Navigation Links
IBD, LCPD health research in 'Westie' dogs may hold answers to similar human diseases
Date:7/18/2011

The Westie Foundation of America (WFA) announced today preliminary findings in two major studies involving the health of West Highland White Terriers also known as Westies. Findings in these and other studies of Westies and other dogs may hold answers for similar human conditions like Inflammatory Bowel Disease (IBD). The studies are jointly funded by the WFA and the AKC Canine Health Foundation (CHF).

In one study, researchers are looking at the role of a mucosal gene driving inflammation Canine IBD, a chronic intestinal disorder that creates a bacterial-driven inflammation in the intestines. In the second, scientists are researching Legg-Calve Perthes Disease (LCPD), a debilitating developmental disease that causes pain, lameness and muscle atrophy of the dogs' hip joints. Both are considering implications for humans since the diseases share commonalities in disease symptoms and pathology.

In IBD, genetic factors are thought to contribute to the cause of the disease in both dogs and humans and researchers are utilizing unique molecular biology tools to identify key genes which regulate intestinal inflammation, similar to human IBD.

"It is our expectation to identify specific genes which serve as biomarkers for diagnosing canine IBD and for monitoring the effects of therapy. We have now identified a grouping of 17 'marker' genes that may be more critically assessed in future studies," said Albert E. Jergens, DVM, PhD of Iowa State University, the study's lead investigator. "We have preliminary evidence that changes in the composition of the intestinal bacteria accompany the abnormal gene patternsthis situation is remarkably similar to the association between people and their intestinal populations causing human IBD (i.e., Crohn's disease and ulcerative colitis)."

LCPD is an orthopedic disease that may require surgery to relieve the clinical signs. Researchers are using a high-throughput technology to assess nearly 127,000 points in the dog genome. The goal of this project is to identify genes that contribute to the development of LCPD.

Preliminary study findings show LCPD may be inherited in much the opposite way previous studies have shown. Eariler studies suggested LCPD is transmitted in an autosomal recessive pattern. "Our current data suggest the LCPD is inherited in either a dominant or complex fashion," said Keith E. Murphy, PhD of Clemson University. "Only with more samples will we begin to understand the genetics controlling LCPD." The investigators currently have samples from 58 Westies, 23 of which have LCPD. One candidate gene identified in humans was investigated in canine LCPD, but was not associated with LCPD in Westies. The results of the candidate gene analysis will be published later this year.

"We are pleased to see such progress in the study of Westies and are even more excited that our work may contribute to human disease research, as well," said Bebe Pinter, president of WFA. "We anxiously await final results in these studies and in other studies currently being funded by WFA and CHA and look forward to continuing our commitment to research and funding for Westie health."


'/>"/>

Contact: Teresa Barnes
TeresaRBarnes@gmail.com
303-521-4080
Westie Foundation of America
Source:Eurekalert

Related medicine news :

1. IADR/AADR publish study on use of Twitter for public health surveillance of dental pain
2. Massachusetts health-care reform increased access to care, particularly among disadvantaged
3. New health-care payment system slows spending while improving patient care
4. Children with public health insurance less likely to receive comprehensive primary care
5. Health care in the home - new report July 18
6. Omega-3 reduces anxiety and inflammation in healthy students
7. Mobile Sensors Track Health of Elderly in Pilot Test
8. Soaring Temps Can Pose Serious Health Risks
9. Severity of spinal cord injury has no impact on how adults rate their health, WSU research finds
10. Overall health effects of alcohol consumption
11. Study: Potassium Boosts Heart Health, Salt Harms It
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/23/2017)... ... , ... “A Respectful Response To Atheist Manifesto”: theological refutation ... is the creation of published author Richard Hostetter, a former missionary in Africa ... graduate degrees from Kent State University and the University of Ghana. , Published ...
(Date:3/22/2017)... ... March 22, 2017 , ... ... publication of the first issue of its companion print magazine. The new magazine, ... cosmetic surgery thanks to information provided by board-certified doctors from across the country. ...
(Date:3/22/2017)... ... ... Old School Labs™, makers of the best-selling Vintage line of natural sports ... who trained with Floyd Mayweather, made his professional debut in London in 2003 and ... number of wins in contests in Britain, Germany and the U.S. , “We ...
(Date:3/22/2017)... ... March 22, 2017 , ... Influence Health, the ... solutions have enabled Children’s Hospital of The King’s Daughters (CHKD) to achieve a ... value of a digital marketing approach, the 206-bed pediatric teaching hospital in Norfolk, ...
(Date:3/22/2017)... ... March 22, 2017 , ... The ... research collaboration to translate advances in basic neuroscience at the BMRI labs into ... collaboration seeks to improve movement, vision, and cognition impaired by stroke, traumatic brain ...
Breaking Medicine News(10 mins):
(Date:3/22/2017)... Research and Markets has announced the addition of the ... Insight 2022" drug pipelines to their offering. ... Global Immune ... gives comprehensive insight on clinical and non-clinical aspects involved in ... main streamline drugs in the immunotherapy treatment. Report helps to ...
(Date:3/22/2017)... Mar 22, 2017 Research and Markets has ... & Trends - Industry Forecast to 2025" report to their ... The ... of around 7.1% over the next decade to reach approximately $129.81 ... estimates and forecasts for all the given segments on global as ...
(Date:3/22/2017)... , March 22, 2017  Applied BioMath ( ... to drug research and development, today announced the ... QSP Day 2017 is a day full of ... systems pharmacology (QSP) community. The focus is to ... de-risking and accelerating drug research and development. ...
Breaking Medicine Technology: