Navigation Links
IDIBELL license to Minoryx a patent of a product to treat a rare neurodegenerative disease

The Bellvittge Biomedical Research Institute (IDIBELL) has signed a licensing agreement with the Spanish biotechnology company Minoryx of a patent for the treatment of X-linked adrenoleukodystrophy, a rare serious neurodegenerative disease which has no effective treatment.

The Neurometabolic Diseases group led by ICREA researcher Aurora Pujol, has developed an animal model to study this disease. Studies using this model have shown that the patented product, a repositioned drug, may be effective against X-linked adrenoleukodystrophy.

The obtaining of the patent and the license has been managed by the Technology Transfer Office of IDIBELL. The license represents an opportunity not only to get this invention into the market and patients, but also to initiate a partnership of trust between the company and IDIBELL in developing new solutions to improve the quality of life of patients with adrenoleukodystrophy.

Hereditary disease

The X-linked adrenoleukodystrophy is an inherited disease that destroys the myelin (white matter that coats the nerves) at the central or peripheral nervous system and causes hormonal changes. Patients have a genetic mutation that impedes the properly degradation of very long chain fatty acids within cells. This causes the accumulation of this type of fat in plasma and tissues, especially in the brain and adrenal gland, causing irreversible damage.

This is a rare disease that affects only male subjects, although female carriers may also experience some symptoms. Its incidence is one case per 17,000 men. It is the most common type of leukodystrophy and the main peroxisome disorder. The peroxisome is the part of the cell responsible for eliminating toxic products. The disease became famous in 1992 with the film Lorenzo's oil, starring by Nick Nolte and Susan Sarandon.

Pioglitazone acts on the nuclear receptor PPAR-gamma and to a lesser extent, on PPAR-alpha. These are proteins that regulate the storage of fatty acids and the glucose metabolism and also enhance peroxisome proliferation in cells.

More studies

The drug has been successful in animal experiments, but more studies will be needed before the product can be applied to X-linked adrenoleukodystrophy patients. In this sense, the signing of the license agreement with Minoryx is an important step to use the drug for this purpose in the future.


Contact: Arantxa Mena
IDIBELL-Bellvitge Biomedical Research Institute

Related medicine news :

1. Coding Certiifcation.Org Under License With the AAPC, Adds Certified Physician Practice Manager to their Product Course Offerings
2. Cosmetic Surgery – Protecting Consumers from Unlicensed Practitioners
3. Dr. Stephen Lazarus Continues to Recognize the Importance of Quality, Medical Skin Care and Products in Welcoming Licensed Paramedical Esthetician, Amye Smith
4. CodingCertification.Org (CCO) Enters a License Agreement With the AAPC to Add the Professional Medical Coding Curriculum (PMCC) to its Course Offerings
5. EverCheck: Healthcare, Human Resources, & License Verification
6. Bridges to Recovery Reaches Ten-Year Milestone as Premiere, Licensed Residential Behavioral Treatment Program and Honors Founding Medical Director Dr. Terry V. Eagan
7. University of Minnesota licenses Clinical Decision Support technology
8. Patent Issued for Apparel and Textile Fabric with Antimicrobial Properties
9. DrugRisks News Update: Bayer Loses Yaz Patent as Blood Clot Settlements Continue
10. Human Gene Patent Case Goes to Supreme Court
11. A New Alarm Clock App (Patent Pending) Helps to Lose Weight and Fat
Post Your Comments:
(Date:11/27/2015)... ... November 27, 2015 , ... Dr. Thomas Dunlap ... Inc. and Dr. Tucker Bierbaum with Emergency Medicine at St., Joseph Health ... both STEMI and Sepsis conditions present in similar ways and require time-critical intervention to ...
(Date:11/26/2015)... ... November 26, 2015 , ... Patients ... central Michigan, have come together on Thanksgiving Day to share the things that ... viewing on the Serenity Point YouTube channel, patients displayed what they wrote on ...
(Date:11/26/2015)... Ashburn, VA (PRWEB) , ... November 26, 2015 ... ... Planners, an American Express Travel Representative. As a franchise owner, Somu now offers ... range of cruise, destination wedding packages, private cruise sales, as well as, cabin ...
(Date:11/26/2015)... ... November 26, 2015 , ... PRMA Plastic Surgery is updating their record ... performed their 6,000th free flap breast reconstruction surgery! , “What an accomplishment for the ... to rebuild lives and it’s an honor to have served all of these women.” ...
(Date:11/26/2015)... ... November 26, 2015 , ... ... consultation, has collaborated with Women’s Web – an online resource for Indian ... on mental and emotional well-being relationship, life balance, stress, professional development, and ...
Breaking Medicine News(10 mins):
(Date:11/26/2015)... Research and Markets ( ) has announced the addition ... 2019 - Rise in Cardiac Disorders and Growing Awareness among ... offering. Boston scientific and ... and others. --> The market is dominated ... scientific and others. Asia ...
(Date:11/26/2015)... ) has ... Future Horizons and Growth Strategies in the ... Shares, Country Segment Forecasts, Competitive Intelligence, Emerging ... --> ) has announced the ... and Growth Strategies in the German Drugs ...
(Date:11/26/2015)... , November 26, 2015 ... the "Self Administration of High Viscosity Drugs" ... ) has announced the addition of the ... report to their offering. --> Research ... addition of the "Self Administration of High ...
Breaking Medicine Technology: