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Icahn School of Medicine at Mount Sinai and Bene Pharmachem Gmbh to Collaborate on Clinical Studies for Mucopolysaccaridoses
Date:5/15/2013

New York, NY (PRWEB) May 15, 2013

The Icahn School of Medicine at Mount Sinai has signed an agreement with bene pharmaChem GmbH to collaborate to conduct clinical studies of pentosan polysulfate (PPS) in patients with mucopolysaccharidoses (MPS). The company, based in Germany, is the sole producer of pharmaceutical pentosan polysulfate.

The announcement was made on Wednesday, May 15, which is International MPS Awareness Day. MPS are a group of inherited metabolic diseases in which a defective or missing enzyme causes large amounts of complex sugar molecules to accumulate in harmful amounts in the body's cells and tissues. This accumulation causes permanent, progressive cellular damage that affects appearance, physical abilities, organ and system functioning, and, in most cases, mental development. Currently there is no cure for these disease syndromes. Medical care is directed at treating systemic conditions and improving the person's quality of life. (To learn more: http://www.ninds.nih.gov/disorders/mucopolysaccharidoses/mucopolysaccharidoses.htm).

The original discoveries demonstrating the utility of (PPS) for the treatment of MPS and other lysosomal storage diseases were made in the Mount Sinai laboratories of Calogera M. Simonaro, MPh, PhD, Associate Professor of Genetics and Genomic Sciences and Edward H. Schuchman, MPh, PhD, Professor of Genetics and Genomic Sciences. Dr. Simonaro and Dr. Schuchman have demonstrated in MPS animal models that PPS has the effect of reducing the chronic inflammation associated with substrate accumulation, resu
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