Navigation Links
IDIBELL researchers discover a substance against the 'dark genome' of cancer

A research study coordinated by Manel Esteller, researcher at Bellvitge Biomedical Research Institute (IDIBELL) has identified a substance that inhibits cancer growth by activating the so‑called "dark genome" (or non‑coding DNA) and micro‑RNA molecules. The study appears this week in the journal Proceedings of the National Academy of Sciences (PNAS).

Human body cells have a genome (the set of our DNA) encoding our proteins such as keratin in the skin or haemoglobin in blood. This genome with encoding DNA represents only the 5% of our genetic material. The remaining 95% is called the 'dark genome' or non-coding DNA and its role is largely unknown. Part of this DNA produces small charged molecules called micro-RNAs that activate or deactivate genes. In recent years it has been shown that alterations in these molecules are related to tumour onset.


Researchers have shown that a small-molecule called enoxacin, used in antibacterial compounds, binds to the protein that builds micro-RNA and stimulates their inhibitory activity of the tumour growth. According to researcher Manel Esteller, that "is like if we have a second hand car and we put on a new engine".

The molecule has been tested both in laboratory cells and in animal models and now its behaviour should be studied in humans. Esteller stresses that the advantage of this compound is that we know its metabolism and its human security. Esteller adds that "although the use of this molecule may not be approved in cancer treatment, this finding opens the door to design new drugs that use microRNA as a therapeutic target. We show the pharmaceutical industry a new direction where to direct their efforts in anti-tumour therapy."


Contact: Arantxa Mena
IDIBELL-Bellvitge Biomedical Research Institute

Page: 1

Related medicine news :

1. Wayne State University researchers publish results settling multiple sclerosis debate
2. E-health must be a priority, researchers say
3. Mayo Clinic researchers confirm value of therapeutic hypothermia after cardiac arrest
4. Mayo researchers, Rochester educators, students to present at science conference
5. Researchers work at the frontiers of islet cell transplantation
6. Brain Appears to Be a Task Machine, Researchers Say
7. Researchers develop outline that may help weigh benefits of new imaging technologies
8. University of Minnesota researchers study the use of computer vision to diagnose mental disorders
9. Researchers find brain insulin plays critical role in the development of diabetes
10. Financial planning a key but neglected component of Alzheimers care, say researchers
11. Researchers find reduced levels of an important neurotransmitter in MS
Post Your Comments:
(Date:6/26/2016)... ... June 26, 2016 , ... PawPaws brand pet supplements ... was developed to enhance the health of felines. The formula is all-natural and is ... herbs in the PawPaws Cat Kidney Support Supplement Soft Chews are Astragalus ...
(Date:6/25/2016)... ... June 25, 2016 , ... The temporary closing of Bruton Memorial Library on June 21 ... brings up a new, often overlooked aspect of head lice: the parasite’s ability to live ... not a common occurrence, but a necessary one in the event that lice have simply ...
(Date:6/25/2016)... ... June 25, 2016 , ... On Friday, June 10, Van Mitchell, Secretary ... Work award to iHire in recognition of their exemplary accomplishments in worksite health promotion. ... Maryland Workplace Health & Wellness Symposium at the BWI Marriott in Linthicum Heights. iHire ...
(Date:6/24/2016)... ... ... Marcy was in a crisis. Her son James, eight, was out of control. Prone to ... , “When something upset him, he couldn’t control his emotions,” remembers Marcy. “If there ... my other children and say he was going to kill them. If we were ...
(Date:6/24/2016)... Rhinebeck, NY (PRWEB) , ... June 24, 2016 , ... Topical BioMedics, Inc, makers of ... of companies that call for a minimum wage raise to $12 an hour by 2020 ... wage. This will restore the lost value of the minimum wage, assure the wage floor ...
Breaking Medicine News(10 mins):
(Date:6/26/2016)... DUBLIN , June 27, 2016 Jazz ... the waiting period under the Hart-Scott-Rodino Antitrust Improvements Act ... proposed acquisition of Celator Pharmaceuticals, Inc. ("Celator"; Nasdaq: ... 11:59 p.m. (Eastern Daylight Time). As previously ... entered into a definitive merger agreement under which Jazz ...
(Date:6/24/2016)... June 24, 2016  Consumers have taken a ... have placed more emphasis on patient outcomes. ... programs in the pharmaceutical industry have evolved beyond ... pharmaceutical companies are focusing on becoming more patient-oriented ... products and services that improve health. ...
(Date:6/24/2016)... 24, 2016   Bay Area Lyme Foundation ... Dean Center for Tick Borne Illness , Harvard ... MIT Hacking Medicine, University of California, Berkeley, and ... the five finalists of Lyme Innovation , ... than 100 scientists, clinicians, researchers, entrepreneurs, and investors ...
Breaking Medicine Technology: