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Ibrutinib continues strong showing against mantle cell lymphoma

causing cell death and decreasing cellular migration and adhesion in malignant B-cells.

In this study, patients were given 560 mg daily ibrutinib in continuous 28-day cycles until disease progressed or side effects became intolerable. To date, 111 patients have participated in the study.

Seventy-seven percent had stage 4 disease, and the median number of prior treatments was three.

Ongoing results continue to show promise

In the past six months, ibrutinib has continued to show excellent results. With a median follow-up period of 15 months:

  • Overall response rate was 68 percent
  • Complete response rate was 21 percent
  • Partial response rate 47 percent

Response and complete remission rates improved with longer duration of treatment.

Among the 75 patients who responded, median:

  • Response duration was 18 months
  • Time to response was two months
  • Progression-free survival was 14 months

Most side effects were minor and included diarrhea, fatigue, upper respiratory tract infections, nausea and rash. Grade 3 or higher effects included low white cell blood counts, anemia and diarrhea.

Next steps

Wang believes further investigation of ibrutinib as a first line therapy and in combination with other targeted therapies and traditional cytotoxic agents is essential.

"This drug, which is the safest option we have for MCL, shows unprecedented durable single agent activity," he said. "The favorable toxicity profile also implies that ibrutinib provides the opportunity for less intense and more effective regimens. The long-term impact of ibrutinib definitely warrants further clinical testing."


Contact: Laura Sussman
University of Texas M. D. Anderson Cancer Center

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