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Hyperfractionated RT improves local-regional control for patients with head and neck cancer
Date:5/1/2014

ld in the afternoon during the last 12 days of treatment). All treatments were delivered five days a week, and twice-daily treatments had a minimum interfraction interval of six hours.

Local-regional failure was analyzed at two years, at five years and at last follow-up. As of October 1, 2012, the median follow-up was 14.1 years. Toxicity and disease recurrence assessment was conducted weekly while patients received radiation therapy; four months after treatment completion; every three months for one-and-a-half years; every four months between one-and-a-half and three years; every six months in years three to five; and then annually until death. Toxicities occurring ≤180 days from the start of radiation were considered acute, and those occurring >180 days after radiation therapy were considered late effects. At the time of this report's analysis in October 2012, 52.7 percent of patients (568) had experienced local-regional failure, with 97.4 percent (553) occurring within the first five years.

Secondary primary cancers were reported for 18.6 percent of patients (200), with 50 percent (100) reported within the first three years, and 75 percent (150) reported within the first 5.5 years. After 5.5 years post-treatment, the rates of secondary malignancies decreased to <1 percent per year. There were no significant differences in the rates of second malignancies among all four study arms.

At five years, the prevalence of grade 3, 4 or 5 toxicity, any feeding tube use after 180 days or feeding tube use at one year did not differ significantly when the SFX arm was compared to the three experimental arms. Grade 3, 4 or 5 toxicity tended to be decreased for patients treated over seven weeks compared to those treated over six weeks (9.0 percent vs. 16.7 percent, respectively), and 4.8 percent of disease-free patients treated with HFX had feeding tubes compared to 13.0 percent of patients treated with AFX-C.

At five-years post-trea
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Contact: Michelle Kirkwood
press@astro.org
703-286-1600
American Society for Radiation Oncology
Source:Eurekalert

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