Navigation Links
Hyperoxia may slow formation of wrinkles
Date:6/29/2010

Bethesda, Md. (June 29, 2010) It's no secret that UVB radiation from the sun causes wrinkles. However, a Japanese study published in the American Journal of PhysiologyRegulatory, Integrative and Comparative Physiology (http://ajpregu.physiology.org/) indicates that oxygen may help combat the formation of wrinkles by lessening tissue damage done by UVB rays.

In the study, mice who were placed in an oxygen chamber after exposure to UVB radiation developed fewer wrinkles and showed fewer signs of tissue damage than mice who were exposed to UVB radiation alone.

UVB and Skin Damage

The readily visible hallmarks of skin damage are wrinkles and a thickening in the outer layer of skin, the epidermis. Together they make skin look and feel leathery.

The "sun-weathered" look is merely evidence of what is happening on a molecular level beneath the skin's surface, however. When skin is repeatedly exposed to UVB radiation, new blood vessels form from existing blood vessels in the skin in a process called cutaneous angiogenesis. Several transcription factorsproteins that bind to specific DNA sequencesplay a role in angiogenesis, including hypoxia inducible factor (HIF-1) and its subunit HIF-1 α and vascular endothelial growth factor (VEGF).

The Study

In the study, the researchers assigned 24 hairless mice into three groups. The control group, the UVB group, and the UVB+HO group. The control group was not exposed to UVB radiation. Both the UVB and the UVB+HO groups were exposed to UVB radiation by a special fluorescent lamp three times per week for five weeks, but the UVB+HO mice were placed in an oxygen chamber for two hours after each irradiation.

Over the five weeks, the mice in the UVB and UVB+HO groups developed wrinkles, but the wrinkles were more pronounced in the UVB group. Likewise, both the UVB and UVB+HO group experienced increased epidermal thickness, but again, this result was more pronounced in the UVB group.

There were differences between the UVB and UVB+HO groups on a molecular level, as well. The level of HIF-1α increased significantly in the UVB group compared to the control group, whereas there was no significant increase in the UVB+HO group. VEGF levels increased in both the UVB and the UVB+HO groups, but the UVB+HO group experienced a smaller increase. This implies that oxygen and the excess amount of oxygen in body tissue, or hyperoxia, that it provides can lessen skin damage and wrinkling caused by UVB radiation.

A Surprising Result

The study had one surprising result, as well, one involving molecules called matrix metalloproteinases (MMPs). Like HIF-1 α and VEGF, they play a role in angiogenesis. Two MMPs in particular, MMP-2 and MMP-9, are thought to accelerate wrinkling by degrading the outer components of cells. However, in this study, MMP-2 levels tended to decrease with exposure to UVB radiation and MMP-9 levels remained the same, even in mice who did not receive oxygen. According to the researchers, this implies that MMP-2 and MMP-9 are not main factors in wrinkle formation and angiogenesis, at least in the early stages of skin damage caused by UVB radiation.

The implications for humans remain to be seen, and the researchers note that further studies are required. In the meantime, the best way to avoid wrinkles caused by UVB radiation is to wear sunscreen.


'/>"/>

Contact: Donna Krupa
DKrupa@the-aps.org
301-634-7209
American Physiological Society
Source:Eurekalert

Related medicine news :

1. Drug Information Association (DIA) Announces New Clinical Safety and Pharmacovigilance Certificate Program
2. Sunquest Information Systems Supports New Meaningful Use Guidelines for Laboratories Transferring H1N1 Results
3. FDA Consumer Health Information - FDAs MedWatch Safety Alerts: January 2010
4. Smoker alert: Information you can live with
5. BridgeGate and Information Builders form Strategic Partnership to Extend Integration Capability for Healthcare and Government Markets
6. FDA Consumer Health Information - Eat for a Healthy Heart
7. Brain Thermostat May Suppress Non-Essential Information
8. Discovery Healths New Year, New You Week Brings Transformation and Inspiration to the Resolution Season
9. Immune memory formation seen in early stages of viral infection
10. Sunquest Information Systems Enters Into Business Relationship with Valley Medical Center of Washington
11. Brain scientists extend map of fear memory formation
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/25/2016)... ... , ... "With 30 hand-drawn hand gesture animations, FCPX users can easily customize ... Pixel Film Studios. , ProHand Cartoon’s package transforms over 1,300 hand-drawn pictures into ... Simply select a ProHand generator and drag it above media or text in the ...
(Date:6/25/2016)... , ... June 25, 2016 , ... On Friday, June ... a Bronze Wellness at Work award to iHire in recognition of their exemplary accomplishments ... of the 7th annual Maryland Workplace Health & Wellness Symposium at the BWI Marriott ...
(Date:6/24/2016)... ... 2016 , ... June 19, 2016 is World Sickle Cell Observance Day. In ... benefits of holistic treatments, Serenity Recovery Center of Marne, Michigan, has issued ... Sickle Cell Disease (SCD) is a disorder of the red blood cells, which can ...
(Date:6/24/2016)... Francisco, CA (PRWEB) , ... June 24, 2016 ... ... CitiDent, is now offering micro-osteoperforation for accelerated orthodontic treatment. Dr. Cheng has extensive ... self-ligating Damon brackets , AcceleDent, and accelerated osteogenic orthodontics. , Micro-osteoperforation ...
(Date:6/24/2016)... ... June 24, 2016 , ... EB ... Decision Making in Emergency Medicine conference in Ponte Vedra Beach, FL. The awards ... in Emergency Medicine Practice and Pediatric Emergency Medicine Practice. , “With ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... Any dentist who has made an implant supported ... Many of them do not even offer this as a ... laboratory costs involved. And those who ARE able to offer ... high cost that the majority of today,s patients would not ... Zadeh , founder of Dental Evolutions Inc. and inventor of ...
(Date:6/23/2016)... June 23, 2016 Roche (SIX: RO, ROG; ... for its Elecsys BRAHMS PCT (procalcitonin) assay as a ... septic shock. With this clearance, Roche is the first ... integrated solution for sepsis risk assessment and management. ... infection and PCT levels in blood can aid clinicians ...
(Date:6/23/2016)... June 23, 2016 Research and Markets ... Issue 52" report to their offering. ... treatment creates a favourable commercial environment for MedImmune to enter. ... base that will serve to drive considerable growth for effective ... serve to cap sales considerably, but development is still in ...
Breaking Medicine Technology: