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I-SPY 2 study speeds up treatment for breast cancer
Date:11/19/2010

AURORA, Colo. (Nov. 16, 2010) A clinical trial that aims to speed up the study of new treatments for certain subtypes of breast cancer now has a designated study site at the Diane O'Connor Thompson Breast Center at the University of Colorado Hospital. This study, called I-SPY 2, (Investigation of Serial Studies to Predict Your Therapeutic Response with Imaging and Molecular Analysis 2) will evaluate which medical treatments are most effective for different types of tumors. So-called "personalized medicine" in cancer is gaining ground as new drugs are developed that target known gene mutations. In the past, "it could take hundreds of thousands of dollars and several years to study a single drug", says Anthony Elias, MD, breast cancer program director and associate director for clinical research at the University of Colorado Cancer Center (UCCC). "This trial sets up a new kind of mechanism that lets us test multiple drugs at nearly two dozen cancer centers at once, starting with three drugs that have been shown to target known gene abnormalities in common subtypes of breast cancer," Elias says. "Rapid discovery is the name of the game."

UCCC is participating with 20 leading cancer centers in the United States and Canada recruiting and treating patients as part of this large-scale clinical trial aimed at quickly developing new breast cancer drugs. Women who participate will have a new diagnosis of breast cancer and can not have received any previous treatment including surgery. Their breast tumor biopsy is tested using three high-tech biological screening tools. The results will tell doctors what gene mutations are driving their cancer. If the gene testing results show a tumor it may be less likely to respond to currently available chemotherapy agents, the patient will be invited to enter the drug trial.

"HER2 and triple negative breast cancers are usually bad actors, but some of the ER positive breast cancers can also be aggressive," Elias says. "E
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Contact: Jackie Brinkman
jackie.brinkman@ucdenver.edu
303-724-1525
University of Colorado Denver
Source:Eurekalert

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