Navigation Links
IU, Paradigm team up to test genomic sequencing for women with aggressive breast cancer
Date:5/15/2014

s blueprint genomic landscape) from the tumors that remain after standard chemotherapy. They will then search for any known therapies that might help eliminate the cancer.

After the sequencing is completed, the IU Simon Cancer Center researchers will evaluate and discuss each patient's results. Each woman in the sequencing group will then be assigned a drug that has been selected to best treat her particular form of triple negative breast cancer based on her individual results. This form of therapeutic individualization that uses the unique genetic blueprint of each tumor to guide therapy is a departure from the "one-size-fits-all" approach that has been commonly used in cancer care.

"This trial is one of only a handful in the world that tests, through a controlled scientific study, whether the use of next-generation sequencing (NGS) to identify specific disease drivers -- and the selection of treatments for women based on those genetic markers -- actually improves survival rates for women," said Paradigm CEO Robert Penny, M.D., Ph.D. "Our ability to interrogate the patient's tumor for DNA mutations, DNA copy number variations, chromosomal changes and mRNA gene expression with next-generation sequencing with clinical quality results is a real differentiator in helping to improve patient care."

Dr. Schneider likened tumor mutations to typos. A minor typo in a sentence doesn't usually prevent a reader from being able to read the sentence. But add a lot of typos or a typo in the wrong place, and the sentence becomes unreadable. Thus, mutations can make a normal, well-behaved cell turn into a problematic cancer cell with a new set of instructions. Dr. Schneider and colleagues will be looking at a set number of targets in which they know the mutations can signal cells to become cancerous.

"If the mutation is taking place in a certain gene or protein that controls a certain function, and if the mutation has caused damage in that pathway,
'/>"/>

Contact: Michael Schug
maschug@iupui.edu
317-278-0953
Indiana University
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. A Revolutionary Dietary Paradigm: New Cookbook Features A SOS-free (Salt, Oil, Sugar ) Diet That Delivers the Optimal Food Plan for Renewing Health
2. AG Bell Symposium Explores a New Paradigm for Delivering Services to Children who are Deaf and Hard of Hearing
3. One Health paradigm for the future featured in medical school textbook
4. Dr. Carol Francis Discusses the DSM-5, Diagnostic Statistical Manual-5 and New Definitions of Mental Health, Treatments and Paradigms
5. Paradigms for Dual Antiplatelet Therapy After PCI Challenged by PARIS Trial
6. Paradigm Malibu Announces the Launch Of Their Academic Support Program For Treatment Of Gifted Teens
7. Paradigm Malibu Launches Academic Support Program for Treatment of Gifted Teens
8. Paradigm Malibu Offers a Wide Range of Treatment Programs for Adolescents
9. Malibu, CA Based Teen Drug and Mental Health Program, Paradigm Malibu Announces New Methods for Treating Eating Disorders in Teens
10. Following the genomic pathways to stop the spread of cancer
11. Genomic study of rare childrens cancer yields possible prognostic tool
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/20/2014)... Los Angeles, CA (PRWEB) August 20, 2014 ... Conference will get a sneak peak at Los Angeles’ ... along with a tour of a blossoming 1.5-acre high ... visit to a shipping container farm in the L.A. ... the wide-ranging diversity of sustainable urban agriculture, will kick ...
(Date:8/20/2014)... 2014 August is Children’s Eye Health ... educated about eye health and safety for their children ... eye condition that must be checked for, according to ... of Water radio show, is pediatric dry eye. With ... dry eye is becoming a very real concern to ...
(Date:8/20/2014)... OXNARD, CA (PRWEB) August 20, 2014 ... Saj Jivraj, founder of the Anacapa Dental Art Institute, ... month. , Dr. Jivraj will be speaking on ... and Laboratory Aspects of Graft Less Solutions” at 12:40 ... Conference Centre in Vancouver, British Columbia, Canada. , “The ...
(Date:8/20/2014)... Inc. Magazine recently named Etransmedia ... annual Inc. 500|5000, an exclusive ranking of the ... most comprehensive look at the most important segment ... Yelp, Pandora, Timberland, Dell, Domino’s Pizza, LinkedIn, Zillow ... as members of the Inc. 500|5000. , “We ...
(Date:8/20/2014)... “Have you recently been involved in an ... injury lawyer serving the greater Seattle area. “Are you still ... then keep reading . , In a recently released article, ... auto accident can use to see if they may qualify ... injury insurance claim will allow an individual to receive medical ...
Breaking Medicine News(10 mins):Health News:Seedstock Sustainable Agriculture Conference’s Urban Farm Field Trip to Offer First Look at Los Angeles’ Premier Food Business Incubator 2Health News:Seedstock Sustainable Agriculture Conference’s Urban Farm Field Trip to Offer First Look at Los Angeles’ Premier Food Business Incubator 3Health News:August is Children’s Eye Health Month, Exams Must Check for Pediatric Dry Eye 2Health News:August is Children’s Eye Health Month, Exams Must Check for Pediatric Dry Eye 3Health News:Internationally Known Oxnard Dentist to Speak at Conference in Vancouver 2Health News:Internationally Known Oxnard Dentist to Speak at Conference in Vancouver 3Health News:Etransmedia Makes Exclusive List for the Eighth Consecutive Year in Inc. Magazine 2Health News:Etransmedia Makes Exclusive List for the Eighth Consecutive Year in Inc. Magazine 3Health News:Five Questions to Determine Who Qualifies for a Personal Injury Claim Recently Released by The Jones Firm in Recent Article 2
... 5 Chiltern, a leading global research,organization, is proud ... Clinical Researcher of the Year ceremony, including the coveted,Clinical ... following awards: Gold: Clinical Department of the Year ... Project Manager category Gold: Kara Tanabe in Clinical ...
... evidence shows that surgery may effectively cure Type 2 diabetes -- ... is treated, but that introduces a new way of thinking about ... to the February issue of Diabetes Care by a leading expert ... small bowel as the possible site of critical mechanisms for the ...
... 5 A protein that governs,development of human ... spread of malignant melanoma, the deadliest skin cancer, ... the transformation of skin pigment cells or melanocytes, ... and a median survival of less than 7.5 ...
... INDIANAPOLIS, March 5 Anthem National Accounts today,announced ... to address,the needs of early retirees -- a ... of products is designed to meet the needs ... and provide affordable,access to medical coverage while helping ...
... to protect their children from exposure to secondhand smoke, ... Hopkins Bloomberg School of Public Health. Exposure to secondhand ... for numerous illnesses and premature death. The household study, ... parents who smoked reported smoking around their children. Measurements ...
... Kids Pledges up to ... Type 1 Diabetes Research, ATLANTA, March 5 White Hat ... announced today the launch of a,three- year partnership with the Juvenile ... 1,diabetes research., As part of this milestone relationship, White Hat ...
Cached Medicine News:Health News:Chiltern Wins Top Prize 2Health News:Type 2 diabetes may be caused by intestinal dysfunction 2Health News:Type 2 diabetes may be caused by intestinal dysfunction 3Health News:Type 2 diabetes may be caused by intestinal dysfunction 4Health News:Protein in Human Embryonic Stem Cells Controls Malignant Tumor Cells 2Health News:Protein in Human Embryonic Stem Cells Controls Malignant Tumor Cells 3Health News:Protein in Human Embryonic Stem Cells Controls Malignant Tumor Cells 4Health News:Anthem National Accounts Introduces New Products for Large Employers' Early Retirees 2Health News:Anthem National Accounts Introduces New Products for Large Employers' Early Retirees 3Health News:Secondhand smoke a risk for children worldwide 2Health News:White Hat Brands, Juvenile Diabetes Research Foundation Offer the 'Juice' on New Partnership 2Health News:White Hat Brands, Juvenile Diabetes Research Foundation Offer the 'Juice' on New Partnership 3
(Date:8/19/2014)... Avizia, Inc., a leading provider of cutting-edge ... equity financing round led by NextGen Angels along with ... will be used to continue to fuel the rapidly ... Edward Kennedy , CEO and president of Tollgrade ... Leonard Kurtzman , CFO of newBrandAnalytics, who joined the ...
(Date:8/19/2014)... , Aug. 19, 2014  Cardiva Medical, Inc. ... tranches of a $16.5 million Series 3 private equity ... GE Capital. The Company will use the proceeds of ... to expand commercial efforts for its VASCADE® Vascular Closure ... Investing in Series 3 private equity ...
(Date:8/19/2014)... August 19, 2014 Oramed ... clinical-stage pharmaceutical company focused on the development of ... Intellectual Property Department of Spain ... invention, titled "Methods and Compositions for Oral Administrations ... Oramed Pharmaceuticals is a technology pioneer in ...
Breaking Medicine Technology:Avizia Closes Funding Round 2Cardiva Medical, Inc. Announces Completion of the first two tranches of Series 3 Private Equity Financing and the Closing of a Senior Secured Debt Facility with GE Capital 2Oramed Granted Patent in Spain for Oral Administration of Insulin 2Oramed Granted Patent in Spain for Oral Administration of Insulin 3
... May 2, 2011 EMBEDDED SYSTEMS CONFERENCE -- Samplify ... availability of Prism FP ™ , the first compression ... floating point data types.   "Distribution of ... of thousands of computing nodes poses a challenge in ...
... May 2, 2011 Prometheus Laboratories Inc., a specialty ... signed an exclusive agreement with WILEX AG for commercialization ... is a Phase III product candidate for adjuvant use ... Under the terms of the agreement, WILEX will receive ...
Cached Medicine Technology:Samplify Systems Announces Availability of Prism FP Floating Point Compression 2Prometheus Obtains Exclusive US Commercialization Rights for RENCAREX® 2Prometheus Obtains Exclusive US Commercialization Rights for RENCAREX® 3
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
Medicine Products: