Navigation Links
Ibuprofen Linked to Lower Parkinson's Disease Risk

By Kathleen Doheny
HealthDay Reporter

WEDNESDAY, March 2 (HealthDay News) -- Regular users of ibuprofen may be reducing their risk of Parkinson's disease, according to new research that echoes previous findings.

"We found ibuprofen, a commonly used drug by Americans, could be neuroprotective against Parkinson's disease," said researcher Dr. Xiang Gao, an instructor in medicine at Harvard Medical School and a research scientist at Harvard School of Public Health. The neurological disorder causes movement problems.

"Protective effects are seen after taking ibuprofen two or more times a week," he said. "That's so-called regular use."

The finding, published online March 2 in the journal Neurology, adds to the results of previous studies, some of those conducted by Gao, showing a protective effect.

"At this time, we still don't know the exact mechanism," Gao said.

The study was funded by the U.S. National Institutes of Health.

As promising as the finding may be, Gao said there are no reasons to start taking ibuprofen to ward off the disorder, which affects 1 million Americans. "I don't recommend ibuprofen to protect against Parkinson's," he said. "We just see an association, not some causal relationship."

Another expert agreed the finding doesn't warrant taking up an ibuprofen habit to reduce Parkinson's risk. "It's way too early for that," said Dr. Michael Rezak, director of the Movement Disorder Center at Central DuPage Hospital, in Illinois.

Overdoing ibuprofen is accompanied by risks, Rezak said. "The major risk is GI hemorrhage and bleeding."

For the study, Gao analyzed data from nearly 99,000 women participating in the Nurses' Health Study and more than 37,000 men enrolled in the Health Professionals Follow-Up Study.

Participants were asked about their use of nonsteroidal anti-inflammatory drugs such as ibuprofen, and their use of other medicines such as aspirin.

During the six-year follow up, 291 cases of Parkinson's disease were identified.

Those who used ibuprofen had a 38 percent reduced risk of developing the disease compared to those who didn't use it, even after taking into account age, smoking and other factors.

When the researchers conducted a larger analysis using data from other studies on ibuprofen, other NSAIDs and disease risk, they found that, overall, ibuprofen users reduced their risk of Parkinson's by 27 percent compared to non-users.

No reduction in risk was found for those who took aspirin or other NSAIDs.

The ibuprofen may reduce inflammation thought to be a factor in the disease, Gao said. Or, it may target a receptor in the brain, peroxisome proliferator-activated receptor y (PPARy).

What is known about PPAR, he said, is that it can inhibit cell death and oxidative damage.

Rezak said the research focus has shifted in recent years from treating symptoms to finding ways to detect Parkinson's disease before symptoms strike so neurons can be protected. Ibuprofen, he said, "may have some disease-modifying, neuroprotective effect in Parkinson's disease."

The finding is made more interesting, Rezak noted, because the link between reduced risk and medicine was limited to the ibuprofen.

In an editorial accompanying the study, Drs. James H. Bower and Beate Ritz bring up another possibility. It's believed that Parkinson's may begin to develop up to 20 years before motor problems appear. They ask: "Could gastrointestinal symptoms cause a patient with preclinical [Parkinson's disease] to be less likely to take ibuprofen regularly, thus explaining the association?"

More information

To learn more about Parkinson's disease, visit the U.S. National Institute of Neurological Disorders and Stroke.

SOURCES: Xiang Gao, M.D., Ph.D., instructor, medicine, Harvard Medical School, and research scientist, Harvard University School of Public Health, Boston; Michael Rezak, M.D., Ph.D., director, movement disorders center, Central DuPage Hospital, DuPage, Ill.; March 2, 2011, Neurology, online

Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Ibuprofen May Help Stave Off Parkinsons
2. Non-steroidal anti-inflammatory drugs linked to increased risk of erectile dysfunction
3. Study Finds Smoking Linked to Breast Cancer Risk
4. Multiple childbirth linked to increased risk of rare, aggressive triple-negative breast cancer
5. PCBs Might Be Linked to Failed IVF Attempts
6. Low vitamin D levels linked to allergies in kids
7. Stress Hormone Linked to PTSD Symptoms in Women
8. Induced Labor Linked to Raised Risks for First-Time Moms
9. High Triglyceride Levels Linked to Increased Stroke Risk: Study
10. Brain function linked to birth size in groundbreaking new study
11. 2 Pesticides Linked to Parkinsons in Study
Post Your Comments:
Related Image:
Ibuprofen Linked to Lower Parkinson's Disease Risk
(Date:6/27/2016)... ... June 27, 2016 , ... A revolution is ... emergency ambulance transport experience for the millions of people who require these medical ... the taxi industry through the use of technology. Now, SmartEMS has put forth ...
(Date:6/26/2016)... , ... June 27, 2016 , ... Quality metrics are ... in many ways they remain in the eye of the beholder, according to experts ... publication of The American Journal of Managed Care. For the full issue, click ...
(Date:6/26/2016)... , ... June 26, 2016 , ... Pixel Film Studios ... X. , "Film editors can give their videos a whole new perspective by using ... - CEO of Pixel Film Studios. , ProSlice Levels contains over 30 Different ...
(Date:6/26/2016)... , ... June 26, 2016 , ... Brent Kasmer, a legally blind and certified personal ... personalized through a fitness app. The fitness app plans to fix the two major problems ... offer a one size fits all type program , They don’t eliminate all ...
(Date:6/25/2016)... ... June 25, 2016 , ... ... issues and applications at AcademyHealth’s Annual Research Meeting June 26-28, 2016, at the ... several important health care topics including advance care planning, healthcare costs and patient ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... 2016  Consumers have taken a more active ... more emphasis on patient outcomes. ... the pharmaceutical industry have evolved beyond just providing ... are focusing on becoming more patient-oriented across their ... services that improve health. ...
(Date:6/24/2016)... , June 24, 2016  Global Blood ... biopharmaceutical company developing novel therapeutics for the treatment ... today announced the closing of its previously announced ... stock, at the public offering price of $18.75 ... offering were offered by GBT. GBT estimates net ...
(Date:6/24/2016)... June 24, 2016 ... announced the addition of the " Global Markets ... This report focuses ... an updated review, including its applications in various applications. ... market, which includes three main industries: pharmaceutical and biotechnology, ...
Breaking Medicine Technology: