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IU, Paradigm team up to test genomic sequencing for women with aggressive breast cancer
Date:5/15/2014

Indiana University cancer researchers are testing whether therapy incorporating advanced genomic technology will provide better outcomes than current treatments for those with an aggressive form of breast cancer.

Researchers at the Indiana University Melvin and Bren Simon Cancer Center, led by Bryan Schneider, M.D., associate professor of medicine, and Milan Radovich, Ph.D., assistant professor of surgery and of medical and molecular genetics, are using targeted DNA sequencing in a new clinical trial for women with triple negative breast cancer, to test whether certain treatment choices improve survival rates.

"This trial takes a group of patients who have received standard chemotherapy but haven't had the response one would hope," said Dr. Schneider, who is also the Vera Bradley Investigator in Oncology, associate professor of medical and molecular genetics, and associate director of the Indiana Institute for Personalized Medicine.

Following chemotherapy and surgery, patients who are at high risk for relapse will be eligible to participate in the trial.

"In this group, we will use our understanding of genomics to identify the gas pedal for each woman's specific cancer and see if we can find a drug that will block the gas pedal in a way that is better than non-specific chemotherapies," Dr. Radovich said.

The researchers' goal for using a genomic approach is to improve survival in this group of patients.

The trial will enroll 130 women. Half will receive the standard of care, while genomic sequencing will direct therapy for the other half. Sequencing is used to find mutations (changes in the blueprint of the tumor) or changes in expression (over- or under-excitement of specific genes) that may drive the cancer.

In partnership with Paradigm, a nonprofit genomic sequencing and molecular information company based in Ann Arbor, Mich., and Phoenix, the researchers will analyze the DNA and RNA (the cancer cell'
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Contact: Michael Schug
maschug@iupui.edu
317-278-0953
Indiana University
Source:Eurekalert

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