Navigation Links
ISU research raises hope for solving Parkinson's disease puzzle
Date:2/28/2011

AMES, Iowa - A protein pathway that may hold the secret to understanding Parkinson's disease has been discovered and explained by Iowa State University researchers.

Anumantha Kanthasamy, a distinguished professor of biomedical sciences and the W. Eugene and Linda R. Lloyd Endowed Chair in Neurotoxicology at the ISU College of Veterinary Medicine, has been working to understand the complex mechanisms of the disease for more than a decade. He believes this recent discovery offers hope for the cure.

The research was funded by the National Institutes of Health and is published in the Journal of Neuroscience.

Parkinson's disease sufferers lack a sufficient amount of a brain chemical called dopamine. In previous research, Kanthasamy has shown that a novel protein -- known as protein kinase-C (specifically PKCδ) - kills essential dopamine-producing cells in the brain.

Now, Kanthasamy has shown how to modify the production of the kinase-C, and, more important, how to inhibit it.

The process begins with a protein called alpha-synuclein (ά-synuclein) that - after interacting with other proteins in cells - becomes part of the protein complex that modifies kinase-C level in the cells.

One of the proteins that alpha-synuclein interacts with inside the cell is known as p300.

By changing the activity of p300 protein, Kanthasamy believes that production of the destructive kinase-C will be inhibited.

"We have identified an essential pathway that regulates the survival of dopamine-producing nerve cells," he said.

"This p300 is an intermediate protein that is implicit in the Parkinson's disease," he said. "By modifying this protein, we can potentially reduce the expression of kinase-C and the associated destructive effects on dopamine-producing cells."

"We found the mechanism," said Kanthasamy of the pathway. "Now we can focus on finding chemicals that may be able to control the mechanism."

Parkinson's disease strikes around 50,000 people each year, and approximately 1 million people have the disease. Parkinson's sufferers include actor Michael J. Fox and former boxing champion Muhammad Ali.

Currently, there is no cure for Parkinson's and available therapies only treat the symptoms.

Symptoms of Parkinson's disease include trembling in hands, arms, legs, jaw, and face; rigidity or stiffness of the limbs and trunk; slowness of movement; and impaired balance and coordination. As these symptoms become more pronounced, patients may have difficulty walking, talking, or completing other simple tasks.

Because the disease typically affects people over the age of 50, the National Institutes of Health anticipates the incidence of Parkinson's will increase as the nation's population ages.


'/>"/>

Contact: Anumantha Kanthasamy
akanthas@iastate.edu
515-294-2516
Iowa State University
Source:Eurekalert  

Related medicine news :

1. Embedded Mobile & M2M Device revenues to Rise to Almost $19 Billion Globally by 2014, Says Juniper Research
2. 2010 HSR Impact Award recognizes surgical safety research
3. MSU launches first anti-counterfeiting research program
4. Researchers map all the fragile sites of the yeast Saccharomyces cerevisiaes genome
5. UH Case Medical Center researchers publish promising findings for advanced cervical cancer
6. Researchers discover new way to kill pediatric brain tumors
7. Family Research Council: Planned Parenthood Report Oversexualizes Ten-Year-Olds, Undermines Parental Authority
8. Michael J. Fox Foundation Awards $1 Million to Drive Critical New Research Tools and Technologies in Parkinsons Drug Development
9. Luth Researchs IndicatorEDG(TM) Study Finds Americans Hopes of Achieving Their Dreams Are Fading
10. International Diabetes Federation awards $2 million to 9 global diabetes research projects
11. Gladstones Robert Mahley to receive Research!America advocacy award
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
ISU research raises hope for solving Parkinson's disease puzzle
(Date:5/4/2016)... NY (PRWEB) , ... May 04, 2016 , ... ... non-profit organization devoted exclusively to funding innovative lymphoma research and serving the lymphoma ... – is set to return to the esteemed Quaker Ridge Golf Club in ...
(Date:5/4/2016)... York, NY (PRWEB) , ... May 04, 2016 ... ... leading private owners, developers and operators of commercial real estate proudly announced that ... 2015 Heart Health initiative. Team members portfolio-wide will continue Olshan Properties’ annual ...
(Date:5/4/2016)... ... May 04, 2016 , ... ... Nurses (WOCN) Society™ and Canadian Association for Enterostomal Therapy (CAET) will be ... saving and planning tools to attendees and exhibitors for the 2016 WOCN Society ...
(Date:5/4/2016)... ... May 04, 2016 , ... ... charity program created to assist the people of their local community. The agency ... organizations and community leaders. Their hope is to bring awareness to important local ...
(Date:5/4/2016)... ... May 04, 2016 , ... Slepkow Slepkow & ... one of the top website design companies to create a state of the ... to the law firm's main practice areas. These practice areas include: real estate, ...
Breaking Medicine News(10 mins):
(Date:5/4/2016)... 4, 2016 Research ... "Global Acute lymphocytic Leukemia Market and Competitive ... offering.       (Logo: http://photos.prnewswire.com/prnh/20160330/349511LOGO ... Leukemia Market and Competitive Landscape Highlights 2016, ... pipeline products, Acute Lymphocytic Leukemia epidemiology, Acute ...
(Date:5/3/2016)... to further expand product development, strengthen its disease modeling capabilities and increase market presence. Photo - ... ... ... ... Sino-German High-Tech Fund (SGHF) is an ...
(Date:5/3/2016)... watching a film or TV show in high definition, you may not be familiar with ...  is a renowned authorized reseller of the medical industry,s top brands as well as a ... ... ... Although initially introduced ...
Breaking Medicine Technology: