Navigation Links
Hypertension, Not Blood Pressure Drugs, Linked to Birth Defects
Date:10/19/2011

WEDNESDAY, Oct. 19 (HealthDay News) -- Although pregnant women who have high blood pressure face a higher risk that their baby will be born with birth defects, new research indicates that the medications typically used to treat the condition will not raise that risk any further.

The finding suggests that the widely used class of high blood pressure medications known as angiotensin-converting enzyme (ACE) inhibitors are safe to use during the first trimester.

Published online Oct. 18 in the BMJ, the study results fill in a piece of the puzzle regarding the use of such medications, given that prior research had indicated that ACE inhibitors can be toxic to a fetus if used in the second and/or third trimester of pregnancy.

"Our finding suggests that it is likely the underlying hypertension, rather than use of antihypertensive drugs in the first trimester, that increases the risk of birth defects in offspring," the study authors, led by Dr. De-Kun Li of the Kaiser Foundation Research Institute in California, said in a news release from the journal.

The authors came to their conclusion after analyzing data collected between 1995 and 2008 on nearly 466,000 pairings of mothers and their children living in northern California.

The bottom line: pregnant women with high blood pressure bore a similar risk that their baby would be born with some type of birth defect whether or not they were prescribed an ACE inhibitor, another kind of high blood pressure control medication or nothing at all.

The authors noted that having high blood pressure during the first trimester did raise the birth defect risk relative to pregnant women with no high blood pressure. But their analysis pointed to the condition itself, rather than the treatment, as the primary cause for concern.

Dr. Arun Jeyabalan, an assistant professor in the division of maternal-fetal medicine in the department of obstetrics, gynecology and reproductive sciences at the University of Pittsburgh's Magee Women's Hospital, described the findings as "reassuring" yet "limited."

"The finding that there is a lack of increase in birth defects associated with [high blood pressure] medications is certainly reassuring," she noted. "But although the study is large, which is a strength, they don't have complete data on other medications that were used or on other conditions that are associated with, or may have caused, the hypertension," she added.

"So, I would say that there are some pieces of information that are missing," Jeyabalan cautioned. "And that would make me hesitate to come to the blanket conclusion they make. More research is needed, that will have more detail about the other underlying medical issues and maternal characteristics, as well as of all the medications that have been used or not used during the pregnancy."

More information

For more on pregnancy and high blood pressure, visit the March of Dimes.

-- Alan Mozes

SOURCES: Arun Jeyabalan, M.D., assistant professor, division of maternal-fetal medicine, department of obstetrics, gynecology and reproductive sciences, Magee Women's Hospital, University of Pittsburgh; BMJ, news release, Oct. 18, 2011


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. MSU researcher identifies links between hypertension, bipolar disorders
2. Obesity, hypertension, alcohol and diuretic use -- gout risk factors for women
3. New U of M start-up may save lives of victims of massive blood loss and trauma
4. Blood Type May Affect Survival After Heart Bypass
5. Stem cells from cord blood could help repair damaged heart muscle
6. Study Suggests Origins of Pregnancy-Linked High Blood Pressure
7. Experts find continuous glucose monitoring beneficial in maintaining target blood glucose levels
8. Restless legs syndrome may raise high blood pressure risk in middle-aged women
9. Restless Legs Syndrome May Boost Blood Pressure
10. Diabetes Education Seems to Help Improve Blood Sugar Control
11. Blood Infection Costliest U.S. Hospital Condition: Report
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Hypertension, Not Blood Pressure Drugs, Linked to Birth Defects 
(Date:12/2/2016)... (PRWEB) , ... December 02, 2016 , ... On Dec. ... the Hard Rock Hotel San Diego honoring the 2016 MPN Heroes—eight individuals who have ... (MPNs) by going above and beyond the standard of care, demonstrating leadership within the ...
(Date:12/2/2016)... ... , ... Center for Autism and Related Disorders (CARD) Portland today announced plans ... (ASD) and other developmental disabilities. The group, which is being launched with the help ... opportunity to share stories and advice, seek help, and continue their education on how ...
(Date:12/2/2016)... , ... December 02, 2016 , ... ... Beverly Hills, California, will be included in the 2016 “Guide to America’s Top ... professionals based on the amalgamation of their education, experience, and professional associations. ...
(Date:12/2/2016)... (PRWEB) , ... December 02, 2016 , ... ... veterinarian diagnostic imaging systems and the first company to offer robotic ... a Heart at their tradeshow booth # 941 for the American Association of ...
(Date:12/2/2016)... CA (PRWEB) , ... December 02, 2016 , ... ... care journeys, announced today that it has raised $6.0 million in an initial ... by Clarify Health’s conviction that patients and their caregivers can receive far better ...
Breaking Medicine News(10 mins):
(Date:12/2/2016)... -- bioLytical Laboratories, ein Weltführer bei schnellen Tests für Infektionskrankheiten, ... von Kenia eingeführt. Continue Reading ... ... (PRNewsFoto/bioLytical Laboratories) ... http://photos.prnewswire.com/prnh/20161201/444905 ) bioLytical wurde durch die Clinton ...
(Date:12/2/2016)... 2, 2016 Lianluo Smart Limited (Nasdaq: ... Company") which develops, markets and sells medical devices ... China and international markets, recently attended ... Treatment New Progress Forum, co-hosted by the Institute ... , Guangdong Provincial People,s Hospital and Cardiology ...
(Date:12/2/2016)... Research and Markets has announced the addition of Jain PharmaBiotech,s ... Companies" to their offering. ... , , Drug delivery ... value of drug delivery technologies and the anticancer drugs are difficult ... organs involved and the types of cancer as well as according ...
Breaking Medicine Technology: