Navigation Links
IUPUI chemists develop Distributed Drug Discovery: Finding drugs for neglected diseases
Date:6/15/2009

INDIANAPOLIS Researchers from Indiana University-Purdue University Indianapolis (IUPUI) have developed Distributed Drug Discovery (D3), a new low-cost strategy to accelerate the discovery of drugs to treat neglected diseases such as tuberculosis, leprosy, leshmaniasis, dengue fever, and Chagas disease.

Even in times of economic prosperity, the pharmaceutical industry has often been reluctant to get involved in developing treatments for diseases that occur primarily in low income countries. The low cost D3 approach, involving distributed global educational resources at the early stage of discovery, is even more attractive in this time of global economic downturn.

A distributed problem solving process breaks large problems into small pieces which are "distributed" to multiple, small, low-cost sites to obtain a solution. For decades astronomers have enlisted the help of the public, asking individuals around the world to leave their home computers on overnight. While normally idle, each one of these computers looks for patterns in a small subset of the incredibly large amount of space noise signals received by arrays of radio telescopes scanning the skies.

Two studies, published this year in the Journal of Combinatorial Chemistry, detail the first two steps in D3, developed by William Scott, Ph.D., research professor, and Martin J. O'Donnell, Ph.D., IUPUI Chancellor's Professor, both of the Department of Chemistry and Chemical Biology at IUPUI.

D3 uses a distributed problem approach at all three key stages of drug discovery. Step one is identifying candidate drug molecules. To do this, IUPUI researchers are soliciting the global advice of computational experts in neglected disease areas and utilizing the computational power of multiple personal computers around the world to scan the almost infinite number of molecules which the D3 synthesis process could make to identify the smaller number of drug candidate molecules the
'/>"/>

Contact: Cindy Fox Aisen
caisen@iupui.edu
317-274-7722
Indiana University
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. IUPUI scientists report first 3-D view of anti-cancer agent
2. Computers help chemists fight emerging infections
3. UIC chemists characterize Alzheimers neurotoxin structure
4. Iowa State chemists track how drug changes, blocks flu virus
5. Stevens chemists identify compounds to lure nutria, a rat-like pest ravaging Gulf Coast wetlands
6. Roche Symposium Showcases Accomplishments of Next Generation of Chemists
7. Brown chemists create cancer-detecting nanoparticles
8. UCR chemists use green chemistry to produce amines, chemical compounds used widely in industry
9. Informex Invites Young Chemists to Attend InformexUSA
10. New Reaxys Solution Improves Workflow Quality and Efficiency for Chemists
11. Waters Corporation Announces U.S. Drug Enforcement Administration Acquires Waters ACQUITY UPLC System to Train Forensic Chemists in Drug Screening and Profiling
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/1/2015)... ... September 01, 2015 , ... The ... the treatment of androgenic alopecia in adults, announces Miami-based medical device manufacturer, Capillus, ... while also demonstrating its safety when used at home to combat hair loss. ...
(Date:9/1/2015)... ... September 01, 2015 , ... ... exclusively to funding innovative lymphoma research and serving the lymphoma community through a ... its annual Light it Red for Lymphoma awareness initiative, the nation’s premier and ...
(Date:9/1/2015)... ... 01, 2015 , ... Horizon Blue Cross Blue Shield of New Jersey (BCBSNJ) ... the LATINA Style 50 Report that recognizes companies that provide the best career opportunities ... BCBSNJ climbs from number 24 to 21 of the 50 Best Companies for Latinas. ...
(Date:9/1/2015)... (PRWEB) , ... September 01, 2015 , ... ... and collaboration, announces Splashtop Business for Remote Support , a solution optimized ... solution. Unhappy with the escalating renewal prices and inadequate customer services of ...
(Date:9/1/2015)... Florida (PRWEB) , ... September ... ... of Professional Background Screeners (NAPBS®) has announced that Edge Information Management ... conducted by the Background Screening Credentialing Council (BSCC). , “Achieving and ...
Breaking Medicine News(10 mins):Health News:Capillus82™ Laser Therapy Cap Receives FDA Clearance for Treatment of Hair Loss 2Health News:Lymphoma Research Foundation Recognizes National Blood Cancer Awareness Month with Light it Red for Lymphoma Campaign 2Health News:Lymphoma Research Foundation Recognizes National Blood Cancer Awareness Month with Light it Red for Lymphoma Campaign 3Health News:Horizon Blue Cross Blue Shield of New Jersey Named One of the 50 Best Companies for Latinas by Latina Style Magazine 2Health News:Horizon Blue Cross Blue Shield of New Jersey Named One of the 50 Best Companies for Latinas by Latina Style Magazine 3Health News:Splashtop Launches Splashtop Business for Remote Support, the Simple, Reliable, and Cost-Effective Solution for MSPs and IT Professionals 2Health News:Splashtop Launches Splashtop Business for Remote Support, the Simple, Reliable, and Cost-Effective Solution for MSPs and IT Professionals 3Health News:Splashtop Launches Splashtop Business for Remote Support, the Simple, Reliable, and Cost-Effective Solution for MSPs and IT Professionals 4Health News:Edge Information Management Granted Continued NAPBS Accreditation 2Health News:Edge Information Management Granted Continued NAPBS Accreditation 3
... Three ... sciences learning opportunities for iPhone and iPod touch , ... Durham, NC (Vocus) November 27, 2009 -- ... Health, today announced the availability of three new anatomy education apps on the App ...
... tetrathiomolybdate (TM) has been shown in studies to be ... caused by an overload of copper, and certain metastatic ... known about how the drug works at the molecular ... researchers now has provided an invaluable clue: the three-dimensional ...
... ... weight loss surgery in Dallas , is one of a growing number of physicians who ... interested in surgical weight loss treatment to fight morbid obesity. Dr. Kim is utilizing Facebook ... ...
... When most people hear the acronym TMJ, they think ... patients the help they need. TMJ stands for the Temporal-Mandibular ... skull (temporal bone). , The most common symptoms associated ... of the jaw. But many other symptoms can be ...
... TORONTO, Nov. 25 /PRNewswire/ - Sentinelle Medical Inc., a ... software launches a suite of new leading edge clinical ... this year,s Radiological Society of North America (RSNA) annual ... (Booth 5800, Hall A). The applications leverage the unique ...
... The Bay Area Air Quality Management District is issuing the season,s first ... Air Alert ... or any other solid fuel, both indoors and outdoors. , "Cold, still ... officer of the Air District. "We,re asking Bay Area residents to respect ...
Cached Medicine News:Health News:Clemente's Anatomy, Rohen's Photographic Anatomy, and Moore's Clinical Anatomy Customizable Apps Now Available on App Store 2Health News:Clemente's Anatomy, Rohen's Photographic Anatomy, and Moore's Clinical Anatomy Customizable Apps Now Available on App Store 3Health News:Clemente's Anatomy, Rohen's Photographic Anatomy, and Moore's Clinical Anatomy Customizable Apps Now Available on App Store 4Health News:Clemente's Anatomy, Rohen's Photographic Anatomy, and Moore's Clinical Anatomy Customizable Apps Now Available on App Store 5Health News:Research sheds light on workings of anti-cancer drug 2Health News:Research sheds light on workings of anti-cancer drug 3Health News:Dallas Texas Weight Loss Surgeon Using Social Media To Reach Out to Patients 2Health News:Dallas Texas Weight Loss Surgeon Using Social Media To Reach Out to Patients 3Health News:Sentinelle Medical Launches Aegis Suite of Oncology 4D Visualization Software with PureWeb(TM) Technology 2Health News:Sentinelle Medical Launches Aegis Suite of Oncology 4D Visualization Software with PureWeb(TM) Technology 3Health News:Sentinelle Medical Launches Aegis Suite of Oncology 4D Visualization Software with PureWeb(TM) Technology 4Health News:Winter Spare the Air Alert in Effect for Thursday, November 26, 2009 2
(Date:9/1/2015)... Calif. , Sept. 1, 2015 ... Care Management (CCM) and Drug Adherence m Health ... help automate the process of non face-to-face monitoring ... "With this new release of our apps, doctors ... management services along with our ONCHIT certified Physician, ...
(Date:9/1/2015)... September 1, 2015 The ... the basis of sectors, products & services and ... coupled with the increasing demand of advanced drugs ... to propel the growth for bioinformatics market. The ... efficiently is known as bioinformatics. Decreasing cost of ...
(Date:9/1/2015)... -- In nur zwei Jahren nach dem Erreichen ... Group schnell weltweit 3.000 Mitarbeiter erreicht. Diese Steigerung ... Markt der injizierbaren Medikamente und das ... SHL wieder. Foto - http://photos.prnewswire.com/prnh/20150820/259886 ... Design und Herstellung automatischer Injektoren und Pen-Injektoren und ...
Breaking Medicine Technology:SPAC International's Drug Adherence and Chronic Care Management App Now available at Apple App and Google Play stores 2Global Bioinformatics Market Valued at Over $1.3 Billion in 2013 and is Expected to Grow at CAGR of 20.3% From 2014 to 2020: Hexa Research 2Global Bioinformatics Market Valued at Over $1.3 Billion in 2013 and is Expected to Grow at CAGR of 20.3% From 2014 to 2020: Hexa Research 3Global Bioinformatics Market Valued at Over $1.3 Billion in 2013 and is Expected to Grow at CAGR of 20.3% From 2014 to 2020: Hexa Research 4SHL Group erreicht wichtigen Markstein von 3.000 Mitarbeitern 2
... 11, 2011 As part of its re-branding initiative, ... website www.xeridiem.com .  Winner of MD+DI,s 2011 Medical ... Supplies Xeridiem has been recognized as an industry leader ... invasive medical devices. For over 25 years, Xeridiem has ...
... Inc. (OTC: HEWA), a leading VIPPS-accredited, retail, mail-order ... have among the lowest total prices for four ... The study was conducted by 43,739 Consumer ... and speed.  "Our national study of prices for ...
Cached Medicine Technology:Consumer Reports Finds HealthWarehouse.com Has Lowest Total Price for Lipitor, Nexium, Plavix, and Singulair 2
... a whole blood hematology control manufactured specifically ... 120, and the Coulter AcT5diff instruments. The ... white cell differential, positioning the populations within ... systems. The product offers 105-day closed-vial stability ...
... assayed hematology control, offers complete assay values ... with the Coulter GENS, STKS, MAXM and ... stability, 105-day closed-vial stability and is available ... 4.0ml pierceable cap vial is compatible with ...
Abiomed introduces its new intra-aortic balloon (IAB); an easy-to-insert, minimally invasive technology designed to enhance blood flow to the heart and other organs for patients with diminished heart...
Diagnosoft HARP is designed for rapid analysis of tagged cardiac MR images using the HARP technology, which is packaged into an intuitive, easy-to-use graphic user interface....
Medicine Products: