Navigation Links
IADR/AADR publish study on dental caries vaccine
Date:10/25/2011

Alexandria, Va., USA - In a report on a preclinical investigation titled "Flagellin Enhances Saliva IgA Response and Protection of Anti-caries DNA Vaccine," lead author Wei Shi, Wuhan Institute of Virology, Chinese Academy of Sciences, and his team of researchers demonstrate that anti-caries DNA vaccines, including pGJA-P/VAX, are promising for preventing dental caries. However, challenges remain because of the low immunogenicity of DNA vaccines. This study is published in the Journal of Dental Research, the official publication of the International and American Associations for Dental Research (IADR/AADR).

In this study, Shi and team used recombinant flagellin protein derived from Salmonella as mucosal adjuvant for anti-caries DNA vaccine (pGJA-P/VAX) and analyzed the effects of Salmonella protein on the serum surface protein immunoglobulin G and saliva surface protein immunoglobulin A antibody responses, the colonization of Streptococcus mutans (S. mutans) on rodent teeth, and the formation of caries lesions. The results showed that Salmonella promoted the production of surface protein immunoglobulin G in serum and secretory immunoglobulin A in saliva of animals by intranasal immunization with pGJA-P/VAX plus Salmonella.

Furthermore, Shi found that enhanced surface protein immunoglobulin A responses in saliva were associated with inhibition of S. mutans colonization of tooth surfaces and endowed better protection with significant less carious lesions. In conclusion, the study demonstrates that recombinant Salmonella could enhance specific immunoglobulin A responses in saliva and protective ability of pGJA-P/VAX, providing an effective mucosal adjuvant candidate for intranasal immunization of an anti-caries DNA vaccine.

Daniel Smith, The Forsyth Institute, wrote a corresponding perspective article in response to the Shi et al report titled "Prospects in Caries Vaccine D
'/>"/>

Contact: Ingrid L. Thomas
ithomas@iadr.org
703-299-8084
International & American Associations for Dental Research
Source:Eurekalert

Page: 1 2

Related medicine news :

1. IADR/AADR publish proceedings from the AADR Fall Focused Symposium on Salivary Diagnostics
2. IADR/AADR publish study on use of Twitter for public health surveillance of dental pain
3. IADR/AADR Journal of Dental Research releases studies on oral health inequalities in older people
4. IADR/AADR Journal of Dental Research releases large studies on osteonecrosis of the jaw
5. Patient advocacy groups turn to open-access publishing to advance research quest
6. Canadian Journal of Cardiology publishes report on delayed vs. immediate coronary stenting
7. First report of increased safety using simultaneous techniques for cardiac testing published
8. TGen/Virginia G. Piper Cancer Center publish results of new drug for pancreatic cancer patients
9. European Journal of Heart Failure publishes new randomized controlled clinical study of RESPeRATE
10. Oncologists publish HPV manual for physicians
11. Sarcophaga of France (Diptera: Sarcophaidae) published by Pensoft
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/28/2014)... November 29, 2014 BambooFlooringChina.com has been ... bamboo industry. Recently, the business has announced its new ... is offering big discount on these new models. , ... scraped by hands, without carpenter machines involved. It is ... It is great for do-it-yourselfers without hard work on ...
(Date:11/28/2014)... (PRWEB) November 28, 2014 Now that ... http://www.rustysautosalvage.com ), one of the nation's leading cash-for-junk-cars companies, ... salvage vehicles to be more competitive and help bring ... during this festive time of year. , Along with ... owners across the US also deal with large travel ...
(Date:11/28/2014)... Dr. Diane Walder, one of the ... addition of Dr. Bridgit Nolan to her practice as ... having completed her dermatology residency at the University of ... Dr. Nolan to join her practice because ... dermatology. Not only does Dr. Nolan strive to provide ...
(Date:11/28/2014)... Gables, Florida (PRWEB) November 28, 2014 ... Thanksgiving, Turbana and Sendik’s will present Feeding America Eastern ... with Sendik’s Food Market to donate a portion of ... participated in Sendik’s promotion, “7 Days, 7 Ways to ... throughout fall, Fyffes pineapples were two for $4 and ...
(Date:11/28/2014)... Dr. Andrew Campbell, one of the ... of Quintessa Aesthetic Center into a third location in ... N1497 Golf Road in Suite 200 and will open ... new Delafield location will offer a variety of ... filler injectables , micro laser peels, chemical peels, ...
Breaking Medicine News(10 mins):Health News:BambooFlooringChina.com Introduces Its New Strand Woven Bamboo Flooring Collection 2Health News:Rusty's Auto Salvage Increasing Their Cash Offers to Help Drivers Save Throughout the Busy Holiday Season 2Health News:Dr. Diane Walder Welcomes New Cosmetic Dermatologist to Practice 2Health News:Turbana Partners With Sendik's Food Market to Donate $11,500 to Local Hunger-Relief Non-Profit 2Health News:Turbana Partners With Sendik's Food Market to Donate $11,500 to Local Hunger-Relief Non-Profit 3Health News:Dr. Andrew Campbell to Expand Quintessa Aesthetic Center into Delafield 2
... heart’s electrical system, which can be inherited or acquired. The ... an electrocardiogram. People with LQTS are prone to develop an ... or loud noise. This improper rhythm interferes with blood flow ... arrest. A new study shows a specific surgery can reduce ...
... Latest researcher show that a few alcoholic beverages a ... disease in men // with high blood pressure. ... had a significantly lower risk of death by nearly ... a reduced risk of cardiovascular disease death as alcohol ...
... study , Asian investigators suggest physicians should not recommend ... ,A therapy routinely given to newborns to prevent or ... and cognitive functioning by school age.Previous research shows dexamethasone, ... in the short-term and allows for early weaning from ...
... of developing breast cancer are not taking a drug that can ... ,Results of the study showed , postmenopausal women over age 50 ... look abnormal or are diagnosed with abnormal cells in the lobules ... to be offered and accept the use of tamoxifen. Worldwide data ...
... pregnancy is just as harmful to kids as is ... long-term smoke exposure in the womb and after birth ... first 10 years.Researchers studied the effect of smoke exposure ... of the children were at “high risk” for allergies. ...
... Fatigue is the most frequent and distressing problem related ... living and has profound // effects on a patient’s ... months or years. New research finds energy conservation and ... going through drug therapy. ,Energy conservation is ...
Cached Medicine News:
(Date:11/26/2014)... Nov. 26, 2014  Cohen, Placitella & Roth, ... investors who purchased Nymox Pharmaceutical Corporation ("Nymox" or ... period from January 31, 2011 through November 2, ... and certain of its officers and directors publically ... of Sections 10(b) and 20(a) of the Securities ...
(Date:11/26/2014)... 2014   Regulus Therapeutics Inc . (NASDAQ: ... and development of innovative medicines targeting microRNAs, today announced ... CEO of Regulus, will present a company overview at ... at the New York Palace Hotel on Wednesday, December ... be webcast at the time of the presentation and ...
(Date:11/26/2014)... -- Investor-Edge has initiated coverage on the following ... PLC (NASDAQ: HZNP ), Endocyte Inc. (NASDAQ: ... ), and Theravance Inc. (NASDAQ: THRX ). Free ... http://investor-edge.com/register . On Tuesday, November 25, 2014, the ... Industrial Average edged 0.02% lower, to finish the day at ...
Breaking Medicine Technology:Cohen, Placitella & Roth, PC Investigating Nymox Pharmaceutical Corporation for Failing to Disclose Material Information 2Cohen, Placitella & Roth, PC Investigating Nymox Pharmaceutical Corporation for Failing to Disclose Material Information 3Regulus to Present at the 26th Annual Piper Jaffray Healthcare Conference and Genetic Rx Conference 2Regulus to Present at the 26th Annual Piper Jaffray Healthcare Conference and Genetic Rx Conference 3Pharma Stocks Highlight - VIVUS, Horizon Pharma, Endocyte, Johnson and Johnson, and Theravance 2Pharma Stocks Highlight - VIVUS, Horizon Pharma, Endocyte, Johnson and Johnson, and Theravance 3Pharma Stocks Highlight - VIVUS, Horizon Pharma, Endocyte, Johnson and Johnson, and Theravance 4Pharma Stocks Highlight - VIVUS, Horizon Pharma, Endocyte, Johnson and Johnson, and Theravance 5
... UBM Canon Medical Device Media Group,s ... the " Technological Advances in Implantable Devices " virtual event ... 5 p.m. Eastern.  The event is dedicated to cutting-edge trends ... conference and trade show offers the opportunity to learn from ...
... N.J., Feb. 1, 2011 Soligenix, Inc. (OTC Bulletin ... a late-stage biopharmaceutical company, announced today that it has ... and Chief Medical Officer. Dr. Horgan is a board-certified ... experience in the care of patients with inflammatory bowel ...
Cached Medicine Technology:UBM Studios Virtual Event Connects the UBM Canon Medical Device Media Group with the Medical Device Design Community 2UBM Studios Virtual Event Connects the UBM Canon Medical Device Media Group with the Medical Device Design Community 3Soligenix Appoints Kevin Horgan, MD, as Chief Medical Officer 2Soligenix Appoints Kevin Horgan, MD, as Chief Medical Officer 3Soligenix Appoints Kevin Horgan, MD, as Chief Medical Officer 4
... The Series I Instrument program offers state-of-the-art ... profile, while maintaining strength and durability. Low ... in tight joint spaces. Series I instruments ... tip style, size and angle required for ...
... facilitates fast and effective resection of meniscal ... meniscal rim. The flat, crescent-shaped tip has ... the tightest joint spaces. Made in the ... of engineering experience in arthroscopy hand instrument ...
... facilitates fast and effective resection of meniscal ... meniscal rim. The flat, crescent-shaped tip has ... the tightest joint spaces. Made in the ... of engineering experience in arthroscopy hand instrument ...
... The WideBiter Punch series facilitates fast and ... a smooth, anatomically shaped meniscal rim. The ... profile to access even the tightest joint ... California, Inc., 20 years of engineering experience ...
Medicine Products: