Navigation Links
Hypertension, Not Blood Pressure Drugs, Linked to Birth Defects
Date:10/19/2011

WEDNESDAY, Oct. 19 (HealthDay News) -- Although pregnant women who have high blood pressure face a higher risk that their baby will be born with birth defects, new research indicates that the medications typically used to treat the condition will not raise that risk any further.

The finding suggests that the widely used class of high blood pressure medications known as angiotensin-converting enzyme (ACE) inhibitors are safe to use during the first trimester.

Published online Oct. 18 in the BMJ, the study results fill in a piece of the puzzle regarding the use of such medications, given that prior research had indicated that ACE inhibitors can be toxic to a fetus if used in the second and/or third trimester of pregnancy.

"Our finding suggests that it is likely the underlying hypertension, rather than use of antihypertensive drugs in the first trimester, that increases the risk of birth defects in offspring," the study authors, led by Dr. De-Kun Li of the Kaiser Foundation Research Institute in California, said in a news release from the journal.

The authors came to their conclusion after analyzing data collected between 1995 and 2008 on nearly 466,000 pairings of mothers and their children living in northern California.

The bottom line: pregnant women with high blood pressure bore a similar risk that their baby would be born with some type of birth defect whether or not they were prescribed an ACE inhibitor, another kind of high blood pressure control medication or nothing at all.

The authors noted that having high blood pressure during the first trimester did raise the birth defect risk relative to pregnant women with no high blood pressure. But their analysis pointed to the condition itself, rather than the treatment, as the primary cause for concern.

Dr. Arun Jeyabalan, an assistant professor in the division of maternal-fetal medicine in the department of obstetrics, gynecology and reproductive sciences at the University of Pittsburgh's Magee Women's Hospital, described the findings as "reassuring" yet "limited."

"The finding that there is a lack of increase in birth defects associated with [high blood pressure] medications is certainly reassuring," she noted. "But although the study is large, which is a strength, they don't have complete data on other medications that were used or on other conditions that are associated with, or may have caused, the hypertension," she added.

"So, I would say that there are some pieces of information that are missing," Jeyabalan cautioned. "And that would make me hesitate to come to the blanket conclusion they make. More research is needed, that will have more detail about the other underlying medical issues and maternal characteristics, as well as of all the medications that have been used or not used during the pregnancy."

More information

For more on pregnancy and high blood pressure, visit the March of Dimes.

-- Alan Mozes

SOURCES: Arun Jeyabalan, M.D., assistant professor, division of maternal-fetal medicine, department of obstetrics, gynecology and reproductive sciences, Magee Women's Hospital, University of Pittsburgh; BMJ, news release, Oct. 18, 2011


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. MSU researcher identifies links between hypertension, bipolar disorders
2. Obesity, hypertension, alcohol and diuretic use -- gout risk factors for women
3. New U of M start-up may save lives of victims of massive blood loss and trauma
4. Blood Type May Affect Survival After Heart Bypass
5. Stem cells from cord blood could help repair damaged heart muscle
6. Study Suggests Origins of Pregnancy-Linked High Blood Pressure
7. Experts find continuous glucose monitoring beneficial in maintaining target blood glucose levels
8. Restless legs syndrome may raise high blood pressure risk in middle-aged women
9. Restless Legs Syndrome May Boost Blood Pressure
10. Diabetes Education Seems to Help Improve Blood Sugar Control
11. Blood Infection Costliest U.S. Hospital Condition: Report
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Hypertension, Not Blood Pressure Drugs, Linked to Birth Defects 
(Date:6/25/2017)... ... , ... Republicans in the United States Senate on Thursday released their ... Act. It differs significantly from the American Health Care Act, which the House passed ... the House will have to take up the Senate version as-is, if it passes. ...
(Date:6/25/2017)... ... June 25, 2017 , ... With a heatwave currently bearing down on Northern California ... at the pool. Being swimsuit ready is easy with laser hair removal. , The ... can be a burdensome routine when all you want to do is get out, dive ...
(Date:6/24/2017)... PA (PRWEB) , ... June 24, 2017 , ... ... held in Erie, PA at the Sheraton Erie Bayfront and Erie Convention Center ... evidence based medicine experience, exhibits, a student quiz bowl, award and scholarship presentations, ...
(Date:6/24/2017)... ... June 24, 2017 , ... Doorknobs are for convenience, deadbolts are for security. ... guard dog or having an alarm system installed. But unless there is a working ... Frenkel, owner of TX Premier Locksmith in Killeen, TX says: “In the majority of ...
(Date:6/23/2017)... ... , ... By scoring 100% for fiscal management and accountability, the Arthritis National ... evaluator, Charity Navigator, validating ANRF's work as a top charity in America. , This ... and earns ANRF a spot on their “ 10 Charities Worth Watching ” list ...
Breaking Medicine News(10 mins):
(Date:6/8/2017)...   Responding to Heath Ledger,s father,s recent ... singer Chris Cornell in May, the mental health ... free online psychiatric drug side effects search ... psychotropic drug risks. The father of the ... accidental overdose, has called for tighter rules on prescription drugs. ...
(Date:6/5/2017)... Cincinnati location of Diplomat Specialty Infusion ... been awarded a Top Workplaces 2017 honor by ... on an employee survey administered by WorkplaceDynamics, LLC, a research ... measures several aspects of workplace culture, including alignment, execution, and ... ...
(Date:5/30/2017)... DarioHealth Corp. (NASDAQ: DRIO), a leading global digital health ... it will be presenting at the 7th annual LD Micro Invitational ... Raphael , CEO, of DarioHealth will be giving the presentation and ... June 6th & 7th, 2017 at the Luxe Sunset Bel Air ... space. About LD Micro LD ...
Breaking Medicine Technology: