Navigation Links
ISU research raises hope for solving Parkinson's disease puzzle
Date:2/28/2011

AMES, Iowa - A protein pathway that may hold the secret to understanding Parkinson's disease has been discovered and explained by Iowa State University researchers.

Anumantha Kanthasamy, a distinguished professor of biomedical sciences and the W. Eugene and Linda R. Lloyd Endowed Chair in Neurotoxicology at the ISU College of Veterinary Medicine, has been working to understand the complex mechanisms of the disease for more than a decade. He believes this recent discovery offers hope for the cure.

The research was funded by the National Institutes of Health and is published in the Journal of Neuroscience.

Parkinson's disease sufferers lack a sufficient amount of a brain chemical called dopamine. In previous research, Kanthasamy has shown that a novel protein -- known as protein kinase-C (specifically PKCδ) - kills essential dopamine-producing cells in the brain.

Now, Kanthasamy has shown how to modify the production of the kinase-C, and, more important, how to inhibit it.

The process begins with a protein called alpha-synuclein (ά-synuclein) that - after interacting with other proteins in cells - becomes part of the protein complex that modifies kinase-C level in the cells.

One of the proteins that alpha-synuclein interacts with inside the cell is known as p300.

By changing the activity of p300 protein, Kanthasamy believes that production of the destructive kinase-C will be inhibited.

"We have identified an essential pathway that regulates the survival of dopamine-producing nerve cells," he said.

"This p300 is an intermediate protein that is implicit in the Parkinson's disease," he said. "By modifying this protein, we can potentially reduce the expression of kinase-C and the associated destructive effects on dopamine-producing cells."

"We found the mechanism," said Kanthasamy of the pathway. "Now we can focus on finding chemicals that may be able to con
'/>"/>

Contact: Anumantha Kanthasamy
akanthas@iastate.edu
515-294-2516
Iowa State University
Source:Eurekalert  

Page: 1 2

Related medicine news :

1. Embedded Mobile & M2M Device revenues to Rise to Almost $19 Billion Globally by 2014, Says Juniper Research
2. 2010 HSR Impact Award recognizes surgical safety research
3. MSU launches first anti-counterfeiting research program
4. Researchers map all the fragile sites of the yeast Saccharomyces cerevisiaes genome
5. UH Case Medical Center researchers publish promising findings for advanced cervical cancer
6. Researchers discover new way to kill pediatric brain tumors
7. Family Research Council: Planned Parenthood Report Oversexualizes Ten-Year-Olds, Undermines Parental Authority
8. Michael J. Fox Foundation Awards $1 Million to Drive Critical New Research Tools and Technologies in Parkinsons Drug Development
9. Luth Researchs IndicatorEDG(TM) Study Finds Americans Hopes of Achieving Their Dreams Are Fading
10. International Diabetes Federation awards $2 million to 9 global diabetes research projects
11. Gladstones Robert Mahley to receive Research!America advocacy award
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
ISU research raises hope for solving Parkinson's disease puzzle
(Date:3/4/2015)... 04, 2015 Theme and plugin developers from ... pack for Final Cut Pro X entitled ProFont NoteBook , ... to any FCPX editors project.” Said Christiana Austin, CEO of ... to add animated font to their FCPX media.” , With ... all within Final Cut Pro X. ProFont Notebook offers users ...
(Date:3/4/2015)... CA (PRWEB) March 04, 2015 Bird ... commercial, industrial and residential applications now offers its popular ... , The humane, highly efficient bird deterrent ... to match the color and décor of the building ... standard colors—brick red, white, crystal clear, light grey, brown, ...
(Date:3/4/2015)... (PRWEB) March 04, 2015 Professionals with ... more targeted outreach from companies, according to a new ... 2014 survey of 235 professionals with disabilities , ... online job search tools, including ones that are geared ... work. Some highlights:, ,     Online job search ...
(Date:3/4/2015)... March 04, 2015 Rocket Builders’ “Ready ... Columbian companies that have the best prospect for growth ... when we choose the Ready to Rocket companies, we ... technical innovation with market opportunity. Prizm Media Inc. is ... right customers at the right time,” said Reg Nordman, ...
(Date:3/4/2015)... (PRWEB) March 04, 2015 The medical ... companies whose management forgot – or ignored or didn't ... Validate the market based on physician input before proceeding ... – more specifically, founders – become so enamored of ... key question: Will physicians use the device?” says ...
Breaking Medicine News(10 mins):Health News:Announcing a New Title Pack from Pixel Film Studios, ProFont NoteBook for Final Cut Pro X 2Health News:Plastic Bird Spikes Now Come in 7 Colors to Blend in With Their Surroundings 2Health News:Job Seekers with Disabilities Seek Targeted Outreach from Employers and Online Job Search Tools, says New Think Beyond The Label Survey 2Health News:Job Seekers with Disabilities Seek Targeted Outreach from Employers and Online Job Search Tools, says New Think Beyond The Label Survey 3Health News:Healthcare Lead Generation Leader Prizm Media Inc. is “Ready to Rocket” 2Health News:Healthcare Lead Generation Leader Prizm Media Inc. is “Ready to Rocket” 3Health News:Want to Succeed in Medical Technology? Don't Innovate in a Vacuum 2Health News:Want to Succeed in Medical Technology? Don't Innovate in a Vacuum 3
... NEW BRUNSWICK, N.J., May 13 Johnson & Johnson ... Deutsche Bank 34th Annual Health Care Conference on Tuesday, ... Sheri McCoy, Worldwide Chairman, Pharmaceuticals Group for Johnson ... scheduled at 10:50 a.m. (Eastern Time).This broadcast will be ...
... 13 Accumetrics, Inc. announces that it has enrolled ... ( G auging R esponsiveness with A ... hrombosis A nd S afety). The trial ... clinicians with actionable information for patients who are poor ...
... Shengtai,Pharmaceutical, Inc. (OTC Bulletin Board: SGTI) ("Shengtai" or ... pharmaceutical grade,glucose products in China, today announced that ... ended March 31, 2009 after the close of ... Management will conduct a conference call,on Friday, May ...
... (Nasdaq: ESRX ) announced that it will present ... May 19, 2009 at 10:10 a.m. EDT at the InterContinental ... the Internet and can be accessed on the investor relations ... RealPlayer or Windows Media Player is needed to listen ...
... Winner Medical Group Inc.,(OTC Bulletin Board: WMDG) ("Winner Medical", or ... ended March 31,2009. The Company,s results are detailed in its ... Commission. , , Second Quarter 2009 Highlights, ... 15.31% over the second quarter of, ...
... expression and activity of Cystathionase is reduced in ... and impaired generation of hydrogen sulphide, two factors ... resistance. , In the present study the analysis ... presence of an inverted repeat sequence. Administration of ...
Cached Medicine News:Health News:Accumetrics, Inc. Announces 1000th Patient Enrolled in GRAVITAS Trial 2Health News:Shengtai Pharmaceutical Schedules 2009 Third Quarter Financial Results and Conference Call 2Health News:Shengtai Pharmaceutical Schedules 2009 Third Quarter Financial Results and Conference Call 3Health News:Winner Medical Reports Second Quarter Fiscal 2009 Results 2Health News:Winner Medical Reports Second Quarter Fiscal 2009 Results 3Health News:Winner Medical Reports Second Quarter Fiscal 2009 Results 4Health News:Winner Medical Reports Second Quarter Fiscal 2009 Results 5Health News:Winner Medical Reports Second Quarter Fiscal 2009 Results 6Health News:Winner Medical Reports Second Quarter Fiscal 2009 Results 7Health News:Winner Medical Reports Second Quarter Fiscal 2009 Results 8Health News:Winner Medical Reports Second Quarter Fiscal 2009 Results 9Health News:Winner Medical Reports Second Quarter Fiscal 2009 Results 10Health News:Winner Medical Reports Second Quarter Fiscal 2009 Results 11Health News:Farnesoid X receptor regulates cystathionase 2
(Date:3/3/2015)... AUSTIN, Texas , March 3, 2015  UnaliWear ... that provides advanced support for seniors that guards against ... The new wearable – the Kanega ... of its kind to use an easy speech interface ... update medical information without human input. ...
(Date:3/3/2015)... 3, 2015  Columbia Laboratories, Inc. (Nasdaq: ... Company"), a specialty pharmaceutical company focused on pharmaceuticals for ... the 27th Annual ROTH Conference, which will take place ... Dana Point, California . Management,s presentation ... a.m. Pacific Time (12:00 p.m. Eastern Time) in the ...
(Date:3/3/2015)... BARCELONA, Spain , March 3, 2015  AT&T ... AEX: PHIA) today announced that  AT&T  is the connectivity ... service. GoSafe was designed to help provide peace of ... giving them the freedom to live active lives with ... when they need it. The AT&T network 2 ...
Breaking Medicine Technology:UnaliWear's Wearable For Seniors Extends Independence With Advanced Technology 2AT&T Providing Connectivity for Philips GoSafe Mobile Medical Alert System, Empowering United States Seniors to be Connected to Emergency Care On-the-Go 2AT&T Providing Connectivity for Philips GoSafe Mobile Medical Alert System, Empowering United States Seniors to be Connected to Emergency Care On-the-Go 3AT&T Providing Connectivity for Philips GoSafe Mobile Medical Alert System, Empowering United States Seniors to be Connected to Emergency Care On-the-Go 4
One inch disposable patch electrode uses a specially formulated adhesive solid gel. Reusable lead wire with snap connector provides economic benefits. Ideal for sleep studies where leg movement or EK...
10-mm (0.4-in) diameter cups have multi-color lead wires and 2-mm (0.08-in) holes for easy paste/collodion application. Available in a variety of lengths to suit many different needs....
... head cap systems are packaged to provide ... Electro-Cap System features pure tin electrodes positioned ... you place your order, please specify which ... cap system and whether you want regular ...
... Made with elastic fabric, these head ... you need to begin testing. Each Electro-Cap ... to the International 10-20 System. When you ... you are using with your head cap ...
Medicine Products: