion Zatz, PhD, who oversees cell death grants at the National Institute of General Medical Sciences, which funded the work. While this research was done in fruit flies, findings made in model organisms are often the first step in understanding what goes on in humans. By shedding light on autophagic cell death, this work may help explain the pathways role in human diseases such as cancer, Alzheimers and Parkinsons.

The role of autophagy during cell death remains controversial but is important to our understanding and treatment of many human disorders including cancer and neurodegeneration, Baehrecke said. It is important to understand the relationship between autophagy and cell death, as the association of autophagy with cell growth, nutrient utilization, survival and death indicates that this catabolic process is relevant to the treatment of many human disorders including cancer.


'/>"/>

Contact: Kelly Bishop
kelly.bishop@umassmed.edu
University of Massachusetts Medical School
Source:Eurekalert

Related medicine news :

1. Community Health Centers Reveal Specific Ramifications of The Medicaid Citizenship and Identification Documentation Requirements
2. Pathway links inflammation, angiogenesis and breast cancer
3. Traffic Fumes Plus Genes Boosts Kids Asthma Risk
4. New Database to Help Speed Search for Bipolar Disorder Genes
5. Is Perfect Pitch All in the Genes?
6. Discovery suggests location of genes for breast density, a strong risk factor for breast cancer
7. Genes Boost Risk for Rheumatoid Arthritis, Lupus
8. The genes involved in rheumatoid arthritis identified
9. If you think cancer genes are simple, you dont know JAK
10. Test for lung cancer looks for discomforting quiet among protective genes
11. Hushed Genes Might Mean Higher Lung Cancer Risk
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... ... 13, 2017 , ... Apple Rehab Shelton Lakes , which specializes in ... the facility as part of a disaster drill on October 3rd. , Apple Rehab ... City Emergency Manager, as well as the Connecticut Long Term Care Mutual Aid ...
(Date:10/13/2017)... Texas (PRWEB) , ... October 13, 2017 , ... Yisrayl ... this week that explains one of the most popular and least understood books in ... like cryptic and puzzling descriptions that have baffled scholars for centuries. Many have tossed ...
(Date:10/12/2017)... ... October 12, 2017 , ... ... for healthcare compliance program management, will showcase a range of technology and learning ... Assisted Living (NCAL) Convention and Expo to be held October 14–18, 2017 at ...
(Date:10/12/2017)... ... ... The American College of Medical Informatics (ACMI) will present the 2017 Morris ... of AMIA’s Annual Symposium in Washington, D.C. AMIA’s Annual Symposium is taking ... in the field of medical informatics, this prestigious award is presented to an individual ...
(Date:10/12/2017)... ... October 12, 2017 , ... Leading pediatric oncology experts at Children’s National ... 49th Congress of the International Society of Paediatric Oncology (SIOP) Oct. 12-15. ... for Cancer and Blood Disorders at Children’s National, and Stephen P. Hunger, M.D., ...
Breaking Medicine News(10 mins):
(Date:10/12/2017)... 2017 AVACEN Medical , Inc. (AVACEN) announced ... 2017 New Product Innovation Award for Its fibromyalgia pain ... secondary medical device market research by Frost & Sullivan,s industry ... drug-free pain relief product, the AVACEN 100, offers a safe ... widespread pain. ...
(Date:10/11/2017)... , Oct. 11, 2017  Caris Life Sciences ® ... fulfilling the promise of precision medicine, today announced that ... Caris, Precision Oncology Alliance™ (POA) as its 17 th ... the St. Jude Crosson Cancer Institute will help develop ... use of tumor profiling, making cancer treatment more precise ...
(Date:10/10/2017)... 2017   West Pharmaceutical Services, Inc. (NYSE: ... drug administration, today shared the results of a study ... the intradermal administration of polio vaccines. The study results ... May 2017 by Dr. Ondrej Mach , Clinical ... Organization (WHO), and recently published in the journal ...
Breaking Medicine Technology: