Navigation Links
Identical Genes From Parents May Raise Cancer Risk
Date:3/25/2008

Finding could someday aid in diagnosis, treatment, experts say

TUESDAY, March 25 (HealthDay News) -- People who have two identical copies of certain genes -- one inherited from the mother and one from the father -- seem to be at greater risk of developing a number of common types of cancer, research shows.

Although the findings need to be validated in more studies, there could be significant implications for patient care, experts say.

"This could represent a new way to do cancer risk-assessment. I suspect this will be added into routine clinical testing," said Dr. Charis Eng, senior author of the paper published in the March 26 issue of the Journal of the American Medical Association. "This is truly 'genetics to keep healthy people healthy,' " she said.

Eng, who is director of the Genomic Medicine Institute at the Cleveland Clinic Foundation, noted that by the time such tests wind their way into clinical practice, doctors should also have more preventative and screening tools at their disposal.

Unlike many currently available genetic tests -- such as those for the BRCA1 and 2 genes thought to play a role in breast cancer -- these anticipated tests could be applicable to everybody, not just people at high risk for a particular malignancy.

Similarly, the new findings suggest that more than 5 percent of all cancers are linked to heredity, the researchers said.

Previously, Eng had noticed that a high level of germline cells (those containing genetic material that can be passed on to children) were homogenous, meaning that two copies of the same gene were identical. Her team was studying heterozygosity, but these cells were "maddeningly homogenous," she said. At first, she attributed the pattern to bad luck, but after years of finding the same thing, she decided it couldn't be a coincidence.

So, Eng and her colleagues decided to look at 400 genetic markers scattered throughout the genome in 385 breast, prostate and head and neck cancer patients and in people without cancer.

All patients were of the same ethnic group.

"Lo and behold, in 16 markers, let's call them 'hot spots,' there were high frequencies of homozygosity compared to the controls," Eng said.

The association was then validated in patients with lung cancer. This time, they streamed through 250,000 markers across the human genome and found that cancer patients were more likely to have homozygosity in the same 16 markers.

"We are saying that lack of genetic diversity or uniformity in hot spots in 16 places seems to be associated with common cancers," Eng said. "This is a novel means of cancer predisposition."

"We don't know the mechanism yet," she added. "Right now, it's an association."

The study authors have postulated that this homozygosity occurs at "common" fragile sites on the genome, sites that are susceptible to DNA damage. These are to be distinguished from "rare" fragile sites that are also sensitive to such damage but are more likely to be associated with less common cancers.

More information

For more on different types of cancer, visit the U.S. National Cancer Institute.



SOURCES: Charis Eng, M.D., Ph.D., director, Genomic Medicine Institute, Cleveland Clinic Foundation; March 26, 2008, Journal of the American Medical Association


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. FDA Warns Against Bio-Identical Hormone Therapy
2. FDA Asserts New Policy to Restrict Womens Access to Bioidentical Hormones
3. Science of Sri Vidya Benefits DNA Genesis, Says Dr. Sunita Rana Agarwal
4. Organogenesis Names Regenerative Medicine Expert Dr. Damien Bates Vice President, Medical Affairs
5. Genes that protect against atherosclerosis identified
6. Genesis Pharmaceuticals Changes Auditors
7. Cell Genesys to Present at the Cowen and Company and the Lehman Brothers Healthcare Investor Conferences
8. Cardiogenesis Corporation Announces Rescheduled Fourth Quarter and Full Year 2007 Earnings Release
9. Cardiogenesis Corporation Reports Delay in Earnings Release and Conference Call
10. Zebrafish provide useful screening tool for genes, drugs that protect against hearing loss
11. Cell Genesys Reports Fourth Quarter and Year-End 2007 Results
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Identical Genes From Parents May Raise Cancer Risk
(Date:6/26/2016)... ... June 26, 2016 , ... On June 10-11, 2016, A Forever Recovery, ... Festival and World’s Longest Breakfast Table in Battle Creek, MI, where the rehabilitation facility ... home to some of the world’s leading providers of cereal and other breakfast foods. ...
(Date:6/26/2016)... ... June 26, 2016 , ... Many ... been diagnosed with endometriosis. These women need a treatment plan to not only ... approach that can help for preservation of fertility and ultimately achieving a pregnancy. ...
(Date:6/25/2016)... Viejo, California (PRWEB) , ... June 25, 2016 , ... ... to fit their specific project," said Christina Austin - CEO of Pixel Film Studios. ... fully customizable and all within Final Cut Pro X . Simply select a ...
(Date:6/25/2016)... ... ... On Friday, June 10, Van Mitchell, Secretary of the Maryland Department of Health ... of their exemplary accomplishments in worksite health promotion. , The Wellness at Work Awards ... at the BWI Marriott in Linthicum Heights. iHire was one of 42 businesses to ...
(Date:6/24/2016)... Michigan (PRWEB) , ... June 24, 2016 , ... June ... about the dangers associated with chronic pain and the benefits of holistic treatments, ... individuals who are suffering with Sickle Cell Disease. , Sickle Cell Disease (SCD) is ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... 2016 Research and Markets has announced ... Forecast to 2022" report to their offering. ... the patients with kidney failure, it replaces the function of ... patient,s blood and thus the treatment helps to keep the ... balance. Increasing number of ESRD patients & ...
(Date:6/23/2016)... June 23, 2016 Roche (SIX: RO, ROG; ... for its Elecsys BRAHMS PCT (procalcitonin) assay as a ... septic shock. With this clearance, Roche is the first ... integrated solution for sepsis risk assessment and management. ... infection and PCT levels in blood can aid clinicians ...
(Date:6/23/2016)... Bracket , a leading clinical trial technology ... outcomes platform, Bracket eCOA (SM) 6.0, at the 52 ... 30, 2016 in Philadelphia , Pennsylvania.  A ... product of its kind to fully integrate with RTSM, will ... 6.0 is a flexible platform for electronic clinical outcomes assessments ...
Breaking Medicine Technology: