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Icahn Responds to Cook and Wilson
Date:4/21/2009

NEW YORK, April 21 /PRNewswire/ -- Carl Icahn announced today that he had sent the following letter to Joseph C. Cook, Jr., Chairman of the Board and James Wilson, Lead Independent Director of Amylin Pharmaceuticals, Inc. (Nasdaq: AMLN) concerning recent discussions between Mr. Icahn and Messrs. Cook and Wilson

                                                           April 21, 2009
    Joseph Cook, Jr., Chairman of the Board
    James Wilson, Lead Independent Director
    Amylin Pharmaceuticals, Inc
    9360 Towne Centre Drive
    San Diego, CA  92121

Dear Joe & Jim:

Your letter of April 20, 2009, completely mischaracterized what was said during the conversations that took place between us during the past weekend.

After Amylin issued its public invitation to a meeting with us and Eastbourne, I called you this past weekend and, during the first of our conversations, I stated I was glad you had indicated (in your media statement of Wednesday, April 15) your willingness to have a three way discussion between Eastbourne, the Company and ourselves. I was therefore absolutely amazed when you denied you had indicated that you were open to a meeting. I then asked you to wait while I got a copy of the statement you issued. I read you your own language which stated, "We have engaged in discussions with both Mr. Icahn and Eastbourne Capital Management, L.L.C. ("Eastbourne"), and welcome the opportunity to meet with them again, either separately or together." I then asked if you intended to keep your word and have the meeting. There was no meaningful reply. I then mentioned that this indecisiveness and reneging on promises could be a major problem if it is how the company has been run during your tenure.

Let us now discuss some of the many misstatements you have made concerning our weekend
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