Navigation Links
Ibuprofen associated with slower lung function decline in children with cystic fibrosis
Date:11/30/2007

Treatment with ibuprofen is associated with a significantly slower rate of decline in lung function in children and adolescents with cystic fibrosis, according to a new study.

Researchers found that patients with cystic fibrosis (CF) who took high doses of ibuprofen had a 29 percent reduction in loss of lung function compared to those who did not use the anti-inflammatory drug twice daily over a period of two to seven years.

It is fairly evident that the lung damage that occurs in cystic fibrosis is due to inflammation, and that this lung damage is what shortens the lives of these patients, said lead researcher Michael W. Konstan, M.D., Director of the Cystic Fibrosis Center at Rainbow Babies and Children's Hospital, and a professor of pediatrics at Case Western Reserve University School of Medicine in Cleveland. Since ibuprofen is an anti-inflammatory drug, we presume that it works by decreasing inflammation in the lung, thereby slowing damage.

The study, which concluded that the benefits of ibuprofen therapy outweigh the small risk of gastrointestinal bleeding, appears in the first issue for December 2007 of the American Journal of Respiratory and Critical Care Medicine, published by the American Thoracic Society.

Cystic fibrosis is a genetic disorder that causes mucus to be thick and sticky. The mucus clogs the lungs, which causes breathing problems and makes it easy for bacteria to grow. The persistence of bacterial infections leads to chronic inflammation, causing lung damage, which eventually proves fatal.

Dr. Konstan led a clinical trial 12 years ago that found ibuprofen reduced the loss of lung function in CF patients, but questions have remained about the safety of regular high-dose ibuprofen use, which in some cases can lead to gastrointestinal bleeding. This study showed that gastrointestinal bleeding was rare, with an annual incidence of 0.37 percent in those taking ibuprofen, compared with 0.14 percen
'/>"/>

Contact: Suzy Martin
smartin@thoracic.org
212-315-8631
American Thoracic Society
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Ibuprofen can slow lung disease in children with cystic fibrosis, Canadian study shows
2. Albemarle to Increase Price of Ibuprofen
3. New study shows promise in reducing surgical risks associated with surgical bleeding
4. Fluctuating eye pressure associated with visual field deterioration in glaucoma patients
5. Study, meta-analysis examine factors associated with death from heatstroke
6. Increased distance to physician associated with thicker skin cancer at diagnosis
7. Minorities more likely to have sleep durations associated with increased mortality
8. Income inequality associated with overnourishment and undernourishment in India
9. Maternal depression and controlling behavior associated with increased stress response in infants
10. Nurses describe dedication, frustration associated with their jobs
11. New research shows ACTOS is associated with a 38 percent lower risk of heart attack
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/19/2014)... 19, 2014 (HealthDay News) -- The U.S. Food and Drug ... Thursday. Trulicity is part of a class of once-a-week injectable ... type 2 diabetes. "Trulicity is a new treatment ... treatment regimens to control blood sugar levels in the overall ... of the FDA,s Office of Drug Evaluation II, said in ...
(Date:9/19/2014)... The Alliance for Bangladesh Worker Safety ... Fire Protection Association (NFPA), a recognized international leader ... a Memorandum of Understanding signed by both organizations, ... stakeholders with information, guidance and access to training ... safety of workers in ready-made garment (RMG) factories ...
(Date:9/19/2014)... MetroMD, a leading anti-ageing clinic has called its ... health. This therapy has grown tremendously across USA in the ... safe and dependable. It has far reaching benefits for ageing ... a very healthy and active lifestyle even beyond their middle ... senior therapist at MetroMD said, “HGH or Human Growth hormones ...
(Date:9/19/2014)... September 19, 2014 "I have difficulty ... wrinkles due to stretching the skin around my eyes ... "This inspired me to design a more convenient method ... LENS SYSTEM provides a quicker, easier, more sanitary method ... to perform this task manually, saves time and effort, ...
(Date:9/19/2014)... - New research published today in the online journal ... reach 6,800 in West Africa by the end of ... , Arizona State University and Harvard University researchers ... rise in cases significantly increased in August in Liberia ... was put in place, indicating that the mass quarantine ...
Breaking Medicine News(10 mins):Health News:FDA Approves Another Weekly Injectable Drug for Type 2 Diabetes 2Health News:Alliance for Bangladesh Worker Safety and NFPA Sign Memorandum of Understanding to Strengthen Safety in Bangladesh Garment Factories 2Health News:Alliance for Bangladesh Worker Safety and NFPA Sign Memorandum of Understanding to Strengthen Safety in Bangladesh Garment Factories 3Health News:MetroMD Announces Better HGH Therapy - the ‘God Particle’ of Human Health 2Health News:Research predicts possible 6,800 new Ebola cases this month 2
... North Carolina in Chapel Hill that was published in the ... two genes - C282Y and H63D, which are linked to ... increased risk of developing colon cancer. For the research, the ... which, more than 400 already had colon cancer, and were ...
... at Trinity College, Dublin, Ireland, have found from a ... arterial stiffness after smoking even one cigarette in both ... effects of smoking on large artery properties in 185 ... years. 116 non-smokers// were compared with 41 chronic smokers ...
... have traditionally been treated by removing a disc or placing ... together. Now, an artificial disc which is being studied as ... phase one study that was recently completed compared the prosthesis ... patients// were randomized, with one having a fusion operation for ...
... is being reassessed to find out if it could again ... and leprosy. The drug which is unlicensed in Europe was ... morning// sickness. However, it was banned after mothers who took ... for the Evaluation of Medicinal Products (EMEA) is now considering ...
... among children that were known until now were chickenpox, ... neurologists have found that stroke is also among one ... go unnoticed. A National Hospital's database analysis by Dr. ... California showed that four in 1000 newborns had a ...
... recent health survey across England showed that many do ... cancer and other serious diseases. The survey included nearly// ... trends were revealed by the study. ,The survey ... eating and household income. Almost 40% of women in ...
Cached Medicine News:Health News:Artificial discs available as replacements for damaged discs 2Health News:Stroke also in list of common childhood ailments 2
(Date:9/19/2014)... and ORLANDO, Fla. , ... supporting Inspire therapy continues to grow, with the publication ... published on-line in Otolaryngology – Head and ... causes a worsening of both objective and subjective measures ... directly attribute Inspire therapy for the reduction in obstructive ...
(Date:9/19/2014)... 2014 Intarcia Therapeutics, Inc. today ... its lead candidate ITCA 650 (continuous subcutaneous delivery of ... HbA1c levels at the 50 th Annual Meeting ... (EASD). Data from the open-label, phase 3 FREEDOM-HBL (high ... in patients with poorly controlled type 2 diabetes. The ...
(Date:9/19/2014)... September 19, 2014 Reductions in ... many years in people with diabetes type 2 ... term benefits for the kidneys." Australian researchers ... type 2 diabetes leads to persistent reductions in kidney ... The global study has found that, five and ...
Breaking Medicine Technology:New Data shows Reductions in obstructive sleep apnea (OSA) severity and improvement of quality of life with Inspire therapy 2New Data shows Reductions in obstructive sleep apnea (OSA) severity and improvement of quality of life with Inspire therapy 3New Data shows Reductions in obstructive sleep apnea (OSA) severity and improvement of quality of life with Inspire therapy 4Intarcia Announces Presentation of Phase 3 Data at EASD Showing ITCA 650 Markedly Reduces Blood Sugar In Patients With Poorly Controlled Type 2 Diabetes 2Intarcia Announces Presentation of Phase 3 Data at EASD Showing ITCA 650 Markedly Reduces Blood Sugar In Patients With Poorly Controlled Type 2 Diabetes 3Intarcia Announces Presentation of Phase 3 Data at EASD Showing ITCA 650 Markedly Reduces Blood Sugar In Patients With Poorly Controlled Type 2 Diabetes 4ADVANCE-ON Post-trial Observational Study: Blood Pressure Arm and Glucose Arm Results 2ADVANCE-ON Post-trial Observational Study: Blood Pressure Arm and Glucose Arm Results 3
... July 20, 2011 One of Frantz Medical Group,s ... it has been awarded an Ohio Third Frontier grant ... system for penetrating through vascular Chronic Total Occlusions (CTOs), ... Coronary Artery Bypass Graft (CABG).   VasoStar,s ...
... VEGAS, July 20, 2011 Cardinal Health today announced ... national trade show for independent pharmacies, is the largest ... attendees. This year,s event, taking place ... Palazzo resort hotel, features a 100,000-square-foot trade show floor, ...
Cached Medicine Technology:Frantz Medical Group Subsidiary, VasoStar, Awarded $1 Million Research Grant 2Frantz Medical Group Subsidiary, VasoStar, Awarded $1 Million Research Grant 3Nearly 7,000 Participate in Cardinal Health's Largest-Ever Annual Trade Show for Independent Pharmacies 2Nearly 7,000 Participate in Cardinal Health's Largest-Ever Annual Trade Show for Independent Pharmacies 3Nearly 7,000 Participate in Cardinal Health's Largest-Ever Annual Trade Show for Independent Pharmacies 4
... Bird and Cronin, Inc. ... of Patient Footwear, Orthopedic ... Care Products. Our products ... quality and available in ...
... Splint uses safe, mild to moderate force ... at the MP joints. Dorsal-based splint does ... ulnar polycentric hinges located at the MP ... malleable finger rings can be individually shaped ...
... constructed of a durable heat moldable thermoplastic for ... of the hand and fingers from stress following ... later stages of the healing process. , ... positions the wrist at 30° of flexion, the ...
Bunell Mini-Modified Safety Finger Pin reduces PIP flexion contractures....
Medicine Products: