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INBRACED awards $400,000 grant to launch an international neuroblastoma clinical trial
Date:5/22/2014

Solving Kids' Cancer, the Neuroblastoma Children's Cancer Alliance (NCCA UK), and Joining Against Cancer in Kids (J-A-C-K) awarded its first grant through their INBRACED (International Neuroblastoma Research and Collaboration for Effective Delivery) initiative, which aims to improve access of promising clinical trials for children with high-risk neuroblastoma in North America, the UK and in Europe. The grant amount of $400,000 will create a new immunotherapy treatment option in the U.S., UK, and in Spain, for children with relapsed or refractory disease. The international phase I clinical trial will use a vaccine that targets the GD2 and GD3 antigens, which has already shown promising results in children with neuroblastoma in the U.S.

The low-toxicity vaccine was developed by researchers at Memorial Sloan-Kettering Cancer Center (MSKCC) in New York City, which is participating in the trial alongside Bristol Children's Hospital in the UK, and the Hospital Sant Joan de Du Barcelona, in Spain. The vaccine utilizes a child's own immune system to help the body recognize and destroy cancer cells that express the two antigens most commonly found on the surface of neuroblastoma cellsGD2 and GD3, potentially promoting long-term remissions in these children. A phase I trial with this same vaccine was recently completed at MSKCC with 15 patients and demonstrated very promising results; the results were published in the March 2014 issue of Clinical Cancer Research.

This is the first international clinical trial for children with cancer that has been initiated and sponsored solely by pediatric cancer nonprofits. "The success of this new partnership lies in the amazing determination of UK and U.S. charities, parents, research institutions, doctors and pharmaceutical organization to help more children survive," said Bettina Bungay-Balway, Chief Executive of the London-based NCCA UK.

"We truly hope this will speed the exploration and evoluti
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Contact: Jenny
jenny@solvingkidscancer.org
212-588-6625
Solving Kids' Cancer
Source:Eurekalert

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