Navigation Links
IL-10 from donor skin cells helps the body incorporate skin grafts
Date:7/31/2012

Scientists have found that the anti-inflammatory molecule, IL-10, may improve success rates of skin autografts (skin moved from one site of the body to another). This information provides a valuable drug target that may benefit burn and accident victims. Specifically, researchers from Portugal and Brazil show that IL-10 plays an important role in whether or not an isogenic skin graft (skin from one individual grafted into another genetically identical) is successful and that the cells responsible for this effect are from the donor skin and not from any tissue of the recipient. This finding appears in the August 2012 issue of the Journal of Leukocyte Biology (http://www.jleukbio.org).

"Much work is needed to advance from mouse experiments to finding in humans," said Luciana Vieira de Moraes, Ph.D., a researcher involved in the work from the Disease Genetics Lab at Instituto Gulbenkian de Cincia in Oeiras, Portugal. "However, monitoring IL-10 levels in the graft tissue may improve therapeutic success."

To make this discovery, scientists conducted experiments using different groups of mice, some of which were genetically modified to not produce IL-10. The first group, which produced IL-10, received a tail skin graft from mice that lacked IL-10. These grafts were not accepted by the recipient. The second group that did not produce IL-10 received tail skin from donors that had IL-10. In this case grafts were accepted. These findings suggest that IL-10 is important immediately after transplantation.

"This study shows that donor skin is not a passive player in the grafting process. Indeed, immune cells in the skin play an active role in whether or not the graft is accepted or rejected by the body. While considerable work remains, these findings open the door to exploit the IL-10 pathway to aid in skin grafting procedures in a variety of clinical settings," said John Wherry, Ph.D., Deputy Editor of the Journal of Leukocyte Biology.


'/>"/>
Contact: Cody Mooneyhan
cmooneyhan@faseb.org
301-634-7104
Federation of American Societies for Experimental Biology
Source:Eurekalert

Related medicine news :

1. Antibodies from rabbits reduce risks associated with unrelated donor stem cell transplantation
2. Donor aortic graft improves reconstruction after partial laryngectomy
3. Donor Kidney Re-Used in Second Patient After Failing in First
4. Tumor cells inner workings predict cancer progression
5. State stem cell research funding agency awards $20 million to UCI, StemCells Inc.
6. How the fluid between cells affects tumors
7. Mount Sinai researchers discover new target for vaccine development in abundant immune cells
8. Stem Cells Show Promise as Heart Failure Treatment
9. Neural precursor cells induce cell death in certain brain tumors
10. Inflammatory pathway spurs cancer stem cells to resist HER2-targeted breast cancer treatment
11. Patients Skin Cells Yield Research Model for Alzheimers
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/26/2016)... ... May 26, 2016 , ... Power Systems, a ... first PowerWave Instructor Certification Course in Stoughton, Massachusetts. The course was led by ... through the 8 hour interactive course to qualify participants as certified PowerWave trainers. ...
(Date:5/26/2016)... ... May 26, 2016 , ... The introduction of our professional ... TO YOUR HEAD ™”. , “We are proud to introduce Meghan Klingenberg, ... front we have Brian Quick, wide receiver for Los Angeles who was a second ...
(Date:5/26/2016)... (PRWEB) , ... May 26, 2016 , ... Dr. LeRoy ... identifies the impact of mobile devices on the billions of users, hundreds of millions ... necks. While not life threatening, the frequent and common action of looking down ...
(Date:5/26/2016)... ... May 26, 2016 , ... In Madeira Beach Florida, a small town ... drawbridge, citizens formed an organization, Madeira Beach United, to oppose two development projects undertaken ... town center to a high rise urban environment. , According to the Tampa ...
(Date:5/26/2016)... ... ... HealthPostures, ergonomics designer and maker of the bestselling TaskMate sit/stand series, has ... Potential benefits of using the Stance Angle chair include the prevention of fluid buildup ... and standing. , Need for the ergonomics furniture may be growing, in part because ...
Breaking Medicine News(10 mins):
(Date:5/25/2016)... May 25, 2016 According to ... Development, Growth and Demand Forecast to 2022 - Industry ... and Others)" published by P&S Market Research, the global ... in 2015, and it is expected to grow at ... the insulin pump segment is expected to witness the ...
(Date:5/25/2016)... 25, 2016 Inivata, a ... of circulating tumour DNA (ctDNA) analysis to improve ... of Professor Clive Morris as Chief ... the clinical development programme, scientific collaborations, and through ... significant improvements in clinical outcomes for patients. ...
(Date:5/24/2016)...   , Study met both ... in , Excellent plus Good ... of the ascending colon   ,      ... announced new positive data from the phase III MORA study for ... litre PEG with ascorbate. The study met both primary endpoints showing ...
Breaking Medicine Technology: