Navigation Links
IU researchers report first effective treatment of tumors arising from common genetic disease NF1
Date:11/1/2012

Physician-researchers at Indiana University School of Medicine have reported the first effective therapy for a class of previously untreatable and potentially life-threatening tumors often found in children.

Announcing their findings in the online first edition of Lancet Oncology, the researchers said the drug imatinib mesylate, marketed as Gleevec as a treatment for chronic myeloid leukemia, provided relief to a significant number of patients with plexiform neurofibromas, tumors caused by neurofibromatosis type 1, or NF1.

"Although this was a small study, the results were significant, particularly given that such patients have had few treatment options for what can be a very debilitating disease," said first author Kent Robertson, M.D., Ph.D., associate professor of pediatrics. "We believe these findings warrant larger trials of both imatinib mesylate as well as other similar compounds that would appear promising in laboratory tests."

Affecting about 1 in every 3,000 children born, NF1 is the most common neurological disorder caused by mutations in a single gene. Including a much rarer related type, NF2, neurofibromatosis is a genetic disorder that is more prevalent than cystic fibrosis, Duchenne muscular dystrophy and Huntington's disease combined, according to the Children's Tumor Foundation.

The mutation produces a variety of symptoms, from mild to severe. Patients can develop caf au lait spots and disfiguring tumors on or just under the skin. Internally, tumors can develop along nerve tissue and cause problems if they begin to press against vital organs or the windpipe. Some patients suffer from chronic pain.

The tumors have been nearly impossible to treat effectively. Because they are relatively slow growing, they are not affected by radiation treatments or cancer chemotherapy drugs. They also are often not good candidates for surgery because they are dangerously close to vital organs.

In the stu
'/>"/>

Contact: Eric Schoch
eschoch@iu.edu
317-274-7722
Indiana University
Source:Eurekalert  

Page: 1 2 3

Related medicine news :

1. OHSU researchers discover potential way to repair brain damage in multiple sclerosis
2. Penn researchers find error reporting improves perceptions of safety and may reduce incidents
3. Common Antidepressants Too Risky During Pregnancy, Researchers Say
4. Mechanism found for destruction of key allergy-inducing complexes, Stanford researchers say
5. Feinstein Institute researchers discover that bean used in Chinese food could protect against sepsis
6. Mayo Clinic researchers develop new tools to better treat ADHD patients in early stages
7. Moffitt Researchers find genetic predictors of fatigue for some prostate cancer patients
8. Penn Medicine researchers map strategy for choosing wisely on low-value health care services
9. Researchers ID potential patient population who may benefit from novel anti-platelet treatment
10. Moffitt researchers identify unique immune gene signature across thousands of patients solid tumors
11. Mount Sinai researchers identify predictors for inpatient pain
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
IU researchers report first effective treatment of tumors arising from common genetic disease NF1
(Date:9/21/2014)... 2014 Expert witness work is in! ... from its 2014 Expert Witness Fees & Practices Survey. ... demand and compensation for qualified and credentialed expert witnesses ... 16-year history. , The nearly 600 experts surveyed ... expert work, an increase of 3.2% from ExpertPages’ 2012 ...
(Date:9/21/2014)... "I wanted to be able to obtain ... foul-tasting energy drinks," said an inventor from Fresh Meadows, ... drink plain, old coffee. That is why I came ... ENERG CHEWING GUM to provide a healthy energy boost ... contains nutritious vitamins, minerals and antioxidants. It also features ...
(Date:9/21/2014)... September 21, 2014 "I want to ... and back but haven’t the money for chiropractors," said ... to have such a product for myself." , The ... to stretch the thigh muscles and align the spine ... as relieves discomfort of pinched nerves. Compact and easy ...
(Date:9/21/2014)... (PRWEB) September 21, 2014 Best Cheap ... recently announced that Arvixe, Bluehost and GreenGeeks are the ... to find a good reseller hosting supplier. Actually, these ... server speed and customer support. People can get the ... manager says. , According to the manager, reseller ...
(Date:9/21/2014)... To accommodate the ever-growing customer base, Angeldress.co.uk decided ... items. Recently, the company has unveiled its 2014 ... elegant wedding gowns, Angeldress.co.uk wants to make sure that ... easy way. Its high quality vintage wedding outfits are ... to 62% off. , Online shopping is becoming more ...
Breaking Medicine News(10 mins):Health News:ExpertPages 2014 Survey Reports Expert Witness Hourly Fees Record All-Time Highs as Demand for Qualified Experts Continues to Grow 2Health News:Best Cheap Hosting USA Announces The Best Reseller Hosting Suppliers In 2014 2Health News:Angeldress.co.uk Launches New Range Of 2014 Vintage Wedding Dresses In Its Online Store 2
... Nov. 17 Shopko Stores Operating Co., LLC announced the ... www.shopko.com . Shopko partnered with SpeedFC, a ... advance the Company,s online selling initiatives. , The new online ... in apparel, home, accessories, gift cards and more. The site ...
... is one of 12 sites nationwide participating in the ... treatment for Alzheimer,s disease. The study is the first ... The experimental treatment utilizes a viral-based gene transfer ... naturally occurring protein that helps maintain nerve cell survival ...
... a new model of comprehensive health care for people ... Economics Award for Innovation in Practice Improvement from the ... Teachers of Family Medicine (STFM) and Medical Economics magazine. ... the Guided Care study and director of the Roger ...
... Hughes Medical Institute (HHMI) today committed four years, ... program between Rice University and the University of ... program -- founded with a 2006 HHMI grant ... bioengineering program and M.D. Anderson,s internationally renowned clinical ...
... ... successfully blended custom EDM machining and lights-out automation for greater speed and accuracy for ... are critical to optimized performance. , ... Tucker, GA (PRWEB) November 17, 2009 -- A proprietary new technology ...
... might help reduce heart attacks, researchers say , ... soybeans boosts levels of an important omega-3 fatty acid in ... U.S. researchers say. , They created soybeans that produce oils ... body into an omega-3 fatty acid called eicosapentaenoic acid (EPA). ...
Cached Medicine News:Health News:Shopko Announces Launch of e-Commerce Platform 2Health News:Mount Sinai researchers to test first gene therapy For Alzheimer's patients 2Health News:'Guided Care' receives Award for Innovation in Practice Improvement 2Health News:New funds for Rice, M.D. Anderson program 2Health News:Proprietary EDM Machining Technology Boosts Speed and Accuracy for Medical Components 2Health News:Biotech Soybeans Good Source of Omega-3 2
(Date:9/19/2014)... , Sept. 19, 2014  Diplomat, the nation,s largest ... David Dreyer to the Board of Directors on ... and will also serve as chair of the Audit ... years of accounting, financial, compliance and operating experience in ... has served as chief financial officer, chief operating officer ...
(Date:9/19/2014)... WOONSOCKET, R.I. , Sept. 19, 2014 Five MinuteClinic ... Memphis metropolitan area. Three clinics opened in ... earlier this month. A fourth clinic will be added in ... in Bartlett is expected to open October ... medical clinics in the United States . ...
(Date:9/19/2014)... According to market research ... Industrial, & Laboratory), Industry (Food, Pharmaceutical, Biotechnology, Surgical ... & Geography - Global Trends & Forecast to ... lyophilization market on the basis of various types, ... the market size of each of these segments ...
Breaking Medicine Technology:David Dreyer Appointed to Diplomat Board of Directors 2MinuteClinic Walk-in Medical Clinics Opening in Memphis 2MinuteClinic Walk-in Medical Clinics Opening in Memphis 3Lyophilization Market Worth $5,121.5 Million by 2019 2Lyophilization Market Worth $5,121.5 Million by 2019 3
... Inc., (Ticker: AVTC) ( www.autoretail.com ), is a leading ... for use in hospitals, pharmacies, medical offices and clinics. ... reduce and even eliminate prescription medicine dispensing errors.   ... of Pharmacy Practice reviewed 60 research papers that analyzed ...
... of reusable medical device cleaning validations, resulting from the U.S. ... CFR 610 , is discussed in a new management brief ... . The FDA,s proposed amendments to 21 CFR ... Register on June 21, 2011, for review and comment, ...
Cached Medicine Technology:Automated Medicine Dispensing Units Developed by AVT Can Reduce Errors 2Summary of Proposed Changes to 21 CFR 610 is Detailed in New Management Brief from Microtest Laboratories 2
... Axiovert 40 inverted ... you have ever expected from a microscope in ... outstanding quality, and functionality. Axiovert 40 has been ... safe as possible thus increasing the efficiency ...
... is an advanced inverted microscope ... exclusive CFI60 optical system, extendible ... it ideal for high precision, ... inverted microscope to take full ...
... Eclipse TE2000E is an advanced inverted microscope ... five imaging ports, high resolution CFI60 optics, ... perfect imaging workstation. In addition, its super-nanoprecision ... control is perfect for precise imaging in ...
... The IX71's modular frame ... 9 access ports for ... devices. Up to four ... access to a primary ...
Medicine Products: