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IFX anti-TNF therapy associated with clinical benefit over 5 years in patients with active AS
Date:6/12/2009

0 vs 2.2 (p<0.001)
  • Patient global disease VAS (visual analogue score): 7.0 vs 2.8 (p<0.001)
  • CRP: 2.9 mg/dl vs 0.5 mg/dl (p<0.001)
  • Swollen joint count: 1.6 vs 0.6 (p<0.001)
  • Enthesitis Index: 9.0 vs 0.4 (p<0.001)

    Importantly, the patients who completed the trial under therapy demonstrated a state of low disease activity (mean BASDAI 2.5), had a good functional status (mean BASFI 3.1) and a favourable spinal mobility (mean BASMI 2.2) over time. These assessments had been substantially worse at baseline of ASSERT. During the last year of EASIC, almost 80% (78.4%) of the patients who completed the trial under therapy (n=81) had no arthritis and 85% had no enthesitis. Over time, these patients also continued to show low or normal CRP levels.

    Dr Frank Heldmann continues: "The EASIC cohort has been a success for European rheumatologists because the trial was directly organised and performed by the investigators and showed the the study drug, infliximab, to be effective and safe in long-term treatment over a period of 5 years."


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  • Contact: Rory Berrie
    eularpressoffice@uk.cohnwolfe.com
    44-789-438-6425
    European League Against Rheumatism
    Source:Eurekalert

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