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IU, Paradigm team up to test genomic sequencing for women with aggressive breast cancer
Date:5/15/2014

s blueprint genomic landscape) from the tumors that remain after standard chemotherapy. They will then search for any known therapies that might help eliminate the cancer.

After the sequencing is completed, the IU Simon Cancer Center researchers will evaluate and discuss each patient's results. Each woman in the sequencing group will then be assigned a drug that has been selected to best treat her particular form of triple negative breast cancer based on her individual results. This form of therapeutic individualization that uses the unique genetic blueprint of each tumor to guide therapy is a departure from the "one-size-fits-all" approach that has been commonly used in cancer care.

"This trial is one of only a handful in the world that tests, through a controlled scientific study, whether the use of next-generation sequencing (NGS) to identify specific disease drivers -- and the selection of treatments for women based on those genetic markers -- actually improves survival rates for women," said Paradigm CEO Robert Penny, M.D., Ph.D. "Our ability to interrogate the patient's tumor for DNA mutations, DNA copy number variations, chromosomal changes and mRNA gene expression with next-generation sequencing with clinical quality results is a real differentiator in helping to improve patient care."

Dr. Schneider likened tumor mutations to typos. A minor typo in a sentence doesn't usually prevent a reader from being able to read the sentence. But add a lot of typos or a typo in the wrong place, and the sentence becomes unreadable. Thus, mutations can make a normal, well-behaved cell turn into a problematic cancer cell with a new set of instructions. Dr. Schneider and colleagues will be looking at a set number of targets in which they know the mutations can signal cells to become cancerous.

"If the mutation is taking place in a certain gene or protein that controls a certain function, and if the mutation has caused damage in that pathway,
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Contact: Michael Schug
maschug@iupui.edu
317-278-0953
Indiana University
Source:Eurekalert

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