Navigation Links
IFX anti-TNF therapy associated with clinical benefit over 5 years in patients with active AS
Date:6/12/2009

ients with this chronic condition."

The 103 AS patients from 6 European countries (Belgium, Finland, France, Germany, the Netherlands and the United Kingdom) recruited to the 96-week open-label EASIC (European

Ankylosing Spondylitis Infliximab Cohort) trial had previously participated in the 2-year randomised controlled trial ASSERT (Ankylosing Spondylitis Study for the Evaluation of Recombinant Infliximab Therapy). The EASIC population consisted of 82.5% men and 17.5% women, with a mean age of 43.5 years. There was no major difference between the EASIC and ASSERT study populations in terms of demographics or age.

Between the two trials, patients had a break from their clinical trial-prescribed treatment regime of 1.30.9 years, during which they were treated according to local clinical practice. According to differences in such local standards, one group of patients continued to receive IFX (group 2, n=89, 83 of whom went forward for analysis) and one group did not (group 1, n=14 all analysed). Of the latter, group 1a had relapsed (BASDAI >4 and physician global VAS >4) (n=9) and group 1b were in remission (n=5). Interestingly, all these relapsed patients (group 1a), who had not been treated with IFX during the period between the trials, flared at the time of start of EASIC.

During EASIC, all patients (except for those who had remained in remission) were continuously treated with IFX 5mg/kg (mean dosage) at intervals of 6-8 weeks (at the discretion of the investigator, according to local clinical practice). The patients in group 2 (who had also continuously received IFX between the trials) and completed the trial (n=76) showed significant improvement at week 96 compared to the ASSERT trial baseline data in a number of assessments:

  • BASDAI (Bath AS Disease Activity Index): 6.4 at ASSERT baseline vs 2.5 at week 96 of EASIC (p<0.001)
  • BASFI (Bath AS Functional Index): 5.9 vs 3.1 (p<0.001)
  • BASMI (Bath AS Metrology Index): 4.
    '/>"/>

Contact: Rory Berrie
eularpressoffice@uk.cohnwolfe.com
44-789-438-6425
European League Against Rheumatism
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. SIMPONI(TM) (golimumab) Receives FDA Approval as First Once-Monthly Anti-TNF for Treatment of Rheumatoid Arthritis, Psoriatic Arthritis and Ankylosing Spondylitis
2. 30 percent RA patients refractory to anti-TNFs achieve disease remission with tocilizumab plus metho
3. Adalimumab therapy effective in AS, RA and PsA patients refractory to other anti-TNF therapies
4. Study shows promise for new cancer-stopping therapy
5. MORE WOMEN SHUN HORMONE REPLACEMENT THERAPY Garden of Life Offers a Natural Solution with Oceans 3&#8482; Healthy Hormones&#8482;
6. Hormone therapy may confer more aggressive properties to prostate tumors
7. Pharmacy Organizations Brief Congress on Medication Therapy Management
8. Vaporized viral vector shows promise in anti-cancer gene therapy
9. Death rates same for diabetes and heart disease patients receiving drug therapy or surgery
10. Cant Sleep? Try Online Therapy
11. Astellas Adds CNS Therapy Area Leader to Global R&D Team
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/30/2014)... WEDNESDAY, July 30, 2014 (HealthDay News) -- For patients ... is enough to trigger airway inflammation for at least ... just what you smell, but also what you think ... Monell Chemical Senses Center in Philadelphia, said in a ... about scents and fragrances. When we expect that an ...
(Date:7/30/2014)... jockeying for supremacy within a cancerous tumor, the most ... fastest, researchers at Dana-Farber Cancer Institute report in a ... journal Nature . The findings have important ... the study authors explained: Doctors need to ascertain which ... metastasis and select drugs that target the critical genes ...
(Date:7/30/2014)... 2014 On July 29, 2014, Freedom ... Institute of Public Health, Gandhinagar released a new report ... II: The Way Forward .” The report was released ... and Practices to Improve Nutrition Security in New Delhi, ... the Green Revolution" and chair of the Coalition ...
(Date:7/30/2014)... 2014 Shabaikai is an ambitious historical ... the Pomo Indians located on the shores of Russian ... Shabaikai, meaning ‘crooked snake’. Clarkson takes the reader into ... violence of prohibition and organized crime, providing a glimpse ... the most powerful men in the world convene the ...
(Date:7/30/2014)... (PRWEB) July 30, 2014 With the recent ... Ground Zero, the Ground Zero Museum Workshop in the Meatpacking ... bookings. Says the Museum Workshop's Carole Barnes, "We have had ... all the major travel sites who sell us so tourists ... crystal clear as to what we do and what the ...
Breaking Medicine News(10 mins):Health News:Even Thinking an Odor is Harmful May Spur Asthma Symptoms 2Health News:Target growth-driving cells within tumors, not fastest-proliferating cells 2Health News:Target growth-driving cells within tumors, not fastest-proliferating cells 3Health News:New Report on Integrated Health and Microfinance in India Shows the Way Forward 2Health News:New Report on Integrated Health and Microfinance in India Shows the Way Forward 3Health News:New Report on Integrated Health and Microfinance in India Shows the Way Forward 4Health News:Bill E. Clarkson Releases Debut Fact-Based Novel, Shabaikai 2Health News:Despite Some Confusion over 9/11 Memorial Opening, Kid-Friendly Ground Zero Museum Workshop on 14th Street Continues It's Mission 2Health News:Despite Some Confusion over 9/11 Memorial Opening, Kid-Friendly Ground Zero Museum Workshop on 14th Street Continues It's Mission 3Health News:Despite Some Confusion over 9/11 Memorial Opening, Kid-Friendly Ground Zero Museum Workshop on 14th Street Continues It's Mission 4Health News:Despite Some Confusion over 9/11 Memorial Opening, Kid-Friendly Ground Zero Museum Workshop on 14th Street Continues It's Mission 5
... reported in the Journal Psychological bulletin that having positive ... gives better health and long life.// This research study ... that emotions had a direct impact on health as ... also protects from psychological stress. The researchers feel that ...
... raided on Wednesday doctors and hospitals in the global healthcare ... ,Six hospitals in Chennai, two in Kumbakonam, 350 km ... doctors were raided by 300 IT officials simultaneously. About Rs.6 ... investments worth several millions were seized in the raids from ...
... study it has been found that a herbal supplement can ... (NAC) which is a potential agent to modulate the effects ... models for the treatment of heroin addiction, and possibly alcoholism. ... herbal supplement known for its antioxidant effects. Antioxidants are agents ...
... Plants belonging to Brassica family like cabbage and cauliflower ... cancer prevention. This chemical works very much like anti ... on this aspect is taking place across the globe ... use in therapeutic nutrition is underway. ,These are ...
... the Oregon National Primate Research Center at Oregon Health ... stem cells becoming other brain cells.// New therapies can ... injury as a result of continued research. The brain ... before birth, which become glial cells in later stages. ...
... of Toronto stimulates the muscles of patients with spinal ... those with no hope of walking.// ... (FES), a process that sends controlled bursts of electricity ... enhance their walking skills by improving their step frequency, ...
Cached Medicine News:Health News:A herbal drug addiction releiver 2
(Date:7/30/2014)... PITTSBURGH , July 30, 2014   ... Markets Groups Inc.: OTC Pink: UPZS), a Delaware ... a distribution agreement with Larasan Pharmaceutical Corporation ("Larasan"), a ... products.  According to the agreement, US-based Larasan will ... gourmet 6" frozen pizza through Larasan,s vast distribution ...
(Date:7/30/2014)... 30, 2014 Cynosure, Inc. (NASDAQ: ... treatments for non-invasive and minimally invasive applications, today announced that ... Operating Officer and Chief Financial Officer Timothy W. Baker ... Baker, 53, will continue to serve as CFO and will ... who remains Chairman and Chief Executive Officer. ...
(Date:7/30/2014)... 30, 2014  DigiPath, Inc. (OTCBB and OTCQB: DIGP), ... the cannabis testing and education markets, announced today that ... affairs not previously disclosed or, to its knowledge, any ... action. "We have noticed unusual price and ... trading days," said Steve Barbee , CEO of ...
Breaking Medicine Technology:Unique Pizza and Subs Announces Asian Distribution Agreement with Larasan Pharmaceutical Corporation 2Unique Pizza and Subs Announces Asian Distribution Agreement with Larasan Pharmaceutical Corporation 3Cynosure Appoints Chief Operating Officer and Chief Financial Officer Timothy W. Baker as President 2DigiPath No New Corporate Developments 2
... June 28, 2011 The Mirixa Corporation and ... are pleased to announce that MirixaPro(SM), a Web-based ... patient care service delivery, will be deployed in ... agreement enabling CACDS to use a scalable, localized ...
... 2011 ,   The ... range of,new clinical data. The "Late-Breaking Clinical Trials" were ... SHPT study,(Evaluation of the Effectiveness of Paricalcitol Versus Cinacalcet,With ... June the,principal investigator of this study, Prof. Markus Ketteler,(Coburg, ...
Cached Medicine Technology:Mirixa and CACDS Sign Agreement for Clinical Service Delivery Platform 2Mirixa and CACDS Sign Agreement for Clinical Service Delivery Platform 3Update on IMPACT Study Results 2
... The Finnpipette BioControl multichannel ... features as the single ... handle fits all seven ... channel tip cone modules. ...
... The Finnpipette Digital Multichannel, ... even lighter work of routine ... all these advanced features: Soft-touch ... micro volume pipetting (0.5-10ul models), ...
... operate in a wide variety of applications. • ... manifold can be freely rotated against the handle ... at an optimum angle towards the microtiter plate. ... use of most common pipette tips, and provides ...
... Digital Multichannel, with it's streamlined ... of routine laboratory tasks. The ... features: Soft-touch tip ejection, Super ... (0.5-10ul models), Entire pipette autoclavable, ...
Medicine Products: