Navigation Links
Ibuprofen Linked to Lower Parkinson's Disease Risk
Date:3/2/2011

By Kathleen Doheny
HealthDay Reporter

WEDNESDAY, March 2 (HealthDay News) -- Regular users of ibuprofen may be reducing their risk of Parkinson's disease, according to new research that echoes previous findings.

"We found ibuprofen, a commonly used drug by Americans, could be neuroprotective against Parkinson's disease," said researcher Dr. Xiang Gao, an instructor in medicine at Harvard Medical School and a research scientist at Harvard School of Public Health. The neurological disorder causes movement problems.

"Protective effects are seen after taking ibuprofen two or more times a week," he said. "That's so-called regular use."

The finding, published online March 2 in the journal Neurology, adds to the results of previous studies, some of those conducted by Gao, showing a protective effect.

"At this time, we still don't know the exact mechanism," Gao said.

The study was funded by the U.S. National Institutes of Health.

As promising as the finding may be, Gao said there are no reasons to start taking ibuprofen to ward off the disorder, which affects 1 million Americans. "I don't recommend ibuprofen to protect against Parkinson's," he said. "We just see an association, not some causal relationship."

Another expert agreed the finding doesn't warrant taking up an ibuprofen habit to reduce Parkinson's risk. "It's way too early for that," said Dr. Michael Rezak, director of the Movement Disorder Center at Central DuPage Hospital, in Illinois.

Overdoing ibuprofen is accompanied by risks, Rezak said. "The major risk is GI hemorrhage and bleeding."

For the study, Gao analyzed data from nearly 99,000 women participating in the Nurses' Health Study and more than 37,000 men enrolled in the Health Professionals Follow-Up Study.

Participants were asked about their use of nonsteroidal anti-inflammatory drugs such as ibuprofen, and their use of other medicines such as aspirin.

During the six-year follow up, 291 cases of Parkinson's disease were identified.

Those who used ibuprofen had a 38 percent reduced risk of developing the disease compared to those who didn't use it, even after taking into account age, smoking and other factors.

When the researchers conducted a larger analysis using data from other studies on ibuprofen, other NSAIDs and disease risk, they found that, overall, ibuprofen users reduced their risk of Parkinson's by 27 percent compared to non-users.

No reduction in risk was found for those who took aspirin or other NSAIDs.

The ibuprofen may reduce inflammation thought to be a factor in the disease, Gao said. Or, it may target a receptor in the brain, peroxisome proliferator-activated receptor y (PPARy).

What is known about PPAR, he said, is that it can inhibit cell death and oxidative damage.

Rezak said the research focus has shifted in recent years from treating symptoms to finding ways to detect Parkinson's disease before symptoms strike so neurons can be protected. Ibuprofen, he said, "may have some disease-modifying, neuroprotective effect in Parkinson's disease."

The finding is made more interesting, Rezak noted, because the link between reduced risk and medicine was limited to the ibuprofen.

In an editorial accompanying the study, Drs. James H. Bower and Beate Ritz bring up another possibility. It's believed that Parkinson's may begin to develop up to 20 years before motor problems appear. They ask: "Could gastrointestinal symptoms cause a patient with preclinical [Parkinson's disease] to be less likely to take ibuprofen regularly, thus explaining the association?"

More information

To learn more about Parkinson's disease, visit the U.S. National Institute of Neurological Disorders and Stroke.

SOURCES: Xiang Gao, M.D., Ph.D., instructor, medicine, Harvard Medical School, and research scientist, Harvard University School of Public Health, Boston; Michael Rezak, M.D., Ph.D., director, movement disorders center, Central DuPage Hospital, DuPage, Ill.; March 2, 2011, Neurology, online


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Ibuprofen May Help Stave Off Parkinsons
2. Non-steroidal anti-inflammatory drugs linked to increased risk of erectile dysfunction
3. Study Finds Smoking Linked to Breast Cancer Risk
4. Multiple childbirth linked to increased risk of rare, aggressive triple-negative breast cancer
5. PCBs Might Be Linked to Failed IVF Attempts
6. Low vitamin D levels linked to allergies in kids
7. Stress Hormone Linked to PTSD Symptoms in Women
8. Induced Labor Linked to Raised Risks for First-Time Moms
9. High Triglyceride Levels Linked to Increased Stroke Risk: Study
10. Brain function linked to birth size in groundbreaking new study
11. 2 Pesticides Linked to Parkinsons in Study
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Ibuprofen Linked to Lower Parkinson's Disease Risk
(Date:2/20/2017)... ... February 20, 2017 , ... Houston dentist , ... dental care at his office, Antoine Dental Center. Emergency dentistry encompasses many treatments ... are at risk for serious complications and often experience severe pain. Not only ...
(Date:2/20/2017)... , ... February 20, 2017 , ... ... Constellation Brands to purchase a new ultrasound-enhanced thrombolysis machine, a state-of-the-art device that ... gift was facilitated by the Pepin Family Foundation. , “We greatly appreciate this ...
(Date:2/19/2017)... ... February 19, 2017 , ... "At your ... care, and MEDfx and the Delaware Health Information Network (DHIN) have partnered to ... nation’s first state-wide health information exchange, DHIN stores and shares real-time health data ...
(Date:2/18/2017)... (PRWEB) , ... February 17, 2017 , ... Butler Mobility ... the Stannah Stairlift and other Butler products. Ken was impressed with the safety ... agreed to endorse the product on his show. This endorsement by Ken Matthews ...
(Date:2/18/2017)... ... 2017 , ... A new directory from the Senior Veterans ... connect elderly veterans of America's armed forces to a range of senior care ... on this year's increase in the Veterans Pension with Aid & Attendance for ...
Breaking Medicine News(10 mins):
(Date:2/20/2017)... 2017 Acute, Chronic and Prophylaxis GVHD ... a CAGR of 7% from 2016-2021 and CAGR of 3% from 2021-2027. ... 2016 to 2027. The market is estimated at $0.36bn in 2016, $0.51bn ... ... how you can exploit the future business opportunities emerging in this sector. ...
(Date:2/19/2017)... 19, 2017  nThrive™, an independent Patient-to-Payment? solutions ... thought leadership at the 2017 HIMSS Conference. The ... award from KLAS. nThrive will host ... how market trends shape the holistic, integrated revenue ... comprehensive Patient Access solution. The panel will reveal ...
(Date:2/19/2017)... ORLANDO, Fla. , Feb. 18, 2017 /PRNewswire/ ... announced that positive Phase 1 clinical data for Nektar,s ... carcinoma (RCC) were presented at ASCO GU 2017.  NKTR-214 ... cancer-fighting T cells and Natural Killer (NK) cell abundance ... PD-1 on these immune cells.  The results were presented ...
Breaking Medicine Technology: