Navigation Links
Ibuprofen destroys aspirin's positive effect on stroke risk
Date:3/12/2008

BUFFALO, N.Y. -- Stroke patients who use ibuprofen for arthritis pain or other conditions while taking aspirin to reduce the risk of a second stroke undermine aspirins ability to act as an anti-platelet agent, researchers at the University at Buffalo have shown.

In a cohort of patients seen by physicians at two offices of the Dent Neurologic Institute, 28 patients were identified as taking both aspirin and ibuprofen (a nonsteroidal anti-inflammatory drug, or NSAID) daily and all were found to have no anti-platelet effect from their daily aspirin.

Thirteen of these patients were being seen because they had a second stroke/TIA while taking aspirin and a NSAID, and were platelet non-responsive to aspirin (aspirin resistant) at the time of that stroke.

The researchers found that when 18 of the 28 patients returned for a second neurological visit after discontinuing NSAID use and were tested again, all had regained their aspirin sensitivity and its ability to prevent blood platelets from aggregating and blocking arteries.

The study is the first to show the clinical consequences of the aspirin/NSAID interaction in patients being treated for prevention of a second stroke, and presents a possible explanation of the mechanism of action.

The Food and Drug Administration currently warns that ibuprofen might make aspirin less effective, but states that the clinical implications of the interaction have not been evaluated.

This interaction between aspirin and ibuprofen or prescription NSAIDs is one of the best-known, but well-kept secrets in stroke medicine, said Francis M. Gengo, Pharm.D., lead researcher on the study.

Its unfortunate that clinicians and patients often are unaware of this interaction. Whatever number of patients who have had strokes because of the interaction between aspirin and NSAIDs, those strokes were preventable.

Gengo is professor of neurology in the UB School of Medicine
'/>"/>

Contact: Lois Baker
ljbaker@buffalo.edu
716-645-5000 x1417
University at Buffalo
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Ibuprofen Preserves Lung Function in Kids With Cystic Fibrosis
2. Ibuprofen associated with slower lung function decline in children with cystic fibrosis
3. Albemarle to Increase Price of Ibuprofen
4. Ibuprofen can slow lung disease in children with cystic fibrosis, Canadian study shows
5. Researchers train the immune system to deliver virus that destroys cancer in lab models
6. Peregrine Pharmaceuticals Announces Positive Data From Cotara(R) Brain Cancer Trials
7. Positive results from phase 1 clinical trials of cuprindro
8. Single reader with CAD more efficient, yields fewer false positives, and possibly more sensitive
9. HPV-positive head and neck cancer patients fare better than HPV-negative patients
10. HPV-Positive Head and Neck Cancers Fare Better
11. Labopharm Reports Positive Results for Phase III Study on Once-daily Trazodone
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/22/2015)... Deer Path of Huntley -- a BMA affordable assisted living ... p.m. to 4 p.m. on Feb. 13. , The community, which ... with physical disabilities between the ages of 22 and 64. , ... sweetheart-themed karaoke. , For more information about the event or Deer ...
(Date:1/22/2015)... Hawley, PA (PRWEB) January 22, 2015 Woodloch ... Pocono Mountains, has been selected by TripAdvisor as the number ... and the 6th best in the world for their annual ... online travel community . The website is home to ...
(Date:1/22/2015)... Angelweddingdress is a famous wedding dress company offering ... follow it on Facebook, Twitter, and Pinterest. The fans will ... draws a lottery every week. , Moreover, the company has ... Click Angelweddingdress homepage for more information. , ...
(Date:1/22/2015)... A new white paper by The ... in the long-term care environment as well as provides ... The paper, “The Power of Person-Centeredness in Long-Term Care: ... of the patient, resident and family experience in long-term ...
(Date:1/22/2015)... Joan Lunden, award-winning American journalist, beloved ... upcoming 32nd Annual Miami Breast Cancer Conference ... LLC (PER®) , shares that “a fast-growing, virulent” cancer ... she had not followed up her clean mammogram with ...
Breaking Medicine News(10 mins):Health News:Deer Path of Huntley Affordable Assisted Living to Host Valentine's Day Happy Hour 2Health News:TripAdvisor Names Woodloch Pines Best Hotel for Families in America 2Health News:TripAdvisor Names Woodloch Pines Best Hotel for Families in America 3Health News:Angelweddingdress Invites Its Customers To Follow It On Facebook, Twitter, And Pinterest 2Health News:The Power of Person-Centeredness in Long-Term Care Explored by The Beryl Institute 2Health News:The Power of Person-Centeredness in Long-Term Care Explored by The Beryl Institute 3Health News:Joan Lunden Reveals Diagnostic Approach That Led To Early Detection;To Keynote 32nd Annual Miami Breast Cancer Conference® 2Health News:Joan Lunden Reveals Diagnostic Approach That Led To Early Detection;To Keynote 32nd Annual Miami Breast Cancer Conference® 3Health News:Joan Lunden Reveals Diagnostic Approach That Led To Early Detection;To Keynote 32nd Annual Miami Breast Cancer Conference® 4Health News:Joan Lunden Reveals Diagnostic Approach That Led To Early Detection;To Keynote 32nd Annual Miami Breast Cancer Conference® 5Health News:Joan Lunden Reveals Diagnostic Approach That Led To Early Detection;To Keynote 32nd Annual Miami Breast Cancer Conference® 6
... /PRNewswire-FirstCall/ -- Cell Therapeutics, Inc. (the ... final results of its separate concurrent fixed price exchange offers ... any and all of the approximately $118.9 million outstanding principal ... The Exchange Offers expired at 5:00 p.m., New York ...
... As President Obama prepares to sign a bill giving ... tobacco industry, a new study from Harvard School of ... continually changed the ingredients and the design of their ... acceptable product variance guidelines. The result, say the researchers, ...
... The Damon Runyon Cancer Research Foundation, a non-profit ... and innovative cancer research, named 17 new Damon ... Committee review. The recipients of this prestigious, three-year ... translational cancer research in the laboratories of leading ...
... in Williamson County ... Round Rock Medical Center today announced that the hospital will seek ... Williamson County. , , "St. David,s Round Rock Medical Center ... has the busiest emergency department in the City of Round Rock ...
... their choice , FRIDAY, June 19 (HealthDay News) -- ... can,t list any actual benefits, a new British study ... BMC Public Health , stemmed from interviews that University ... sports center. , "The majority of participants believed that ...
... WLP ) will release second quarter 2009 financial results on July 29, ... and its outlook during a conference call at 8:30 a.m. EDT that same ... its start with the following numbers: , , , ... 800-475-6701 (Domestic Replay), ...
Cached Medicine News:Health News:Cell Therapeutics Announces Final Results of its Fixed Price Exchange Offers for Any and All of its $118.9 Million Convertible Notes Outstanding 2Health News:Cell Therapeutics Announces Final Results of its Fixed Price Exchange Offers for Any and All of its $118.9 Million Convertible Notes Outstanding 3Health News:Study finds that tobacco companies changed design of cigarettes without alerting smokers 2Health News:Damon Runyon Cancer Research Foundation awards prestigious fellowships to 17 top young scientists 2Health News:Damon Runyon Cancer Research Foundation awards prestigious fellowships to 17 top young scientists 3Health News:Damon Runyon Cancer Research Foundation awards prestigious fellowships to 17 top young scientists 4Health News:Damon Runyon Cancer Research Foundation awards prestigious fellowships to 17 top young scientists 5Health News:St. David's Round Rock Medical Center to Seek Level II Trauma Designation 2Health News:St. David's Round Rock Medical Center to Seek Level II Trauma Designation 3Health News:St. David's Round Rock Medical Center to Seek Level II Trauma Designation 4Health News:WellPoint to Hold Conference Call and Webcast to Discuss Second Quarter Results on July 29, 2009 2
(Date:1/23/2015)... January 23, 2015 Heptares Therapeutics, the clinical-stage ... announce that the Malcolm Campbell Memorial Prize for ... President of Chemistry), Fiona Marshall (Chief Scientific Officer ... and co-founder) for the seminal contributions to GPCR drug discovery ...
(Date:1/22/2015)... , Jan. 22, 2015  BiOptix is pleased to announce ... Vice President of Chemistry and Biochemistry. Scott joins the company ... Pharmaceuticals, and Amgen throughout the course of his nearly ... "Scott is a nationally recognized thought leader in ...
(Date:1/22/2015)... ON , Jan. 22, 2015 /PRNewswire/ - Pivotal Therapeutics Inc. ... with a focus on Omega-3 therapies for cardiovascular disease and ... of the Company,s accomplishments in 2014 and its outlook for ... Dear Fellow Shareholders, We would like to ...
Breaking Medicine Technology:Heptares Scientists to Receive the Malcolm Campbell Memorial Prize for 2015 in Recognition of Their Outstanding Contribution to GPCR Drug Discovery 2Heptares Scientists to Receive the Malcolm Campbell Memorial Prize for 2015 in Recognition of Their Outstanding Contribution to GPCR Drug Discovery 3Heptares Scientists to Receive the Malcolm Campbell Memorial Prize for 2015 in Recognition of Their Outstanding Contribution to GPCR Drug Discovery 4BiOptix Expands Leadership Team with the Appointment of Dr. Scott Klakamp as Vice President of Chemistry and Biochemistry 2Pivotal Therapeutics: Year in Review and CEO Update 2Pivotal Therapeutics: Year in Review and CEO Update 3Pivotal Therapeutics: Year in Review and CEO Update 4Pivotal Therapeutics: Year in Review and CEO Update 5Pivotal Therapeutics: Year in Review and CEO Update 6Pivotal Therapeutics: Year in Review and CEO Update 7
... Jan. 19, 2011 RFID Journal features ... Someone can live or die depending on the ... agree leveraging better tracking of a drug,s expiration dates, ... levels, all performed in REAL TIME, would assist in ...
... PRINCETON, N.J., Jan. 18, 2011 Pharmasset, Inc. (Nasdaq: ... commenced an underwritten public offering, subject to market and ... pursuant to an effective shelf registration statement.  Of the ... the selling stockholders are selling 1,000,000 shares.  Pharmasset intends ...
Cached Medicine Technology:MEPS Real Time's New RFID Drug Management System Provides Critical Error Solution for California Hospital 2Pharmasset Announces Proposed Public Offering of Common Stock 2Pharmasset Announces Proposed Public Offering of Common Stock 3