Navigation Links
IPM Reaches Landmark Agreement with Pfizer to Develop FDA-Approved Antiretroviral Drug as Vaginal Microbicide
Date:1/30/2008

SILVER SPRING, Md., Jan. 30 /PRNewswire-USNewswire/ -- Expanding the pipeline of HIV prevention tools in development, the International Partnership for Microbicides (IPM) today announced that Pfizer Inc. (Pfizer) has agreed to give IPM a royalty-free license to maraviroc, its newly-approved HIV treatment, as a microbicide for the prevention of HIV infection. Maraviroc, sold under the trade name Selzentry(TM)/Celsentri(R), is one of a new class of antiretroviral drugs known as CCR5 blockers, which works to prevent HIV infection by preventing the virus from gaining entry into target cells.

This agreement marks only the second time a pharmaceutical company has licensed an already approved HIV therapy to be developed as a microbicide. Researchers hope that maraviroc's safety and efficacy data as a therapeutic will speed its development as a microbicide.

"This agreement adds a promising new compound to IPM's pipeline, allowing us to explore new ways to prevent HIV infection," said Dr. Zeda Rosenberg, CEO of the International Partnership for Microbicides. "Pfizer and IPM's other industry partners deserve recognition for their significant leadership in the global effort to protect women from HIV."

Microbicides are products, such as gels and films, that could be applied vaginally to prevent transmission of HIV during vaginal intercourse. IPM is also developing other delivery methods such as long-lasting vaginal rings that release drug gradually over time.

"Pfizer is proud to contribute to the effort to develop a safe and effective microbicide with the potential to give women around the world new ways to protect themselves from HIV," said Pfizer Vice President Dr. Jack Watters. "Given maraviroc's mechanism of action blocking entry of HIV into the CD4 cells, the possibility for use in a microbicide is exciting. In addition to developing new drugs to treat AIDS, we are committed to searching for ways our drugs can be used to slow down or stop this epidemic."

Under this agreement, IPM would work to develop maraviroc as a vaginal microbicide with the right to develop, manufacture and distribute the microbicide in developing countries. Pfizer has granted these rights to IPM without a royalty.

"Women in the developing world are especially vulnerable to HIV, and urgently need new ways to protect themselves," said Dr. Tachi Yamada, president of the Bill & Melinda Gates Foundation's Global Health Program. "For Pfizer to offer one of its most important new drugs to benefit the poorest of the poor shows a special act of commitment. I hope their example will point the way for other companies to consider how they can address major global health challenges as well."

To date, five leading pharmaceutical companies have entered partnerships with IPM. In March 2004, IPM signed an agreement with Johnson & Johnson subsidiary Tibotec Pharmaceuticals Ltd. to develop the company's non-nucleoside reverse transcriptase inhibitor dapivirine as a microbicide. In October 2005, IPM entered agreements with Merck & Co. and Bristol-Myers Squibb to develop CCR5 blocker and entry inhibitor compounds early in development, and in December 2006 IPM reached an agreement with Gilead Sciences to develop tenofovir (PMPA), a nucleoside reverse transcriptase inhibitor.

HIV/AIDS ranks among the world's most devastating diseases because it has spread rapidly and mainly afflicts young people in their most productive years. Women, particularly those in developing countries, bear an increasing burden of the epidemic as both caregivers for the ill and because of their heightened risk of infection due to greater physiological, economic and social vulnerabilities. According to the UN, in sub-Saharan Africa, almost 61 percent of adults living with HIV are women. In many African countries, women and girls aged 15 to 24 are three times more likely to be HIV-infected than their male counterparts.

About IPM: The International Partnership for Microbicides was established in 2002 to accelerate the development and accessibility of microbicides to prevent HIV transmission in women. By screening compounds, designing optimal formulations, establishing manufacturing capacity, developing trial sites and conducting clinical trials, IPM works to improve the efficiency of all efforts to develop and deliver safe and effective microbicides as soon as possible. http://www.ipm-microbicides.org

About Pfizer: Founded in 1849, Pfizer is the world's largest research-based pharmaceutical company taking new approaches to better health. Pfizer discovers, develops, manufactures and delivers quality, safe and effective prescription medicines to treat and help prevent disease for both people and animals. Pfizer also partners with health care providers, governments and local communities around the world to expand access to its medicines and to provide better quality health care and health system support. http://www.pfizer.com


'/>"/>
SOURCE International Partnership for Microbicides
Copyright©2008 PR Newswire.
All rights reserved

Related medicine news :

1. Spiritual Healer/Psychic-Medium Reaches International Status!
2. EMBL reaches north
3. AK Steel Reaches VEBA Health Care Settlement With Middletown Works Retirees
4. Sun Safety Awareness Reaches New Heights at Plano Hot Air Balloon Festival
5. 40 Days for Life Reaches Halfway Point; Planned Parenthood Now in Crisis Mode
6. Blue Cross of California Reaches Out to Members Impacted by Southern California Fires
7. Free Site Offering Patient-Physician Dialog Reaches Milestone
8. Sharp HealthCare Foundation Reaches $50 Million Goal
9. Nyer Medical Group Reaches Agreement to Acquire Minority Interest in Pharmacy Chain Subsidiary
10. MB Software Corporation Reaches Agreement with Keystone Equity Partners
11. New York City death rate reaches historic low
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/30/2016)... ... April 30, 2016 , ... Dr. Trevor Gardner, ... EMED, today signed a multifaceted agreement which will allow for the research and ... Department of Natural and Applied Sciences, Allied Health and Nursing will work together ...
(Date:4/29/2016)... Dobbs Ferry, New York (PRWEB) , ... April 30, 2016 , ... ... and the Dobbs Ferry campus. The following programs will be expanding due to ... Resources Management (HRM). The expansion will begin this summer. , School ...
(Date:4/29/2016)... ... ... Our bodies are bombarded daily by environmental and lifestyle factors that can ... to adopt a more healthful diet, but too many people think that food has ... and the creator of the Newport Beach Cleanse and 14-Day Eating Plan, disagrees whole-heartedly. ...
(Date:4/29/2016)... ... April 29, 2016 , ... Conditions were ideal for Global Lyme Alliance’s ... Sunday, with sunny skies, a light breeze and temperatures in the 60s. Over 400 ... 5k Run and Walk and 1-mile walk were held to increase awareness about ...
(Date:4/29/2016)... ... 2016 , ... Mobility Designed is redefining mobility with their patent pending ... Crutch evenly distributes body weight from the elbow to the forearm. In consumer ... than with other crutches. , Co-founders Max and Liliana Younger were inspired to design ...
Breaking Medicine News(10 mins):
(Date:4/28/2016)... -- Treato , the single largest ... that it has been named a Cool Vendor by ... Sciences, 2016, Stephen Davies , Michael ... life-science- oriented analytics, algorithms and smart machine technology in ... medication ingestion, and analyze unstructured information.   ...
(Date:4/28/2016)... 28, 2016   Acsis , a leading provider ... IT market research and advisory firm IDC has named ... MarketScape: Worldwide Pharmaceutical Track and Trace Software 2016 Vendor ... an assessment of the capabilities and business strategies of ... market. Logo - http://photos.prnewswire.com/prnh/20160427/360791LOGO ...
(Date:4/27/2016)... MARLBOROUGH, Mass., April 27, 2016  Hologic, Inc. ... Company,s financial results for the fiscal second quarter ... share (EPS) of $0.24 increased 41.2%, and non-GAAP ... $693.3 million increased 5.8% on a reported basis, ... "We posted another good quarter, highlighted ...
Breaking Medicine Technology: