Navigation Links
Identification of 5 genes involved in the metastasis of breast tumors to the lung
Date:6/20/2008

This release is available in Spanish.

The identification of five genes involve in the metastasis of breast tumours to the lung is the principal finding of a scientific team made up of two bodies from the University of Navarra, the Applied Medical Research Centre (CIMA) and the University Hospital of the University of Navarra.

Doctor Alfonso Calvo, researcher in the area of Oncology at the CIMA, led the work with the special collaboration of Doctor Ignacio Gil Bazo, cancer specialist from the University Hospital. The study made up a significant part of Mr Ral Catena's PhD thesis.

For this research, recently published in the scientific journal Oncogene, a transgenic mouse model which presented a greater tendency for developing metastasis was employed. The increase in what is known as the Vascular Endothelial Growth Factor (VEGF) in its mammary glands triggered profound changes in the tumoural structure, which enabled the malignant cells to leave the tumour and invade the lungs.

Finally, the pattern of genes responsible for this tumoural migration to the lungs was analysed and this was compared to that shown by women with breast tumours with pulmonary metastatic affectation. It was shown that five of these genes were common to the animal model and patients with breast cancer.

Most effective ways of treatment

According to the results of this study, of the five genes identified, the Tenascina-C gene seems to be a good therapeutic target for the treatment of metastatic breast cancer. In fact, the blocking of the expression of this gene in the animal model enabled a significant reduction, both in tumour growth and in the incidence of pulmonary metastasis.

This new discovery in the complex network that is the metastasis process of tumours provides key data on the knowledge of cancer and its spreading, at
'/>"/>

Contact: Egoitz Etxebeste
egoitz@elhuyar.com
Elhuyar Fundazioa
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Winning Method - Effective Identification and Development of Clinical Investigators
2. Worried Your Pet Will Get Lost or Stolen? Invest in Pet Identification
3. Identification of dopamine mother cells could lead to future Parkinsons treatments
4. Body identification by facial reconstruction will cost less time and money
5. Isis Announces Approximately $2.8 Million in Government Grants and Contracts Awarded to its Ibis Subsidiary to Advance Ibis Pathogen Identification Technology
6. Forsyth launches 1-of-a-kind core service to enable rapid identification of bacterial samples
7. Identification of new genes shows a complex path to cell death
8. Community Health Centers Reveal Specific Ramifications of The Medicaid Citizenship and Identification Documentation Requirements
9. Metabolic Syndrome May Be in the Genes
10. Genome sequence of lancelet shows how genes quadrupled during vertebrate evolution
11. Cardiogenesis Announces Preliminary Results Combining TMR + Platelet Rich Plasma (PRP)
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/22/2014)... October 22, 2014 Isabel Healthcare ... Allied Health Professions (ASAHP) Conference on October 22-24 in ... will participate in a panel discussion on Technology in ... Isabel Healthcare provides a diagnostic decision support tool and ... diagnosis skills of students and clinical learners. The Isabel ...
(Date:10/22/2014)... Shriners Hospitals for Children® and UK HealthCare ... location of Shriners Hospitals for Children - Lexington from ... University of Kentucky Albert B. Chandler Hospital. The new ... and operated by Shriners Hospitals for Children, and designed ... their families well into the future. , “The quality ...
(Date:10/22/2014)... October 22, 2014 During the Western ... water supply runs dangerously low, Southern Oregon’s water is ... rivers, despite the lowest mountain snow pack on record ... summer and early autumn.* That was the observation of ... new book “Hiking Southern Oregon,” during an interview with ...
(Date:10/22/2014)... only 24 hours in a day, that doesn’t seem to be ... their busy schedules for exercise and fitness. Fortunately, one does not ... shape. Here are five ways you can reach your fitness and ... Commute , Consider riding a bike or taking the bus or ... If you must use your car to get to work, start ...
(Date:10/22/2014)... Steven Reinberg HealthDay Reporter ... quickly add weight and length may be showing a genetic ... In adults, certain genes have been linked to increased body ... in fat and lean muscle, the researchers said. At ... taller. By ages 2 and 3, however, these genes were ...
Breaking Medicine News(10 mins):Health News:Isabel Healthcare to Participate in The Association of Schools of Allied Health Professions (ASAHP) 2014 Conference 2Health News:Shriners Hospitals for Children - Lexington Announces Plan to Build New $47 Million Facility 2Health News:Shriners Hospitals for Children - Lexington Announces Plan to Build New $47 Million Facility 3Health News:Southern Oregon Is West’s Most Drought Proof Fresh Water Region Say Hiking Guide Authors 2Health News:Southern Oregon Is West’s Most Drought Proof Fresh Water Region Say Hiking Guide Authors 3Health News:Southern Oregon Is West’s Most Drought Proof Fresh Water Region Say Hiking Guide Authors 4Health News:HealthGuideMD Presents Ways to Improve Your Exercise and Fitness 2Health News:Tall, Heavy 1-Year-Olds May Be at Risk for Obesity Later, Study Finds 2
... and disabling a protein frequently found in melanoma tumors, ... vulnerable to chemotherapy, according to early results of a ... Cancer Center. , "In this pilot study, we gave ... been shown in pre-clinical studies to weaken melanoma tumors ...
... ALOKA Co., Ltd. will be unveiling a new ... - ECR2009 - to be held from March 6th, ... for ultrasound systems with higher cost-effectiveness, flexibility, ease of ... stand-alone, black-and-white system with the latest digital technologies engineered ...
... nurse and allied professional are already at the heart ... and Professor Christi Deaton, Chairperson of the ESC Council ... even greater role given the complex needs of people ... prevent cardiovascular disease," says Professor Deaton, "and we have ...
... MIAMI, March 6 Eight projects in the Miami-Dade ... for projects focused on addressing transportation and mobility options ... for all. The winning projects were chosen based on ... counties, "Aging in Place" services.The grants were the result ...
... Important information on display at 10 Rockefeller Plaza through ... the month of March, the Alzheimer,s Association, New York ... Chapter services. This is due to the generosity ... construct a 115-square foot display in its window at ...
... stores, studies find , , FRIDAY, March 6 (HealthDay News) ... are much less likely to offer healthy foods than ... live matters in terms of your diet," said study ... Hopkins Bloomberg School of Public Health in Baltimore. "If ...
Cached Medicine News:Health News:Drug combination may be effective against deadly melanoma, pilot study shows 2Health News:ALOKA Showcases a New Diagnostic Ultrasound System ProSound 4 at ECR 2009 in Vienna, Austria 2Health News:Nurses and allied professionals at heart of cardiovascular prevention and management programs 2Health News:Nurses and allied professionals at heart of cardiovascular prevention and management programs 3Health News:Miami-Dade and Monroe County Organizations Receive Grants to 'JumpStart the Conversation' 2Health News:Miami-Dade and Monroe County Organizations Receive Grants to 'JumpStart the Conversation' 3Health News:Miami-Dade and Monroe County Organizations Receive Grants to 'JumpStart the Conversation' 4Health News:EHE International Helps Alzheimer's Association, New York City Chapter to Raise Awareness About Alzheimer's Disease 2Health News:Healthy Foods Harder to Find in Poor Neighborhoods 2Health News:Healthy Foods Harder to Find in Poor Neighborhoods 3Health News:Healthy Foods Harder to Find in Poor Neighborhoods 4
(Date:10/22/2014)... RPh, of Vernak Farms Pharmacy in Skaneateles, ... Roentsch Scholarship by the Professional Compounding Centers of America ... during PCCA,s International Seminar, held October 8-10, ... pharmacist and PCCA member who embodies the innovative and ... pharmacist in the compounding community. George ...
(Date:10/22/2014)... 2014 A new report by ... type, Form, End user, Application and Geography) - Size, ... Report, Opportunities, Segmentation and Forecast, 2013 - 2020", considers ... on key trends tracked, it is anticipated that the ... by 2020, registering a CAGR of 6.2% from 2014 ...
(Date:10/22/2014)... LOUIS , Oct. 21, 2014  Early ... often subtle or unnoticed, but new technology, coupled ... outcomes and leading to earlier detection of eye ... affects 29 million Americans. If left untreated, these ... even blindness. Recently, optometric researchers ...
Breaking Medicine Technology:PCCA Awards Charlene Vernak, RPh, the George Roentsch Scholarship 2Global Disposable Gloves Market Expected to Grow to $7.9 Billion by 2020 - Allied Market Research 2Global Disposable Gloves Market Expected to Grow to $7.9 Billion by 2020 - Allied Market Research 3Global Disposable Gloves Market Expected to Grow to $7.9 Billion by 2020 - Allied Market Research 4Technology Advancements Enhance Early Detection of Eye Diseases Associated with Diabetes 2Technology Advancements Enhance Early Detection of Eye Diseases Associated with Diabetes 3
... Vitros 250 is a flexible ... in multiple environments small ... clinics and satellite locations. The ... dilution, and can be automated ...
The IMx system is an automated analyzer designed to perform microparticle enzyme immunoassay (MEIA), fluorescence polarization immunoassay (FPIA) and ion capture technologies....
Architect i2000 is a flexible solution for your evolving laboratory providing high throughput and walkaway time with built-in flexibility....
... The Bayer Immuno 1 provides ... immunoassay instrument with over 50 ... endocrinology, tumor marker, therapeutic drug, ... can be performed on a ...
Medicine Products: