Navigation Links
IAVI and VaxDesign partner to develop a clinical trial in a test tube for AIDS vaccines

NEW YORK, March 3, 2008 The International AIDS Vaccine Initiative (IAVI) today announced the first award from its Innovation Fund, a new funding mechanism that will identify and advance potential breakthrough technologies and apply them in the AIDS vaccine research field. This initial project will apply an exciting new technology, a simulated human immune system the size of a small coin, which has the potential to predict human immune responses to new vaccines and drugs.

Under development by VaxDesign Corporation, the Modular IMmune In vitro Construct (MIMIC) system could radically transform AIDS vaccine research and development. The technology uses human immune cells from volunteers to create simulated human immune responses. The MIMIC models reproduce both innate and adaptive immune responses, and exhibit both humoral and cellular immunity. VaxDesign has the capacity to run thousands of these immune simulations per month. IAVI will first test the technology on licensed vaccines for yellow fever and rabies to see whether the immune responses generated in vitro are the same as those elicited in humans who receive the vaccine. If the technology proves successful, IAVI and VaxDesign will further develop and apply it to the screening of novel immunogens for AIDS vaccines at its AIDS Vaccine Development Laboratory in Brooklyn, New York.

Currently, pre-clinical testing of AIDS vaccines is a labor-intensive, lengthy and expensive process. We hope this pioneering technology will enable us to rapidly test AIDS vaccine candidates and predict their effectiveness in humans in a way that has never before been possible with animal models, said Dr. Wayne Koff, IAVIs Senior Vice President for Research and Development. Whats more, by collecting immune cells from different donors, promising vaccine candidates can be tested in diverse populations before they enter human testing.

HIV is a formidable adversary, and evaluating AIDS vaccine candidates will be the ultimate test for our MIMIC technology. We are excited to partner with IAVI to help develop the next generation of AIDS vaccine candidates, said Dr. William Warren, President and CEO of VaxDesign.

Targeted primarily to small- and medium-sized biotechnology companies, IAVIs Innovation Fund will proactively seek out and finance nascent technologies that could help solve some of the main technical and scientific hurdles facing AIDS vaccine research and ultimately lead to the development of more promising candidates for human testing. With an initial three-year commitment of US$10 million, half of which will be financed by a US$5 million grant to IAVI from the Bill & Melinda Gates Foundation, the Innovation Fund will provide rapid and flexible funding in just eight weeks from application to award for pioneering ideas outside the traditional realm of AIDS vaccine research.

Now more than ever, the AIDS vaccine field needs out-of-the-box concepts that can help us develop better candidates for testing, said Dr. Seth Berkley, IAVI President and CEO. VaxDesigns novel technology is one of many hidden gems that we plan to seek out and develop for AIDS vaccine research.

"The Gates Foundation is proud to support IAVI in exploring innovative approaches for addressing the challenges of discovering an effective HIV vaccine," said Dr. Jos Esparza, Senior Advisor on HIV Vaccines for the Gates Foundation. "IAVI and its partners have a track record of advancing novel vaccine technologies, and of moving promising concepts rapidly into development."


Contact: Megan Youmans
International AIDS Vaccine Initiative

Related medicine news :

1. Valley Baptist Health System Leveraging TITAN Technology Partners Hosting and Managed Services
2. Jiffy Lube(R) Continues Drive Against Heart Disease with Maintenance Partners for Life Campaign
3. Emeril Lagasse and Planet Green Partner with Whole Foods Market(R) on Innovative New Series
4. YMCA of the USA and McNeil Consumer Healthcare Partner to Promote Health for Older Adults
5. Leading Asbestos-Cancer Group Urges Congress to Partner with Them and Support Funding Provisions in Asbestos Ban Legislation
6. AAPD Announces Partnership With Head Start to Address Childhood Epidemic
7. Novartis and Sony Pictures Television Internationals Latin American Advertising Sales Group Launch Partnership to Create Multi-Media Platform for Breast Cancer Awareness, Detection, and Treatment in Latin America
8. CBS Outernet Partners With Lifeclinic International to Bring Interactive Health Programming and Advertising to Pharmacy Locations Nationwide
9. Avista Capital Partners Enhances Energy Practice With Appointment of Gerhard Kurz
10. Van Andel Institute and Childrens Memorial Research Center of Chicago Form a Partnership to Facilitate Pediatric Research
11. Partners Center for Connected Health and EMC Corporation Launch New Web-Based Remote Monitoring Program to Help Employees Fight Hypertension
Post Your Comments:
(Date:6/26/2016)... ... 2016 , ... PawPaws brand pet supplements owned by Whole Health ... the health of felines. The formula is all-natural and is made from Chinese herbs ... Cat Kidney Support Supplement Soft Chews are Astragalus Root Extract and Rehmannia ...
(Date:6/25/2016)... ... June 25, 2016 , ... The temporary closing of Bruton Memorial Library on June ... , brings up a new, often overlooked aspect of head lice: the parasite’s ability to ... is not a common occurrence, but a necessary one in the event that lice have ...
(Date:6/25/2016)... ... ... On Friday, June 10, Van Mitchell, Secretary of the Maryland Department of Health and ... their exemplary accomplishments in worksite health promotion. , The Wellness at Work Awards took ... the BWI Marriott in Linthicum Heights. iHire was one of 42 businesses to receive ...
(Date:6/24/2016)... ... ... was in a crisis. Her son James, eight, was out of control. Prone to extreme ... “When something upset him, he couldn’t control his emotions,” remembers Marcy. “If there was ... other children and say he was going to kill them. If we were driving ...
(Date:6/24/2016)... ... 2016 , ... Topical BioMedics, Inc, makers of Topricin and MyPainAway Pain Relief Products, join The ... raise to $12 an hour by 2020 and then adjusting it yearly to increase at ... the minimum wage, assure the wage floor does not erode again, and make future increases ...
Breaking Medicine News(10 mins):
(Date:6/26/2016)... 2016 Story Highlights: ... within the health care industry is causing providers to ... , Deloitte offers a suite of solutions for health ... efficient cost optimization: labor resource analysis, revenue cycle optimization ... better outcomes and better economics ...
(Date:6/24/2016)... 2016   Bay Area Lyme Foundation , ... Center for Tick Borne Illness , Harvard Medical ... Hacking Medicine, University of California, Berkeley, and the ... five finalists of Lyme Innovation , the ... 100 scientists, clinicians, researchers, entrepreneurs, and investors from ...
(Date:6/24/2016)... -- Dehaier Medical Systems Ltd. (NASDAQ: DHRM ... sells medical devices and wearable sleep respiratory products in ... agreement with Hongyuan Supply Chain Management Co., Ltd. (hereinafter ... 2016, to develop Dehaier,s new Internet medical technology business. ... leverage Hongyuan Supply Chain,s sales platform to reach Dehaier,s ...
Breaking Medicine Technology: