Navigation Links
IU researchers report first effective treatment of tumors arising from common genetic disease NF1
Date:11/1/2012

Physician-researchers at Indiana University School of Medicine have reported the first effective therapy for a class of previously untreatable and potentially life-threatening tumors often found in children.

Announcing their findings in the online first edition of Lancet Oncology, the researchers said the drug imatinib mesylate, marketed as Gleevec as a treatment for chronic myeloid leukemia, provided relief to a significant number of patients with plexiform neurofibromas, tumors caused by neurofibromatosis type 1, or NF1.

"Although this was a small study, the results were significant, particularly given that such patients have had few treatment options for what can be a very debilitating disease," said first author Kent Robertson, M.D., Ph.D., associate professor of pediatrics. "We believe these findings warrant larger trials of both imatinib mesylate as well as other similar compounds that would appear promising in laboratory tests."

Affecting about 1 in every 3,000 children born, NF1 is the most common neurological disorder caused by mutations in a single gene. Including a much rarer related type, NF2, neurofibromatosis is a genetic disorder that is more prevalent than cystic fibrosis, Duchenne muscular dystrophy and Huntington's disease combined, according to the Children's Tumor Foundation.

The mutation produces a variety of symptoms, from mild to severe. Patients can develop caf au lait spots and disfiguring tumors on or just under the skin. Internally, tumors can develop along nerve tissue and cause problems if they begin to press against vital organs or the windpipe. Some patients suffer from chronic pain.

The tumors have been nearly impossible to treat effectively. Because they are relatively slow growing, they are not affected by radiation treatments or cancer chemotherapy drugs. They also are often not good candidates for surgery because they are dangerously close to vital organs.

In the stu
'/>"/>

Contact: Eric Schoch
eschoch@iu.edu
317-274-7722
Indiana University
Source:Eurekalert  

Page: 1 2 3

Related medicine news :

1. OHSU researchers discover potential way to repair brain damage in multiple sclerosis
2. Penn researchers find error reporting improves perceptions of safety and may reduce incidents
3. Common Antidepressants Too Risky During Pregnancy, Researchers Say
4. Mechanism found for destruction of key allergy-inducing complexes, Stanford researchers say
5. Feinstein Institute researchers discover that bean used in Chinese food could protect against sepsis
6. Mayo Clinic researchers develop new tools to better treat ADHD patients in early stages
7. Moffitt Researchers find genetic predictors of fatigue for some prostate cancer patients
8. Penn Medicine researchers map strategy for choosing wisely on low-value health care services
9. Researchers ID potential patient population who may benefit from novel anti-platelet treatment
10. Moffitt researchers identify unique immune gene signature across thousands of patients solid tumors
11. Mount Sinai researchers identify predictors for inpatient pain
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
IU researchers report first effective treatment of tumors arising from common genetic disease NF1
(Date:7/7/2015)... ... July 07, 2015 , ... ... stores throughout the Southwest, including Giant, Mustang, Sun Dial and Howdy’s, raised ... surpassing their original 2015 fundraising goal by nearly $100,000, to help support ...
(Date:7/7/2015)... , ... July 07, 2015 , ... ... MRI services, is debuting their brand new website. The website’s goal is to ... a wider selection of patient tools, including requesting appointments online. , Part of ...
(Date:7/7/2015)... ... July 07, 2015 , ... Greatist today ... website that helps active people find the most fun activities to do with friends. ... for millennials. It also increases Greatist’s opportunity for events, e-commerce, and brand partnerships. , ...
(Date:7/7/2015)... ... July 07, 2015 , ... SC&H Group, a leading ... aims to give back to the community through company-wide volunteering efforts. , On an ... dedicate the day to assisting those in need throughout Baltimore and Washington D.C. ...
(Date:7/7/2015)... ... July 07, 2015 , ... Summer is a great time to get outside ... is sharing some safety tips. , Jean Tapley, senior wellness coordinator at Amica, suggests ... , Start slowly. Going from no activity to several hours of ...
Breaking Medicine News(10 mins):Health News:Western Refining Raises $524,286 to Help Send Kids with Neuromuscular Disease to MDA Summer Camp 2Health News:Western Refining Raises $524,286 to Help Send Kids with Neuromuscular Disease to MDA Summer Camp 3Health News:Northeast Nebraska Imaging Launches New Patient Friendly Website 2Health News:Greatist Acquires Active Lifestyle Brand Blood, Sweat & Cheers 2Health News:SC&H Group Celebrates 9th Annual Day of Service 2Health News:Amica Insurance Has 7 Summer Safety Tips 2
... Program will celebrate inspiring scientists and their commitment to ... advance global ... to,scientific advancement, Pfizer Inc will launch Think Science Now, a science,awareness ... the mysteries of biology, chemistry and human disease.,A major part of ...
... 24 Americans are experiencing,rising prices on many ... drugs represent one of the fastest-growing medical,expenses. From ... from,$40.3 billion to $200.7 billion, according to a ... To help, Giant is introducing a new way ...
... Devices known as brain-machine interfaces could someday be used ... limbs with just their thoughts. Now, University of Florida ... a way for computerized devices not only to translate ... the brain as it learns. , Instead of simply ...
... Kristen Michelle,Masterson is this year,s Miss Fairfield ... has supervised Kristen,s volunteer,patient care activities over these ... a nurse. "Her compassion for those that are ... one of our pediatric patients or,to our young ...
... June 24 , WHO: Martin Payne, Executive ... Leigh Hocker Radtke, Director, Software Product ... 2:00 PM - ... Inventory Management DESCRIPTION: Medical sales processes are becoming increasingly ...
... Systems Further Royal, Brompton and Harefield NHS Trust,s Leadership ... ... LOUIS, June 24 Stereotaxis, Inc. (Nasdaq:,STXS) announced that British Prime ... of the art electrophysiology lab at,Royal Brompton Hospital in London. The ...
Cached Medicine News:Health News:Pfizer Launches 'Think Science Now' 2Health News:Pfizer Launches 'Think Science Now' 3Health News:Pfizer Launches 'Think Science Now' 4Health News:New Giant Pharmacy Program Offers Relief for Your Family and Your Wallet 2Health News:Researchers develop neural implant that learns with the brain 2Health News:Researchers develop neural implant that learns with the brain 3Health News:Connecticut Hospice Has Miss Fairfield on Its Side 2Health News:Connecticut Hospice Has Miss Fairfield on Its Side 3Health News:SkyeTek to Host Webinar Discussing RFID-Based Solution for Medical Sales Processes Automation 2Health News:London's Royal Brompton Hospital Opens New Electrophysiology Lab With State of the Art Magnetic Technology to Treat Arrhythmias 2Health News:London's Royal Brompton Hospital Opens New Electrophysiology Lab With State of the Art Magnetic Technology to Treat Arrhythmias 3
(Date:7/7/2015)... , 7. Juli 2015 BioClinica®, ... für klinische Studien, gab heute bekannt, dass es ... Unternehmen bei Gewinnung und Erhalt von Patienten übernommen ... MediciGlobal , Ltd. und Access to Patients, ... einen Dienst zum Auffinden von Patienten, die für ...
(Date:7/7/2015)... , July 7, 2015 /PRNewswire/ -- Mindray Medical ... leading developer, manufacturer and marketer of medical devices ... the remaining stake in Wuhan Dragonbio Surgical Implant ... Dragonbio is a domestic medical orthopedic-product ... other surgical products. Prior to today,s announcement, Mindray ...
(Date:7/7/2015)... , July 7, 2015 Oasmia ... drugs within human and veterinary oncology, has filed a ... Exchange Commission, in connection with the proposed public offering ... Market. The number of American Depositary Shares, representing ordinary ... the offering have not yet been determined. An Investor ...
Breaking Medicine Technology:BioClinica übernimmt MediciGroup 2BioClinica übernimmt MediciGroup 3BioClinica übernimmt MediciGroup 4Mindray Medical to Acquire the Remaining Stake in Wuhan Dragonbio 2Mindray Medical to Acquire the Remaining Stake in Wuhan Dragonbio 3Mindray Medical to Acquire the Remaining Stake in Wuhan Dragonbio 4Oasmia Pharmaceutical Files a Registration Statement on Form F-1/A for its Proposed Public Offering and an Application with NASDAQ for a US Listing and Announces Investor Roadshow 2
Operate with confidence. Autosuture is advancing the sate of both open and minimally invasive surgery by providing surgical tools that feel right, function right, and facilitate the right outcome eve...
Operate with confidence. Autosuture is advancing the sate of both open and minimally invasive surgery by providing surgical tools that feel right, function right, and facilitate the right outcome eve...
Operate with confidence. Autosuture is advancing the sate of both open and minimally invasive surgery by providing surgical tools that feel right, function right, and facilitate the right outcome eve...
... offered as 1-piece or modular, in regular ... may be customized with handles of choice ... and flush ports. Many standard patterns are ... affect delivery times. , Please Note: ...
Medicine Products: