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IPM Receives Worldwide Rights to HIV Prevention Medicine
Date:5/8/2014

ther ARVs. Through the worldwide rights agreement with Janssen, IPM has opened the door to women's future access to prevention products in all countries through affordable pricing strategies.

IPM's most advanced technology containing dapivirine is a monthly sustained-release vaginal ring designed to prevent HIV. The dapivirine-only microbicide ring is now in two parallel Phase III trials in Africa, with results expected in late 2015. Building on Janssen's earlier work with dapivirine, IPM designed and developed the ring, conducting all the preclinical and clinical work needed to bring the product to late-stage efficacy trials in just seven years. A successful microbicide would be a key tool in helping to reduce new HIV infections in developing countries in the future.

"Our worldwide rights agreement with Janssen is a powerful example of how public-private partnerships can accelerate access to urgently needed, affordable health products," added Dr. Rosenberg. "By pooling the expertise of partners across sectors, we can more effectively help women at risk for HIV and, ultimately, end the spread of HIV/AIDS altogether."

Dapivirine belongs to a class of ARVs called non-nucleoside reverse transcriptase inhibitors (NNRTIs) that prevent HIV from making copies of itself. Other dapivirine-based products in IPM's development portfolio include a combination dapivirine-maraviroc ring, as well as a 90-day MPT ring that combines dapivirine with the contraceptive levonogestrel for dual protection against HIV and unintended pregnancy. IPM's long-acting MPT ring is now in preclinical studies under a grant from USAID, with a clinical trial planned for 2015.

"This agreement could have profound implications for women's health," said Dr. Peter Piot, director of the London School of Hygiene & Tropical Medicine and founding executive director of UNAIDS. "Not only will it expand women's access to affordable, potentially lifesaving prevention prod
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Contact: Holly Seltzer
hseltzer@ipmglobal.org
301-608-4277
International Partnership for Microbicides (IPM)
Source:Eurekalert

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