Navigation Links
Identification of 5 genes involved in the metastasis of breast tumors to the lung
Date:6/20/2008

This release is available in Spanish.

The identification of five genes involve in the metastasis of breast tumours to the lung is the principal finding of a scientific team made up of two bodies from the University of Navarra, the Applied Medical Research Centre (CIMA) and the University Hospital of the University of Navarra.

Doctor Alfonso Calvo, researcher in the area of Oncology at the CIMA, led the work with the special collaboration of Doctor Ignacio Gil Bazo, cancer specialist from the University Hospital. The study made up a significant part of Mr Ral Catena's PhD thesis.

For this research, recently published in the scientific journal Oncogene, a transgenic mouse model which presented a greater tendency for developing metastasis was employed. The increase in what is known as the Vascular Endothelial Growth Factor (VEGF) in its mammary glands triggered profound changes in the tumoural structure, which enabled the malignant cells to leave the tumour and invade the lungs.

Finally, the pattern of genes responsible for this tumoural migration to the lungs was analysed and this was compared to that shown by women with breast tumours with pulmonary metastatic affectation. It was shown that five of these genes were common to the animal model and patients with breast cancer.

Most effective ways of treatment

According to the results of this study, of the five genes identified, the Tenascina-C gene seems to be a good therapeutic target for the treatment of metastatic breast cancer. In fact, the blocking of the expression of this gene in the animal model enabled a significant reduction, both in tumour growth and in the incidence of pulmonary metastasis.

This new discovery in the complex network that is the metastasis process of tumours provides key data on the knowledge of cancer and its spreading, at the same time identifying new targets for which new pharmaceutical medicines that contribute to more efficacious treatment of this disease can be designed.


'/>"/>

Contact: Egoitz Etxebeste
egoitz@elhuyar.com
Elhuyar Fundazioa
Source:Eurekalert

Related medicine news :

1. Winning Method - Effective Identification and Development of Clinical Investigators
2. Worried Your Pet Will Get Lost or Stolen? Invest in Pet Identification
3. Identification of dopamine mother cells could lead to future Parkinsons treatments
4. Body identification by facial reconstruction will cost less time and money
5. Isis Announces Approximately $2.8 Million in Government Grants and Contracts Awarded to its Ibis Subsidiary to Advance Ibis Pathogen Identification Technology
6. Forsyth launches 1-of-a-kind core service to enable rapid identification of bacterial samples
7. Identification of new genes shows a complex path to cell death
8. Community Health Centers Reveal Specific Ramifications of The Medicaid Citizenship and Identification Documentation Requirements
9. Metabolic Syndrome May Be in the Genes
10. Genome sequence of lancelet shows how genes quadrupled during vertebrate evolution
11. Cardiogenesis Announces Preliminary Results Combining TMR + Platelet Rich Plasma (PRP)
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/20/2017)... ... 2017 , ... Source Vitál Apothecary, a skin and body care company dedicated ... company had a successful visit to the 2017 ECRM Diet, Vitamin & Sports Nutrition ... in the nutritional, sports and health industries a chance to meet in private sessions ...
(Date:1/20/2017)... ... January 20, 2017 , ... Lice Troopers, the lice removal company ... with school-aged children since the holiday season. , “It happens every year around ... sharing hugs and taking photos, which is the head-to-head gateway that lice need to ...
(Date:1/20/2017)... ... 2017 , ... Michael and Betsy Brauser celebrated 5 years of Betsy’s participation ... trial has been life-saving as she has been on the trial for more ... diagnosed with ovarian cancer in 2009. She underwent standard chemotherapy but a year later ...
(Date:1/20/2017)... ... ... Magdalene: Grace is Greater than Sin”: a unique and memorable piece of literature ... Grace is Greater than Sin” is the creation of published author, Brenda Roberts, a ... had little knowledge of the female characters portrayed in the Holy Bible. , ...
(Date:1/20/2017)... ... ... examination of how God handles sin, including how to let go of lingering guilt and ... ten long years has been waiting to release this powerful insight about forgiveness that the ... the Lord for over twenty years, and he has been preaching and teaching the Word ...
Breaking Medicine News(10 mins):
(Date:1/21/2017)... ARMO BioSciences, Inc., a late-stage immuno-oncology company, ... lead investigational immuno-oncology drug AM0010 (PEGylated Interleukin-10) at the ... of Clinical Oncology (ASCO), taking place January 19-21, 2017 ... "AM0010 induces the expansion of novel T ... in the blood and tumors of our patients," said ...
(Date:1/20/2017)... , Jan 20, 2017 Research ... Testing Market By Type ([CBC, HGB/HCT, BMP, BUN Creatinine, Electrolyte Testing, ... By End-use, And Segment Forecasts, 2013 - 2024" report to ... ... 198.5 billion by 2024 Introduction of innovative solutions on ...
(Date:1/20/2017)... DUBLIN , Jan 20, 2017 ... Pharmaceutical Stability Testing Market Trends, Opportunities, and Future" report to ... ... market sizing, emerging trends, and technologies, and provides a snapshot of ... year is 2015 and forecasts are provided from 2016 to 2020. ...
Breaking Medicine Technology: