Navigation Links
IAVI and VaxDesign partner to develop a clinical trial in a test tube for AIDS vaccines
Date:3/3/2008

NEW YORK, March 3, 2008 The International AIDS Vaccine Initiative (IAVI) today announced the first award from its Innovation Fund, a new funding mechanism that will identify and advance potential breakthrough technologies and apply them in the AIDS vaccine research field. This initial project will apply an exciting new technology, a simulated human immune system the size of a small coin, which has the potential to predict human immune responses to new vaccines and drugs.

Under development by VaxDesign Corporation, the Modular IMmune In vitro Construct (MIMIC) system could radically transform AIDS vaccine research and development. The technology uses human immune cells from volunteers to create simulated human immune responses. The MIMIC models reproduce both innate and adaptive immune responses, and exhibit both humoral and cellular immunity. VaxDesign has the capacity to run thousands of these immune simulations per month. IAVI will first test the technology on licensed vaccines for yellow fever and rabies to see whether the immune responses generated in vitro are the same as those elicited in humans who receive the vaccine. If the technology proves successful, IAVI and VaxDesign will further develop and apply it to the screening of novel immunogens for AIDS vaccines at its AIDS Vaccine Development Laboratory in Brooklyn, New York.

Currently, pre-clinical testing of AIDS vaccines is a labor-intensive, lengthy and expensive process. We hope this pioneering technology will enable us to rapidly test AIDS vaccine candidates and predict their effectiveness in humans in a way that has never before been possible with animal models, said Dr. Wayne Koff, IAVIs Senior Vice President for Research and Development. Whats more, by collecting immune cells from different donors, promising vaccine candidates can be tested in diverse populations before they enter human testing.

HIV is a formidable adversary, and evaluating AIDS vaccine candidates will be the ultimate test for our MIMIC technology. We are excited to partner with IAVI to help develop the next generation of AIDS vaccine candidates, said Dr. William Warren, President and CEO of VaxDesign.

Targeted primarily to small- and medium-sized biotechnology companies, IAVIs Innovation Fund will proactively seek out and finance nascent technologies that could help solve some of the main technical and scientific hurdles facing AIDS vaccine research and ultimately lead to the development of more promising candidates for human testing. With an initial three-year commitment of US$10 million, half of which will be financed by a US$5 million grant to IAVI from the Bill & Melinda Gates Foundation, the Innovation Fund will provide rapid and flexible funding in just eight weeks from application to award for pioneering ideas outside the traditional realm of AIDS vaccine research.

Now more than ever, the AIDS vaccine field needs out-of-the-box concepts that can help us develop better candidates for testing, said Dr. Seth Berkley, IAVI President and CEO. VaxDesigns novel technology is one of many hidden gems that we plan to seek out and develop for AIDS vaccine research.

"The Gates Foundation is proud to support IAVI in exploring innovative approaches for addressing the challenges of discovering an effective HIV vaccine," said Dr. Jos Esparza, Senior Advisor on HIV Vaccines for the Gates Foundation. "IAVI and its partners have a track record of advancing novel vaccine technologies, and of moving promising concepts rapidly into development."


'/>"/>

Contact: Megan Youmans
myoumans@iavi.org
212-328-7419
International AIDS Vaccine Initiative
Source:Eurekalert

Related medicine news :

1. Valley Baptist Health System Leveraging TITAN Technology Partners Hosting and Managed Services
2. Jiffy Lube(R) Continues Drive Against Heart Disease with Maintenance Partners for Life Campaign
3. Emeril Lagasse and Planet Green Partner with Whole Foods Market(R) on Innovative New Series
4. YMCA of the USA and McNeil Consumer Healthcare Partner to Promote Health for Older Adults
5. Leading Asbestos-Cancer Group Urges Congress to Partner with Them and Support Funding Provisions in Asbestos Ban Legislation
6. AAPD Announces Partnership With Head Start to Address Childhood Epidemic
7. Novartis and Sony Pictures Television Internationals Latin American Advertising Sales Group Launch Partnership to Create Multi-Media Platform for Breast Cancer Awareness, Detection, and Treatment in Latin America
8. CBS Outernet Partners With Lifeclinic International to Bring Interactive Health Programming and Advertising to Pharmacy Locations Nationwide
9. Avista Capital Partners Enhances Energy Practice With Appointment of Gerhard Kurz
10. Van Andel Institute and Childrens Memorial Research Center of Chicago Form a Partnership to Facilitate Pediatric Research
11. Partners Center for Connected Health and EMC Corporation Launch New Web-Based Remote Monitoring Program to Help Employees Fight Hypertension
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... ... ... On The Brink”: the Christian history of the United States and the loss of ... William Nowers. Captain Nowers and his wife, Millie, have six children, ten grandchildren, ... Navy. Following his career as a naval aviator and carrier pilot, he spent ...
(Date:10/12/2017)... (PRWEB) , ... October 12, 2017 , ... ... products to meet the demand of today’s consumer and regulatory authorities worldwide. From ... probiotic experts and tested to meet the highest standard. , These products ...
(Date:10/12/2017)... ... 12, 2017 , ... Information about the technology: , Otomagnetics ... enable prevention of a major side effect of chemotherapy in children. Cisplatin and ... For cisplatin, hearing loss is FDA listed on-label as a dose limiting toxicity. ...
(Date:10/12/2017)... Chapel, FL (PRWEB) , ... October 12, 2017 , ... ... is holding a treadmill relay – Miles by Moonlight to raise money for the ... donating $300 or more. , Teams will work together to keep their treadmills ...
(Date:10/12/2017)... ... 12, 2017 , ... Vohra Chief Medical Officer Dr. Shark ... skilled nursing facility medical directors and other clinicians at various events in October. ... "At many of these conferences we get to educate other physicians, facility nurses, ...
Breaking Medicine News(10 mins):
(Date:9/23/2017)... , Sept. 22, 2017 Janssen Biotech, ... complete response letter from the U.S. Food and Drug ... approval of sirukumab for the treatment of moderately to ... indicates additional clinical data are needed to further evaluate ... to severely active RA. ...
(Date:9/19/2017)... , Sept. 19, 2017   ZirMed Inc ., a ... today announced that it has been ranked #1 by its ... Book™ Rankings 2017 User Survey. ZirMed was recognized as ... large hospitals and medical centers over 200 beds and holds ... healthcare technology user survey history. ...
(Date:9/12/2017)... , Sept. 12, 2017   EcoVadis , the leading platform for ... the first annual edition of its Global CSR Risk and Performance Index. ... by EcoVadis, based on Scorecard Ratings that analyzed nearly 800,000 data points ... ... ...
Breaking Medicine Technology: