Navigation Links
Ibuprofen Linked to Lower Parkinson's Disease Risk
Date:3/2/2011

By Kathleen Doheny
HealthDay Reporter

WEDNESDAY, March 2 (HealthDay News) -- Regular users of ibuprofen may be reducing their risk of Parkinson's disease, according to new research that echoes previous findings.

"We found ibuprofen, a commonly used drug by Americans, could be neuroprotective against Parkinson's disease," said researcher Dr. Xiang Gao, an instructor in medicine at Harvard Medical School and a research scientist at Harvard School of Public Health. The neurological disorder causes movement problems.

"Protective effects are seen after taking ibuprofen two or more times a week," he said. "That's so-called regular use."

The finding, published online March 2 in the journal Neurology, adds to the results of previous studies, some of those conducted by Gao, showing a protective effect.

"At this time, we still don't know the exact mechanism," Gao said.

The study was funded by the U.S. National Institutes of Health.

As promising as the finding may be, Gao said there are no reasons to start taking ibuprofen to ward off the disorder, which affects 1 million Americans. "I don't recommend ibuprofen to protect against Parkinson's," he said. "We just see an association, not some causal relationship."

Another expert agreed the finding doesn't warrant taking up an ibuprofen habit to reduce Parkinson's risk. "It's way too early for that," said Dr. Michael Rezak, director of the Movement Disorder Center at Central DuPage Hospital, in Illinois.

Overdoing ibuprofen is accompanied by risks, Rezak said. "The major risk is GI hemorrhage and bleeding."

For the study, Gao analyzed data from nearly 99,000 women participating in the Nurses' Health Study and more than 37,000 men enrolled in the Health Professionals Follow-Up Study.

Participants were asked about their use of nonsteroidal anti-inflammatory drugs such as ibuprofen, and their use of other medicines such as aspirin.

During the six-year follow up, 291 cases of Parkinson's disease were identified.

Those who used ibuprofen had a 38 percent reduced risk of developing the disease compared to those who didn't use it, even after taking into account age, smoking and other factors.

When the researchers conducted a larger analysis using data from other studies on ibuprofen, other NSAIDs and disease risk, they found that, overall, ibuprofen users reduced their risk of Parkinson's by 27 percent compared to non-users.

No reduction in risk was found for those who took aspirin or other NSAIDs.

The ibuprofen may reduce inflammation thought to be a factor in the disease, Gao said. Or, it may target a receptor in the brain, peroxisome proliferator-activated receptor y (PPARy).

What is known about PPAR, he said, is that it can inhibit cell death and oxidative damage.

Rezak said the research focus has shifted in recent years from treating symptoms to finding ways to detect Parkinson's disease before symptoms strike so neurons can be protected. Ibuprofen, he said, "may have some disease-modifying, neuroprotective effect in Parkinson's disease."

The finding is made more interesting, Rezak noted, because the link between reduced risk and medicine was limited to the ibuprofen.

In an editorial accompanying the study, Drs. James H. Bower and Beate Ritz bring up another possibility. It's believed that Parkinson's may begin to develop up to 20 years before motor problems appear. They ask: "Could gastrointestinal symptoms cause a patient with preclinical [Parkinson's disease] to be less likely to take ibuprofen regularly, thus explaining the association?"

More information

To learn more about Parkinson's disease, visit the U.S. National Institute of Neurological Disorders and Stroke.

SOURCES: Xiang Gao, M.D., Ph.D., instructor, medicine, Harvard Medical School, and research scientist, Harvard University School of Public Health, Boston; Michael Rezak, M.D., Ph.D., director, movement disorders center, Central DuPage Hospital, DuPage, Ill.; March 2, 2011, Neurology, online


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Ibuprofen May Help Stave Off Parkinsons
2. Non-steroidal anti-inflammatory drugs linked to increased risk of erectile dysfunction
3. Study Finds Smoking Linked to Breast Cancer Risk
4. Multiple childbirth linked to increased risk of rare, aggressive triple-negative breast cancer
5. PCBs Might Be Linked to Failed IVF Attempts
6. Low vitamin D levels linked to allergies in kids
7. Stress Hormone Linked to PTSD Symptoms in Women
8. Induced Labor Linked to Raised Risks for First-Time Moms
9. High Triglyceride Levels Linked to Increased Stroke Risk: Study
10. Brain function linked to birth size in groundbreaking new study
11. 2 Pesticides Linked to Parkinsons in Study
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Ibuprofen Linked to Lower Parkinson's Disease Risk
(Date:2/23/2017)... VA – , ... ... coming. It’s the perfect opportunity for the nation to come ... a college basketball bracket – with its favorite fruit – ... is encouraging apple lovers to join the “Apple Madness” bracket ...
(Date:2/23/2017)... ... February 23, 2017 , ... Top cosmetic and periodontal ... program today with a new Indiegogo campaign . Individuals are now able ... in the Los Angeles area, either as a participating patient or through an Indiegogo ...
(Date:2/23/2017)... ... February 23, 2017 , ... HealthPostures, the desk for standing ... sit stand solutions representative to the Minneapolis Home and Garden Show which is being ... that is garnering national attention is the Minneapolis Convention Center. , From its ...
(Date:2/23/2017)... FALLS CHURCH, Va. (PRWEB) , ... February 23, 2017 , ... ... , worries, or problems. He has also continued to spiritually evolve, which is the ... his published book “ Our Spiritual Truths ” (published by Balboa Press) attempts to ...
(Date:2/22/2017)... ... February 22, 2017 , ... Our high-octane society ... even the sharpest brain. , Power On, a mental performance enhancer from Modus ... the brain. Each capsule contains Cognizin® Citicoline, a branded form of the brain ...
Breaking Medicine News(10 mins):
(Date:2/23/2017)... LEXINGTON, Mass. , February 23, 2017 ... Organizations   ... Campaign Honoring Rare Disease Day Open to All at http://www.shire.com/RareCount ... ) today announced the launch of ,Rare Count, in honor of ... rare diseases, which equates to nearly one in 20 global citizens. ...
(Date:2/22/2017)... , Feb. 22, 2017 IRIDEX Corporation ... will release financial results for the fourth quarter and ... 8, 2017.  The Company,s management team will host a ... 5:00 p.m. ET. Investors interested in listening ... (844) 707-0665 for domestic callers or (703) 326-3030 for ...
(Date:2/22/2017)... 2017 Summary Provides understanding and ... entered into by the worlds leading healthcare companies. ... The Global Spinal Cord Partnering Terms and Agreements since ... and agreements entered into by the world,s leading healthcare ... - Top deals by value - Deals listed ...
Breaking Medicine Technology: