Navigation Links
Hypertension may predict dementia in older adults with certain cognitive deficits
Date:2/8/2010

High blood pressure appears to predict the progression to dementia in older adults with impaired executive functions (ability to organize thoughts and make decisions) but not in those with memory dysfunction, according to a report in the February issue of Archives of Neurology, one of the JAMA/Archives journals.

"Although midlife hypertension has been confirmed as a risk factor for the development of dementia in late life, there have been conflicting findings about the role of late-life hypertension," the authors write as background information in the article. Individuals with mild cognitive (thinking, learning and memory) impairmentthe state between aging-related brain changes and fully developed dementiamay experience deficits in different domains. For instance, some have impairments only in memory function and are more likely to develop Alzheimer's disease, whereas those whose impairment follows a stroke or other vascular (blood vesselrelated) event often experience executive dysfunction.

"Because hypertension is a major risk factor for vascular brain diseases and vascular cognitive impairment, we postulated that the cognitive domain of dysfunction may be the crucial factor that determines the association between hypertension and cognitive deterioration," the authors write. To test this hypothesis, Shahram Oveisgharan, M.D., of University of Western Ontario, Canada, and Isfahan University of Medical Sciences, Isfahan, Iran, and Vladimir Hachinski, M.D., F.R.C.P.C., D.Sc.(Lond)., also of University of Western Ontario, studied 990 older adults (average age 83) with cognitive impairment but no dementia.

Over a five-year follow-up period, dementia developed at approximately the same rate among participants with and without hypertension (59.5 percent of individuals with high blood pressure vs. 64.2 percent of those without). A similar pattern was observed among those with memory dysfunction alone and with both memory and executive dysfunction. However, among patients with executive dysfunction only, presence of hypertension was associated with an increased risk of developing dementia (57.7 percent of those with high blood pressure progressed to dementia, vs. 28 percent of those without).

"This study may have profound implications for community dwellers with cognitive impairment, no dementia," the authors write. "Worldwide, neurologic disorders are the most frequent cause of disability-adjusted life years; among these, cerebrovascular disease is the most common risk factor, and dementia is the second most common. There is no preventive or therapeutic intervention to mitigate this public health burden."

"We show herein that the presence of hypertension predicts progression to dementia in a subgroup of about one-third of subjects with cognitive impairment, no dementia," they conclude. "Control of hypertension in this population could decrease by one-half the projected 50-percent five-year rate of progression to dementia."


'/>"/>

Contact: Kathy Wallis
kathy.wallis@schulich.uwo.ca
519-661-2111 x81136
JAMA and Archives Journals
Source:Eurekalert

Related medicine news :

1. Hypertension linked to dementia in older women
2. PharmaSmart International, Inc and AstraZeneca Canada Enter Into Strategic Partnership to Elevate Pharmacy Based Hypertension Management
3. MyCareTeam™ Significantly Extends Diabetes Offering to Include Management of Hypertension, Obesity, and Congestive Heart Failure
4. UC San Diego researchers reverse pulmonary arterial hypertension in mouse models
5. Clues to Hypertension in Kids May Be Seen in Bones
6. Mayo Clinic Health Manager Now Includes Features for People Managing Hypertension and High Cholesterol
7. Drug Offers Hope Against Tough-to-Treat Hypertension
8. Whole Grains, Bran May Fight Hypertension in Men
9. Hypertension Linked to Thinking Problems in Middle Age
10. Scientists Learn How Cancer Drugs Cause Hypertension
11. FDA Approves TYVASO (Treprostinil) Inhalation Solution for the Treatment of Pulmonary Arterial Hypertension
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/25/2017)... ... ... Swissray is pleased to announce the release of the ELITE DXA, a new bone ... scan window, which is more than double that of existing bone densitometers. Historically, subjects ... an accurate total body bone density or body composition study. The ELITE DXA ...
(Date:3/24/2017)... , ... March 24, 2017 , ... Digital Scientists, a ... to announce the opening of a Greenville, South Carolina location. The lab ... progress in Greenville. , “We’ve been working with South Carolina clients for years from ...
(Date:3/24/2017)... ... March 24, 2017 , ... Mlynarek Insurance ... to families and business owners across eastern Michigan, is connecting with the Oxford/Orion ... with financial difficulties. , The Oxford/Orion FISH Food Pantry works to ensure homeless, ...
(Date:3/24/2017)... ... March 24, 2017 , ... On June 9, 2017, Cassie ... Litigation seminar in Chicago, Illinois. She will present on: , Filing Benefit ... under ERISA involve claims for long-term disability benefits. This session will address ...
(Date:3/24/2017)... ... March 24, 2017 , ... Judy Buchanan, co-owner of ... Frederick, MD. Judy says, “I am passionate about sharing Reiki as a holistic, ... difficult and challenging time.” , A Certified Medical Reiki™ Master trained by Raven ...
Breaking Medicine News(10 mins):
(Date:3/24/2017)... 2017 Research and Markets has announced the ... Report" report to their offering. ... The report provides separate comprehensive analytics for the US, ... , Asia-Pacific , Latin America ... the period 2015 through 2022. Also, a six-year historic analysis is provided ...
(Date:3/24/2017)... 2017  HealthMine surveys with 9,250 insured consumers fielded ... plan members want help from their plans in five ... their health, 2) help closing gaps in care, 3) ... and 5) relevant, real-time guidance. Meeting these needs is ... A Reason to Stay Engaged ...
(Date:3/24/2017)... GENEVA , March 24, 2017 ... efforts to develop sutezolid as effective response to infectious ... TB Alliance and the Medicines Patent Pool (MPP) announced ... an antibiotic drug candidate which demonstrated encouraging results in ... sutezolid in combination with other TB drugs and follows ...
Breaking Medicine Technology: