Navigation Links
IADR/AADR publish study on dental caries vaccine
Date:10/25/2011

Alexandria, Va., USA - In a report on a preclinical investigation titled "Flagellin Enhances Saliva IgA Response and Protection of Anti-caries DNA Vaccine," lead author Wei Shi, Wuhan Institute of Virology, Chinese Academy of Sciences, and his team of researchers demonstrate that anti-caries DNA vaccines, including pGJA-P/VAX, are promising for preventing dental caries. However, challenges remain because of the low immunogenicity of DNA vaccines. This study is published in the Journal of Dental Research, the official publication of the International and American Associations for Dental Research (IADR/AADR).

In this study, Shi and team used recombinant flagellin protein derived from Salmonella as mucosal adjuvant for anti-caries DNA vaccine (pGJA-P/VAX) and analyzed the effects of Salmonella protein on the serum surface protein immunoglobulin G and saliva surface protein immunoglobulin A antibody responses, the colonization of Streptococcus mutans (S. mutans) on rodent teeth, and the formation of caries lesions. The results showed that Salmonella promoted the production of surface protein immunoglobulin G in serum and secretory immunoglobulin A in saliva of animals by intranasal immunization with pGJA-P/VAX plus Salmonella.

Furthermore, Shi found that enhanced surface protein immunoglobulin A responses in saliva were associated with inhibition of S. mutans colonization of tooth surfaces and endowed better protection with significant less carious lesions. In conclusion, the study demonstrates that recombinant Salmonella could enhance specific immunoglobulin A responses in saliva and protective ability of pGJA-P/VAX, providing an effective mucosal adjuvant candidate for intranasal immunization of an anti-caries DNA vaccine.

Daniel Smith, The Forsyth Institute, wrote a corresponding perspective article in response to the Shi et al report titled "Prospects in Caries Vaccine D
'/>"/>

Contact: Ingrid L. Thomas
ithomas@iadr.org
703-299-8084
International & American Associations for Dental Research
Source:Eurekalert

Page: 1 2

Related medicine news :

1. IADR/AADR publish proceedings from the AADR Fall Focused Symposium on Salivary Diagnostics
2. IADR/AADR publish study on use of Twitter for public health surveillance of dental pain
3. IADR/AADR Journal of Dental Research releases studies on oral health inequalities in older people
4. IADR/AADR Journal of Dental Research releases large studies on osteonecrosis of the jaw
5. Patient advocacy groups turn to open-access publishing to advance research quest
6. Canadian Journal of Cardiology publishes report on delayed vs. immediate coronary stenting
7. First report of increased safety using simultaneous techniques for cardiac testing published
8. TGen/Virginia G. Piper Cancer Center publish results of new drug for pancreatic cancer patients
9. European Journal of Heart Failure publishes new randomized controlled clinical study of RESPeRATE
10. Oncologists publish HPV manual for physicians
11. Sarcophaga of France (Diptera: Sarcophaidae) published by Pensoft
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/31/2015)... ... 31, 2015 , ... NSF International, an independent global organization ... sciences and consumer goods industries, has recognized Clean Water Systems & Stores Inc ... Manganese Dioxide. , Developed by a team of scientists and industry experts NSF/ANSI ...
(Date:8/31/2015)... ... August 31, 2015 , ... ... its physician related services by test marketing a doctor note service to be ... will be charged under $50 for each generated excuse, much less than the ...
(Date:8/30/2015)... Aliso Viejo, CA (PRWEB) , ... August 30, 2015 , ... ... for Final Cut Pro X. ProTrailer Party contains 30 styled and detailed presets, ... kinetic animations to reveal each title, these titles will help film makers save time ...
(Date:8/30/2015)... ... August 31, 2015 , ... Negotiating an FDA Import Hold Crisis:, ... 3:00 p.m. EDT, http://www.fdanews.com/importholdcrisis , US authorities are holding imports more than ... from India. , With alerts on an uptick and a new final rule, having ...
(Date:8/30/2015)... ... August 30, 2015 , ... The ... that Partner Daniel M. Kotin was recently elected to membership in the American ... highest degree of peer recognition and outstanding professionalism. , ABOTA is an ...
Breaking Medicine News(10 mins):Health News:NSF International Has Recognized Clean Water Systems & Stores Inc Facility 2Health News:NSF International Has Recognized Clean Water Systems & Stores Inc Facility 3Health News:FCPX Effects Developer Releases ProTrailer Party for Final Cut Pro X 2Health News:FDAnews Announces — Negotiating an FDA Import Hold Crisis: Strategies for Challenging FDA Findings Webinar, Sept. 22, 2015 2Health News:FDAnews Announces — Negotiating an FDA Import Hold Crisis: Strategies for Challenging FDA Findings Webinar, Sept. 22, 2015 3Health News:Chicago Personal Injury Lawyer Daniel M. Kotin Elected to the American Board of Trial Advocates 2Health News:Chicago Personal Injury Lawyer Daniel M. Kotin Elected to the American Board of Trial Advocates 3
... Smoke-Free in 90 Days, HARRISBURG, Pa., June 13 ... Clean Indoor Air Act, which will protect,Pennsylvanians from the ... most public places, including restaurants,workplaces and a portion of ... persistence of advocates and,legislators who refused to quit working ...
... sickened in the ongoing salmonella outbreak , , FRIDAY, June ... reported illnesses from salmonella-tainted tomatoes continued to climb, U.S. ... of the contamination. , The number of people sickened ... states, with 25 hospitalizations, health officials announced Thursday. Six ...
... Paris, France, Friday 13 June 2008: Certain cardiovascular disease (CVD) ... similar effect on an RA patient,s risk of experiencing myocardial ... today at EULAR 2008, the Annual Congress of the European ... researchers studied 10,870 RA patients for a median of 24 ...
... bioengineers and bioscientists at Rice University and Radboud University ... bone tissue by sprinkling stick-like nanoparticles throughout the porous ... is available online and slated to appear in the ... the burgeoning field of tissue engineering. The new discipline ...
... Award, MINNEAPOLIS, June 13 Minneapolis-based Courage ... its deadline,for nominations for its annual Jay and ... by Courage Center to people with disabilities who ... deadline is,Thursday, July 3, 2008., The Phillips ...
... Paris, France, Friday 13 June 2008: Two new initiatives ... patient participation were presented today at EULAR 2008, the ... Paris, France. , The RAID disease impact ... and validation of the EULAR patient-derived Rheumatoid Arthritis Impact ...
Cached Medicine News:Health News:Governor Rendell Signs Bill Restricting Smoking in Most Public Places in Pennsylvania 2Health News:Governor Rendell Signs Bill Restricting Smoking in Most Public Places in Pennsylvania 3Health News:Source of Contaminated Tomatoes Still Unknown: FDA 2Health News:Source of Contaminated Tomatoes Still Unknown: FDA 3Health News:Source of Contaminated Tomatoes Still Unknown: FDA 4Health News:Rheumatoid arthritis factors equal to cardiovascular factors in risk of severe cardiovascular events 2Health News:Nanoparticles aid bone growth 2Health News:Courage Center Extends Nomination Deadline for 2008 Phillips Awards to July 3 2Health News:New insight into RA patient priorities and motivators for clinical trial involvement 2Health News:New insight into RA patient priorities and motivators for clinical trial involvement 3
(Date:8/28/2015)... FARUM, Denmark and ATLANTA ... July 31, 2015 the US Food and Drug Administration (FDA) ... Major Depressive Disorder in adult patients who have failed to ... episode. TMS is a non-invasive technique for stimulating neural tissue ... from Major Depressive Disorder. The procedure has been proven safe ...
(Date:8/28/2015)... August 28, 2015 The report "Eubiotics Market by ... Poultry, Ruminant, and Aquaculture), & by Region ( North ... Asia-Pacific , and Rest of the World) - Global ... market for Eubiotics was valued at USD 4.62 Billion in ... 2020, at a CAGR of 7.4% from 2015 to 2020. ...
(Date:8/28/2015)... SAN FRANCISCO , August 28, 2015 ... is expected to reach USD 49.12 billion by 2020, ... 2020, according to a new report by Grand View ... an estimated CAGR of 49.7% from 2014 to 2020. ... Growing aging population along with rising incidences of ...
Breaking Medicine Technology:Therapy System for Treating Major Depressive Disorder Receives FDA Clearance 2Therapy System for Treating Major Depressive Disorder Receives FDA Clearance 3Eubiotics Market Worth 7.05 Billion USD by 2020 2Eubiotics Market Worth 7.05 Billion USD by 2020 3Eubiotics Market Worth 7.05 Billion USD by 2020 4Eubiotics Market Worth 7.05 Billion USD by 2020 5mHealth Market is Expected to Reach $49.12 Billion By 2020: Grand View Research, Inc. 2mHealth Market is Expected to Reach $49.12 Billion By 2020: Grand View Research, Inc. 3mHealth Market is Expected to Reach $49.12 Billion By 2020: Grand View Research, Inc. 4mHealth Market is Expected to Reach $49.12 Billion By 2020: Grand View Research, Inc. 5
... 6, 2011 Bayer HealthCare Pharmaceuticals Inc. today announced ... SYM ptomatic P rostate CA ncer) ... exclusively licensed from Algeta ASA, in patients with castration-resistant ... endpoint by significantly improving overall survival.  Based on a ...
... Eli Lilly and Company (NYSE: LLY ) ... ALIMTA® (pemetrexed for injection) in the continuation maintenance setting, ... time a patient is alive without their disease worsening, ... called advanced nonsquamous non-small cell lung cancer (NSCLC). ...
Cached Medicine Technology:Bayer's Investigational Compound Radium-223 Chloride Met its Primary Endpoint of Significantly Improving Overall Survival in a Phase III Trial in Patients with Castration-Resistant Prostate Cancer That Has Spread to the Bone 2Bayer's Investigational Compound Radium-223 Chloride Met its Primary Endpoint of Significantly Improving Overall Survival in a Phase III Trial in Patients with Castration-Resistant Prostate Cancer That Has Spread to the Bone 3New Study Released Today Showed Patients With Deadly Form of Lung Cancer Lived Longer Without Disease Worsening 2New Study Released Today Showed Patients With Deadly Form of Lung Cancer Lived Longer Without Disease Worsening 3New Study Released Today Showed Patients With Deadly Form of Lung Cancer Lived Longer Without Disease Worsening 4New Study Released Today Showed Patients With Deadly Form of Lung Cancer Lived Longer Without Disease Worsening 5New Study Released Today Showed Patients With Deadly Form of Lung Cancer Lived Longer Without Disease Worsening 6New Study Released Today Showed Patients With Deadly Form of Lung Cancer Lived Longer Without Disease Worsening 7
Duckbill type, sharp. 3 mm x 8 mm curved blade. Octagonal handle....
10 mm wide tip....
9 mm wide tip. 35 mm from angle to tip....
Designated most popular model or size. 4 mm wide tip....
Medicine Products: