Navigation Links
IU researchers receive $3.2 million to develop, improve therapies for pancreatic cancer
Date:3/13/2013

INDIANAPOLIS -- Two Indiana University researchers have been awarded a multi-year, $3.2 million grant to develop and improve therapies for pancreatic cancer, the fourth leading cause of cancer death in the United States.

Mark R. Kelley, Ph.D., Betty and Earl Herr Professor of Pediatric Oncology Research, and Melissa L. Fishel, Ph.D., assistant research professor of pediatrics, both at the IU School of Medicine, were awarded a 5-year grant (CA167291) from the National Cancer Institute of the National Institutes of Health. The two Indiana University Melvin and Bren Simon Cancer Center researchers will focus on investigating the signaling pathways and molecular mechanisms that contribute to pancreatic tumor progression and resistance to therapy.

Signaling pathway describes a group of molecules in a cell that work together to control one or more cell functions, such as cell division or cell death. After the first molecule in a pathway receives a signal, it activates another molecule. This process is repeated until the last molecule is activated and the cell function is carried out. Abnormal activation of signaling pathways can lead to cancer.

In their laboratory research, Drs. Kelley and Fishel plan to block a protein, redox factor 1 (Ref-1), which is crucial to regulating pancreatic tumor growth and metastasis. They will use a protein inhibitor that Dr. Kelley and colleagues developed that has shown promise in the lab in blocking Ref-1.

"We will study a particular protein, Ref-1, that we believe is involved in signaling between the tumor and the tumor's environment," Dr. Fishel said. "We hope to better understand how this protein signals and functions in the tumor microenvironment as well as in the tumor cells. We're hoping that if we can inhibit the function of Ref-1, we can blunt the tumor's ability to live."

Researchers have been learning that a tumor's microenvironment plays a significant role in the life and dea
'/>"/>

Contact: Michael Schug
maschug@iupui.edu
317-278-0953
Indiana University
Source:Eurekalert  

Page: 1 2 3

Related medicine news :

1. Cancer researchers discover new type of retinoblastoma in babies
2. Researchers Turn from Drugs to Mini Organs for Diabetes Cure, According to Yasmin Malhotra
3. Researchers develop new tool to eliminate 30-day hospital readmissions in heart failure patients
4. UTHealth researchers say more rapid test for Group B strep successful
5. U of M researchers find wide variation in cesarean delivery rates among US hospitals
6. BUSM researchers use goal-oriented therapy to treat diabetic neuropathies
7. Researchers Describe 1st Functional Cure of HIV in Baby
8. Industry and academic researchers gather for innovative accelerating cancer cures research symposium
9. Researchers describe first functional HIV cure in an infant
10. Researchers discover how to shutdown cancers powerful master protein
11. UGA researchers identify brain pathway triggering impulsive eating
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
IU researchers receive $3.2 million to develop, improve therapies for pancreatic cancer
(Date:8/29/2014)... August 29, 2014 According to this latest ... detection tool at the moment, as it is amazingly effective. ... hardware detection tool in the industry. , Driver Robot ... hardware driver. The new program is highly effective in finding ... work perfectly. , Daily Gossip writes in its Driver ...
(Date:8/29/2014)... Daily Gossip reveals in its Stop Sciatica in 8 ... naturally curing this disease. , The program promises to ... in only one week. This is described as a unique ... sacrifices. , Moreover, with this new method patients might ... in just 8 minutes. , Interested customers can check ...
(Date:8/29/2014)... Famous review website Top10BestSEOHosting.com compares many popular hosting ... most recommended suppliers for webmasters for webmasters who want ... cloud hosting) at affordable prices. , GoDaddy offers ... shared hosting plans depends on the length of a ... for its flexible hosting packages, decent uptime record and ...
(Date:8/29/2014)... The new review that can be read ... holistic system that will permanently eliminate the symptoms of this ... can achieve a cure in as fast as 30 to ... only about one week. , The Tinnitus Miracle review ... as mild hearing loss, pain in the ear and dizziness. ...
(Date:8/29/2014)... August 29, 2014 Cosmetic Town has ... and authenticity of its doctors. Cosmetic Town utilizes ... most renowned doctors in their field are chosen to ... patients have a direct link to potentially hundreds of ... will be able to communicate through the site’s community ...
Breaking Medicine News(10 mins):Health News:Driver Robot Review Exposes Popular Hardware Detection Tool 2Health News:Stop Sciatica in 8 Minutes Review Exposes Steven Guo's Complete Sciatica Cure 2Health News:Tinnitus Miracle Review Reveals How to Gain Tinnitus Relief in 7 Days 2Health News:Cosmetic Town Now Advocates for the Rights of Cosmetic Patients Using Novel Approach 2
... at Washington University School of Medicine in St. Louis ... the immune cells long thought to be responsible for ... examine the immune cells from isolated insulin-making structures in ... caught the immune cells, known as dendritic cells, "red-handed": ...
... Retired Air Force,Colonel Mike Turner, a Democratic candidate for ... Care Countdown" inspired by MSNBC host,Keith Olbermann. Today is ... and a key architect of Hillary Clinton,s,notorious 1993 health ... to tell 10th District voters what, if any, plan ...
... Grant of Emergency Aid through Dubai Cares, DUBAI, ... bin Rashid Al Maktoum, Vice President and Prime Minister ... provision of 200,temporary structures to be used as schools ... has accepted Dubai,s donation. The,official death toll currently stands ...
... SANTA MONICA, Calif., May 9 Dakim, Inc., ... iconic figure in,health and fitness, has signed on ... the company,s [m]Power Cognitive Fitness System, joining the,company,s ... Dakim,s [m]Power is a touch screen-based brain workout ...
... Roche announced today that Sarah,Vidal, M.P.H., product ... a 2008 Rising Star by the Healthcare Businesswomen,s,Association ... May 8,2008 in New York City., "Sarah ... of,confidence, energy, experience, contagious enthusiasm and respect for,others ...
... visible presence for world,s largest surgical,organization, WASHINGTON, May ... ground for a new home for its Washington, D.C.,office ... Hill. The,10-story, class A office building, located at 20 ... of 2010. ACS headquarters will remain in its,current location ...
Cached Medicine News:Health News:Suspected cause of type 1 diabetes caught 'red-handed' for the first time 2Health News:Suspected cause of type 1 diabetes caught 'red-handed' for the first time 3Health News:Mike Turner, Virginia Congressional Candidate, Starts Healthcare Countdown 2Health News:Dubai Provides Aid for Cyclone Nargis Victims In Myanmar 2Health News:Physical Fitness 'Godfather' Jack LaLanne Turns to Brain Fitness, Becoming Ambassador for Dakim's [m]Power System 2Health News:Roche's Vidal Honored as 2008 HBA Rising Star 2Health News:American College of Surgeons Breaks Ground on New Office Building on Capitol Hill 2
(Date:8/29/2014)... , Aug. 29, 2014 /PRNewswire-iReach/ -- Market Research ... Industry, 2009-2019 is a professional and in-depth market ... Scanner industry . The report firstly reviews the ... classification, application and manufacturing technology. The report then ... Crystallography Scanner listing their product specification, capacity, Production ...
(Date:8/29/2014)... , Aug. 29, 2014  Chuma Holdings, ... financing alternatives and turnkey support services for the ... that FINRA processed and approved the Company,s name ... 2014, CannaMed Corporation will be known as Chuma ... was accomplished through a merger with the Company,s ...
(Date:8/29/2014)... CHAPEL HILL, N.C. , Aug. 29, 2014 /PRNewswire/ ... Opinion Leaders (KOLs) can be the difference between a ... struggle to effectively map and stratify KOL targets – ... to build the type of strong relationships upon which ... recent research, savvy pharma companies have identified internal inconsistencies ...
Breaking Medicine Technology:X-Ray Crystallography Scanner Industry For Global and Chinese Market Forecast to 2019 2X-Ray Crystallography Scanner Industry For Global and Chinese Market Forecast to 2019 3X-Ray Crystallography Scanner Industry For Global and Chinese Market Forecast to 2019 4X-Ray Crystallography Scanner Industry For Global and Chinese Market Forecast to 2019 5CannaMed Announces Name Change and Trading Symbol Change 2CannaMed Announces Name Change and Trading Symbol Change 3Implementing a Strategic Thought Leader Management & Engagement System 2
... Our breadth of infectious disease ELISA ... field. With standard assay protocols for faster ... Disease ELISA products provide increased reliability and ... includes antibody detection assays for a wide ...
... breadth of infectious disease ELISA products make ... standard assay protocols for faster integration into ... products provide increased reliability and run-to-run consistency. ... detection assays for a wide range of ...
... breadth of infectious disease ELISA products make ... standard assay protocols for faster integration into ... products provide increased reliability and run-to-run consistency. ... detection assays for a wide range of ...
... ELISA products make us a leader in ... faster integration into the busy laboratory, our ... and run-to-run consistency. Our Infectious Disease ELISA ... wide range of serological assays including ToRCH, ...
Medicine Products: