Identification of dopamine 'mother cells' could lead to future Parkinson's ... (o create and support the young dopamine-...)

Identification of dopamine 'mother cells' could lead to future Parkinson's treatments

Date:4/7/2008

o create and support the young dopamine-producing neurons which are essential for important human functions including motor activity, cognition and some behaviours.

Now that we understand how these neurons are produced, we hope that this knowledge can be used to develop novel therapies including techniques to create replacement neurons for people with Parkinsons which could be implanted into the brain to bolster their vital supplies of dopamine.

Dr Hall adds, however, that more research is needed to work out how exactly these glia-like cells could be used: Using these mother cells to grow new neurons in the lab which are fit to be transplanted into humans will be complicated, and extensive further research is needed before this becomes a clinical reality. For example, were not yet sure whether the mother cells themselves would need to be transplanted too, in order to facilitate successful dopamine production in the brain of a Parkinsons patient, she said.

In the UK, one in every 500 people approximately 120,000 individuals has Parkinsons disease. Around 10,000 people are diagnosed with the disease every year. The symptoms of Parkinsons disease usually appear when about 80% of the brains dopamine has been lost. The level of dopamine in the brain then continues to fall slowly over many years. The reasons why the loss of dopamine occurs in the brains of people with Parkinsons is currently unknown.

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Contact: Danielle Reeves
danielle.reeves@imperial.ac.uk
44-020-759-42198
Imperial College London
Source:Eurekalert

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Identification of dopamine 'mother cells' could lead to future Parkinson's ...(o create and support the young dopamine-...),Health